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Items: 1 to 50 of 134

1.

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.

König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O.

Cell Chem Biol. 2019 Apr 18;26(4):524-534.e5. doi: 10.1016/j.chembiol.2019.01.001. Epub 2019 Feb 7.

PMID:
30745237
2.

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A.

Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5.

3.

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.

Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O.

Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w.

4.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S, Pergola C, Dehm F, Rossi A, Gerstmeier J, Troisi F, Pein H, Schaible AM, Weinigel C, Rummler S, Northoff H, Laufer S, Maier TJ, Rådmark O, Samuelsson B, Koeberle A, Sautebin L, Werz O.

J Clin Invest. 2017 Aug 1;127(8):3167-3176. doi: 10.1172/JCI92885. Epub 2017 Jul 24.

5.

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.

Pein H, Koeberle SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A.

FASEB J. 2017 Oct;31(10):4566-4577. doi: 10.1096/fj.201700078R. Epub 2017 Jul 7.

PMID:
28687611
6.

Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy.

Pace S, Sautebin L, Werz O.

Biochem Pharmacol. 2017 Dec 1;145:1-11. doi: 10.1016/j.bcp.2017.06.128. Epub 2017 Jun 22. Review.

PMID:
28647490
7.

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation.

Pace S, Rossi A, Krauth V, Dehm F, Troisi F, Bilancia R, Weinigel C, Rummler S, Werz O, Sautebin L.

Sci Rep. 2017 Jun 19;7(1):3759. doi: 10.1038/s41598-017-03696-8.

8.

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.

Svouraki A, Garscha U, Kouloura E, Pace S, Pergola C, Krauth V, Rossi A, Sautebin L, Halabalaki M, Werz O, Gaboriaud-Kolar N, Skaltsounis AL.

J Nat Prod. 2017 Mar 24;80(3):699-706. doi: 10.1021/acs.jnatprod.6b01008. Epub 2017 Feb 27.

PMID:
28240894
9.

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly.

Garscha U, Voelker S, Pace S, Gerstmeier J, Emini B, Liening S, Rossi A, Weinigel C, Rummler S, Schubert US, Scriba GK, Çelikoğlu E, Çalışkan B, Banoglu E, Sautebin L, Werz O.

Biochem Pharmacol. 2016 Nov 1;119:17-26. doi: 10.1016/j.bcp.2016.08.023. Epub 2016 Aug 31.

PMID:
27592027
10.

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.

Di Capua A, Sticozzi C, Brogi S, Brindisi M, Cappelli A, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Valacchi G, Giorgi G, Giordani A, Poce G, Biava M, Anzini M.

Eur J Med Chem. 2016 Feb 15;109:99-106. doi: 10.1016/j.ejmech.2015.12.044. Epub 2015 Dec 28.

PMID:
26774035
11.

Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids.

Galuppo M, Rossi A, Giacoppo S, Pace S, Bramanti P, Sautebin L, Mazzon E.

Pharmacol Res. 2015 Sep;99:316-28. doi: 10.1016/j.phrs.2015.07.013. Epub 2015 Jul 17.

PMID:
26192346
12.

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, Collado JA, Werz O.

J Med Chem. 2014 Jul 10;57(13):5638-48. doi: 10.1021/jm500308c. Epub 2014 Jun 24.

PMID:
24920381
13.

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release.

Battilocchio C, Guetzoyan L, Cervetto C, Di Cesare Mannelli L, Frattaroli D, Baxendale IR, Maura G, Rossi A, Sautebin L, Biava M, Ghelardini C, Marcoli M, Ley SV.

ACS Med Chem Lett. 2013 May 22;4(8):704-9. doi: 10.1021/ml400079h. eCollection 2013 Aug 8.

14.

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis.

Rossi A, Pergola C, Pace S, Rådmark O, Werz O, Sautebin L.

Pharmacol Res. 2014 Sep;87:1-7. doi: 10.1016/j.phrs.2014.05.011. Epub 2014 Jun 2.

PMID:
24892983
15.

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).

Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O.

Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625.

16.

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M.

Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18.

PMID:
24373735
17.

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15.

PMID:
24171493
18.

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.

Martelli A, Testai L, Anzini M, Cappelli A, Di Capua A, Biava M, Poce G, Consalvi S, Giordani A, Caselli G, Rovati L, Ghelardini C, Patrignani P, Sautebin L, Breschi MC, Calderone V.

Pharmacol Res. 2013 Dec;78:1-9. doi: 10.1016/j.phrs.2013.09.008. Epub 2013 Sep 29.

PMID:
24083950
19.

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.

Battilocchio C, Poce G, Alfonso S, Porretta GC, Consalvi S, Sautebin L, Pace S, Rossi A, Ghelardini C, Di Cesare Mannelli L, Schenone S, Giordani A, Di Francesco L, Patrignani P, Biava M.

Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031. Epub 2013 Apr 26.

PMID:
23680444
20.

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

Anzini M, Di Capua A, Valenti S, Brogi S, Rovini M, Giuliani G, Cappelli A, Vomero S, Chiasserini L, Sega A, Poce G, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Benetti V, Giordani A, Anzellotti P, Dovizio M, Patrignani P, Biava M.

J Med Chem. 2013 Apr 25;56(8):3191-206. doi: 10.1021/jm301370e. Epub 2013 Apr 11. Erratum in: J Med Chem. 2013 Jun 13;56(11):4821.

PMID:
23534442
21.

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats.

Gerbeth K, Hüsch J, Meins J, Rossi A, Sautebin L, Wiechmann K, Werz O, Skarke C, Barrett JS, Schubert-Zsilavecz M, Abdel-Tawab M.

Planta Med. 2012 Dec;78(18):1932-8. doi: 10.1055/s-0032-1327881. Epub 2012 Nov 13.

PMID:
23150076
22.

Evaluation of cosmetic product exposures reported to the Milan Poison Control Centre, Italy from 2005 to 2010.

Ruggiero S, Moro PA, Davanzo F, Capuano A, Rossi F, Sautebin L.

Clin Toxicol (Phila). 2012 Dec;50(10):902-10. doi: 10.3109/15563650.2012.740484. Epub 2012 Nov 8.

PMID:
23134375
23.

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Porretta GC, Schenone S, Calderone V, Martelli A, Testai L, Ghelardini C, Di Cesare Mannelli L, Sautebin L, Rossi A, Giordani A, Patrignani P, Anzini M.

Eur J Med Chem. 2012 Dec;58:287-98. doi: 10.1016/j.ejmech.2012.10.014. Epub 2012 Oct 18.

PMID:
23131542
24.

The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo.

Rossi A, Dehm F, Kiesselbach C, Haunschild J, Sautebin L, Werz O.

Fitoterapia. 2012 Jun;83(4):715-20. doi: 10.1016/j.fitote.2012.02.008. Epub 2012 Mar 2.

PMID:
22406452
25.

Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo.

Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G.

J Pharmacol Exp Ther. 2012 Mar;340(3):716-22. doi: 10.1124/jpet.111.189308. Epub 2011 Dec 13.

PMID:
22171091
26.

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.

Biava M, Porretta GC, Poce G, Battilocchio C, Alfonso S, Rovini M, Valenti S, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Papa G, Ghelardini C, Di Cesare Mannelli L, Giordani A, Anzellotti P, Bruno A, Patrignani P, Anzini M.

J Med Chem. 2011 Nov 24;54(22):7759-71. doi: 10.1021/jm200715n. Epub 2011 Oct 31.

PMID:
21992176
27.

On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.

Pergola C, Jazzar B, Rossi A, Northoff H, Hamburger M, Sautebin L, Werz O.

Br J Pharmacol. 2012 Feb;165(3):765-76. doi: 10.1111/j.1476-5381.2011.01605.x.

28.

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.

Pergola C, Rogge A, Dodt G, Northoff H, Weinigel C, Barz D, Rådmark O, Sautebin L, Werz O.

FASEB J. 2011 Oct;25(10):3377-87. doi: 10.1096/fj.11-182758. Epub 2011 Jun 21.

PMID:
21693622
29.

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo.

Koeberle A, Rossi A, Bauer J, Dehm F, Verotta L, Northoff H, Sautebin L, Werz O.

Front Pharmacol. 2011 Feb 18;2:7. doi: 10.3389/fphar.2011.00007. eCollection 2011.

30.

2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo.

Greiner C, Hörnig C, Rossi A, Pergola C, Zettl H, Schubert-Zsilavecz M, Steinhilber D, Sautebin L, Werz O.

Br J Pharmacol. 2011 Sep;164(2b):781-93. doi: 10.1111/j.1476-5381.2011.01451.x.

31.

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase.

Pergola C, Jazzar B, Rossi A, Buehring U, Luderer S, Dehm F, Northoff H, Sautebin L, Werz O.

J Pharmacol Exp Ther. 2011 Jul;338(1):205-13. doi: 10.1124/jpet.111.180794. Epub 2011 Mar 29.

PMID:
21447614
32.

Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Biava M, Porretta GC, Poce G, Battilocchio C, Botta M, Manetti F, Rovini M, Cappelli A, Sautebin L, Rossi A, Pergola C, Ghelardini C, Galeotti N, Makovec F, Giordani A, Anzellotti P, Tacconelli S, Patrignani P, Anzini M.

Curr Med Chem. 2011;18(10):1540-54. Review.

PMID:
21428878
33.

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.

Bauer J, Koeberle A, Dehm F, Pollastro F, Appendino G, Northoff H, Rossi A, Sautebin L, Werz O.

Biochem Pharmacol. 2011 Jan 15;81(2):259-68. doi: 10.1016/j.bcp.2010.09.025. Epub 2010 Oct 8.

PMID:
20933508
34.

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages.

Rossi A, Pergola C, Koeberle A, Hoffmann M, Dehm F, Bramanti P, Cuzzocrea S, Werz O, Sautebin L.

Br J Pharmacol. 2010 Oct;161(3):555-70. doi: 10.1111/j.1476-5381.2010.00930.x.

35.

Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.

Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier TJ, Jauch J, Northoff H, Bernhard F, Doetsch V, Sautebin L, Werz O.

Br J Pharmacol. 2011 Jan;162(1):147-62. doi: 10.1111/j.1476-5381.2010.01020.x.

36.

Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.

di Villa Bianca Rd, Coletta C, Mitidieri E, De Dominicis G, Rossi A, Sautebin L, Cirino G, Bucci M, Sorrentino R.

Br J Pharmacol. 2010 Dec;161(8):1835-42. doi: 10.1111/j.1476-5381.2010.01016.x.

37.

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.

Biava M, Porretta GC, Poce G, Battilocchio C, Manetti F, Botta M, Forli S, Sautebin L, Rossi A, Pergola C, Ghelardini C, Galeotti N, Makovec F, Giordani A, Anzellotti P, Patrignani P, Anzini M.

J Med Chem. 2010 Jan 28;53(2):723-33. doi: 10.1021/jm901269y.

PMID:
19957931
38.

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24.

PMID:
19934399
39.

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O.

Bioorg Med Chem. 2009 Dec 1;17(23):7924-32. doi: 10.1016/j.bmc.2009.10.025. Epub 2009 Oct 31.

PMID:
19884011
40.

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O.

Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5.

PMID:
19579006
41.

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O.

J Med Chem. 2009 Jun 11;52(11):3474-83. doi: 10.1021/jm900212y.

PMID:
19492852
42.

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock.

Rossi A, Cuzzocrea S, Sautebin L.

Curr Vasc Pharmacol. 2009 Apr;7(2):185-97. Review.

PMID:
19356002
43.

Drug safety information through the internet: the experience of an Italian website.

Polimeni G, Russo A, Catania MA, Aiello A, Oteri A, Trifirò G, Calapai G, Sautebin L, Iacobelli M, Caputi AP.

Drug Saf. 2009;32(3):245-53. doi: 10.2165/00002018-200932030-00007.

PMID:
19338382
44.

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.

Pergola C, Dodt G, Rossi A, Neunhoeffer E, Lawrenz B, Northoff H, Samuelsson B, Rådmark O, Sautebin L, Werz O.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19881-6. doi: 10.1073/pnas.0809120105. Epub 2008 Dec 8.

45.

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo.

Rossi A, Di Paola R, Mazzon E, Genovese T, Caminiti R, Bramanti P, Pergola C, Koeberle A, Werz O, Sautebin L, Cuzzocrea S.

J Pharmacol Exp Ther. 2009 Apr;329(1):76-86. doi: 10.1124/jpet.108.143214. Epub 2008 Dec 4.

PMID:
19056932
46.

Notification of undesirable effects of cosmetics and toiletries.

Sportiello L, Cammarota S, de Portu S, Sautebin L.

Pharmacol Res. 2009 Feb;59(2):101-6. doi: 10.1016/j.phrs.2008.10.008. Epub 2008 Nov 6.

PMID:
19028583
47.

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Biava M, Porretta GC, Poce G, Supino S, Manetti F, Forli S, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Makovec F, Giordani A, Anzellotti P, Cirilli R, Ferretti R, Gallinella B, La Torre F, Anzini M, Patrignani P.

Bioorg Med Chem. 2008 Sep 1;16(17):8072-81. doi: 10.1016/j.bmc.2008.07.058. Epub 2008 Jul 24.

PMID:
18752957
48.

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.

Anzini M, Rovini M, Cappelli A, Vomero S, Manetti F, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Giordani A, Makovec F, Anzellotti P, Patrignani P, Biava M.

J Med Chem. 2008 Aug 14;51(15):4476-81. doi: 10.1021/jm800084s. Epub 2008 Jul 4.

PMID:
18598017
49.
50.

Effects of zileuton and montelukast in mouse experimental spinal cord injury.

Genovese T, Rossi A, Mazzon E, Di Paola R, Muià C, Caminiti R, Bramanti P, Sautebin L, Cuzzocrea S.

Br J Pharmacol. 2008 Feb;153(3):568-82. Epub 2007 Dec 3.

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