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A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1).

Abokhrais IM, Denison FC, Whitaker LHR, Saunders PTK, Doust A, Williams LJ, Horne AW.

PLoS One. 2020 Jan 17;15(1):e0227695. doi: 10.1371/journal.pone.0227695. eCollection 2020.


SnapShot: Endometriosis.

Horne AW, Saunders PTK.

Cell. 2019 Dec 12;179(7):1677-1677.e1. doi: 10.1016/j.cell.2019.11.033. Epub 2019 Dec 12.


Repurposing dichloroacetate for the treatment of women with endometriosis.

Horne AW, Ahmad SF, Carter R, Simitsidellis I, Greaves E, Hogg C, Morton NM, Saunders PTK.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25389-25391. doi: 10.1073/pnas.1916144116. Epub 2019 Dec 2.


The ERβ5 splice variant increases oestrogen responsiveness of ERαpos Ishikawa cells.

Collins F, Itani N, Esnal-Zufiaurre A, Gibson DA, Fitzgerald C, Saunders PTK.

Endocr Relat Cancer. 2020 Feb;27(2):55-66. doi: 10.1530/ERC-19-0291.


Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.

Simitsidellis I, Esnal-Zuffiaure A, Kelepouri O, O'Flaherty E, Gibson DA, Saunders PTK.

J Endocrinol. 2019 Sep;242(3):227-239. doi: 10.1530/JOE-19-0153.


Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.

Forster R, Sarginson A, Velichkova A, Hogg C, Dorning A, Horne AW, Saunders PTK, Greaves E.

FASEB J. 2019 Oct;33(10):11210-11222. doi: 10.1096/fj.201900797R. Epub 2019 Jul 10.


Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2.

Governa P, Marchi M, Cocetta V, De Leo B, Saunders PTK, Catanzaro D, Miraldi E, Montopoli M, Biagi M.

Pharmaceuticals (Basel). 2018 Nov 20;11(4). pii: E126. doi: 10.3390/ph11040126.


Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.

Gibson DA, Simitsidellis I, Collins F, Saunders PTK.

Int J Mol Sci. 2018 Oct 22;19(10). pii: E3276. doi: 10.3390/ijms19103276. Review.


Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models.

Boyle AK, Rinaldi SF, Rossi AG, Saunders PTK, Norman JE.

FASEB J. 2019 Feb;33(2):2743-2758. doi: 10.1096/fj.201801104R. Epub 2018 Oct 12.


SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis.

Piccinato CA, Malvezzi H, Gibson DA, Saunders PTK.

J Mol Endocrinol. 2018 Aug;61(2):T253-T270. doi: 10.1530/JME-17-0297. Review.


Animal models of endometriosis: Replicating the aetiology and symptoms of the human disorder.

Simitsidellis I, Gibson DA, Saunders PTK.

Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):257-269. doi: 10.1016/j.beem.2018.03.004. Epub 2018 Apr 6. Review.


A pilot randomised double blind controlled trial of the efficacy of purified fatty acids for the treatment of women with endometriosis-associated pain (PurFECT): study protocol.

Abokhrais IM, Saunders PTK, Denison FC, Doust A, Williams L, Horne AW.

Pilot Feasibility Stud. 2018 Apr 25;4:83. doi: 10.1186/s40814-018-0274-8. eCollection 2018.


SULFATION PATHWAYS: A role for steroid sulphatase in intracrine regulation of endometrial decidualisation.

Gibson DA, Foster PA, Simitsidellis I, Critchley HOD, Kelepouri O, Collins F, Saunders PTK.

J Mol Endocrinol. 2018 Aug;61(2):M57-M65. doi: 10.1530/JME-18-0037. Epub 2018 May 2. Review.


Androgens and androgen receptor: Above and beyond.

Gibson DA, Saunders PTK, McEwan IJ.

Mol Cell Endocrinol. 2018 Apr 15;465:1-3. doi: 10.1016/j.mce.2018.02.013. Epub 2018 Feb 24. No abstract available.


Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age.

Gibson DA, Simitsidellis I, Kelepouri O, Critchley HOD, Saunders PTK.

Fertil Steril. 2018 Apr;109(4):728-734.e2. doi: 10.1016/j.fertnstert.2017.12.024. Epub 2018 Feb 15.


The impact of 27-hydroxycholesterol on endometrial cancer proliferation.

Gibson DA, Collins F, Cousins FL, Esnal Zufiaurre A, Saunders PTK.

Endocr Relat Cancer. 2018 Apr;25(4):381-391. doi: 10.1530/ERC-17-0449. Epub 2018 Jan 25.


Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.

Maybin JA, Murray AA, Saunders PTK, Hirani N, Carmeliet P, Critchley HOD.

Nat Commun. 2018 Jan 23;9(1):295. doi: 10.1038/s41467-017-02375-6.


Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model.

Armstrong GM, Maybin JA, Murray AA, Nicol M, Walker C, Saunders PTK, Rossi AG, Critchley HOD.

Sci Rep. 2017 Dec 12;7(1):17416. doi: 10.1038/s41598-017-17565-x.


Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition.

Rinaldi SF, Makieva S, Saunders PT, Rossi AG, Norman JE.

Mol Hum Reprod. 2017 Oct 1;23(10):708-724. doi: 10.1093/molehr/gax038.


Androgens and endometrium: New insights and new targets.

Simitsidellis I, Saunders PTK, Gibson DA.

Mol Cell Endocrinol. 2018 Apr 15;465:48-60. doi: 10.1016/j.mce.2017.09.022. Epub 2017 Sep 15. Review.


Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor.

De Leo B, Esnal-Zufiaurre A, Collins F, Critchley HOD, Saunders PTK.

Version 2. F1000Res. 2017 May 12 [revised 2017 Jan 1];6:667. doi: 10.12688/f1000research.11432.2. eCollection 2017.


Top ten endometriosis research priorities in the UK and Ireland.

Horne AW, Saunders PTK, Abokhrais IM, Hogg L; Endometriosis Priority Setting Partnership Steering Group (appendix).

Lancet. 2017 Jun 3;389(10085):2191-2192. doi: 10.1016/S0140-6736(17)31344-2. Epub 2017 May 18. No abstract available.


Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

Giakoumelou S, Wheelhouse N, Brown J, Wade J, Simitsidellis I, Gibson D, Saunders PTK, Horner P, Entrican G, Howie SEM, Horne AW.

Sci Rep. 2017 May 17;7(1):2001. doi: 10.1038/s41598-017-02223-z.


Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair.

Maybin JA, Thiruchelvam U, Madhra M, Saunders PTK, Critchley HOD.

J Clin Endocrinol Metab. 2017 Jun 1;102(6):1851-1860. doi: 10.1210/jc.2016-3604.


EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis.

Greaves E, Horne AW, Jerina H, Mikolajczak M, Hilferty L, Mitchell R, Fleetwood-Walker SM, Saunders PT.

Sci Rep. 2017 Mar 10;7:44169. doi: 10.1038/srep44169.


Relevant human tissue resources and laboratory models for use in endometriosis research.

Greaves E, Critchley HOD, Horne AW, Saunders PTK.

Acta Obstet Gynecol Scand. 2017 Jun;96(6):644-658. doi: 10.1111/aogs.13119. Epub 2017 Apr 5. Review.


Being Clear About the Precautionary Principle.

Saunders PT.

Am J Bioeth. 2017 Mar;17(3):47-48. doi: 10.1080/15265161.2016.1274797. No abstract available.


Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis.

Peter AW, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GAJ, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT; WES/WERF Consortium for Research Priorities in Endometriosis.

Reprod Sci. 2017 Feb;24(2):202-226. doi: 10.1177/1933719116654991.


Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium.

Whitaker LH, Murray AA, Matthews R, Shaw G, Williams AR, Saunders PT, Critchley HO.

Hum Reprod. 2017 Mar 1;32(3):531-543. doi: 10.1093/humrep/dew359.


New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT.

Hum Reprod Update. 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. Review.


Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

Cousins FL, Kirkwood PM, Saunders PT, Gibson DA.

Sci Rep. 2016 Nov 9;6:36748. doi: 10.1038/srep36748.


Research Priorities for Endometriosis.

Rogers PA, Adamson GD, Al-Jefout M, Becker CM, D'Hooghe TM, Dunselman GA, Fazleabas A, Giudice LC, Horne AW, Hull ML, Hummelshoj L, Missmer SA, Montgomery GW, Stratton P, Taylor RN, Rombauts L, Saunders PT, Vincent K, Zondervan KT; WES/WERF Consortium for Research Priorities in Endometriosis.

Reprod Sci. 2017 Feb;24(2):202-226. doi: 10.1177/1933719116654991. Epub 2016 Sep 27.


Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women.

Sharp GC, Hutchinson JL, Hibbert N, Freeman TC, Saunders PT, Norman JE.

PLoS One. 2016 May 13;11(5):e0155413. doi: 10.1371/journal.pone.0155413. eCollection 2016.


Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies.

Wagenfeld A, Saunders PT, Whitaker L, Critchley HO.

Expert Opin Ther Targets. 2016 Sep;20(9):1045-54. doi: 10.1080/14728222.2016.1180368. Epub 2016 May 14. Review.


Androgens regulate scarless repair of the endometrial "wound" in a mouse model of menstruation.

Cousins FL, Kirkwood PM, Murray AA, Collins F, Gibson DA, Saunders PT.

FASEB J. 2016 Aug;30(8):2802-11. doi: 10.1096/fj.201600078R. Epub 2016 Apr 27.


Regulation of androgen action during establishment of pregnancy.

Gibson DA, Simitsidellis I, Saunders PT.

J Mol Endocrinol. 2016 Jul;57(1):R35-47. doi: 10.1530/JME-16-0027. Epub 2016 Apr 11. Review.


A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus.

Simitsidellis I, Gibson DA, Cousins FL, Esnal-Zufiaurre A, Saunders PT.

Endocrinology. 2016 May;157(5):2116-28. doi: 10.1210/en.2015-2032. Epub 2016 Mar 10.


Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes.

Gibson DA, Simitsidellis I, Cousins FL, Critchley HO, Saunders PT.

Sci Rep. 2016 Jan 28;6:19970. doi: 10.1038/srep19970.


Hypoxyprobe™ reveals dynamic spatial and temporal changes in hypoxia in a mouse model of endometrial breakdown and repair.

Cousins FL, Murray AA, Scanlon JP, Saunders PT.

BMC Res Notes. 2016 Jan 19;9:30. doi: 10.1186/s13104-016-1842-8.


Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation.

Makieva S, Hutchinson LJ, Rajagopal SP, Rinaldi SF, Brown P, Saunders PT, Norman JE.

J Clin Endocrinol Metab. 2016 Mar;101(3):1055-65. doi: 10.1210/jc.2015-2851. Epub 2016 Jan 11.


Beyond the neo-Darwinist paradigm.

Saunders PT.

Theor Biol Forum. 2016 Jan 1;109(1-2):123-130. doi: 10.19272/201611402009.


Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells.

Thiruchelvam U, Maybin JA, Armstrong GM, Greaves E, Saunders PT, Critchley HO.

J Leukoc Biol. 2016 Jun;99(6):1165-71. doi: 10.1189/jlb.5A0215-061RR. Epub 2015 Dec 23.


Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

Dubois V, Simitsidellis I, Laurent MR, Jardi F, Saunders PT, Vanderschueren D, Claessens F.

Endocrinology. 2015 Dec;156(12):4522-33. doi: 10.1210/en.2015-1479. Epub 2015 Sep 22.


Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PT, Huhtaniemi I, Vanhaesebroeck B.

PLoS Genet. 2015 Jul 1;11(7):e1005304. doi: 10.1371/journal.pgen.1005304. eCollection 2015 Jul.


Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis.

Greaves E, Temp J, Esnal-Zufiurre A, Mechsner S, Horne AW, Saunders PT.

Am J Pathol. 2015 Aug;185(8):2286-97. doi: 10.1016/j.ajpath.2015.04.012. Epub 2015 Jun 12.


Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2.

Gibson DA, Greaves E, Critchley HO, Saunders PT.

Hum Reprod. 2015 Jun;30(6):1290-301. doi: 10.1093/humrep/dev067. Epub 2015 Mar 27.


Immune cells and preterm labour: do invariant NKT cells hold the key?

Rinaldi SF, Rossi AG, Saunders PT, Norman JE.

Mol Hum Reprod. 2015 Apr;21(4):309-12. doi: 10.1093/molehr/gav002. Epub 2015 Jan 14. No abstract available.


Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).

Warner P, Weir CJ, Hansen CH, Douglas A, Madhra M, Hillier SG, Saunders PT, Iredale JP, Semple S, Walker BR, Critchley HO.

BMJ Open. 2015 Jan 14;5(1):e006837. doi: 10.1136/bmjopen-2014-006837.


The peritoneum is both a source and target of TGF-β in women with endometriosis.

Young VJ, Brown JK, Saunders PT, Duncan WC, Horne AW.

PLoS One. 2014 Sep 10;9(9):e106773. doi: 10.1371/journal.pone.0106773. eCollection 2014.


Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.

Greaves E, Collins F, Esnal-Zufiaurre A, Giakoumelou S, Horne AW, Saunders PT.

Endocrinology. 2014 Oct;155(10):4015-26. doi: 10.1210/en.2014-1086. Epub 2014 Jul 22.


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