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Items: 16


Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma.

Spino M, Kurz SC, Chiriboga L, Serrano J, Zeck B, Sen N, Patel S, Shen G, Vasudevaraja V, Tsirigos A, Suryadevara CM, Frenster JD, Tateishi K, Wakimoto H, Jain R, Riina HA, Nicolaides TP, Sulman EP, Cahill DP, Golfinos JG, Isse K, Saunders LR, Zagzag D, Placantonakis DG, Snuderl M, Chi AS.

Clin Cancer Res. 2019 Feb 15;25(4):1261-1271. doi: 10.1158/1078-0432.CCR-18-2312. Epub 2018 Nov 5.


Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target.

Koshkin VS, Garcia JA, Reynolds J, Elson P, Magi-Galluzzi C, McKenney JK, Isse K, Bishop E, Saunders LR, Balyimez A, Rashid S, Hu M, Stephenson AJ, Fergany AF, Lee BH, Haber GP, Dowlati A, Gilligan T, Ornstein MC, Rini BI, Abazeed ME, Mian OY, Grivas P.

Clin Cancer Res. 2019 Jan 1;25(1):210-221. doi: 10.1158/1078-0432.CCR-18-1278. Epub 2018 Oct 16.


Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Lochmann TL, Floros KV, Naseri M, Powell KM, Cook W, March RJ, Stein GT, Greninger P, Maves YK, Saunders LR, Dylla SJ, Costa C, Boikos SA, Leverson JD, Souers AJ, Krystal GW, Harada H, Benes CH, Faber AC.

Clin Cancer Res. 2018 Jan 15;24(2):360-369. doi: 10.1158/1078-0432.CCR-17-1606. Epub 2017 Nov 8.


A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ.

Sci Transl Med. 2015 Aug 26;7(302):302ra136. doi: 10.1126/scitranslmed.aac9459.


Specification to biomineralization: following a single cell type as it constructs a skeleton.

Lyons DC, Martik ML, Saunders LR, McClay DR.

Integr Comp Biol. 2014 Oct;54(4):723-33. doi: 10.1093/icb/icu087. Epub 2014 Jul 9.


Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.

Saunders LR, McClay DR.

Development. 2014 Apr;141(7):1503-13. doi: 10.1242/dev.101436. Epub 2014 Mar 5.


Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E.

Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6.


miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.

Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E.

Aging (Albany NY). 2010 Jul;2(7):415-31.


Cell biology. Stress response and aging.

Saunders LR, Verdin E.

Science. 2009 Feb 20;323(5917):1021-2. doi: 10.1126/science.1170007. No abstract available.


Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6.

Scott GK, Marx C, Berger CE, Saunders LR, Verdin E, Schäfer S, Jung M, Benz CC.

Mol Cancer Res. 2008 Jul;6(7):1250-8. doi: 10.1158/1541-7786.MCR-07-2110.


Sirtuins: critical regulators at the crossroads between cancer and aging.

Saunders LR, Verdin E.

Oncogene. 2007 Aug 13;26(37):5489-504. Review.


The dsRNA binding protein family: critical roles, diverse cellular functions.

Saunders LR, Barber GN.

FASEB J. 2003 Jun;17(9):961-83. Review.


The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.

Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV.

Nucleic Acids Res. 2003 Mar 1;31(5):1470-80.


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