Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 216

1.

Deciphering the universe of genetic context-dependencies using mouse models of cancer.

Falcomatà C, Bärthel S, Schneider G, Saur D, Veltkamp C.

Curr Opin Genet Dev. 2019 May 8;54:97-104. doi: 10.1016/j.gde.2019.04.002. [Epub ahead of print] Review.

PMID:
31078084
2.

The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis.

Perkowska A, Flisikowska T, Perleberg C, Flisikowski K, Stachowiak M, Nowacka-Woszuk J, Saur D, Kind A, Schnieke A, Switonski M.

Anim Biotechnol. 2019 Apr 5:1-8. doi: 10.1080/10495398.2019.1590377. [Epub ahead of print]

PMID:
30950765
3.

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.

Fabian A, Stegner S, Miarka L, Zimmermann J, Lenk L, Rahn S, Buttlar J, Viol F, Knaack H, Esser D, Schäuble S, Großmann P, Marinos G, Häsler R, Mikulits W, Saur D, Kaleta C, Schäfer H, Sebens S.

Cancer Lett. 2019 Jul 1;453:95-106. doi: 10.1016/j.canlet.2019.03.039. Epub 2019 Mar 28.

PMID:
30930235
4.

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.

Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R.

Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3.

5.

Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging.

Jesinghaus M, Brühl F, Steiger K, Klare P, Reiser M, Scheiter A, Konukiewitz B, Kuhn P, Münch S, Quante M, Schmid RM, Wilhelm D, Feith M, Friess H, Combs SE, Saur D, Boxberg M, Weichert W.

Am J Surg Pathol. 2019 May;43(5):618-627. doi: 10.1097/PAS.0000000000001230.

PMID:
30807302
6.

Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses.

Besnard A, Gao Y, TaeWoo Kim M, Twarkowski H, Reed AK, Langberg T, Feng W, Xu X, Saur D, Zweifel LS, Davison I, Sahay A.

Nat Neurosci. 2019 Mar;22(3):436-446. doi: 10.1038/s41593-018-0330-y. Epub 2019 Feb 4.

PMID:
30718902
7.

When less is more: Structural correlates of core executive functions in young adults - A VBM and cortical thickness study.

Weise CM, Bachmann T, Schroeter ML, Saur D.

Neuroimage. 2019 Apr 1;189:896-903. doi: 10.1016/j.neuroimage.2019.01.070. Epub 2019 Feb 1.

PMID:
30716455
8.

Dual Time-Point [18F]Florbetaben PET Delivers Dual Biomarker Information in Mild Cognitive Impairment and Alzheimer's Disease.

Florek L, Tiepolt S, Schroeter ML, Berrouschot J, Saur D, Hesse S, Jochimsen T, Luthardt J, Sattler B, Patt M, Hoffmann KT, Villringer A, Classen J, Gertz HJ, Sabri O, Barthel H.

J Alzheimers Dis. 2018;66(3):1105-1116. doi: 10.3233/JAD-180522.

PMID:
30400095
9.

c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells.

Kwak M, Ninche N, Klein S, Saur D, Ghazizadeh S.

Sci Rep. 2018 Sep 21;8(1):14193. doi: 10.1038/s41598-018-32557-1.

10.

Pharmacokinetics of Single-dose Ertugliflozin in Patients With Hepatic Impairment.

Sahasrabudhe V, Terra SG, Hickman A, Saur D, Raje S, Shi H, Matschke K, Zhou S, Cutler DL.

Clin Ther. 2018 Oct;40(10):1701-1710. doi: 10.1016/j.clinthera.2018.06.015. Epub 2018 Sep 14.

PMID:
30224193
11.

Delayed Post-hypoxic Leukoencephalopathy (DPHL)-An Uncommon Variant of Hypoxic Brain Damage in Adults.

Beeskow AB, Oberstadt M, Saur D, Hoffmann KT, Lobsien D.

Front Neurol. 2018 Aug 27;9:708. doi: 10.3389/fneur.2018.00708. eCollection 2018.

12.

Effect of Rifampin on the Pharmacokinetics of Ertugliflozin in Healthy Subjects.

Dawra VK, Sahasrabudhe V, Liang Y, Matschke K, Shi H, Hickman A, Saur D, Terra SG, Cutler DL.

Clin Ther. 2018 Sep;40(9):1538-1547. doi: 10.1016/j.clinthera.2018.07.014. Epub 2018 Aug 28.

PMID:
30170758
13.

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program.

Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R.

EMBO Mol Med. 2018 Oct;10(10). pii: e9085. doi: 10.15252/emmm.201809085.

14.

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.

Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.

J Clin Invest. 2018 Aug 1;128(8):3475-3489. doi: 10.1172/JCI94287. Epub 2018 Jul 16.

15.

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer.

Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK.

Dev Cell. 2018 Jun 18;45(6):696-711.e8. doi: 10.1016/j.devcel.2018.05.025.

PMID:
29920275
16.

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.

Cheung PF, Neff F, Neander C, Bazarna A, Savvatakis K, Liffers ST, Althoff K, Lee CL, Moding EJ, Kirsch DG, Saur D, Bazhin AV, Trajkovic-Arsic M, Heikenwalder MF, Siveke JT.

Cancer Res. 2018 Sep 1;78(17):4997-5010. doi: 10.1158/0008-5472.CAN-18-0052. Epub 2018 May 29.

PMID:
29844119
17.

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H.

Nat Med. 2018 Jul;24(7):954-960. doi: 10.1038/s41591-018-0024-8. Epub 2018 May 28.

PMID:
29808009
18.

Assessment of the Drug Interaction Potential of Ertugliflozin With Sitagliptin, Metformin, Glimepiride, or Simvastatin in Healthy Subjects.

Dawra VK, Cutler DL, Zhou S, Krishna R, Shi H, Liang Y, Alvey C, Hickman A, Saur D, Terra SG, Sahasrabudhe V.

Clin Pharmacol Drug Dev. 2019 Apr;8(3):314-325. doi: 10.1002/cpdd.472. Epub 2018 May 22.

PMID:
29786959
19.

Homoharringtonine could induce quick protein synthesis of PSMD11 through activating MEK1/ERK1/2 signaling pathway in pancreatic cancer cells.

Wang L, Zhao L, Wei G, Saur D, Seidler B, Wang J, Wang C, Qi T.

J Cell Biochem. 2018 Aug;119(8):6644-6656. doi: 10.1002/jcb.26847. Epub 2018 Apr 17.

PMID:
29665121
20.

Novel Application of the Two-Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin.

Raje S, Callegari E, Sahasrabudhe V, Vaz A, Shi H, Fluhler E, Woolf EJ, Schildknegt K, Matschke K, Alvey C, Zhou S, Papadopoulos D, Fountaine R, Saur D, Terra SG, Stevens L, Gaunt D, Cutler DL.

Clin Transl Sci. 2018 Jul;11(4):405-411. doi: 10.1111/cts.12549. Epub 2018 Mar 25.

21.

Kitcre knock-in mice fail to fate-map cardiac stem cells.

Vicinanza C, Aquila I, Cianflone E, Scalise M, Marino F, Mancuso T, Fumagalli F, Giovannone ED, Cristiano F, Iaccino E, Marotta P, Torella A, Latini R, Agosti V, Veltri P, Urbanek K, Isidori AM, Saur D, Indolfi C, Nadal-Ginard B, Torella D.

Nature. 2018 Mar 21;555(7697):E1-E5. doi: 10.1038/nature25771. No abstract available.

PMID:
29565363
22.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.

Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

23.

MTOR inhibitor-based combination therapies for pancreatic cancer.

Hassan Z, Schneeweis C, Wirth M, Veltkamp C, Dantes Z, Feuerecker B, Ceyhan GO, Knauer SK, Weichert W, Schmid RM, Stauber R, Arlt A, Krämer OH, Rad R, Reichert M, Saur D, Schneider G.

Br J Cancer. 2018 Feb 6;118(3):366-377. doi: 10.1038/bjc.2017.421. Epub 2018 Jan 2.

24.

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.

Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, Konukiewitz B, Öllinger R, Zwiebel M, Strong A, Yen HY, Banerjee R, Louzada S, Fu B, Seidler B, Götzfried J, Schuck K, Hassan Z, Arbeiter A, Schönhuber N, Klein S, Veltkamp C, Friedrich M, Rad L, Barenboim M, Ziegenhain C, Hess J, Dovey OM, Eser S, Parekh S, Constantino-Casas F, de la Rosa J, Sierra MI, Fraga M, Mayerle J, Klöppel G, Cadiñanos J, Liu P, Vassiliou G, Weichert W, Steiger K, Enard W, Schmid RM, Yang F, Unger K, Schneider G, Varela I, Bradley A, Saur D, Rad R.

Nature. 2018 Feb 1;554(7690):62-68. doi: 10.1038/nature25459. Epub 2018 Jan 24.

25.

A Phase 1, Randomized, Placebo- and Active-Controlled Crossover Study to Determine the Effect of Single-Dose Ertugliflozin on QTc Interval in Healthy Volunteers.

Sahasrabudhe V, Saur D, Matschke K, Terra SG, Hickman A, Huyghe I, Shi H, Cutler DL.

Clin Pharmacol Drug Dev. 2018 Jun;7(5):513-523. doi: 10.1002/cpdd.421. Epub 2018 Jan 18.

PMID:
29346837
26.

Simulated Microgravity Impairs Cardiac Autonomic Neurogenesis from Neural Crest Cells.

Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede DL, Hare JM.

Stem Cells Dev. 2018 Jun 15;27(12):819-830. doi: 10.1089/scd.2017.0265. Epub 2018 Mar 20.

27.

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.

Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017.

28.

Successful systemic thrombolysis with rtPA in a patient with history of a life-threatening rtPA-associated orolingual angioedema.

Pelz JO, Michalski D, Saur D.

eNeurologicalSci. 2017 Aug 2;8:36-37. doi: 10.1016/j.ensci.2017.08.002. eCollection 2017 Sep. No abstract available.

29.

Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?

Trinkmann F, Götzmann J, Saur D, Schroeter M, Roth K, Stach K, Borggrefe M, Saur J, Akin I, Michels JD.

BMC Pulm Med. 2017 Dec 11;17(1):185. doi: 10.1186/s12890-017-0543-y.

30.

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait.

Koch SC, Del Barrio MG, Dalet A, Gatto G, Günther T, Zhang J, Seidler B, Saur D, Schüle R, Goulding M.

Neuron. 2017 Dec 20;96(6):1419-1431.e5. doi: 10.1016/j.neuron.2017.11.011. Epub 2017 Dec 7.

31.

Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.

Rahn S, Zimmermann V, Viol F, Knaack H, Stemmer K, Peters L, Lenk L, Ungefroren H, Saur D, Schäfer H, Helm O, Sebens S.

Cancer Lett. 2018 Feb 28;415:129-150. doi: 10.1016/j.canlet.2017.12.004. Epub 2017 Dec 6.

PMID:
29222037
32.

Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis.

Stachowiak M, Flisikowska T, Bauersachs S, Perleberg C, Pausch H, Switonski M, Kind A, Saur D, Schnieke A, Flisikowski K.

Oncotarget. 2017 Oct 10;8(56):96154-96160. doi: 10.18632/oncotarget.21774. eCollection 2017 Nov 10.

33.

Neuroimaging of stroke recovery from aphasia - Insights into plasticity of the human language network.

Hartwigsen G, Saur D.

Neuroimage. 2019 Apr 15;190:14-31. doi: 10.1016/j.neuroimage.2017.11.056. Epub 2017 Nov 23. Review.

PMID:
29175498
34.

The neuronal network involved in self-attribution of an artificial hand: A lesion network-symptom-mapping study.

Wawrzyniak M, Klingbeil J, Zeller D, Saur D, Classen J.

Neuroimage. 2018 Feb 1;166:317-324. doi: 10.1016/j.neuroimage.2017.11.011. Epub 2017 Nov 6.

PMID:
29122723
35.

Hyperpolarized 13C Diffusion MRS of Co-Polarized Pyruvate and Fumarate to Measure Lactate Export and Necrosis.

Feuerecker B, Durst M, Michalik M, Schneider G, Saur D, Menzel M, Schwaiger M, Schilling F.

J Cancer. 2017 Sep 2;8(15):3078-3085. doi: 10.7150/jca.20250. eCollection 2017.

36.

Resting-state functional connectivity: An emerging method for the study of language networks in post-stroke aphasia.

Klingbeil J, Wawrzyniak M, Stockert A, Saur D.

Brain Cogn. 2019 Apr;131:22-33. doi: 10.1016/j.bandc.2017.08.005. Epub 2017 Aug 31.

PMID:
28865994
37.

Effect of ertugliflozin on glucose control, body weight, blood pressure and bone density in type 2 diabetes mellitus inadequately controlled on metformin monotherapy (VERTIS MET).

Rosenstock J, Frias J, Páll D, Charbonnel B, Pascu R, Saur D, Darekar A, Huyck S, Shi H, Lauring B, Terra SG.

Diabetes Obes Metab. 2018 Mar;20(3):520-529. doi: 10.1111/dom.13103. Epub 2017 Oct 2. Erratum in: Diabetes Obes Metab. 2018 Nov;20(11):2708.

PMID:
28857451
38.

Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.

Flisikowska T, Stachowiak M, Xu H, Wagner A, Hernandez-Caceres A, Wurmser C, Perleberg C, Pausch H, Perkowska A, Fischer K, Frishman D, Fries R, Switonski M, Kind A, Saur D, Schnieke A, Flisikowski K.

Sci Rep. 2017 Jul 26;7(1):6613. doi: 10.1038/s41598-017-06741-8.

39.

In Vivo RNAi Screening for Pancreatic Cancer Drivers: PILOTing the WDR5-MYC Axis.

Schneider G, Saur D.

Trends Cancer. 2016 Aug;2(8):391-392. doi: 10.1016/j.trecan.2016.07.002. Epub 2016 Jul 19.

PMID:
28741490
40.

The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus.

Sahasrabudhe V, Terra SG, Hickman A, Saur D, Shi H, O'Gorman M, Zhou Z, Cutler DL.

J Clin Pharmacol. 2017 Nov;57(11):1432-1443. doi: 10.1002/jcph.955. Epub 2017 Jul 13.

41.

[Network disorders in neurology].

Claßen J, Saur D, Fink GR.

Nervenarzt. 2017 Aug;88(8):837-838. doi: 10.1007/s00115-017-0372-5. German. No abstract available.

PMID:
28676944
42.

Differential spatial representation of precision and power grasps in the human motor system.

Fricke C, Gentner R, Rumpf JJ, Weise D, Saur D, Classen J.

Neuroimage. 2017 Sep;158:58-69. doi: 10.1016/j.neuroimage.2017.06.080. Epub 2017 Jun 30.

PMID:
28673880
43.

Evidence for a retinal progenitor cell in the postnatal and adult mouse.

Chen X, Wang S, Xu H, Pereira JD, Hatzistergos KE, Saur D, Seidler B, Hare JM, Perrella MA, Yin ZQ, Liu X.

Stem Cell Res. 2017 Aug;23:20-32. doi: 10.1016/j.scr.2017.06.010. Epub 2017 Jun 24.

44.

Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

Zhang H, Brainson CF, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, Chen Z, Wang X, Akbay EA, Zheng M, Palakurthi S, Sholl LM, Rustgi AK, Kwiatkowski DJ, Alan Diehl J, Bass AJ, Sharpless NE, Dranoff G, Hammerman PS, Ji H, Bardeesy N, Saur D, Watanabe H, Kim CF, Wong KK.

Nat Commun. 2017 Jun 9;8:15901. doi: 10.1038/ncomms15901.

45.

[Aphasia: a neuronal network disorder].

Stockert A, Saur D.

Nervenarzt. 2017 Aug;88(8):866-873. doi: 10.1007/s00115-017-0356-5. Review. German.

PMID:
28597028
46.

Rapid short-term reorganization in the language network.

Hartwigsen G, Bzdok D, Klein M, Wawrzyniak M, Stockert A, Wrede K, Classen J, Saur D.

Elife. 2017 May 24;6. pii: e25964. doi: 10.7554/eLife.25964.

47.

Fronto-temporal interactions are functionally relevant for semantic control in language processing.

Wawrzyniak M, Hoffstaedter F, Klingbeil J, Stockert A, Wrede K, Hartwigsen G, Eickhoff SB, Classen J, Saur D.

PLoS One. 2017 May 15;12(5):e0177753. doi: 10.1371/journal.pone.0177753. eCollection 2017.

48.

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

Zhang H, Fillmore Brainson C, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, Chen Z, Wang X, Akbay EA, Zheng M, Palakurthi S, Sholl LM, Rustgi AK, Kwiatkowski DJ, Diehl JA, Bass AJ, Sharpless NE, Dranoff G, Hammerman PS, Ji H, Bardeesy N, Saur D, Watanabe H, Kim CF, Wong KK.

Nat Commun. 2017 Apr 7;8:14922. doi: 10.1038/ncomms14922. Erratum in: Nat Commun. 2017 Jun 09;8:15901.

49.

Tissue-specific tumorigenesis: context matters.

Schneider G, Schmidt-Supprian M, Rad R, Saur D.

Nat Rev Cancer. 2017 Apr;17(4):239-253. doi: 10.1038/nrc.2017.5. Epub 2017 Mar 3. Review.

50.

Phase III, efficacy and safety study of ertugliflozin monotherapy in people with type 2 diabetes mellitus inadequately controlled with diet and exercise alone.

Terra SG, Focht K, Davies M, Frias J, Derosa G, Darekar A, Golm G, Johnson J, Saur D, Lauring B, Dagogo-Jack S.

Diabetes Obes Metab. 2017 May;19(5):721-728. doi: 10.1111/dom.12888. Epub 2017 Feb 22.

PMID:
28116776

Supplemental Content

Support Center