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Items: 1 to 50 of 80

1.

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons.

Moutaux E, Christaller W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M, Saudou F.

Sci Rep. 2018 Sep 7;8(1):13429. doi: 10.1038/s41598-018-31759-x.

2.

Region-specific and state-dependent action of striatal GABAergic interneurons.

Fino E, Vandecasteele M, Perez S, Saudou F, Venance L.

Nat Commun. 2018 Aug 21;9(1):3339. doi: 10.1038/s41467-018-05847-5.

3.

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E.

Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057.

4.

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington's Disease.

Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F.

Cell Rep. 2018 Jan 2;22(1):110-122. doi: 10.1016/j.celrep.2017.12.013.

5.

Gpr158 mediates osteocalcin's regulation of cognition.

Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G.

J Exp Med. 2017 Oct 2;214(10):2859-2873. doi: 10.1084/jem.20171320. Epub 2017 Aug 29.

6.

A randomized, double-blind, placebo-controlled trial evaluating cysteamine in Huntington's disease.

Verny C, Bachoud-Lévi AC, Durr A, Goizet C, Azulay JP, Simonin C, Tranchant C, Calvas F, Krystkowiak P, Charles P, Youssov K, Scherer C, Prundean A, Olivier A, Reynier P, Saudou F, Maison P, Allain P, von Studnitz E, Bonneau D; CYST-HD Study Group.

Mov Disord. 2017 Jun;32(6):932-936. doi: 10.1002/mds.27010. Epub 2017 Apr 24.

PMID:
28436572
7.

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport.

Hinckelmann MV, Virlogeux A, Niehage C, Poujol C, Choquet D, Hoflack B, Zala D, Saudou F.

Nat Commun. 2016 Oct 24;7:13233. doi: 10.1038/ncomms13233.

8.

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S.

J Clin Invest. 2016 Sep 1;126(9):3585-97. doi: 10.1172/JCI80339. Epub 2016 Aug 15.

9.

The Biology of Huntingtin.

Saudou F, Humbert S.

Neuron. 2016 Mar 2;89(5):910-26. doi: 10.1016/j.neuron.2016.02.003. Review.

10.

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F.

EMBO J. 2015 Sep 2;34(17):2255-71. doi: 10.15252/embj.201490808. Epub 2015 Jul 12.

11.

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

Marquer C, Laine J, Dauphinot L, Hanbouch L, Lemercier-Neuillet C, Pierrot N, Bossers K, Le M, Corlier F, Benstaali C, Saudou F, Thinakaran G, Cartier N, Octave JN, Duyckaerts C, Potier MC.

Mol Neurodegener. 2014 Dec 18;9:60. doi: 10.1186/1750-1326-9-60.

12.

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94. doi: 10.1073/pnas.1420103111. Epub 2014 Nov 10.

13.

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.

Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N.

PLoS One. 2014 Jun 13;9(6):e99341. doi: 10.1371/journal.pone.0099341. eCollection 2014.

14.

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

Naia L, Ferreira IL, Cunha-Oliveira T, Duarte AI, Ribeiro M, Rosenstock TR, Laço MN, Ribeiro MJ, Oliveira CR, Saudou F, Humbert S, Rego AC.

Mol Neurobiol. 2015 Feb;51(1):331-48. doi: 10.1007/s12035-014-8735-4. Epub 2014 May 20.

PMID:
24841383
15.

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms.

Pla P, Orvoen S, Saudou F, David DJ, Humbert S.

Front Behav Neurosci. 2014 Apr 23;8:135. doi: 10.3389/fnbeh.2014.00135. eCollection 2014. Review.

16.

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

Lopes C, Ribeiro M, Duarte AI, Humbert S, Saudou F, Pereira de Almeida L, Hayden M, Rego AC.

Mol Neurobiol. 2014 Jun;49(3):1126-42. doi: 10.1007/s12035-013-8585-5. Epub 2013 Dec 18.

PMID:
24347322
17.

Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.

Hinckelmann MV, Zala D, Saudou F.

Trends Cell Biol. 2013 Dec;23(12):634-43. doi: 10.1016/j.tcb.2013.08.007. Epub 2013 Sep 30. Review.

PMID:
24091156
18.

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.

Pla P, Orvoen S, Benstaali C, Dodier S, Gardier AM, David DJ, Humbert S, Saudou F.

PLoS One. 2013 Sep 3;8(9):e73902. doi: 10.1371/journal.pone.0073902. eCollection 2013.

19.

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Ben M'Barek K, Pla P, Orvoen S, Benstaali C, Godin JD, Gardier AM, Saudou F, David DJ, Humbert S.

J Neurosci. 2013 May 15;33(20):8608-20. doi: 10.1523/JNEUROSCI.5110-12.2013.

20.

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

Liot G, Zala D, Pla P, Mottet G, Piel M, Saudou F.

J Neurosci. 2013 Apr 10;33(15):6298-309. doi: 10.1523/JNEUROSCI.2033-12.2013.

21.

Huntingtin's function in axonal transport is conserved in Drosophila melanogaster.

Zala D, Hinckelmann MV, Saudou F.

PLoS One. 2013;8(3):e60162. doi: 10.1371/journal.pone.0060162. Epub 2013 Mar 28.

22.

Vesicular glycolysis provides on-board energy for fast axonal transport.

Zala D, Hinckelmann MV, Yu H, Lyra da Cunha MM, Liot G, Cordelières FP, Marco S, Saudou F.

Cell. 2013 Jan 31;152(3):479-91. doi: 10.1016/j.cell.2012.12.029.

23.

A "so cilia" network: cilia proteins start "social" networking.

Saudou F.

J Clin Invest. 2012 Apr;122(4):1198-202. doi: 10.1172/JCI62971. Epub 2012 Mar 26.

24.

[Unexpected link between Huntington disease and Rett syndrome].

Roux JC, Zala D, Panayotis N, Borges-Correia A, Saudou F, Villard L.

Med Sci (Paris). 2012 Jan;28(1):44-6. doi: 10.1051/medsci/2012281016. Epub 2012 Jan 27. French. No abstract available.

25.

Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation.

Orvoen S, Pla P, Gardier AM, Saudou F, David DJ.

Neurosci Lett. 2012 Jan 24;507(2):127-32. doi: 10.1016/j.neulet.2011.11.063. Epub 2011 Dec 9.

PMID:
22178857
26.

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway.

Roux JC, Zala D, Panayotis N, Borges-Correia A, Saudou F, Villard L.

Neurobiol Dis. 2012 Feb;45(2):786-95. doi: 10.1016/j.nbd.2011.11.002. Epub 2011 Nov 15.

PMID:
22127389
27.

Identifying polyglutamine protein species in situ that best predict neurodegeneration.

Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, Saudou F, Segal M, Yang XW, Masliah E, Thompson LM, Muchowski PJ, Weisgraber KH, Finkbeiner S.

Nat Chem Biol. 2011 Oct 30;7(12):925-34. doi: 10.1038/nchembio.694. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.

28.

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.

Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F.

J Clin Invest. 2011 Nov;121(11):4372-82. doi: 10.1172/JCI57552. Epub 2011 Oct 10.

29.

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

Marquer C, Devauges V, Cossec JC, Liot G, Lécart S, Saudou F, Duyckaerts C, Lévêque-Fort S, Potier MC.

FASEB J. 2011 Apr;25(4):1295-305. doi: 10.1096/fj.10-168633. Epub 2011 Jan 21. Erratum in: FASEB J. 2012 Jan;26(1):468.

PMID:
21257714
30.

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.

Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S.

Neuron. 2010 Aug 12;67(3):392-406. doi: 10.1016/j.neuron.2010.06.027.

31.

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

del Toro D, Xifró X, Pol A, Humbert S, Saudou F, Canals JM, Alberch J.

J Neurochem. 2010 Oct;115(1):153-67. doi: 10.1111/j.1471-4159.2010.06912.x. Epub 2010 Aug 12.

32.

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.

Pardo R, Molina-Calavita M, Poizat G, Keryer G, Humbert S, Saudou F.

Mol Brain. 2010 Jun 1;3:17. doi: 10.1186/1756-6606-3-17.

33.

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT.

Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.

34.

Elongator - an emerging role in neurological disorders.

Nguyen L, Humbert S, Saudou F, Chariot A.

Trends Mol Med. 2010 Jan;16(1):1-6. doi: 10.1016/j.molmed.2009.11.002. Epub 2009 Dec 23.

PMID:
20036197
35.

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.

Pineda JR, Pardo R, Zala D, Yu H, Humbert S, Saudou F.

Mol Brain. 2009 Oct 27;2:33. doi: 10.1186/1756-6606-2-33.

36.

Serotonin transporter oligomerization documented in RN46A cells and neurons by sensitized acceptor emission FRET and fluorescence lifetime imaging microscopy.

Fjorback AW, Pla P, Müller HK, Wiborg O, Saudou F, Nyengaard JR.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):724-8. doi: 10.1016/j.bbrc.2009.01.128. Epub 2009 Jan 27.

PMID:
19338744
37.

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F.

Hum Mol Genet. 2008 Dec 15;17(24):3837-46. doi: 10.1093/hmg/ddn281. Epub 2008 Sep 4.

PMID:
18772195
38.

The biology of Huntington's disease.

Saudou F, Humbert S.

Handb Clin Neurol. 2008;89:619-29. doi: 10.1016/S0072-9752(07)01257-2. No abstract available.

PMID:
18631783
39.

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.

Colin E, Zala D, Liot G, Rangone H, Borrell-Pagès M, Li XJ, Saudou F, Humbert S.

EMBO J. 2008 Aug 6;27(15):2124-34. doi: 10.1038/emboj.2008.133. Epub 2008 Jul 10.

40.

Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments.

Roze E, Saudou F, Caboche J.

Curr Opin Neurol. 2008 Aug;21(4):497-503. doi: 10.1097/WCO.0b013e328304b692. Review.

PMID:
18607213
42.

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.

Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, Saudou F.

J Neurosci. 2007 Mar 28;27(13):3571-83.

43.

[Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease].

Saudou F, Humbert S.

Med Sci (Paris). 2006 Nov;22(11):906-8. French. No abstract available.

44.

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

Borrell-Pagès M, Zala D, Humbert S, Saudou F.

Cell Mol Life Sci. 2006 Nov;63(22):2642-60. Review.

PMID:
17041811
45.

The ataxia-ome: connecting disease proteins of the cerebellum.

Humbert S, Saudou F.

Cell. 2006 May 19;125(4):645-7.

46.

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

Borrell-Pagès M, Canals JM, Cordelières FP, Parker JA, Pineda JR, Grange G, Bryson EA, Guillermier M, Hirsch E, Hantraye P, Cheetham ME, Néri C, Alberch J, Brouillet E, Saudou F, Humbert S.

J Clin Invest. 2006 May;116(5):1410-24. Epub 2006 Apr 6.

47.

[Huntington's disease: intracellular signaling pathways and neuronal death].

Humbert S, Saudou F.

J Soc Biol. 2005;199(3):247-51. Review. French.

PMID:
16471265
48.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F.

J Neurosci. 2006 Feb 1;26(5):1635-45.

49.

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.

Benchoua A, Trioulier Y, Zala D, Gaillard MC, Lefort N, Dufour N, Saudou F, Elalouf JM, Hirsch E, Hantraye P, Déglon N, Brouillet E.

Mol Biol Cell. 2006 Apr;17(4):1652-63. Epub 2006 Feb 1.

50.

Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease.

Charrin BC, Saudou F, Humbert S.

Pathol Biol (Paris). 2005 May;53(4):189-92. No abstract available.

PMID:
15850950

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