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Items: 1 to 50 of 74

1.

Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure.

Vorobyeva AG, Saunders AJ.

Cilia. 2018 Aug 17;7:5. doi: 10.1186/s13630-018-0059-y. eCollection 2018.

3.

Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine Quadruplex.

Crenshaw E, Leung BP, Kwok CK, Sharoni M, Olson K, Sebastian NP, Ansaloni S, Schweitzer-Stenner R, Akins MR, Bevilacqua PC, Saunders AJ.

PLoS One. 2015 Nov 30;10(11):e0143160. doi: 10.1371/journal.pone.0143160. eCollection 2015.

4.

Synthesis of 3-stannyl and 3-silyl propargyl phosphanes and the formation of a phosphinoallene.

Saunders AJ, Crossley IR.

Dalton Trans. 2016 Feb 7;45(5):2148-55. doi: 10.1039/c5dt03558a. Epub 2015 Nov 9.

PMID:
26549252
5.

Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation.

Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Kandelwal PJ, Kim FJ, Marenda DR, Saunders AJ.

J Biol Chem. 2014 Nov 28;289(48):33258-74. doi: 10.1074/jbc.M114.591792. Epub 2014 Oct 3.

6.

Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.

Mhatre SD, Michelson SJ, Gomes J, Tabb LP, Saunders AJ, Marenda DR.

Exp Neurol. 2014 Nov;261:772-81. doi: 10.1016/j.expneurol.2014.08.021. Epub 2014 Aug 27.

PMID:
25173219
8.

Synaptic abnormalities in a Drosophila model of Alzheimer's disease.

Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR.

Dis Model Mech. 2014 Mar;7(3):373-85. doi: 10.1242/dmm.012104. Epub 2014 Jan 30.

9.

Fibrolipomas masquerading as abdominal hernias.

Watson HI, Saunders AJ.

BMJ Case Rep. 2013 Dec 16;2013. pii: bcr2013201691. doi: 10.1136/bcr-2013-201691.

10.

Automated analysis of courtship suppression learning and memory in Drosophila melanogaster.

Reza MA, Mhatre SD, Morrison JC, Utreja S, Saunders AJ, Breen DE, Marenda DR.

Fly (Austin). 2013 Apr-Jun;7(2):105-11. doi: 10.4161/fly.24110. Epub 2013 Apr 1.

11.

Invertebrate models of Alzheimer's disease.

Mhatre SD, Paddock BE, Saunders AJ, Marenda DR.

J Alzheimers Dis. 2013;33(1):3-16. doi: 10.3233/JAD-2012-121204. Review.

PMID:
22886023
12.

Facile self-assembly of the first diphosphametacyclophane.

Saunders AJ, Crossley IR, Coles MP, Roe SM.

Chem Commun (Camb). 2012 Jun 11;48(46):5766-8. doi: 10.1039/c2cc32247a. Epub 2012 May 2.

PMID:
22552266
13.

Role of common and rare APP DNA sequence variants in Alzheimer disease.

Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L.

Neurology. 2012 Apr 17;78(16):1250-7. doi: 10.1212/WNL.0b013e3182515972. Epub 2012 Apr 4.

14.

Drosophila lilliputian is required for proneural gene expression in retinal development.

Distefano GM, Gangemi AJ, Khandelwal PJ, Saunders AJ, Marenda DR.

Dev Dyn. 2012 Mar;241(3):553-62. doi: 10.1002/dvdy.23738. Epub 2012 Jan 25.

15.

Genetic risk factors: their function and comorbidities in Alzheimer's disease.

Hiltunen M, Bertram L, Saunders AJ.

Int J Alzheimers Dis. 2011;2011:925362. doi: 10.4061/2011/925362. Epub 2011 Aug 11. No abstract available.

16.

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.

Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR.

PLoS One. 2011;6(6):e20799. doi: 10.1371/journal.pone.0020799. Epub 2011 Jun 6.

17.

TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains.

Ansaloni S, Leung BP, Sebastian NP, Samudralwar R, Gadaleta M, Saunders AJ.

Int J Alzheimers Dis. 2011 Feb 24;2011:729382. doi: 10.4061/2011/729382.

18.

A streamlined sub-cloning procedure to transfer shRNA from a pSM2 vector to a pGIPZ lentiviral vector.

Ansaloni S, Lelkes N, Snyder J, Epstein C, Dubey A, Saunders AJ.

J RNAi Gene Silencing. 2010 Oct 27;6(2):411-5.

19.
20.

Characterization of human lysophospholipid acyltransferase 3.

Jain S, Zhang X, Khandelwal PJ, Saunders AJ, Cummings BS, Oelkers P.

J Lipid Res. 2009 Aug;50(8):1563-70. doi: 10.1194/jlr.M800398-JLR200. Epub 2009 Apr 7.

21.

MicroRNAs can regulate human APP levels.

Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC, Saunders AJ.

Mol Neurodegener. 2008 Aug 6;3:10. doi: 10.1186/1750-1326-3-10.

22.
23.

An AICD-based functional screen to identify APP metabolism regulators.

Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ.

Mol Neurodegener. 2007 Aug 24;2:15.

24.

In vivo selection for metastasis promoting genes in the mouse.

Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6696-701. Epub 2007 Apr 9.

25.

Spontaneously hypertensive, Wistar Kyoto and Sprague-Dawley rats differ in their use of place and response strategies in the water radial arm maze.

Clements KM, Saunders AJ, Robertson BA, Wainwright PE.

Neurobiol Learn Mem. 2007 Feb;87(2):285-94. Epub 2006 Oct 23.

PMID:
17056285
26.

Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit.

McCall SJ, Nassar R, Malouf NN, Saunders AJ, Oakeley AE, Henderson PM, Solaro RJ, Pielak GJ, Alexander KA, Anderson PA.

Pediatr Res. 2006 Sep;60(3):276-81. Epub 2006 Jul 20.

PMID:
16857772
27.

Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis.

Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM.

J Mol Recognit. 2006 Jul-Aug;19(4):354-62.

PMID:
16775845
28.

Substituent dependence of the reactions of [RuCl2(PPh3)3] with bulky aromatic thiols.

Bishop PT, Cowley AR, Dilworth JR, Saunders AJ, Woollard-Shore JG.

Dalton Trans. 2006 Mar 14;(10):1267-70. Epub 2006 Jan 10.

PMID:
16505904
29.

Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.

Chylack LT Jr, Fu L, Mancini R, Martin-Rehrmann MD, Saunders AJ, Konopka G, Tian D, Hedley-Whyte ET, Folkerth RD, Goldstein LE.

Exp Eye Res. 2004 Dec;79(6):941-8.

PMID:
15642333
30.

Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease.

Saunders AJ, Tanzi RE.

Exp Neurol. 2003 Nov;184(1):50-3. No abstract available.

PMID:
14637079
31.

Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.

Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D.

Hum Mol Genet. 2003 Nov 1;12(21):2765-76. Epub 2003 Sep 9.

PMID:
12966032
32.

No association between marker D10S1423 and Alzheimer's disease.

Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RC, Blacker D, Tanzi RE.

Mol Psychiatry. 2003 Jun;8(6):571-3. No abstract available.

PMID:
12851634
33.

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis.

Puglielli L, Ellis BC, Saunders AJ, Kovacs DM.

J Biol Chem. 2003 May 30;278(22):19777-83. Epub 2003 Mar 20.

34.

Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex.

Engstrom G, Rajagukguk R, Saunders AJ, Patel CN, Rajagukguk S, Merbitz-Zahradnik T, Xiao K, Pielak GJ, Trumpower B, Yu CA, Yu L, Durham B, Millett F.

Biochemistry. 2003 Mar 18;42(10):2816-24.

PMID:
12627947
35.

Results of a high-resolution genome screen of 437 Alzheimer's disease families.

Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, Folstein MF, McInnis MG, Bassett SS, Doheny KJ, Pugh EW, Tanzi RE; NIMH Genetics Initiative Alzheimer's Disease Study Group.

Hum Mol Genet. 2003 Jan 1;12(1):23-32.

PMID:
12490529
36.

Interpreting the effects of small uncharged solutes on protein-folding equilibria.

Davis-Searles PR, Saunders AJ, Erie DA, Winzor DJ, Pielak GJ.

Annu Rev Biophys Biomol Struct. 2001;30:271-306. Review.

PMID:
11340061
37.

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE.

Science. 2000 Dec 22;290(5500):2302-3.

38.

Presenilin-mediated modulation of capacitative calcium entry.

Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW.

Neuron. 2000 Sep;27(3):561-72.

39.

3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.

Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT Jr, Bowden EF, Tanzi RE, Bush AI.

Biochemistry. 2000 Jun 20;39(24):7266-75.

PMID:
10852726
40.

Osmolyte-induced changes in protein conformational equilibria.

Saunders AJ, Davis-Searles PR, Allen DL, Pielak GJ, Erie DA.

Biopolymers. 2000 Apr 5;53(4):293-307.

PMID:
10685050
41.

Renovascular disease.

Rankin SC, Saunders AJ, Cook GJ, Scoble JE.

Clin Radiol. 2000 Jan;55(1):1-12. Review.

PMID:
10650104
42.

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, Bowden EF, Masters CL, Fairlie DP, Tanzi RE, Bush AI.

J Biol Chem. 1999 Dec 24;274(52):37111-6.

43.

Cystic kidney disease presenting in infancy.

Saunders AJ, Denton E, Stephens S, Reid C.

Clin Radiol. 1999 Jun;54(6):370-6.

PMID:
10406337
44.

Partially formed native tertiary interactions in the A-state of cytochrome c.

Hostetter DR, Weatherly GT, Beasley JR, Bortone K, Cohen DS, Finger SA, Hardwidge P, Kakouras DS, Saunders AJ, Trojak SK, Waldner JC, Pielak GJ.

J Mol Biol. 1999 Jun 11;289(3):639-44.

PMID:
10356334
45.

Sugar-induced molten-globule model.

Davis-Searles PR, Morar AS, Saunders AJ, Erie DA, Pielak GJ.

Biochemistry. 1998 Dec 1;37(48):17048-53.

PMID:
9836600
46.

Case of the month. Painless testicular nodularity in a young man.

Howlett DC, Jones AJ, Saunders AJ.

Br J Radiol. 1997 Nov;70(839):1195-6. No abstract available.

PMID:
9536916
47.

The ultrasound appearances of neonatal renal vein thrombosis.

Hibbert J, Howlett DC, Greenwood KL, MacDonald LM, Saunders AJ.

Br J Radiol. 1997 Nov;70(839):1191-4. Review.

PMID:
9536915
48.

Ultrasound examination of neonate's hip joints.

Poul J, Garvie D, Grahame R, Saunders AJ.

J Pediatr Orthop B. 1998 Jan;7(1):59-61.

PMID:
9481659
49.

The incidence of transient renal medullary hyperechogenicity in neonatal ultrasound examination.

Howlett DC, Greenwood KL, Jarosz JM, MacDonald LM, Saunders AJ.

Br J Radiol. 1997 Feb;70:140-3.

PMID:
9135439
50.

Unusual effects of an engineered disulfide on global and local protein stability.

Betz SF, Marmorino JL, Saunders AJ, Doyle DF, Young GB, Pielak GJ.

Biochemistry. 1996 Jun 11;35(23):7422-8.

PMID:
8652519

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