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Items: 1 to 50 of 55

1.

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation.

Bax M, McKenna J, Do-Ha D, Stevens CH, Higginbottom S, Balez R, Cabral-da-Silva MEC, Farrawell NE, Engel M, Poronnik P, Yerbury JJ, Saunders DN, Ooi L.

Cells. 2019 Jun 13;8(6). pii: E581. doi: 10.3390/cells8060581.

2.

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR.

Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y.

3.

Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.

Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ.

Mol Cancer Res. 2019 Apr;17(4):949-962. doi: 10.1158/1541-7786.MCR-18-0347. Epub 2019 Jan 15.

PMID:
30647103
4.

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis.

Balaban S, Lee LS, Varney B, Aishah A, Gao Q, Shearer RF, Saunders DN, Grewal T, Hoy AJ.

Mol Oncol. 2018 Sep;12(9):1623-1638. doi: 10.1002/1878-0261.12368. Epub 2018 Aug 29.

5.

Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP).

Hastings JF, Han JZR, Shearer RF, Kennedy SP, Iconomou M, Saunders DN, Croucher DR.

J Vis Exp. 2018 Jun 15;(136). doi: 10.3791/57109.

PMID:
29985350
6.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ.

J Cell Sci. 2018 Jun 12;131(11). pii: jcs209122. doi: 10.1242/jcs.209122.

7.

The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia.

Shearer RF, Frikstad KM, McKenna J, McCloy RA, Deng N, Burgess A, Stokke T, Patzke S, Saunders DN.

Mol Biol Cell. 2018 Jul 1;29(13):1542-1554. doi: 10.1091/mbc.E17-04-0248. Epub 2018 May 9.

8.

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities.

Belfiore L, Saunders DN, Ranson M, Thurecht KJ, Storm G, Vine KL.

J Control Release. 2018 May 10;277:1-13. doi: 10.1016/j.jconrel.2018.02.040. Epub 2018 Mar 1. Review.

PMID:
29501721
9.

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

Chen L, Watson C, Morsch M, Cole NJ, Chung RS, Saunders DN, Yerbury JJ, Vine KL.

Front Neurosci. 2017 Aug 30;11:476. doi: 10.3389/fnins.2017.00476. eCollection 2017.

10.

Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver.

Nagarajan SR, Brandon AE, McKenna JA, Shtein HC, Nguyen TQ, Suryana E, Poronnik P, Cooney GJ, Saunders DN, Hoy AJ.

PLoS One. 2017 Sep 8;12(9):e0184610. doi: 10.1371/journal.pone.0184610. eCollection 2017.

11.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10.

12.

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.

Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP; Australian Pancreatic Cancer Genome Initiative, Biankin AV, Ranson M, Timpson P, Saunders DN.

Oncogene. 2017 Jul 27;36(30):4288-4298. doi: 10.1038/onc.2017.63. Epub 2017 Mar 27.

13.

Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer.

Hoy AJ, Balaban S, Saunders DN.

Trends Mol Med. 2017 May;23(5):381-392. doi: 10.1016/j.molmed.2017.02.009. Epub 2017 Mar 19. Review.

PMID:
28330687
14.

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver.

Nagarajan SR, Brandon AE, McKenna JA, Shtein HC, Nguyen TQ, Suryana E, Poronnik P, Cooney GJ, Saunders DN, Hoy AJ.

PLoS One. 2017 Mar 22;12(3):e0174431. doi: 10.1371/journal.pone.0174431. eCollection 2017. Erratum in: PLoS One. 2017 Sep 8;12 (9):e0184610.

15.

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.

16.

Mitochondrial mutations and metabolic adaptation in pancreatic cancer.

Hardie RA, van Dam E, Cowley M, Han TL, Balaban S, Pajic M, Pinese M, Iconomou M, Shearer RF, McKenna J, Miller D, Waddell N, Pearson JV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Sazanov L, Biankin AV, Villas-Boas S, Hoy AJ, Turner N, Saunders DN.

Cancer Metab. 2017 Jan 30;5:2. doi: 10.1186/s40170-017-0164-1. eCollection 2017.

17.

Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.

Balaban S, Shearer RF, Lee LS, van Geldermalsen M, Schreuder M, Shtein HC, Cairns R, Thomas KC, Fazakerley DJ, Grewal T, Holst J, Saunders DN, Hoy AJ.

Cancer Metab. 2017 Jan 13;5:1. doi: 10.1186/s40170-016-0163-7. eCollection 2017.

18.

Regulation of primary cilia formation by the ubiquitin-proteasome system.

Shearer RF, Saunders DN.

Biochem Soc Trans. 2016 Oct 15;44(5):1265-1271. Review.

PMID:
27911708
19.

Systematic approaches to identify E3 ligase substrates.

Iconomou M, Saunders DN.

Biochem J. 2016 Nov 15;473(22):4083-4101. Review.

20.

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.

Liu L, Phua YW, Lee RS, Ma X, Jenkins Y, Novy K, Humphrey ES, Chan H, Shearer R, Ong PC, Dai W, Saunders DN, Lucet IS, Daly RJ.

J Biol Chem. 2016 Oct 7;291(41):21571-21583. Epub 2016 Aug 16.

21.

Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

Croucher DR, Iconomou M, Hastings JF, Kennedy SP, Han JZ, Shearer RF, McKenna J, Wan A, Lau J, Aparicio S, Saunders DN.

Sci Signal. 2016 Jul 12;9(436):ra69. doi: 10.1126/scisignal.aaf0793.

PMID:
27405979
22.

Walking the tightrope: proteostasis and neurodegenerative disease.

Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, Ecroyd H.

J Neurochem. 2016 May;137(4):489-505. doi: 10.1111/jnc.13575. Epub 2016 Mar 8. Review.

23.

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.

Shearer RF, Iconomou M, Watts CK, Saunders DN.

Mol Cancer Res. 2015 Dec;13(12):1523-32. doi: 10.1158/1541-7786.MCR-15-0383. Epub 2015 Oct 13. Review.

24.

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions.

Farrawell NE, Lambert-Smith IA, Warraich ST, Blair IP, Saunders DN, Hatters DM, Yerbury JJ.

Sci Rep. 2015 Aug 21;5:13416. doi: 10.1038/srep13416.

25.

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

Lee JA, Yerbury JJ, Farrawell N, Shearer RF, Constantinescu P, Hatters DM, Schroder WA, Suhrbier A, Wilson MR, Saunders DN, Ranson M.

PLoS One. 2015 Jun 17;10(6):e0130136. doi: 10.1371/journal.pone.0130136. eCollection 2015.

26.

Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.

Shearer RF, Saunders DN.

Genes Cells. 2015 Jan;20(1):1-10. doi: 10.1111/gtc.12183. Epub 2014 Oct 13. Review.

27.

High-throughput approaches to measuring cell death.

Saunders DN, Falkenberg KJ, Simpson KJ.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):591-601. doi: 10.1101/pdb.top072561.

PMID:
24890217
28.

A high-throughput, multiplex cell death assay using an RNAi screening approach.

Falkenberg KJ, Saunders DN, Simpson KJ.

Cold Spring Harb Protoc. 2014 Jun 2;2014(6):663-76. doi: 10.1101/pdb.prot080267.

PMID:
24890208
29.

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway.

Croucher DR, Hochgräfe F, Zhang L, Liu L, Lyons RJ, Rickwood D, Tactacan CM, Browne BC, Ali N, Chan H, Shearer R, Gallego-Ortega D, Saunders DN, Swarbrick A, Daly RJ.

Cancer Res. 2013 Mar 15;73(6):1969-80. doi: 10.1158/0008-5472.CAN-12-1472. Epub 2013 Feb 1.

30.

A novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency.

Saunders DN, Tindall EA, Shearer RF, Roberson J, Decker A, Wilson JA, Hayes VM.

PLoS One. 2012;7(12):e51762. doi: 10.1371/journal.pone.0051762. Epub 2012 Dec 12.

31.

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

Röring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T.

EMBO J. 2012 May 30;31(11):2629-47. doi: 10.1038/emboj.2012.100. Epub 2012 Apr 17.

32.

Effects of EDD on p53 function are context-specific.

Watts CK, Saunders DN.

J Biol Chem. 2011 Jul 15;286(28):le13; author reply le14. doi: 10.1074/jbc.L110.182527. No abstract available.

33.

Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancer.

Cochran BJ, Croucher DR, Lobov S, Saunders DN, Ranson M.

J Biol Chem. 2011 Jul 8;286(27):24467-75. doi: 10.1074/jbc.M111.225706. Epub 2011 May 23.

34.

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.

Potratz JC, Saunders DN, Wai DH, Ng TL, McKinney SE, Carboni JM, Gottardis MM, Triche TJ, Jürgens H, Pollak MN, Aparicio SA, Sorensen PH.

Cancer Res. 2010 Nov 1;70(21):8770-81. doi: 10.1158/0008-5472.CAN-10-1093. Epub 2010 Oct 19.

35.

Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers.

Schrader KA, Masciari S, Boyd N, Salamanca C, Senz J, Saunders DN, Yorida E, Maines-Bandiera S, Kaurah P, Tung N, Robson ME, Ryan PD, Olopade OI, Domchek SM, Ford J, Isaacs C, Brown P, Balmana J, Razzak AR, Miron P, Coffey K, Terry MB, John EM, Andrulis IL, Knight JA, O'Malley FP, Daly M, Bender P; kConFab, Moore R, Southey MC, Hopper JL, Garber JE, Huntsman DG.

J Med Genet. 2011 Jan;48(1):64-8. doi: 10.1136/jmg.2010.079814. Epub 2010 Oct 4.

36.

Modulation of myocardin function by the ubiquitin E3 ligase UBR5.

Hu G, Wang X, Saunders DN, Henderson M, Russell AJ, Herring BP, Zhou J.

J Biol Chem. 2010 Apr 16;285(16):11800-9. doi: 10.1074/jbc.M109.079384. Epub 2010 Feb 18. Erratum in: J Biol Chem. 2011 Jul 15;286(28):25416.

37.

Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells.

Poon SS, Wong JT, Saunders DN, Ma QC, McKinney S, Fee J, Aparicio SA.

Cytometry A. 2008 Oct;73(10):904-17. doi: 10.1002/cyto.a.20624.

38.
39.

Revisiting the biological roles of PAI2 (SERPINB2) in cancer.

Croucher DR, Saunders DN, Lobov S, Ranson M.

Nat Rev Cancer. 2008 Jul;8(7):535-45. doi: 10.1038/nrc2400. Epub 2008 Jun 12. Review.

PMID:
18548086
40.

The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro.

O'Brien PM, Davies MJ, Scurry JP, Smith AN, Barton CA, Henderson MJ, Saunders DN, Gloss BS, Patterson KI, Clancy JL, Heinzelmann-Schwarz VA, Murali R, Scolyer RA, Zeng Y, Williams ED, Scurr L, Defazio A, Quinn DI, Watts CK, Hacker NF, Henshall SM, Sutherland RL.

Br J Cancer. 2008 Mar 25;98(6):1085-93. doi: 10.1038/sj.bjc.6604281. Epub 2008 Mar 18. Erratum in: Br J Cancer. 2008 Jun 3;98(11):1880. Murali, Rajmohan [added].

41.

The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.

Munoz MA, Saunders DN, Henderson MJ, Clancy JL, Russell AJ, Lehrbach G, Musgrove EA, Watts CK, Sutherland RL.

Cell Cycle. 2007 Dec 15;6(24):3070-7. Epub 2007 Sep 7.

PMID:
18073532
42.

Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.

McGowan EM, Russell AJ, Boonyaratanakornkit V, Saunders DN, Lehrbach GM, Sergio CM, Musgrove EA, Edwards DP, Sutherland RL.

Cancer Res. 2007 Sep 15;67(18):8942-51.

43.

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells.

Croucher DR, Saunders DN, Stillfried GE, Ranson M.

Biochem J. 2007 Dec 1;408(2):203-10.

44.

Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.

Horvath LG, Lelliott JE, Kench JG, Lee CS, Williams ED, Saunders DN, Grygiel JJ, Sutherland RL, Henshall SM.

Prostate. 2007 Jul 1;67(10):1081-90.

PMID:
17476687
45.
46.

EDD mediates DNA damage-induced activation of CHK2.

Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK.

J Biol Chem. 2006 Dec 29;281(52):39990-40000. Epub 2006 Oct 30.

47.

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta.

Withington SL, Scott AN, Saunders DN, Lopes Floro K, Preis JI, Michalicek J, Maclean K, Sparrow DB, Barbera JP, Dunwoodie SL.

Dev Biol. 2006 Jun 1;294(1):67-82. Epub 2006 Mar 31.

48.

The urokinase/PAI-2 complex: a new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related protein.

Croucher D, Saunders DN, Ranson M.

J Biol Chem. 2006 Apr 14;281(15):10206-13. Epub 2006 Feb 3.

49.

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.

Saunders DN, Hird SL, Withington SL, Dunwoodie SL, Henderson MJ, Biben C, Sutherland RL, Ormandy CJ, Watts CK.

Mol Cell Biol. 2004 Aug;24(16):7225-34.

50.

Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro.

Horvath LG, Henshall SM, Kench JG, Saunders DN, Lee CS, Golovsky D, Brenner PC, O'Neill GF, Kooner R, Stricker PD, Grygiel JJ, Sutherland RL.

Clin Cancer Res. 2004 Jan 15;10(2):615-25.

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