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Items: 1 to 50 of 434

1.

Capacity for instantaneous catabolism of preferred and non-preferred carbon sources in Escherichia coli and Bacillus subtilis.

Buffing MF, Link H, Christodoulou D, Sauer U.

Sci Rep. 2018 Aug 6;8(1):11760. doi: 10.1038/s41598-018-30266-3.

2.

Moving towards same-day provision of Level 3 care in sexual and reproductive health services.

Sauer U, Mann S, Stephenson JM.

BMJ Sex Reprod Health. 2018 Feb 26. pii: jfprhc-2017-101817. doi: 10.1136/bmjsrh-2017-101817. [Epub ahead of print] No abstract available.

PMID:
29972365
3.

Concepts and applications of foliar spray for microbial inoculants.

Preininger C, Sauer U, Bejarano A, Berninger T.

Appl Microbiol Biotechnol. 2018 Sep;102(17):7265-7282. doi: 10.1007/s00253-018-9173-4. Epub 2018 Jun 30. Review.

PMID:
29961100
4.

Author Correction: Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120.

Mishra Y, Hall M, Locmelis R, Nam K, Söderberg CAG, Storm P, Chaurasia N, Rai LC, Jansson S, Schröder WP, Sauer UH.

Sci Rep. 2018 May 30;8(1):8658. doi: 10.1038/s41598-018-26715-8.

5.

Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress.

Christodoulou D, Link H, Fuhrer T, Kochanowski K, Gerosa L, Sauer U.

Cell Syst. 2018 May 23;6(5):569-578.e7. doi: 10.1016/j.cels.2018.04.009. Epub 2018 May 9.

PMID:
29753645
6.

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.

Schmaler M, Colone A, Spagnuolo J, Zimmermann M, Lepore M, Kalinichenko A, Bhatia S, Cottier F, Rutishauser T, Pavelka N, Egli A, Azzali E, Pieroni M, Costantino G, Hruz P, Sauer U, Mori L, De Libero G.

Mucosal Immunol. 2018 Jul;11(4):1060-1070. doi: 10.1038/s41385-018-0020-9. Epub 2018 May 9.

PMID:
29743612
7.

Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F.

J Med Chem. 2018 May 10;61(9):4165-4175. doi: 10.1021/acs.jmedchem.8b00289. Epub 2018 Apr 27.

PMID:
29667825
8.

In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO₂.

Wiemann M, Sauer UG, Vennemann A, Bäcker S, Keller JG, Ma-Hock L, Wohlleben W, Landsiedel R.

Nanomaterials (Basel). 2018 Mar 13;8(3). pii: E160. doi: 10.3390/nano8030160.

9.

Molecular mechanism of ATP versus GTP selectivity of adenylate kinase.

Rogne P, Rosselin M, Grundström C, Hedberg C, Sauer UH, Wolf-Watz M.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3012-3017. doi: 10.1073/pnas.1721508115. Epub 2018 Mar 5.

PMID:
29507216
10.

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.

Zampieri M, Szappanos B, Buchieri MV, Trauner A, Piazza I, Picotti P, Gagneux S, Borrell S, Gicquel B, Lelievre J, Papp B, Sauer U.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaal3973. doi: 10.1126/scitranslmed.aal3973.

PMID:
29467300
11.

Application of open-path Fourier transform infrared spectroscopy for atmospheric monitoring of a CO2 back-production experiment at the Ketzin pilot site (Germany).

Sauer U, Borsdorf H, Dietrich P, Liebscher A, Möller I, Martens S, Möller F, Schlömer S, Schütze C.

Environ Monit Assess. 2018 Feb 3;190(3):114. doi: 10.1007/s10661-018-6488-7.

PMID:
29396669
12.

Comment on "Alternative acute oral toxicity assessment under REACH based on sub-acute toxicity values".

Buesen R, Oberholz U, Sauer UG, Landsiedel R.

ALTEX. 2018;35(1):119-121. doi: 10.14573/altex.1710111. No abstract available.

13.

Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer.

Gogalic S, Sauer U, Doppler S, Preininger C.

Biosensors (Basel). 2018 Jan 24;8(1). pii: E10. doi: 10.3390/bios8010010.

14.

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication.

Piazza I, Kochanowski K, Cappelletti V, Fuhrer T, Noor E, Sauer U, Picotti P.

Cell. 2018 Jan 11;172(1-2):358-372.e23. doi: 10.1016/j.cell.2017.12.006. Epub 2018 Jan 4.

PMID:
29307493
15.

Editorial: Applying 'omics technologies in chemicals risk assessment.

van Ravenzwaay B, Sauer UG, de Matos O, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S1-S2. doi: 10.1016/j.yrtph.2017.11.017. No abstract available.

16.

Disentangling metabolic functions of bacteria in the honey bee gut.

Kešnerová L, Mars RAT, Ellegaard KM, Troilo M, Sauer U, Engel P.

PLoS Biol. 2017 Dec 12;15(12):e2003467. doi: 10.1371/journal.pbio.2003467. eCollection 2017 Dec.

17.

Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.

Blattmann P, Henriques D, Zimmermann M, Frommelt F, Sauer U, Saez-Rodriguez J, Aebersold R.

Cell Syst. 2017 Dec 27;5(6):604-619.e7. doi: 10.1016/j.cels.2017.11.002. Epub 2017 Dec 6.

18.

Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7210.

Mishra Y, Hall M, Locmelis R, Nam K, Söderberg CAG, Storm P, Chaurasia N, Rai LC, Jansson S, Schröder WP, Sauer UH.

Sci Rep. 2017 Dec 7;7(1):17151. doi: 10.1038/s41598-017-17044-3. Erratum in: Sci Rep. 2018 May 30;8(1):8658.

19.

A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis.

Gant TW, Sauer UG, Zhang SD, Chorley BN, Hackermüller J, Perdichizzi S, Tollefsen KE, van Ravenzwaay B, Yauk C, Tong W, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S36-S45. doi: 10.1016/j.yrtph.2017.11.001. Epub 2017 Nov 4.

20.

Framework for the quantitative weight-of-evidence analysis of 'omics data for regulatory purposes.

Bridges J, Sauer UG, Buesen R, Deferme L, Tollefsen KE, Tralau T, van Ravenzwaay B, Poole A, Pemberton M.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S46-S60. doi: 10.1016/j.yrtph.2017.10.010. Epub 2017 Oct 14.

21.

Framework for the quality assurance of 'omics technologies considering GLP requirements.

Kauffmann HM, Kamp H, Fuchs R, Chorley BN, Deferme L, Ebbels T, Hackermüller J, Perdichizzi S, Poole A, Sauer UG, Tollefsen KE, Tralau T, Yauk C, van Ravenzwaay B.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S27-S35. doi: 10.1016/j.yrtph.2017.10.007. Epub 2017 Oct 5.

22.

Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow.

Ponomarova O, Gabrielli N, Sévin DC, Mülleder M, Zirngibl K, Bulyha K, Andrejev S, Kafkia E, Typas A, Sauer U, Ralser M, Patil KR.

Cell Syst. 2017 Oct 25;5(4):345-357.e6. doi: 10.1016/j.cels.2017.09.002. Epub 2017 Sep 27.

23.

In chemico, in vitro and in vivo comparison of the skin sensitizing potential of eight unsaturated and one saturated lipid compounds.

Kreiling R, Gehrke H, Broschard TH, Dreeßen B, Eigler D, Hart D, Höpflinger V, Kleber M, Kupny J, Li Q, Ungeheuer P, Sauer UG.

Regul Toxicol Pharmacol. 2017 Nov;90:262-276. doi: 10.1016/j.yrtph.2017.09.023. Epub 2017 Sep 27.

PMID:
28958912
24.

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

Buesen R, Chorley BN, da Silva Lima B, Daston G, Deferme L, Ebbels T, Gant TW, Goetz A, Greally J, Gribaldo L, Hackermüller J, Hubesch B, Jennen D, Johnson K, Kanno J, Kauffmann HM, Laffont M, McMullen P, Meehan R, Pemberton M, Perdichizzi S, Piersma AH, Sauer UG, Schmidt K, Seitz H, Sumida K, Tollefsen KE, Tong W, Tralau T, van Ravenzwaay B, Weber RJM, Worth A, Yauk C, Poole A.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S3-S13. doi: 10.1016/j.yrtph.2017.09.002. Epub 2017 Sep 25.

25.

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook.

Sauer UG, Deferme L, Gribaldo L, Hackermüller J, Tralau T, van Ravenzwaay B, Yauk C, Poole A, Tong W, Gant TW.

Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1:S14-S26. doi: 10.1016/j.yrtph.2017.09.020. Epub 2017 Sep 18.

26.

Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity.

Reznik E, Christodoulou D, Goldford JE, Briars E, Sauer U, Segrè D, Noor E.

Cell Rep. 2017 Sep 12;20(11):2666-2677. doi: 10.1016/j.celrep.2017.08.066.

27.

Prediction of skin sensitization potency sub-categories using peptide reactivity data.

Wareing B, Urbisch D, Kolle SN, Honarvar N, Sauer UG, Mehling A, Landsiedel R.

Toxicol In Vitro. 2017 Dec;45(Pt 1):134-145. doi: 10.1016/j.tiv.2017.08.015. Epub 2017 Sep 4.

28.

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection.

Zimmermann M, Kogadeeva M, Gengenbacher M, McEwen G, Mollenkopf HJ, Zamboni N, Kaufmann SHE, Sauer U.

mSystems. 2017 Aug 22;2(4). pii: e00057-17. doi: 10.1128/mSystems.00057-17. eCollection 2017 Jul-Aug.

29.

Towards detecting regulatory protein-metabolite interactions.

Diether M, Sauer U.

Curr Opin Microbiol. 2017 Oct;39:16-23. doi: 10.1016/j.mib.2017.07.006. Epub 2017 Aug 12. Review.

PMID:
28810194
30.

Design and development of a workflow for microbial spray formulations including decision criteria.

Bejarano A, Sauer U, Preininger C.

Appl Microbiol Biotechnol. 2017 Oct;101(19):7335-7346. doi: 10.1007/s00253-017-8447-6. Epub 2017 Aug 8.

PMID:
28791444
31.

A Chip for Estrogen Receptor Action: Detection of Biomarkers Released by MCF-7 Cells through Estrogenic and Anti-Estrogenic Effects.

Gier K, Preininger C, Sauer U.

Sensors (Basel). 2017 Aug 1;17(8). pii: E1760. doi: 10.3390/s17081760.

32.

Modern science for better quality control of medicinal products "Towards global harmonization of 3Rs in biologicals": The report of an EPAA workshop.

Schutte K, Szczepanska A, Halder M, Cussler K, Sauer UG, Stirling C, Uhlrich S, Wilk-Zasadna I, John D, Bopst M, Garbe J, Glansbeek HL, Levis R, Serreyn PJ, Smith D, Stickings P.

Biologicals. 2017 Jul;48:55-65. doi: 10.1016/j.biologicals.2017.05.006. Epub 2017 Jun 7.

33.

Structural basis for ligand binding to an enzyme by a conformational selection pathway.

Kovermann M, Grundström C, Sauer-Eriksson AE, Sauer UH, Wolf-Watz M.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6298-6303. doi: 10.1073/pnas.1700919114. Epub 2017 May 30.

34.

Safety assessment of nanomaterials using an advanced decision-making framework, the DF4nanoGrouping.

Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, Sauer UG.

J Nanopart Res. 2017;19(5):171. doi: 10.1007/s11051-017-3850-6. Epub 2017 May 9.

35.

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.

36.

Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations.

Zampieri M, Zimmermann M, Claassen M, Sauer U.

Cell Rep. 2017 May 9;19(6):1214-1228. doi: 10.1016/j.celrep.2017.04.002.

37.

Microarray-Based Immunoassay with Synthetic Mimotopes for the Detection of Fumonisin B1.

Peltomaa R, Benito-Peña E, Barderas R, Sauer U, González Andrade M, Moreno-Bondi MC.

Anal Chem. 2017 Jun 6;89(11):6216-6223. doi: 10.1021/acs.analchem.7b01178. Epub 2017 May 16.

PMID:
28475831
38.

Metabolic constraints on the evolution of antibiotic resistance.

Zampieri M, Enke T, Chubukov V, Ricci V, Piddock L, Sauer U.

Mol Syst Biol. 2017 Mar 6;13(3):917. doi: 10.15252/msb.20167028.

39.

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A.

Dev Cell. 2017 Feb 27;40(4):331-341.e4. doi: 10.1016/j.devcel.2017.01.015.

40.

Analytical Protein Microarrays: Advancements Towards Clinical Applications.

Sauer U.

Sensors (Basel). 2017 Jan 29;17(2). pii: E256. doi: 10.3390/s17020256. Review.

41.

Genomewide landscape of gene-metabolome associations in Escherichia coli.

Fuhrer T, Zampieri M, Sévin DC, Sauer U, Zamboni N.

Mol Syst Biol. 2017 Jan 16;13(1):907. doi: 10.15252/msb.20167150.

42.

Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast.

Gonçalves E, Raguz Nakic Z, Zampieri M, Wagih O, Ochoa D, Sauer U, Beltrao P, Saez-Rodriguez J.

PLoS Comput Biol. 2017 Jan 10;13(1):e1005297. doi: 10.1371/journal.pcbi.1005297. eCollection 2017 Jan.

43.

Frontiers of high-throughput metabolomics.

Zampieri M, Sekar K, Zamboni N, Sauer U.

Curr Opin Chem Biol. 2017 Feb;36:15-23. doi: 10.1016/j.cbpa.2016.12.006. Epub 2017 Jan 5. Review.

PMID:
28064089
44.

Few regulatory metabolites coordinate expression of central metabolic genes in Escherichia coli.

Kochanowski K, Gerosa L, Brunner SF, Christodoulou D, Nikolaev YV, Sauer U.

Mol Syst Biol. 2017 Jan 3;13(1):903. doi: 10.15252/msb.20167402.

45.

Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer.

Gogalic S, Sauer U, Doppler S, Heinzel A, Perco P, Lukas A, Simpson G, Pandha H, Horvath A, Preininger C.

Biomarkers. 2017 Nov;22(7):674-681. doi: 10.1080/1354750X.2016.1276628. Epub 2017 Jan 19.

PMID:
28010124
46.

Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.

Sévin DC, Fuhrer T, Zamboni N, Sauer U.

Nat Methods. 2017 Feb;14(2):187-194. doi: 10.1038/nmeth.4103. Epub 2016 Dec 12.

PMID:
27941785
47.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.

Hall M, Grundström C, Begum A, Lindberg MJ, Sauer UH, Almqvist F, Johansson J, Sauer-Eriksson AE.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14733-14738. doi: 10.1073/pnas.1614028114. Epub 2016 Dec 5.

48.

Glycolysis without pyruvate kinase in Clostridium thermocellum.

Olson DG, Hörl M, Fuhrer T, Cui J, Zhou J, Maloney MI, Amador-Noguez D, Tian L, Sauer U, Lynd LR.

Metab Eng. 2017 Jan;39:169-180. doi: 10.1016/j.ymben.2016.11.011. Epub 2016 Dec 1.

PMID:
27914869
49.

Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae.

Raguz Nakic Z, Seisenbacher G, Posas F, Sauer U.

BMC Syst Biol. 2016 Nov 15;10(1):104.

50.

Acute oral toxicity testing: Scientific evidence and practicability should govern Three Rs activities.

Buesen R, Oberholz U, Sauer UG, Landsiedel R.

Altern Lab Anim. 2016 Sep;44(4):391-398.

PMID:
27685189

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