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PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.

Smith RJ, Cordeiro MH, Davey NE, Vallardi G, Ciliberto A, Gross F, Saurin AT.

Cell Rep. 2019 Aug 20;28(8):2206-2219.e8. doi: 10.1016/j.celrep.2019.07.067.


PLZF limits enhancer activity during hematopoietic progenitor aging.

Poplineau M, Vernerey J, Platet N, N'guyen L, Hérault L, Esposito M, Saurin AJ, Guilouf C, Iwama A, Duprez E.

Nucleic Acids Res. 2019 May 21;47(9):4509-4520. doi: 10.1093/nar/gkz174.


Division of labour between PP2A-B56 isoforms at the centromere and kinetochore.

Vallardi G, Allan LA, Crozier L, Saurin AT.

Elife. 2019 Mar 4;8. pii: e42619. doi: 10.7554/eLife.42619.


Fattening the perspective of Hox protein specificity through SLiMming.

Rinaldi L, Saurin AJ, Graba Y.

Int J Dev Biol. 2018;62(11-12):755-766. doi: 10.1387/ijdb.180306yg.


The Generic Facet of Hox Protein Function: (Trends in Genetics 34, 941-953, 2018).

Saurin AJ, Delfini MC, Maurel-Zaffran C, Graba Y.

Trends Genet. 2019 Apr;35(4):316. doi: 10.1016/j.tig.2018.11.006. Epub 2018 Dec 7. No abstract available.


Publisher Correction: Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.

Arechederra M, Daian F, Yim A, Bazai SK, Richelme S, Dono R, Saurin AJ, Habermann BH, Maina F.

Nat Commun. 2018 Sep 25;9(1):3976. doi: 10.1038/s41467-018-06482-w.


The Generic Facet of Hox Protein Function.

Saurin AJ, Delfini MC, Maurel-Zaffran C, Graba Y.

Trends Genet. 2018 Dec;34(12):941-953. doi: 10.1016/j.tig.2018.08.006. Epub 2018 Sep 18. Review. Erratum in: Trends Genet. 2019 Apr;35(4):316.


Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.

Arechederra M, Daian F, Yim A, Bazai SK, Richelme S, Dono R, Saurin AJ, Habermann BH, Maina F.

Nat Commun. 2018 Aug 8;9(1):3164. doi: 10.1038/s41467-018-05550-5. Erratum in: Nat Commun. 2018 Sep 25;9(1):3976.


Kinase and Phosphatase Cross-Talk at the Kinetochore.

Saurin AT.

Front Cell Dev Biol. 2018 Jun 19;6:62. doi: 10.3389/fcell.2018.00062. eCollection 2018. Review.


The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression.

Sen O, Saurin AT, Higgins JMG.

Sci Rep. 2018 May 21;8(1):7898. doi: 10.1038/s41598-018-26307-6.


USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability.

Skowyra A, Allan LA, Saurin AT, Clarke PR.

Cell Rep. 2018 Apr 17;23(3):852-865. doi: 10.1016/j.celrep.2018.03.100.


Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles.

Gelens L, Saurin AT.

Dev Cell. 2018 Mar 26;44(6):659-663. doi: 10.1016/j.devcel.2018.03.002.


Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity.

Koubi M, Poplineau M, Vernerey J, N'Guyen L, Tiberi G, Garciaz S, El-Kaoutari A, Maqbool MA, Andrau JC, Guillouf C, Saurin AJ, Duprez E.

Nucleic Acids Res. 2018 Apr 20;46(7):3339-3350. doi: 10.1093/nar/gky080.


The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.

Smith L, Farzan R, Ali S, Buluwela L, Saurin AT, Meek DW.

Sci Rep. 2017 Nov 23;7(1):16115. doi: 10.1038/s41598-017-16394-2. Erratum in: Sci Rep. 2018 Mar 22;8(1):5237.


A fine balancing act: A delicate kinase-phosphatase equilibrium that protects against chromosomal instability and cancer.

Cordeiro MH, Smith RJ, Saurin AT.

Int J Biochem Cell Biol. 2018 Mar;96:148-156. doi: 10.1016/j.biocel.2017.10.017. Epub 2017 Nov 3. Review.


The Importance of Kinase-Phosphatase Integration: Lessons from Mitosis.

Gelens L, Qian J, Bollen M, Saurin AT.

Trends Cell Biol. 2018 Jan;28(1):6-21. doi: 10.1016/j.tcb.2017.09.005. Epub 2017 Oct 28. Review.


The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.

Zouaz A, Auradkar A, Delfini MC, Macchi M, Barthez M, Ela Akoa S, Bastianelli L, Xie G, Deng WM, Levine SS, Graba Y, Saurin AJ.

EMBO J. 2017 Oct 2;36(19):2887-2906. doi: 10.15252/embj.201695751. Epub 2017 Sep 4.


A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC.

Vallardi G, Cordeiro MH, Saurin AT.

Prog Mol Subcell Biol. 2017;56:457-484. doi: 10.1007/978-3-319-58592-5_19. Review.


Hox functional diversity: Novel insights from flexible motif folding and plastic protein interaction.

Ortiz-Lombardia M, Foos N, Maurel-Zaffran C, Saurin AJ, Graba Y.

Bioessays. 2017 Apr;39(4). doi: 10.1002/bies.201600246. Epub 2017 Jan 16. Review.


Hox Service Warranty Extends to Adult Bone Repair.

Saurin AJ, Delfini MC, Graba Y.

Dev Cell. 2016 Dec 19;39(6):627-629. doi: 10.1016/j.devcel.2016.12.007.


Studying Kinetochore Kinases.

Saurin AT, Kops GJ.

Methods Mol Biol. 2016;1413:333-47. doi: 10.1007/978-1-4939-3542-0_21.


Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis.

Kerridge S, Munjal A, Philippe JM, Jha A, de las Bayonas AG, Saurin AJ, Lecuit T.

Nat Cell Biol. 2016 Mar;18(3):261-70. doi: 10.1038/ncb3302. Epub 2016 Jan 18.


Meeting report--Getting Into and Out of Mitosis.

Mchedlishvili N, Jonak K, Saurin AT.

J Cell Sci. 2015 Nov 15;128(22):4035-8. doi: 10.1242/jcs.181107.


Cellular and molecular insights into Hox protein action.

Rezsohazy R, Saurin AJ, Maurel-Zaffran C, Graba Y.

Development. 2015 Apr 1;142(7):1212-27. doi: 10.1242/dev.109785. Review.


Mitotic kinases and phosphatases cooperate to shape the right response.

Vallardi G, Saurin AT.

Cell Cycle. 2015;14(6):795-6. doi: 10.1080/15384101.2015.1006546.


A flexible extension of the Drosophila ultrabithorax homeodomain defines a novel Hox/PBC interaction mode.

Foos N, Maurel-Zaffran C, Maté MJ, Vincentelli R, Hainaut M, Berenger H, Pradel J, Saurin AJ, Ortiz-Lombardía M, Graba Y.

Structure. 2015 Feb 3;23(2):270-9. doi: 10.1016/j.str.2014.12.011.


Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.

Müllers E, Silva Cascales H, Jaiswal H, Saurin AT, Lindqvist A.

Cell Cycle. 2014;13(17):2733-43. doi: 10.4161/15384101.2015.945831.


Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT.

Nat Cell Biol. 2014 Dec;16(12):1257-64. doi: 10.1038/ncb3065. Epub 2014 Nov 17.


Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJ, Voest EE, Medema RH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7313-8. doi: 10.1073/pnas.1322021111. Epub 2014 Apr 7.


Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.

Kuijt TE, Omerzu M, Saurin AT, Kops GJ.

Chromosoma. 2014 Oct;123(5):471-80. doi: 10.1007/s00412-014-0458-9. Epub 2014 Apr 4.


Assessing kinetics from fixed cells reveals activation of the mitotic entry network at the S/G2 transition.

Akopyan K, Silva Cascales H, Hukasova E, Saurin AT, Müllers E, Jaiswal H, Hollman DA, Kops GJ, Medema RH, Lindqvist A.

Mol Cell. 2014 Mar 6;53(5):843-53. doi: 10.1016/j.molcel.2014.01.031. Epub 2014 Feb 27.


Hox proteins mediate developmental and environmental control of autophagy.

Banreti A, Hudry B, Sass M, Saurin AJ, Graba Y.

Dev Cell. 2014 Jan 13;28(1):56-69. doi: 10.1016/j.devcel.2013.11.024. Epub 2014 Jan 2.


Mps1 promotes rapid centromere accumulation of Aurora B.

van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM.

EMBO Rep. 2012 Sep;13(9):847-54. doi: 10.1038/embor.2012.93. Epub 2012 Jun 26.


Characterisation of genome-wide PLZF/RARA target genes.

Spicuglia S, Vincent-Fabert C, Benoukraf T, Tibéri G, Saurin AJ, Zacarias-Cabeza J, Grimwade D, Mills K, Calmels B, Bertucci F, Sieweke M, Ferrier P, Duprez E.

PLoS One. 2011;6(9):e24176. doi: 10.1371/journal.pone.0024176. Epub 2011 Sep 20.


mTORC2 targets AGC kinases through Sin1-dependent recruitment.

Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ.

Biochem J. 2011 Oct 15;439(2):287-97. doi: 10.1042/BJ20110678.


Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ.

Nat Commun. 2011;2:316. doi: 10.1038/ncomms1319.


Finding the middle ground: how kinetochores power chromosome congression.

Kops GJ, Saurin AT, Meraldi P.

Cell Mol Life Sci. 2010 Jul;67(13):2145-61. doi: 10.1007/s00018-010-0321-y. Epub 2010 Mar 16. Review.


Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.

Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ.

EMBO Rep. 2009 Sep;10(9):983-9. doi: 10.1038/embor.2009.150. Epub 2009 Aug 7.


PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

Cameron AJ, Escribano C, Saurin AT, Kostelecky B, Parker PJ.

Nat Struct Mol Biol. 2009 Jun;16(6):624-30. doi: 10.1038/nsmb.1606. Epub 2009 May 24.


The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

Boukarabila H, Saurin AJ, Batsché E, Mossadegh N, van Lohuizen M, Otte AP, Pradel J, Muchardt C, Sieweke M, Duprez E.

Genes Dev. 2009 May 15;23(10):1195-206. doi: 10.1101/gad.512009.


Protein kinase C epsilon in cell division: control of abscission.

Saurin AT, Brownlow N, Parker PJ.

Cell Cycle. 2009 Feb 15;8(4):549-55. Epub 2009 Feb 19.


The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis.

Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ.

Nat Cell Biol. 2008 Aug;10(8):891-901. doi: 10.1038/ncb1749. Epub 2008 Jul 6.


The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.


Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.

Diop SB, Bertaux K, Vasanthi D, Sarkeshik A, Goirand B, Aragnol D, Tolwinski NS, Cole MD, Pradel J, Yates JR 3rd, Mishra RK, Graba Y, Saurin AJ.

EMBO Rep. 2008 Mar;9(3):260-6. doi: 10.1038/embor.2008.8. Epub 2008 Feb 8.


The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily.

Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ.

Biochem J. 2008 Apr 15;411(2):319-31. doi: 10.1042/bj20071348.


Protein kinases, from B to C.

Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1013-7. Review.


Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress.

Muqit MM, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, Eaton S, Payne Smith MD, Venner K, Matilla A, Healy DG, Gilks WP, Lees AJ, Holton J, Revesz T, Parker PJ, Harvey RJ, Wood NW, Latchman DS.

J Neurochem. 2006 Jul;98(1):156-69.


Widespread sulfenic acid formation in tissues in response to hydrogen peroxide.

Saurin AT, Neubert H, Brennan JP, Eaton P.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17982-7. Epub 2004 Dec 16.


Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.

Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS.

Circ Res. 2003 Aug 8;93(3):254-61. Epub 2003 Jun 26.


Reptin and pontin antagonistically regulate heart growth in zebrafish embryos.

Rottbauer W, Saurin AJ, Lickert H, Shen X, Burns CG, Wo ZG, Kemler R, Kingston R, Wu C, Fishman M.

Cell. 2002 Nov 27;111(5):661-72.

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