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Combinations of Spok genes create multiple meiotic drivers in Podospora.

Vogan AA, Ament-Velásquez SL, Granger-Farbos A, Svedberg J, Bastiaans E, Debets AJ, Coustou V, Yvanne H, Clavé C, Saupe SJ, Johannesson H.

Elife. 2019 Jul 26;8. pii: e46454. doi: 10.7554/eLife.46454.


Rational Structure-Based Design of Fluorescent Probes for Amyloid Folds.

Orts J, Aulikki Wälti M, Ghosh D, Campioni S, Saupe SJ, Riek R.

Chembiochem. 2019 May 2;20(9):1161-1166. doi: 10.1002/cbic.201800664. Epub 2019 Mar 7.


Functional Amyloids in Health and Disease.

Loquet A, Saupe SJ, Romero D.

J Mol Biol. 2018 Oct 12;430(20):3629-3630. doi: 10.1016/j.jmb.2018.07.024. Epub 2018 Jul 25. No abstract available.


Retrograde type a dissection in a 24th gestational week pregnant patient - the importance of interdisciplinary interaction to a successful outcome.

Easo J, Horst M, Schmuck B, Thomas RP, Saupe S, Book M, Weymann A.

J Cardiothorac Surg. 2018 May 2;13(1):36. doi: 10.1186/s13019-018-0724-7.


Detection of side-chain proton resonances of fully protonated biosolids in nano-litre volumes by magic angle spinning solid-state NMR.

Tolchard J, Pandey MK, Berbon M, Noubhani A, Saupe SJ, Nishiyama Y, Habenstein B, Loquet A.

J Biomol NMR. 2018 Mar;70(3):177-185. doi: 10.1007/s10858-018-0168-3. Epub 2018 Mar 3.


NLR surveillance of essential SEC-9 SNARE proteins induces programmed cell death upon allorecognition in filamentous fungi.

Heller J, Clavé C, Gladieux P, Saupe SJ, Glass NL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2292-E2301. doi: 10.1073/pnas.1719705115. Epub 2018 Feb 20.


Geriatric assessment and biomarkers in patients with metastatic breast cancer receiving first-line mono-chemotherapy: Results from the randomized phase III PELICAN trial.

Honecker F, Harbeck N, Schnabel C, Wedding U, Waldenmaier D, Saupe S, Jäger E, Schmidt M, Kreienberg R, Müller L, Otremba B, Dorn J, Warm M, Al-Batran SE, de Wit M; PELICAN investigators.

J Geriatr Oncol. 2018 Mar;9(2):163-169. doi: 10.1016/j.jgo.2017.09.009. Epub 2017 Oct 18.


Diversity of Amyloid Motifs in NLR Signaling in Fungi.

Loquet A, Saupe SJ.

Biomolecules. 2017 Apr 13;7(2). pii: E38. doi: 10.3390/biom7020038. Review.


Amyloid Prions in Fungi.

Saupe SJ, Jarosz DF, True HL.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.FUNK-0029-2016. Review.


Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing.

Ferrer RA, Saalbach A, Grünwedel M, Lohmann N, Forstreuter I, Saupe S, Wandel E, Simon JC, Franz S.

J Invest Dermatol. 2017 Apr;137(4):941-950. doi: 10.1016/j.jid.2016.11.035. Epub 2016 Dec 23.


NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils.

Stanek J, Andreas LB, Jaudzems K, Cala D, Lalli D, Bertarello A, Schubeis T, Akopjana I, Kotelovica S, Tars K, Pica A, Leone S, Picone D, Xu ZQ, Dixon NE, Martinez D, Berbon M, El Mammeri N, Noubhani A, Saupe S, Habenstein B, Loquet A, Pintacuda G.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15504-15509. doi: 10.1002/anie.201607084. Epub 2016 Nov 16.


A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study.

Harbeck N, Saupe S, Jäger E, Schmidt M, Kreienberg R, Müller L, Otremba BJ, Waldenmaier D, Dorn J, Warm M, Scholz M, Untch M, de Wit M, Barinoff J, Lück HJ, Harter P, Augustin D, Harnett P, Beckmann MW, Al-Batran SE; PELICAN Investigators.

Breast Cancer Res Treat. 2017 Jan;161(1):63-72. doi: 10.1007/s10549-016-4033-3. Epub 2016 Oct 31.


The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls.

Deeken R, Saupe S, Klinkenberg J, Riedel M, Leide J, Hedrich R, Mueller TD.

Plant Physiol. 2016 Nov;172(3):1911-1927. Epub 2016 Sep 29. Erratum in: Plant Physiol. 2017 Mar;173(3):1936.


The HET-S/s Prion Motif in the Control of Programmed Cell Death.

Riek R, Saupe SJ.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a023515. doi: 10.1101/cshperspect.a023515. Review.


Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines.

Hinkes S, Wuttke A, Saupe SM, Ivanova T, Wagner S, Knörlein A, Heine A, Klebe G, Steinmetzer T.

J Med Chem. 2016 Jul 14;59(13):6370-86. doi: 10.1021/acs.jmedchem.6b00606. Epub 2016 Jun 17.


Overlapping Podospora anserina Transcriptional Responses to Bacterial and Fungal Non Self Indicate a Multilayered Innate Immune Response.

Lamacchia M, Dyrka W, Breton A, Saupe SJ, Paoletti M.

Front Microbiol. 2016 Apr 19;7:471. doi: 10.3389/fmicb.2016.00471. eCollection 2016.


Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis.

Daskalov A, Habenstein B, Sabaté R, Berbon M, Martinez D, Chaignepain S, Coulary-Salin B, Hofmann K, Loquet A, Saupe SJ.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2720-5. doi: 10.1073/pnas.1522361113. Epub 2016 Feb 22.


Theme and variations: evolutionary diversification of the HET-s functional amyloid motif.

Daskalov A, Dyrka W, Saupe SJ.

Sci Rep. 2015 Jul 29;5:12494. doi: 10.1038/srep12494.


As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion.

Daskalov A, Saupe SJ.

Prion. 2015;9(3):184-9. doi: 10.1080/19336896.2015.1038018. Review.


Signal transduction by a fungal NOD-like receptor based on propagation of a prion amyloid fold.

Daskalov A, Habenstein B, Martinez D, Debets AJ, Sabaté R, Loquet A, Saupe SJ.

PLoS Biol. 2015 Feb 11;13(2):e1002059. doi: 10.1371/journal.pbio.1002059. eCollection 2015 Feb.


Diversity and variability of NOD-like receptors in fungi.

Dyrka W, Lamacchia M, Durrens P, Kobe B, Daskalov A, Paoletti M, Sherman DJ, Saupe SJ.

Genome Biol Evol. 2014 Nov 13;6(12):3137-58. doi: 10.1093/gbe/evu251.


Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability.

Daskalov A, Gantner M, Wälti MA, Schmidlin T, Chi CN, Wasmer C, Schütz A, Ceschin J, Clavé C, Cescau S, Meier B, Riek R, Saupe SJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004158. doi: 10.1371/journal.ppat.1004158. eCollection 2014 Jun.


Natural variation of heterokaryon incompatibility gene het-c in Podospora anserina reveals diversifying selection.

Bastiaans E, Debets AJ, Aanen DK, van Diepeningen AD, Saupe SJ, Paoletti M.

Mol Biol Evol. 2014 Apr;31(4):962-74. doi: 10.1093/molbev/msu047. Epub 2014 Jan 20.


Two fatty acid desaturases, STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE6 and FATTY ACID DESATURASE3, are involved in drought and hypoxia stress signaling in Arabidopsis crown galls.

Klinkenberg J, Faist H, Saupe S, Lambertz S, Krischke M, Stingl N, Fekete A, Mueller MJ, Feussner I, Hedrich R, Deeken R.

Plant Physiol. 2014 Feb;164(2):570-83. doi: 10.1104/pp.113.230326. Epub 2013 Dec 24.


Thioflavin-T excimer formation upon interaction with amyloid fibers.

Sabate R, Rodriguez-Santiago L, Sodupe M, Saupe SJ, Ventura S.

Chem Commun (Camb). 2013 Jun 28;49(51):5745-7. doi: 10.1039/c3cc42040j.


The transcriptional response to nonself in the fungus Podospora anserina.

Bidard F, Clavé C, Saupe SJ.

G3 (Bethesda). 2013 Jun 21;3(6):1015-30. doi: 10.1534/g3.113.006262.


The mechanism of toxicity in HET-S/HET-s prion incompatibility.

Seuring C, Greenwald J, Wasmer C, Wepf R, Saupe SJ, Meier BH, Riek R.

PLoS Biol. 2012;10(12):e1001451. doi: 10.1371/journal.pbio.1001451. Epub 2012 Dec 27.


Development of new cyclic plasmin inhibitors with excellent potency and selectivity.

Saupe SM, Leubner S, Betz M, Klebe G, Steinmetzer T.

J Med Chem. 2013 Feb 14;56(3):820-31. doi: 10.1021/jm3012917. Epub 2013 Jan 23.


A fungal gene reinforces Mendel's laws by counteracting genetic cheating.

Saupe SJ.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11900-1. doi: 10.1073/pnas.1209748109. Epub 2012 Jul 9. No abstract available.


High natural prevalence of a fungal prion.

Debets AJ, Dalstra HJ, Slakhorst M, Koopmanschap B, Hoekstra RF, Saupe SJ.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10432-7. doi: 10.1073/pnas.1205333109. Epub 2012 Jun 12.


The [Het-s] prion, an amyloid fold as a cell death activation trigger.

Saupe SJ, Daskalov A.

PLoS Pathog. 2012;8(5):e1002687. doi: 10.1371/journal.ppat.1002687. Epub 2012 May 24. No abstract available.


Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes.

Daskalov A, Paoletti M, Ness F, Saupe SJ.

PLoS One. 2012;7(4):e34854. doi: 10.1371/journal.pone.0034854. Epub 2012 Apr 6.


A new strategy for the development of highly potent and selective plasmin inhibitors.

Saupe SM, Steinmetzer T.

J Med Chem. 2012 Feb 9;55(3):1171-80. doi: 10.1021/jm2011996. Epub 2012 Jan 25.


Two structurally similar fungal prions efficiently cross-seed in vivo but form distinct polymers when coexpressed.

Benkemoun L, Ness F, Sabaté R, Ceschin J, Breton A, Clavé C, Saupe SJ.

Mol Microbiol. 2011 Dec;82(6):1392-405. doi: 10.1111/j.1365-2958.2011.07893.x. Epub 2011 Nov 3.


Localization of HET-S to the cell periphery, not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity.

Mathur V, Seuring C, Riek R, Saupe SJ, Liebman SW.

Mol Cell Biol. 2012 Jan;32(1):139-53. doi: 10.1128/MCB.06125-11. Epub 2011 Oct 28.


Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. doi: 10.1016/j.bmcl.2011.06.033. Epub 2011 Jun 21.


The various facets of the protein-folding activity of the ribosome.

Voisset C, Saupe SJ, Blondel M.

Biotechnol J. 2011 Jun;6(6):668-73. doi: 10.1002/biot.201100021. Epub 2011 May 12. Review.


The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility.

Saupe SJ.

Semin Cell Dev Biol. 2011 Jul;22(5):460-8. doi: 10.1016/j.semcdb.2011.02.019. Epub 2011 Feb 18. Review.


Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.

Dheur S, Saupe SJ, Genier S, Vazquez S, Javerzat JP.

Mol Cell Biol. 2011 Mar;31(5):1088-97. doi: 10.1128/MCB.01290-10. Epub 2010 Dec 28.


The mechanism of prion inhibition by HET-S.

Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R.

Mol Cell. 2010 Jun 25;38(6):889-99. doi: 10.1016/j.molcel.2010.05.019.


Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity.

Wasmer C, Zimmer A, Sabaté R, Soragni A, Saupe SJ, Ritter C, Meier BH.

J Mol Biol. 2010 Sep 17;402(2):311-25. doi: 10.1016/j.jmb.2010.06.053. Epub 2010 Jul 1.


WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family.

Chevanne D, Saupe SJ, Clavé C, Paoletti M.

BMC Evol Biol. 2010 May 6;10:134. doi: 10.1186/1471-2148-10-134.


Dislocation of Intravenous Port Systems - Three Case Reports.

Seck K, Saupe S, Kiechle M, Harbeck N.

Breast Care (Basel). 2009 Nov;4(5):328-331. doi: 10.1159/000236066. Epub 2009 Oct 22.


Characterization of the amyloid bacterial inclusion bodies of the HET-s fungal prion.

Sabaté R, Espargaró A, Saupe SJ, Ventura S.

Microb Cell Fact. 2009 Oct 28;8:56. doi: 10.1186/1475-2859-8-56.


Fungal incompatibility: evolutionary origin in pathogen defense?

Paoletti M, Saupe SJ.

Bioessays. 2009 Nov;31(11):1201-10. doi: 10.1002/bies.200900085.


Energy barriers for HET-s prion forming domain amyloid formation.

Sabaté R, Castillo V, Espargaró A, Saupe SJ, Ventura S.

FEBS J. 2009 Sep;276(18):5053-64. doi: 10.1111/j.1742-4658.2009.07202.x. Epub 2009 Aug 4.


Preservation of liquid drug preparations for oral administration.

Scheler S, Saupe S, Herre A, Fahr A.

J Pharm Sci. 2010 Jan;99(1):357-67. doi: 10.1002/jps.21828.


Solid-state NMR spectroscopy reveals that E. coli inclusion bodies of HET-s(218-289) are amyloids.

Wasmer C, Benkemoun L, Sabaté R, Steinmetz MO, Coulary-Salin B, Wang L, Riek R, Saupe SJ, Meier BH.

Angew Chem Int Ed Engl. 2009;48(26):4858-60. doi: 10.1002/anie.200806100.


Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family.

Chevanne D, Bastiaans E, Debets A, Saupe SJ, Clavé C, Paoletti M.

Curr Genet. 2009 Feb;55(1):93-102. doi: 10.1007/s00294-008-0227-5. Epub 2009 Jan 10.


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