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Items: 1 to 50 of 53

1.

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling.

Rikard SM, Athey TL, Nelson AR, Christiansen SLM, Lee JJ, Holmes JW, Peirce SM, Saucerman JJ.

Front Physiol. 2019 Dec 17;10:1481. doi: 10.3389/fphys.2019.01481. eCollection 2019.

2.

Mechanical regulation of gene expression in cardiac myocytes and fibroblasts.

Saucerman JJ, Tan PM, Buchholz KS, McCulloch AD, Omens JH.

Nat Rev Cardiol. 2019 Jun;16(6):361-378. doi: 10.1038/s41569-019-0155-8. Review.

PMID:
30683889
3.

High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.

Woo LA, Tkachenko S, Ding M, Plowright AT, Engkvist O, Andersson H, Drowley L, Barrett I, Firth M, Akerblad P, Wolf MJ, Bekiranov S, Brautigan DL, Wang QD, Saucerman JJ.

J Mol Cell Cardiol. 2019 Feb;127:204-214. doi: 10.1016/j.yjmcc.2018.12.015. Epub 2018 Dec 28.

4.

Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.

Xu P, Damschroder D, Zhang M, Ryall KA, Adler PN, Saucerman JJ, Wessells RJ, Yan Z.

J Mol Cell Cardiol. 2019 Feb;127:116-124. doi: 10.1016/j.yjmcc.2018.12.006. Epub 2018 Dec 17.

5.

Network-based predictions of in vivo cardiac hypertrophy.

Frank DU, Sutcliffe MD, Saucerman JJ.

J Mol Cell Cardiol. 2018 Aug;121:180-189. doi: 10.1016/j.yjmcc.2018.07.243. Epub 2018 Jul 17.

6.

Mapping macrophage polarization over the myocardial infarction time continuum.

Mouton AJ, DeLeon-Pennell KY, Rivera Gonzalez OJ, Flynn ER, Freeman TC, Saucerman JJ, Garrett MR, Ma Y, Harmancey R, Lindsey ML.

Basic Res Cardiol. 2018 Jun 4;113(4):26. doi: 10.1007/s00395-018-0686-x.

7.

A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure.

Santolini M, Romay MC, Yukhtman CL, Rau CD, Ren S, Saucerman JJ, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Karma A.

NPJ Syst Biol Appl. 2018 Feb 24;4:12. doi: 10.1038/s41540-018-0046-3. eCollection 2018.

8.

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ.

Sci Rep. 2018 Jan 19;8(1):1258. doi: 10.1038/s41598-018-19539-z.

9.

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling.

Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ.

PLoS Comput Biol. 2017 Nov 13;13(11):e1005854. doi: 10.1371/journal.pcbi.1005854. eCollection 2017 Nov.

10.

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Shim JV, Chun B, van Hasselt JGC, Birtwistle MR, Saucerman JJ, Sobie EA.

Front Physiol. 2017 Sep 8;8:651. doi: 10.3389/fphys.2017.00651. eCollection 2017.

11.

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy.

Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z.

Nat Commun. 2017 Sep 15;8(1):548. doi: 10.1038/s41467-017-00520-9.

12.

An engineering design approach to systems biology.

Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA.

Integr Biol (Camb). 2017 Jul 17;9(7):574-583. doi: 10.1039/c7ib00014f. Review.

13.

Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction.

Lindsey ML, Saucerman JJ, DeLeon-Pennell KY.

Biochim Biophys Acta. 2016 Dec;1862(12):2288-2292. doi: 10.1016/j.bbadis.2016.05.013. Epub 2016 May 27. Review.

14.

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation.

Zeigler AC, Richardson WJ, Holmes JW, Saucerman JJ.

J Mol Cell Cardiol. 2016 May;94:72-81. doi: 10.1016/j.yjmcc.2016.03.008. Epub 2016 Mar 23.

15.

Computational modeling of cardiac fibroblasts and fibrosis.

Zeigler AC, Richardson WJ, Holmes JW, Saucerman JJ.

J Mol Cell Cardiol. 2016 Apr;93:73-83. doi: 10.1016/j.yjmcc.2015.11.020. Epub 2015 Dec 1. Review.

16.

Automated microscopy of cardiac myocyte hypertrophy: a case study on the role of intracellular α-adrenergic receptors.

Ryall KA, Saucerman JJ.

Methods Mol Biol. 2015;1234:123-34. doi: 10.1007/978-1-4939-1755-6_11.

PMID:
25304353
17.

Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling.

Amanfu RK, Saucerman JJ.

Mol Pharmacol. 2014 Aug;86(2):222-30. doi: 10.1124/mol.113.090951. Epub 2014 May 27.

18.

A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.

Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z.

J Biol Chem. 2014 Apr 25;289(17):12005-15. doi: 10.1074/jbc.M113.530527. Epub 2014 Mar 18.

19.

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL.

Mol Metab. 2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014 Apr.

20.

Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation.

Ryall KA, Bezzerides VJ, Rosenzweig A, Saucerman JJ.

J Mol Cell Cardiol. 2014 Jul;72:74-84. doi: 10.1016/j.yjmcc.2014.02.013. Epub 2014 Mar 5.

21.

Mechanisms of cyclic AMP compartmentation revealed by computational models.

Saucerman JJ, Greenwald EC, Polanowska-Grabowska R.

J Gen Physiol. 2014 Jan;143(1):39-48. doi: 10.1085/jgp.201311044. No abstract available.

22.

Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling.

Greenwald EC, Redden JM, Dodge-Kafka KL, Saucerman JJ.

J Biol Chem. 2014 Jan 24;289(4):2353-60. doi: 10.1074/jbc.M113.497941. Epub 2013 Dec 3.

23.

PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.

Yang JH, Polanowska-Grabowska RK, Smith JS, Shields CW 4th, Saucerman JJ.

J Mol Cell Cardiol. 2014 Jan;66:83-93. doi: 10.1016/j.yjmcc.2013.11.001. Epub 2013 Nov 10.

24.

Integrating fluorescent biosensor data using computational models.

Greenwald EC, Polanowska-Grabowska RK, Saucerman JJ.

Methods Mol Biol. 2014;1071:227-48. doi: 10.1007/978-1-62703-622-1_18.

PMID:
24052393
25.

Modeling mitochondrial ROS: a great balancing act.

Saucerman JJ.

Biophys J. 2013 Sep 17;105(6):1287-8. doi: 10.1016/j.bpj.2013.08.013. No abstract available. Erratum in: Biophys J. 2013 Dec 3;105(11):2606.

26.

Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling.

Ryall KA, Holland DO, Delaney KA, Kraeutler MJ, Parker AJ, Saucerman JJ.

J Biol Chem. 2012 Dec 7;287(50):42259-68. doi: 10.1074/jbc.M112.382937. Epub 2012 Oct 22.

27.

Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.

Cui WY, Zhao S, Polanowska-Grabowska R, Wang J, Wei J, Dash B, Chang SL, Saucerman JJ, Gu J, Li MD.

Mol Pharmacol. 2013 Jan;83(1):61-72. doi: 10.1124/mol.112.081497. Epub 2012 Oct 1.

28.

Automated imaging reveals a concentration dependent delay in reversibility of cardiac myocyte hypertrophy.

Ryall KA, Saucerman JJ.

J Mol Cell Cardiol. 2012 Aug;53(2):282-90. doi: 10.1016/j.yjmcc.2012.04.016. Epub 2012 May 8.

29.

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.

Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J.

Nat Chem Biol. 2012 Feb 26;8(4):375-82. doi: 10.1038/nchembio.799. Erratum in: Nat Chem Biol. 2013 Jun;9(6):406.

30.

Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy.

Yang JH, Saucerman JJ.

J Mol Cell Cardiol. 2012 May;52(5):1048-55. doi: 10.1016/j.yjmcc.2011.12.015. Epub 2012 Jan 20.

31.

Cytokine screening identifies NICU patients with Gram-negative bacteremia.

Raynor LL, Saucerman JJ, Akinola MO, Lake DE, Moorman JR, Fairchild KD.

Pediatr Res. 2012 Mar;71(3):261-6. doi: 10.1038/pr.2011.45. Epub 2012 Jan 25.

32.

Automated image analysis of cardiac myocyte Ca2+ dynamics.

Amanfu RK, Muller JB, Saucerman JJ.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4661-4. doi: 10.1109/IEMBS.2011.6091154.

33.

Cardiac models in drug discovery and development: a review.

Amanfu RK, Saucerman JJ.

Crit Rev Biomed Eng. 2011;39(5):379-95. Review.

34.

Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy.

Bass GT, Ryall KA, Katikapalli A, Taylor BE, Dang ST, Acton ST, Saucerman JJ.

J Mol Cell Cardiol. 2012 May;52(5):923-30. doi: 10.1016/j.yjmcc.2011.11.009. Epub 2011 Dec 1.

35.

Whole-genome metabolic network reconstruction and constraint-based modeling.

Haggart CR, Bartell JA, Saucerman JJ, Papin JA.

Methods Enzymol. 2011;500:411-33. doi: 10.1016/B978-0-12-385118-5.00021-9.

36.

Graphical approach to model reduction for nonlinear biochemical networks.

Holland DO, Krainak NC, Saucerman JJ.

PLoS One. 2011;6(8):e23795. doi: 10.1371/journal.pone.0023795. Epub 2011 Aug 25.

37.

Cardiac biexcitability: two ways to catch a wave.

Saucerman JJ.

Heart Rhythm. 2012 Jan;9(1):123-4. doi: 10.1016/j.hrthm.2011.09.001. Epub 2011 Sep 3. No abstract available.

PMID:
21893138
38.

Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty.

Soltis AR, Saucerman JJ.

Bioinformatics. 2011 Oct 15;27(20):2888-94. doi: 10.1093/bioinformatics/btr496. Epub 2011 Aug 31.

39.

Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes.

Saucerman JJ, Bers DM.

J Mol Cell Cardiol. 2012 Feb;52(2):312-6. doi: 10.1016/j.yjmcc.2011.06.005. Epub 2011 Jun 12. Review.

40.

Bigger, better, faster: principles and models of AKAP anchoring protein signaling.

Greenwald EC, Saucerman JJ.

J Cardiovasc Pharmacol. 2011 Nov;58(5):462-9. doi: 10.1097/FJC.0b013e31822001e3. Review.

41.

Computational models reduce complexity and accelerate insight into cardiac signaling networks.

Yang JH, Saucerman JJ.

Circ Res. 2011 Jan 7;108(1):85-97. doi: 10.1161/CIRCRESAHA.110.223602. Review.

42.

Systems analysis of small signaling modules relevant to eight human diseases.

Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, Skalak TC.

Ann Biomed Eng. 2011 Feb;39(2):621-35. doi: 10.1007/s10439-010-0208-y. Epub 2010 Dec 4.

43.

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model.

Kraeutler MJ, Soltis AR, Saucerman JJ.

BMC Syst Biol. 2010 Nov 18;4:157. doi: 10.1186/1752-0509-4-157.

44.

Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.

Soltis AR, Saucerman JJ.

Biophys J. 2010 Oct 6;99(7):2038-47. doi: 10.1016/j.bpj.2010.08.016.

45.

Endotoxin depresses heart rate variability in mice: cytokine and steroid effects.

Fairchild KD, Saucerman JJ, Raynor LL, Sivak JA, Xiao Y, Lake DE, Moorman JR.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1019-27. doi: 10.1152/ajpregu.00132.2009. Epub 2009 Aug 5.

46.

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

Song Q, Saucerman JJ, Bossuyt J, Bers DM.

J Biol Chem. 2008 Nov 14;283(46):31531-40. doi: 10.1074/jbc.M804902200. Epub 2008 Sep 12.

47.

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes.

Saucerman JJ, Bers DM.

Biophys J. 2008 Nov 15;95(10):4597-612. doi: 10.1529/biophysj.108.128728. Epub 2008 Aug 8.

48.

Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure.

Saucerman JJ, McCulloch AD.

Ann N Y Acad Sci. 2006 Oct;1080:348-61. Review.

PMID:
17132794
49.

Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes.

Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD.

Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12923-8. Epub 2006 Aug 11.

50.

Local plantar pressure relief in therapeutic footwear: design guidelines from finite element models.

Erdemir A, Saucerman JJ, Lemmon D, Loppnow B, Turso B, Ulbrecht JS, Cavanagh PR.

J Biomech. 2005 Sep;38(9):1798-806.

PMID:
16023466

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