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Items: 33

1.

2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds.

Speake JD, Navas F, Bishop MJ, Garrison DT, Bigham EC, Hodson SJ, Saussy DL, Liacos JA, Irving PE, Sherman BW.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1183-6.

PMID:
12643939
2.

Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.

Hodson SJ, Bigham EC, Garrison DT, Gobel MJ, Irving PE, Liacos JA, Navas F 3rd, Saussy DL Jr, Sherman BW, Speake JD, Bishop MJ.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3449-52.

PMID:
12419381
3.

2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.

Hodson SJ, Bishop MJ, Speake JD, Navas F 3rd, Garrison DT, Bigham EC, Saussy DL Jr, Liacos JA, Irving PE, Gobel MJ, Sherman BW.

J Med Chem. 2002 May 23;45(11):2229-39.

PMID:
12014961
4.

2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.

Navas F 3rd, Bishop MJ, Garrison DT, Hodson SJ, Speake JD, Bigham EC, Drewry DH, Saussy DL, Liacos JH, Irving PE, Gobel MJ.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):575-9.

PMID:
11844675
5.

alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.

Bishop MJ, Barvian KA, Berman J, Bigham EC, Garrison DT, Gobel MJ, Hodson SJ, Irving PE, Liacos JA, Navas F 3rd, Saussy DL, Speake JD.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):471-5.

PMID:
11814822
6.

2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.

Bishop MJ, Berman J, Bigham EC, Garrison DT, Gobel MJ, Hodson SJ, Irving PE, Liacos JA, Minick DJ, Navas F, Saussy DL Jr, Speake JD.

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2871-4.

PMID:
11597419
7.

Development of scintillation-proximity assays for alpha adrenoceptors.

Gobel J, Saussy DL, Goetz AS.

J Pharmacol Toxicol Methods. 1999 Dec;42(4):237-44.

PMID:
11033439
8.

Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies.

Jackson WT, Froelich LL, Boyd RJ, Schrementi JP, Saussy DL Jr, Schultz RM, Sawyer JS, Sofia MJ, Herron DK, Goodson T Jr, Snyder DW, Pechous PA, Spaethe SM, Roman CR, Fleisch JH.

J Pharmacol Exp Ther. 1999 Jan;288(1):286-94.

PMID:
9862783
9.

The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.

Sofia MJ, Floreancig P, Bach N, Baker SR, Nelson K, Sawyer JS, Baldwin R, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, Saussy DL Jr, Silbaugh SA, Spaethe SM, Stengel PW.

Adv Exp Med Biol. 1997;400A:381-6. No abstract available.

PMID:
9547580
10.
11.
12.

The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.

Piascik MT, Guarino RD, Smith MS, Soltis EE, Saussy DL Jr, Perez DM.

J Pharmacol Exp Ther. 1995 Dec;275(3):1583-9.

PMID:
8531132
13.

BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors.

Goetz AS, King HK, Ward SD, True TA, Rimele TJ, Saussy DL Jr.

Eur J Pharmacol. 1995 Jan 16;272(2-3):R5-6.

PMID:
7713154
14.

Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes.

Goetz AS, Lutz MW, Rimele TJ, Saussy DL Jr.

J Pharmacol Exp Ther. 1994 Dec;271(3):1228-33.

PMID:
7996431
15.

Effect of alkaline phosphatase on thromboxane mimetic induced platelet activation.

Margolin N, True TA, Saussy DL Jr, Mais DE.

Prostaglandins. 1994 Oct;48(4):235-46.

PMID:
7878191
16.

Characterization of thromboxane A2/prostaglandin H2 binding sites in guinea pig cardiac membrane preparations.

Bowling N, Dubé GP, Kurtz WL, Brune KA, Saussy DL Jr, Dorn GW 2nd, Mais DE.

J Mol Cell Cardiol. 1994 Jul;26(7):915-23.

PMID:
7966360
17.

Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.

Sawyer JS, Baldwin RF, Sofia MJ, Floreancig P, Marder P, Saussy DL Jr, Froelich LL, Silbaugh SA, Stengel PW, Cockerham SL, et al.

J Med Chem. 1993 Nov 26;36(24):3982-4. No abstract available.

PMID:
8254628
18.

Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.

Silbaugh SA, Stengel PW, Cockerham SL, Roman CR, Saussy DL Jr, Spaethe SM, Goodson T Jr, Herron DK, Fleisch JH.

Eur J Pharmacol. 1992 Nov 13;223(1):57-64.

PMID:
1335877
19.

Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes.

Saussy DL Jr, Clark PD, Gunn DL, Mais DE, Froelich LL.

Eicosanoids. 1992;5(1):1-4.

PMID:
1419073
20.

Binding of a radioiodinated agonist to thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors in guinea pig lung membranes.

Mais DE, Saussy DL Jr, Magee DE, Williams CM.

Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:347-50. No abstract available.

PMID:
1825567
21.

Characterization of thromboxane A2/prostaglandin H2 receptors of various tissues using a new radioiodinated thromboxane A2/prostaglandin H2 mimetic, I-BOP.

Morinelli TA, Naka M, Masuda A, Oatis JE Jr, Okwu AK, Mais DE, Saussy DL Jr, Halushka PV.

Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:331-7. No abstract available.

PMID:
1825565
22.

Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic.

Saussy DL Jr, Mais DE, Dubé GP, Magee DE, Brune KA, Kurtz WL, Williams CM.

Mol Pharmacol. 1991 Jan;39(1):72-8.

PMID:
1824791
23.
24.

Mechanisms of leukotriene E4 partial agonist activity at leukotriene D4 receptors in differentiated U-937 cells.

Saussy DL Jr, Sarau HM, Foley JJ, Mong S, Crooke ST.

J Biol Chem. 1989 Nov 25;264(33):19845-55.

25.

Subcellular localization of a thromboxane A2/prostaglandin H2 receptor antagonist binding site in human platelets.

Saussy DL Jr, Mais DE, Baron DA, Pepkowitz SH, Halushka PV.

Biochem Pharmacol. 1988 Feb 15;37(4):647-54.

PMID:
2963640
26.

Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors.

Halushka PV, Mais DE, Saussy DL Jr.

Fed Proc. 1987 Jan;46(1):149-53. Review.

PMID:
2948839
27.

Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes.

Saussy DL Jr, Mais DE, Burch RM, Halushka PV.

J Biol Chem. 1986 Mar 5;261(7):3025-9.

28.

Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to washed human platelets.

Mais DE, Burch RM, Saussy DL Jr, Kochel PJ, Halushka PV.

J Pharmacol Exp Ther. 1985 Dec;235(3):729-34.

PMID:
3001275
29.

Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle.

Saussy DL Jr, Mais DE, Knapp DR, Halushka PV.

Circulation. 1985 Dec;72(6):1202-7.

PMID:
2998641
30.

Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets.

Burch RM, Mais DE, Saussy DL Jr, Halushka PV.

Proc Natl Acad Sci U S A. 1985 Nov;82(21):7434-8.

31.

Binding of an 125I-labeled thromboxane A2/prostaglandin H2 receptor antagonist to washed canine platelets.

Mais DE, Kochel PJ, Saussy DL Jr, Halushka PV.

Mol Pharmacol. 1985 Aug;28(2):163-9.

PMID:
2991736
32.

Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors.

Mais DE, Saussy DL Jr, Chaikhouni A, Kochel PJ, Knapp DR, Hamanaka N, Halushka PV.

J Pharmacol Exp Ther. 1985 May;233(2):418-24.

PMID:
2987481
33.

A novel approach for the study of thromboxane A2 and prostaglandin H2 receptors using an 125I-labeled ligand.

Halushka PV, MacDermot J, Knapp DR, Eller T, Saussy DL Jr, Mais D, Blair IA, Dollery CT.

Biochem Pharmacol. 1985 Apr 15;34(8):1165-70.

PMID:
2986639

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