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Items: 18

1.

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M.

Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108.

2.

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.

Hu H, Nemecz Á, Van Renterghem C, Fourati Z, Sauguet L, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3959-E3968. doi: 10.1073/pnas.1717700115. Epub 2018 Apr 9.

PMID:
29632192
3.

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

Sauguet L, Raia P, Henneke G, Delarue M.

Nat Commun. 2016 Aug 22;7:12227. doi: 10.1038/ncomms12227. [Epub ahead of print]

4.

Sites of Anesthetic Inhibitory Action on a Cationic Ligand-Gated Ion Channel.

Laurent B, Murail S, Shahsavar A, Sauguet L, Delarue M, Baaden M.

Structure. 2016 Apr 5;24(4):595-605. doi: 10.1016/j.str.2016.02.014. Epub 2016 Mar 24.

5.

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel.

Sauguet L, Fourati Z, Prangé T, Delarue M, Colloc'h N.

PLoS One. 2016 Feb 24;11(2):e0149795. doi: 10.1371/journal.pone.0149795. eCollection 2016.

6.

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).

Ostrowski M, Porowinska D, Prochnicki T, Prevost M, Raynal B, Baron B, Sauguet L, Corringer PJ, Faure G.

Toxicon. 2016 Jun 15;116:63-71. doi: 10.1016/j.toxicon.2016.02.002. Epub 2016 Feb 5.

PMID:
26854368
7.

Genuine open form of the pentameric ligand-gated ion channel GLIC.

Fourati Z, Sauguet L, Delarue M.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):454-60. doi: 10.1107/S1399004714026698. Epub 2015 Feb 26.

PMID:
25760595
8.

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M, Delarue M, Corringer PJ.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2865-70. doi: 10.1073/pnas.1417864112. Epub 2015 Feb 17.

9.

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels.

Sauguet L, Shahsavar A, Delarue M.

Biochim Biophys Acta. 2015 Mar;1850(3):511-23. doi: 10.1016/j.bbagen.2014.05.007. Epub 2014 May 14. Review.

PMID:
24836522
10.

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23.

11.

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.

Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M.

Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682.

12.

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.

Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L, Thompson AW, Koehl P, Corringer PJ, Baaden M, Delarue M.

EMBO J. 2013 Mar 6;32(5):728-41. doi: 10.1038/emboj.2013.17. Epub 2013 Feb 12.

13.

Structure and pharmacology of pentameric receptor channels: from bacteria to brain.

Corringer PJ, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP.

Structure. 2012 Jun 6;20(6):941-56. doi: 10.1016/j.str.2012.05.003. Review.

14.

A locally closed conformation of a bacterial pentameric proton-gated ion channel.

Prevost MS, Sauguet L, Nury H, Van Renterghem C, Huon C, Poitevin F, Baaden M, Delarue M, Corringer PJ.

Nat Struct Mol Biol. 2012 May 13;19(6):642-9. doi: 10.1038/nsmb.2307.

PMID:
22580559
15.

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.

Núñez-Ramírez R, Klinge S, Sauguet L, Melero R, Recuero-Checa MA, Kilkenny M, Perera RL, García-Alvarez B, Hall RJ, Nogales E, Pellegrini L, Llorca O.

Nucleic Acids Res. 2011 Oct;39(18):8187-99. doi: 10.1093/nar/gkr534. Epub 2011 Jun 28. Erratum in: Nucleic Acids Res. 2012 May;40(10):4726.

16.

Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.

Sauguet L, Moutiez M, Li Y, Belin P, Seguin J, Le Du MH, Thai R, Masson C, Fonvielle M, Pernodet JL, Charbonnier JB, Gondry M.

Nucleic Acids Res. 2011 May;39(10):4475-89. doi: 10.1093/nar/gkr027. Epub 2011 Feb 3.

17.

Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase.

Sauguet L, Klinge S, Perera RL, Maman JD, Pellegrini L.

PLoS One. 2010 Apr 9;5(4):e10083. doi: 10.1371/journal.pone.0010083.

18.

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courçon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL.

Nat Chem Biol. 2009 Jun;5(6):414-20. doi: 10.1038/nchembio.175.

PMID:
19430487

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