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Items: 1 to 50 of 73

1.

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.

Ajjaji D, Ben M'barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR.

Mol Biol Cell. 2019 Mar 1;30(5):703-716. doi: 10.1091/mbc.E18-08-0534. Epub 2019 Jan 16.

2.

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

Haider A, Wei YC, Lim K, Barbosa AD, Liu CH, Weber U, Mlodzik M, Oras K, Collier S, Hussain MM, Dong L, Patel S, Alvarez-Guaita A, Saudek V, Jenkins BJ, Koulman A, Dymond MK, Hardie RC, Siniossoglou S, Savage DB.

Dev Cell. 2018 May 21;45(4):481-495.e8. doi: 10.1016/j.devcel.2018.04.012. Epub 2018 May 10.

3.

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.

Rocha N, Payne F, Huang-Doran I, Sleigh A, Fawcett K, Adams C, Stears A, Saudek V, O'Rahilly S, Barroso I, Semple RK.

Sci Rep. 2017 Dec 14;7(1):17593. doi: 10.1038/s41598-017-17746-8.

4.

Potential dual function of PQ-loop proteins such as cystinosin.

Saudek V.

J Biol Chem. 2017 Sep 8;292(36):15133. doi: 10.1074/jbc.L117.795278. No abstract available.

5.

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation.

Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, O'Rahilly S, Coll AP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9421-9426. doi: 10.1073/pnas.1707310114. Epub 2017 Aug 15.

6.

The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.

Kostrouchová M, Kostrouch D, Chughtai AA, Kaššák F, Novotný JP, Kostrouchová V, Benda A, Krause MW, Saudek V, Kostrouchová M, Kostrouch Z.

PeerJ. 2017 Jun 6;5:e3390. doi: 10.7717/peerj.3390. eCollection 2017.

7.
8.

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression.

Rocha N, Bulger DA, Frontini A, Titheradge H, Gribsholt SB, Knox R, Page M, Harris J, Payne F, Adams C, Sleigh A, Crawford J, Gjesing AP, Bork-Jensen J, Pedersen O, Barroso I, Hansen T, Cox H, Reilly M, Rossor A, Brown RJ, Taylor SI, McHale D, Armstrong M, Oral EA, Saudek V, O'Rahilly S, Maher ER, Richelsen B, Savage DB, Semple RK.

Elife. 2017 Apr 19;6. pii: e23813. doi: 10.7554/eLife.23813.

9.

Molecular Diagnostics of Copper-Transporting Protein Mutations Allows Early Onset Individual Therapy of Menkes Disease.

Králík L, Flachsová E, Hansíková H, Saudek V, Zeman J, Martásek P.

Folia Biol (Praha). 2017;63(5-6):165-173.

10.

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.

Preissler S, Rato C, Perera L, Saudek V, Ron D.

Nat Struct Mol Biol. 2017 Jan;24(1):23-29. doi: 10.1038/nsmb.3337. Epub 2016 Dec 5.

11.

Hepatoerythropoietic Porphyria Caused by a Novel Homoallelic Mutation in Uroporphyrinogen Decarboxylase Gene in Egyptian Patients.

Farrag MS, Mikula I, Richard E, Saudek V, De Verneuil H, Martásek P.

Folia Biol (Praha). 2015;61(6):219-26.

12.

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.

Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB.

J Biol Chem. 2016 Mar 25;291(13):6664-78. doi: 10.1074/jbc.M115.691048. Epub 2016 Jan 7.

13.

Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans.

Zima V, Šebková K, Šimečková K, Dvořák T, Saudek V, Kostrouchová M.

Folia Biol (Praha). 2015;61(5):168-77.

14.

Perilipin-related protein regulates lipid metabolism in C. elegans.

Chughtai AA, Kaššák F, Kostrouchová M, Novotný JP, Krause MW, Saudek V, Kostrouch Z, Kostrouchová M.

PeerJ. 2015 Sep 1;3:e1213. doi: 10.7717/peerj.1213. eCollection 2015.

15.

FTO is necessary for the induction of leptin resistance by high-fat feeding.

Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O'Rahilly S, Coll AP, Yeo GS.

Mol Metab. 2015 Feb 7;4(4):287-98. doi: 10.1016/j.molmet.2015.01.011. eCollection 2015 Apr.

16.

Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy.

Kozusko K, Tsang V, Bottomley W, Cho YH, Gandotra S, Mimmack ML, Lim K, Isaac I, Patel S, Saudek V, O'Rahilly S, Srinivasan S, Greenfield JR, Barroso I, Campbell LV, Savage DB.

Diabetes. 2015 Jan;64(1):299-310. doi: 10.2337/db14-0104. Epub 2014 Aug 11.

17.

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.

Payne F, Colnaghi R, Rocha N, Seth A, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage D, O'Rahilly S, Carel JC, Barroso I, O'Driscoll M, Semple R.

J Clin Invest. 2014 Sep;124(9):4028-38. doi: 10.1172/JCI73264. Epub 2014 Aug 8.

18.

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.

Patel S, Yang W, Kozusko K, Saudek V, Savage DB.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9163-8. doi: 10.1073/pnas.1318791111. Epub 2014 Jun 9.

19.

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8901-6. doi: 10.1073/pnas.1408523111. Epub 2014 Jun 2.

20.

GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans.

Mikoláš P, Kollárová J, Sebková K, Saudek V, Yilma P, Kostrouchová M, Krause MW, Kostrouch Z, Kostrouchová M.

PLoS One. 2013;8(3):e58462. doi: 10.1371/journal.pone.0058462. Epub 2013 Mar 6.

21.
22.

SMED-TLX-1 (NR2E1) is critical for tissue and body plan maintenance in Schmidtea mediterranea in fasting/feeding cycles.

Raška O, Kostrouchová V, Behenský F, Yilma P, Saudek V, Kostrouch Z, Kostrouchová M.

Folia Biol (Praha). 2011;57(6):223-31.

23.

The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.

Sim MF, Dennis RJ, Aubry EM, Ramanathan N, Sembongi H, Saudek V, Ito D, O'Rahilly S, Siniossoglou S, Rochford JJ.

Mol Metab. 2012 Dec 26;2(1):38-46. doi: 10.1016/j.molmet.2012.11.002. eCollection 2012.

24.

Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5).

Gandotra S, Lim K, Girousse A, Saudek V, O'Rahilly S, Savage DB.

J Biol Chem. 2011 Oct 7;286(40):34998-5006. doi: 10.1074/jbc.M111.278853. Epub 2011 Jul 12.

25.

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression.

Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L, Saudek V, Gaston JS.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17698-703. doi: 10.1073/pnas.1011736107. Epub 2010 Sep 27.

26.

Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation.

Douderova D, Schneider-Yin X, Lautenschlager S, Saudek V, Theiler M, Hofbauer GF, Dziunycz PJ, Oyama N, French LE, Martasek P, Minder EI.

Blood Cells Mol Dis. 2010 Aug 15;45(2):176-9. doi: 10.1016/j.bcmd.2010.04.004. Epub 2010 Jun 26. No abstract available.

PMID:
20580577
27.

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC.

Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magré J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S, Savage DB; LD Screening Consortium.

EMBO Mol Med. 2009 Aug;1(5):280-7. doi: 10.1002/emmm.200900037.

28.

Prevalence of loss-of-function FTO mutations in lean and obese individuals.

Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS.

Diabetes. 2010 Jan;59(1):311-8. doi: 10.2337/db09-0703. Epub 2009 Oct 15.

29.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, O'Rahilly S, Munnich A, Colleaux L.

Am J Hum Genet. 2009 Jul;85(1):106-11. doi: 10.1016/j.ajhg.2009.06.002. Epub 2009 Jun 25.

30.

Acute intermittent porphyria--impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties.

Ulbrichova D, Hrdinka M, Saudek V, Martasek P.

FEBS J. 2009 Apr;276(7):2106-15. doi: 10.1111/j.1742-4658.2009.06946.x.

31.

Correlation between biochemical findings, structural and enzymatic abnormalities in mutated HMBS identified in six Israeli families with acute intermittent porphyria.

Ulbrichova D, Schneider-Yin X, Mamet R, Saudek V, Martasek P, Minder EI, Schoenfeld N.

Blood Cells Mol Dis. 2009 Mar-Apr;42(2):167-73. doi: 10.1016/j.bcmd.2008.11.001. Epub 2009 Jan 12.

PMID:
19138865
32.

A new mutation within the porphobilinogen deaminase gene leading to a truncated protein as a cause of acute intermittent porphyria in an extended Indian family.

Flachsová E, Verma IC, Ulbrichová D, Saxena R, Zeman J, Saudek V, Raman CS, Martásek P.

Folia Biol (Praha). 2007;53(6):194-201.

PMID:
18070416
33.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

34.

BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development.

Kostrouchova M, Kostrouch Z, Saudek V, Piatigorsky J, Rall JE.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5240-5. Epub 2003 Apr 7.

35.

Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.

George S, Johansen A, Soos MA, Mortensen H, Gammeltoft S, Saudek V, Siddle K, Hansen L, O'Rahilly S.

Endocrinology. 2003 Feb;144(2):631-7.

PMID:
12538626
36.

Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.

Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T.

J Biol Chem. 2003 Feb 21;278(8):6521-31. Epub 2002 Dec 6.

37.

Structure activity relationship by NMR and by computer: a comparative study.

Sirockin F, Sich C, Improta S, Schaefer M, Saudek V, Froloff N, Karplus M, Dejaegere A.

J Am Chem Soc. 2002 Sep 18;124(37):11073-84.

PMID:
12224955
38.

SKIP is an indispensable factor for Caenorhabditis elegans development.

Kostrouchova M, Housa D, Kostrouch Z, Saudek V, Rall JE.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9254-9. Epub 2002 Jun 25.

39.

The direct determination of protein structure by NMR without assignment.

Atkinson RA, Saudek V.

FEBS Lett. 2002 Jan 2;510(1-2):1-4. Review.

40.

Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics.

Sich C, Improta S, Cowley DJ, Guenet C, Merly JP, Teufel M, Saudek V.

Eur J Biochem. 2000 Sep;267(17):5342-55.

41.

Mapping the active site of factor Xa by selective inhibitors: an NMR and MD study.

Fraternali F, Do QT, Doan BT, Atkinson RA, Palmas P, Sklenar V, Safar P, Wildgoose P, Strop P, Saudek V.

Proteins. 1998 Feb 15;30(3):264-74.

PMID:
9517542
42.

7Li nuclear-magnetic-resonance study of lithium binding to myo-inositolmonophosphatase.

Saudek V, Vincendon P, Do QT, Atkinson RA, Sklenar V, Pelton PD, Piriou F, Ganzhorn AJ.

Eur J Biochem. 1996 Aug 15;240(1):288-91.

43.

Echistatin: the refined structure of a disintegrin in solution by 1H NMR and restrained molecular dynamics.

Atkinson RA, Saudek V, Pelton JT.

Int J Pept Protein Res. 1994 Jun;43(6):563-72.

PMID:
7928087
45.
46.

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions.

Piotto M, Saudek V, Sklenár V.

J Biomol NMR. 1992 Nov;2(6):661-5.

PMID:
1490109
47.

Structure of neuropeptide Y dimer in solution.

Cowley DJ, Hoflack JM, Pelton JT, Saudek V.

Eur J Biochem. 1992 May 1;205(3):1099-106.

48.

Three-dimensional structure of acylphosphatase. Refinement and structure analysis.

Pastore A, Saudek V, Ramponi G, Williams RJ.

J Mol Biol. 1992 Mar 20;224(2):427-40.

PMID:
1313885
49.

The secondary structure of echistatin from 1H-NMR, circular-dichroism and Raman spectroscopy.

Saudek V, Atkinson RA, Lepage P, Pelton JT.

Eur J Biochem. 1991 Dec 5;202(2):329-38.

50.

1H NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper.

Atkinson RA, Saudek V, Huggins JP, Pelton JT.

Biochemistry. 1991 Oct 1;30(39):9387-95.

PMID:
1892839

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