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Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Aug;51(8):1295. doi: 10.1038/s41588-019-0482-z.


Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.

Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchêne S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ.

Nat Genet. 2019 Jun;51(6):1035-1043. doi: 10.1038/s41588-019-0417-8. Epub 2019 May 27. Erratum in: Nat Genet. 2019 Jul 19;:.


Development of FAcE (Formulated Alhydrogel competitive ELISA) method for direct quantification of OAg present in Shigella sonnei GMMA-based vaccine and its optimization using Design of Experiments approach.

Necchi F, Carducci M, Pisoni I, Rossi O, Saul A, Rondini S.

J Immunol Methods. 2019 Aug;471:11-17. doi: 10.1016/j.jim.2019.04.012. Epub 2019 Apr 27.


Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2.

Navneet S, Zhao J, Wang J, Mysona B, Barwick S, Ammal Kaidery N, Saul A, Kaddour-Djebbar I, Bollag WB, Thomas B, Bollinger KE, Smith SB.

Redox Biol. 2019 Jun;24:101199. doi: 10.1016/j.redox.2019.101199. Epub 2019 Apr 11.


Booster Vaccination With GVGH Shigella sonnei 1790GAHB GMMA Vaccine Compared to Single Vaccination in Unvaccinated Healthy European Adults: Results From a Phase 1 Clinical Trial.

Launay O, Ndiaye AGW, Conti V, Loulergue P, Sciré AS, Landre AM, Ferruzzi P, Nedjaai N, Schütte LD, Auerbach J, Marchetti E, Saul A, Martin LB, Podda A.

Front Immunol. 2019 Mar 8;10:335. doi: 10.3389/fimmu.2019.00335. eCollection 2019.


The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2.

Wang J, Zhao J, Cui X, Mysona BA, Navneet S, Saul A, Ahuja M, Lambert N, Gazaryan IG, Thomas B, Bollinger KE, Smith SB.

Free Radic Biol Med. 2019 Apr;134:604-616. doi: 10.1016/j.freeradbiomed.2019.02.001. Epub 2019 Feb 10.


A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse.

Ibrahim AS, Elmasry K, Wan M, Abdulmoneim S, Still A, Khan F, Khalil A, Saul A, Hoda MN, Al-Shabrawey M.

Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5548-5557. doi: 10.1167/iovs.18-24773.


Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella.

Micoli F, Rondini S, Alfini R, Lanzilao L, Necchi F, Negrea A, Rossi O, Brandt C, Clare S, Mastroeni P, Rappuoli R, Saul A, MacLennan CA.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10428-10433. doi: 10.1073/pnas.1807655115. Epub 2018 Sep 27.


Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A.

Elife. 2018 Aug 3;7. pii: e36217. doi: 10.7554/eLife.36217.


Setup of luminescence-based serum bactericidal assay against Salmonella Paratyphi A.

Necchi F, Saul A, Rondini S.

J Immunol Methods. 2018 Oct;461:117-121. doi: 10.1016/j.jim.2018.06.025. Epub 2018 Jun 30.


Vestibular rehabilitation therapy and Nintendo Wii balance board training both improve postural control in bilateral vestibulopathy.

Jahn K, Saul AK, Elstner M, Sapa K, Kellerer S.

J Neurol. 2018 Oct;265(Suppl 1):70-73. doi: 10.1007/s00415-018-8882-z. Epub 2018 May 3. No abstract available.


Polymorphism in the serotonin transporter gene polymorphisms ( 5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis.

Saul A, Taylor B, Simpson S Jr, Ponsonby AL, Blizzard L, Dwyer T, McMorran B, Wood B, van der Mei IA.

Mult Scler. 2019 May;25(6):848-855. doi: 10.1177/1352458518770021. Epub 2018 Apr 23.


A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country.

Obiero CW, Ndiaye AGW, Sciré AS, Kaunyangi BM, Marchetti E, Gone AM, Schütte LD, Riccucci D, Auerbach J, Saul A, Martin LB, Bejon P, Njuguna P, Podda A.

Front Immunol. 2017 Dec 22;8:1884. doi: 10.3389/fimmu.2017.01884. eCollection 2017.


The influence of conjugation variables on the design and immunogenicity of a glycoconjugate vaccine against Salmonella Typhi.

Arcuri M, Di Benedetto R, Cunningham AF, Saul A, MacLennan CA, Micoli F.

PLoS One. 2017 Dec 29;12(12):e0189100. doi: 10.1371/journal.pone.0189100. eCollection 2017.


Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa.

Wang J, Saul A, Cui X, Roon P, Smith SB.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4545-4558. doi: 10.1167/iovs.17-21947.


Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1.

Marini A, Rossi O, Aruta MG, Micoli F, Rondini S, Guadagnuolo S, Delany I, Henderson IR, Cunningham AF, Saul A, MacLennan CA, Koeberling O.

PLoS One. 2017 Jul 25;12(7):e0181508. doi: 10.1371/journal.pone.0181508. eCollection 2017.


Piezomagnetism and magnetoelastic memory in uranium dioxide.

Jaime M, Saul A, Salamon M, Zapf VS, Harrison N, Durakiewicz T, Lashley JC, Andersson DA, Stanek CR, Smith JL, Gofryk K.

Nat Commun. 2017 Jul 24;8(1):99. doi: 10.1038/s41467-017-00096-4.


Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe.

Launay O, Lewis DJM, Anemona A, Loulergue P, Leahy J, Sciré AS, Maugard A, Marchetti E, Zancan S, Huo Z, Rondini S, Marhaba R, Finco O, Martin LB, Auerbach J, Cohen D, Saul A, Gerke C, Podda A.

EBioMedicine. 2017 Aug;22:164-172. doi: 10.1016/j.ebiom.2017.07.013. Epub 2017 Jul 15.


Detailed electroretinographic findings in rd8 mice.

Saul AB, Cui X, Markand S, Smith SB.

Doc Ophthalmol. 2017 Jun;134(3):195-203. doi: 10.1007/s10633-017-9585-y. Epub 2017 Mar 27.


The Role of Sigma1R in Mammalian Retina.

Wang J, Cui X, Roon P, Saul A, Smith SB.

Adv Exp Med Biol. 2017;964:267-284. doi: 10.1007/978-3-319-50174-1_18. Review.


Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever.

Giannelli C, Cappelletti E, Di Benedetto R, Pippi F, Arcuri M, Di Cioccio V, Martin LB, Saul A, Micoli F.

J Pharm Biomed Anal. 2017 May 30;139:143-147. doi: 10.1016/j.jpba.2017.02.042. Epub 2017 Feb 24.


Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.

Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J.

EMBO Mol Med. 2017 Apr;9(4):482-497. doi: 10.15252/emmm.201606975.


Development of a high-throughput method to evaluate serum bactericidal activity using bacterial ATP measurement as survival readout.

Necchi F, Saul A, Rondini S.

PLoS One. 2017 Feb 13;12(2):e0172163. doi: 10.1371/journal.pone.0172163. eCollection 2017.


A Systematic Review of the Incidence, Risk Factors and Case Fatality Rates of Invasive Nontyphoidal Salmonella (iNTS) Disease in Africa (1966 to 2014).

Uche IV, MacLennan CA, Saul A.

PLoS Negl Trop Dis. 2017 Jan 5;11(1):e0005118. doi: 10.1371/journal.pntd.0005118. eCollection 2017 Jan. Review.


Prioritizing vaccines for developing world diseases.

Saul A, O'Brien KL.

Vaccine. 2017 Jan 20;35 Suppl 1:A16-A19. doi: 10.1016/j.vaccine.2016.10.087. Epub 2016 Dec 22.


Characterization of O-antigen delivered by Generalized Modules for Membrane Antigens (GMMA) vaccine candidates against nontyphoidal Salmonella.

De Benedetto G, Alfini R, Cescutti P, Caboni M, Lanzilao L, Necchi F, Saul A, MacLennan CA, Rondini S, Micoli F.

Vaccine. 2017 Jan 11;35(3):419-426. doi: 10.1016/j.vaccine.2016.11.089. Epub 2016 Dec 18.


Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury.

Shosha E, Xu Z, Yokota H, Saul A, Rojas M, Caldwell RW, Caldwell RB, Narayanan SP.

Cell Death Dis. 2016 Nov 24;7(11):e2483. doi: 10.1038/cddis.2016.295.


Permanent Indwelling Transmural Stents for Endoscopic Treatment of Patients With Disconnected Pancreatic Duct Syndrome: Long-term Results.

Téllez-Aviña FI, Casasola-Sánchez LE, Ramírez-Luna MÁ, Saúl Á, Murcio-Pérez E, Chan C, Uscanga L, Duarte-Medrano G, Valdovinos-Andraca F.

J Clin Gastroenterol. 2018 Jan;52(1):85-90. doi: 10.1097/MCG.0000000000000754.


Stressful life events and the risk of initial central nervous system demyelination.

Saul A, Ponsonby AL, Lucas RM, Taylor BV, Simpson S Jr, Valery P, Dwyer T, Kilpatrick TJ, Pender MP, van der Mei IA.

Mult Scler. 2017 Jun;23(7):1000-1007. doi: 10.1177/1352458516667566. Epub 2016 Sep 6.


Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review.

Muturi-Kioi V, Lewis D, Launay O, Leroux-Roels G, Anemona A, Loulergue P, Bodinham CL, Aerssens A, Groth N, Saul A, Podda A.

PLoS One. 2016 Aug 4;11(8):e0157385. doi: 10.1371/journal.pone.0157385. eCollection 2016. Review.


Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease.

Promsote W, Powell FL, Veean S, Thounaojam M, Markand S, Saul A, Gutsaeva D, Bartoli M, Smith SB, Ganapathy V, Martin PM.

Antioxid Redox Signal. 2016 Dec 10;25(17):921-935. Epub 2016 Aug 22.


Enumeration of sulphate-reducing bacteria for assessing potential for hydrogen sulphide production in urban drainage systems.

Karunakaran E, Vernon D, Biggs CA, Saul A, Crawford D, Jensen H.

Water Sci Technol. 2016;73(12):3087-94. doi: 10.2166/wst.2016.026.


Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

Wang J, Saul A, Roon P, Smith SB.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3764-72. doi: 10.1073/pnas.1521749113. Epub 2016 Jun 13.


Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection.

Goh YS, Necchi F, O'Shaughnessy CM, Micoli F, Gavini M, Young SP, Msefula CL, Gondwe EN, Mandala WL, Gordon MA, Saul AJ, MacLennan CA.

PLoS Negl Trop Dis. 2016 Apr 8;10(4):e0004604. doi: 10.1371/journal.pntd.0004604. eCollection 2016 Apr.


Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis.

Rossi O, Caboni M, Negrea A, Necchi F, Alfini R, Micoli F, Saul A, MacLennan CA, Rondini S, Gerke C.

Clin Vaccine Immunol. 2016 Apr 4;23(4):304-14. doi: 10.1128/CVI.00023-16. Print 2016 Apr.


Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations.

Maggiore L, Yu L, Omasits U, Rossi O, Dougan G, Thomson NR, Saul A, Choudhary JS, Gerke C.

Int J Med Microbiol. 2016 Feb;306(2):99-108. doi: 10.1016/j.ijmm.2015.12.003. Epub 2015 Dec 23.


The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants.

Thompson CN, Le TP, Anders KL, Nguyen TH, Lu LV, Nguyen VV, Vu TD, Nguyen NM, Tran TH, Ha TT, Tran VT, Pham VM, Tran do HN, Le TQ, Saul A, Martin LB, Podda A, Gerke C, Thwaites G, Simmons CP, Baker S.

Vaccine. 2016 Feb 3;34(6):783-90. doi: 10.1016/j.vaccine.2015.12.047. Epub 2015 Dec 29.


Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease.

Saul A, Wirths O.

Mol Neurobiol. 2017 Jan;54(1):319-327. doi: 10.1007/s12035-015-9674-4. Epub 2016 Jan 7.


Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.

Markand S, Saul A, Tawfik A, Cui X, Rozen R, Smith SB.

Exp Eye Res. 2016 Apr;145:164-172. doi: 10.1016/j.exer.2015.11.013. Epub 2015 Dec 2.


Click Chemistry Applied to the Synthesis of Salmonella Typhimurium O-Antigen Glycoconjugate Vaccine on Solid Phase with Sugar Recycling.

Stefanetti G, Saul A, MacLennan CA, Micoli F.

Bioconjug Chem. 2015 Dec 16;26(12):2507-13. doi: 10.1021/acs.bioconjchem.5b00521. Epub 2015 Nov 18.


Cement As a Waste Form for Nuclear Fission Products: The Case of (90)Sr and Its Daughters.

Dezerald L, Kohanoff JJ, Correa AA, Caro A, Pellenq RJ, Ulm FJ, Saúl A.

Environ Sci Technol. 2015 Nov 17;49(22):13676-83. doi: 10.1021/acs.est.5b02609. Epub 2015 Oct 29.


Strain Selection for Generation of O-Antigen-Based Glycoconjugate Vaccines against Invasive Nontyphoidal Salmonella Disease.

Lanzilao L, Stefanetti G, Saul A, MacLennan CA, Micoli F, Rondini S.

PLoS One. 2015 Oct 7;10(10):e0139847. doi: 10.1371/journal.pone.0139847. eCollection 2015.


Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines.

Stefanetti G, Hu QY, Usera A, Robinson Z, Allan M, Singh A, Imase H, Cobb J, Zhai H, Quinn D, Lei M, Saul A, Adamo R, MacLennan CA, Micoli F.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13198-203. doi: 10.1002/anie.201506112. Epub 2015 Sep 9.


Production of a Shigella sonnei Vaccine Based on Generalized Modules for Membrane Antigens (GMMA), 1790GAHB.

Gerke C, Colucci AM, Giannelli C, Sanzone S, Vitali CG, Sollai L, Rossi O, Martin LB, Auerbach J, Di Cioccio V, Saul A.

PLoS One. 2015 Aug 6;10(8):e0134478. doi: 10.1371/journal.pone.0134478. eCollection 2015.


Monoclonal Antibodies of a Diverse Isotype Induced by an O-Antigen Glycoconjugate Vaccine Mediate In Vitro and In Vivo Killing of African Invasive Nontyphoidal Salmonella.

Goh YS, Clare S, Micoli F, Saul A, Mastroeni P, MacLennan CA.

Infect Immun. 2015 Sep;83(9):3722-31. doi: 10.1128/IAI.00547-15. Epub 2015 Jul 13.


EUS-guided drainage of pancreatic pseudocysts offers similar success and complications compared to surgical treatment but with a lower cost.

Saul A, Ramirez Luna MA, Chan C, Uscanga L, Valdovinos Andraca F, Hernandez Calleros J, Elizondo J, Tellez Avila F.

Surg Endosc. 2016 Apr;30(4):1459-65. doi: 10.1007/s00464-015-4351-2. Epub 2015 Jul 3.


An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei.

Caboni M, Pédron T, Rossi O, Goulding D, Pickard D, Citiulo F, MacLennan CA, Dougan G, Thomson NR, Saul A, Sansonetti PJ, Gerke C.

PLoS Pathog. 2015 Mar 20;11(3):e1004749. doi: 10.1371/journal.ppat.1004749. eCollection 2015 Mar.


Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.

Markand S, Saul A, Roon P, Prasad P, Martin P, Rozen R, Ganapathy V, Smith SB.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2684-95. doi: 10.1167/iovs.14-16190.


Relationship between antibody susceptibility and lipopolysaccharide O-antigen characteristics of invasive and gastrointestinal nontyphoidal Salmonellae isolates from Kenya.

Onsare RS, Micoli F, Lanzilao L, Alfini R, Okoro CK, Muigai AW, Revathi G, Saul A, Kariuki S, MacLennan CA, Rondini S.

PLoS Negl Trop Dis. 2015 Mar 4;9(3):e0003573. doi: 10.1371/journal.pntd.0003573. eCollection 2015 Mar.


Simplified low-cost production of O-antigen from Salmonella Typhimurium Generalized Modules for Membrane Antigens (GMMA).

Meloni E, Colucci AM, Micoli F, Sollai L, Gavini M, Saul A, Di Cioccio V, MacLennan CA.

J Biotechnol. 2015 Mar 20;198:46-52. doi: 10.1016/j.jbiotec.2015.01.020. Epub 2015 Feb 3.

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