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Assessing T Lymphocyte Aging Using Telomere Length and Telomerase Activity Measurements in Low Cell Numbers.

Fali T, K'Ros C, Appay V, Sauce D.

Methods Mol Biol. 2019;2048:231-243. doi: 10.1007/978-1-4939-9728-2_18.


HIV-mediated immune aging in young adults infected perinatally or during childhood.

Fastenackels S, Sauce D, Vigouroux C, Avettand-Fènoël V, Bastard JP, Fellahi S, Nailler L, Arezes E, Rouzioux C, Warszawski J, Viard JP, Appay V; ANRS Co19 COVERTE Study Group.

AIDS. 2019 Sep 1;33(11):1705-1710. doi: 10.1097/QAD.0000000000002275.


Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.

Fastenackels S, Bayard C, Larsen M, Magnier P, Bonnafous P, Seddiki N, Appay V, Gautheret-Dejean A, Sauce D.

J Virol. 2019 Jun 14;93(13). pii: e02321-18. doi: 10.1128/JVI.02321-18. Print 2019 Jul 1.


The hallmarks of CMV-specific CD8 T-cell differentiation.

van den Berg SPH, Pardieck IN, Lanfermeijer J, Sauce D, Klenerman P, van Baarle D, Arens R.

Med Microbiol Immunol. 2019 Aug;208(3-4):365-373. doi: 10.1007/s00430-019-00608-7. Epub 2019 Apr 13. Review.


New Insights into Lymphocyte Differentiation and Aging from Telomere Length and Telomerase Activity Measurements.

Fali T, Papagno L, Bayard C, Mouloud Y, Boddaert J, Sauce D, Appay V.

J Immunol. 2019 Apr 1;202(7):1962-1969. doi: 10.4049/jimmunol.1801475. Epub 2019 Feb 8.


[Aging of the immune system: From fundamental to clinical data].

Vallet H, Fali T, Sauce D.

Rev Med Interne. 2019 Feb;40(2):105-111. doi: 10.1016/j.revmed.2018.07.005. Epub 2018 Jul 21. Review. French.


Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis.

Fali T, Fabre-Mersseman V, Yamamoto T, Bayard C, Papagno L, Fastenackels S, Zoorab R, Koup RA, Boddaert J, Sauce D, Appay V.

JCI Insight. 2018 Jul 12;3(13). pii: 95319. doi: 10.1172/jci.insight.95319.


Impact of stress on aged immune system compartments: Overview from fundamental to clinical data.

Fali T, Vallet H, Sauce D.

Exp Gerontol. 2018 May;105:19-26. doi: 10.1016/j.exger.2018.02.007. Epub 2018 Feb 7. Review.


The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA.

Geroscience. 2017 Dec;39(5-6):499-550. doi: 10.1007/s11357-017-0002-y. Epub 2017 Dec 21. Review.


Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients.

Larsen M, Bayard C, Lepetitcorps H, Cohen-Bittan J, Appay V, Boddaert J, Sauce D.

EBioMedicine. 2017 Dec;26:157-164. doi: 10.1016/j.ebiom.2017.11.003. Epub 2017 Nov 6.


A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.

Souquette A, Frere J, Smithey M, Sauce D, Thomas PG.

Geroscience. 2017 Jun;39(3):293-303. doi: 10.1007/s11357-017-9982-x. Epub 2017 Jun 24. Review.


Aging of the immune system: Focus on inflammation and vaccination.

Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A.

Eur J Immunol. 2016 Oct;46(10):2286-2301. doi: 10.1002/eji.201546178. Review.


Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Angin M, Wong G, Papagno L, Versmisse P, David A, Bayard C, Charmeteau-De Muylder B, Besseghir A, Thiébaut R, Boufassa F, Pancino G, Sauce D, Lambotte O, Brun-Vézinet F, Matheron S, Rowland-Jones SL, Cheynier R, Sáez-Cirión A, Appay V; ANRS CO5 IMMUNOVIR-2 Study Group.

J Immunol. 2016 Oct 1;197(7):2787-95. doi: 10.4049/jimmunol.1600693. Epub 2016 Aug 26.


HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy.

Sauce D, Gorochov G, Larsen M.

Sci Rep. 2016 Jun 21;6:28129. doi: 10.1038/srep28129.


Assessing immune aging in HIV-infected patients.

Appay V, Sauce D.

Virulence. 2017 Jul 4;8(5):529-538. doi: 10.1080/21505594.2016.1195536. Epub 2016 Jun 16. Review.


Reduced Oxidative Burst by Primed Neutrophils in the Elderly Individuals Is Associated With Increased Levels of the CD16bright/CD62Ldim Immunosuppressive Subset.

Sauce D, Dong Y, Campillo-Gimenez L, Casulli S, Bayard C, Autran B, Boddaert J, Appay V, Elbim C.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):163-172. doi: 10.1093/gerona/glw062. Epub 2016 Apr 11.


Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans.

Bayard C, Lepetitcorps H, Roux A, Larsen M, Fastenackels S, Salle V, Vieillard V, Marchant A, Stern M, Boddaert J, Bajolle F, Appay V, Sauce D.

Eur J Immunol. 2016 May;46(5):1168-79. doi: 10.1002/eji.201546179. Epub 2016 Mar 11.


Reduced naïve CD8(+) T-cell priming efficacy in elderly adults.

Briceño O, Lissina A, Wanke K, Afonso G, von Braun A, Ragon K, Miquel T, Gostick E, Papagno L, Stiasny K, Price DA, Mallone R, Sauce D, Karrer U, Appay V.

Aging Cell. 2016 Feb;15(1):14-21. doi: 10.1111/acel.12384. Epub 2015 Oct 15.


Correction: Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection.

Boyd A, Almeida JR, Darrah PA, Sauce D, Seder RA, Appay V, Gorochov G, Larsen M.

PLoS One. 2015 Sep 14;10(9):e0138395. doi: 10.1371/journal.pone.0138395. eCollection 2015. No abstract available.


Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection.

Boyd A, Almeida JR, Darrah PA, Sauce D, Seder RA, Appay V, Gorochov G, Larsen M.

PLoS One. 2015 Jun 5;10(6):e0128714. doi: 10.1371/journal.pone.0128714. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138395.


Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients.

Goulenok T, Boyd A, Larsen M, Fastenackels S, Boccara F, Meynard JL, Hadour N, Samri A, Desvarieux M, Autran B, Appay V, Girard PM, Sauce D; CHIC Study group.

AIDS. 2015 Jan 28;29(3):287-93. doi: 10.1097/QAD.0000000000000539.


Vitamin D supplementation is associated with reduced immune activation levels in HIV-1-infected patients on suppressive antiretroviral therapy.

Fabre-Mersseman V, Tubiana R, Papagno L, Bayard C, Briceno O, Fastenackels S, Dudoit Y, Rostane H, Salmon D, Costagliola D, Caby F, Sauce D, Viard JP, Appay V.

AIDS. 2014 Nov 28;28(18):2677-82. doi: 10.1097/QAD.0000000000000472.


New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.


Naive T cells: the crux of cellular immune aging?

Appay V, Sauce D.

Exp Gerontol. 2014 Jun;54:90-3. doi: 10.1016/j.exger.2014.01.003. Epub 2014 Jan 15. Review.


The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate.

Lissina A, Fastenackels S, Inglesias MC, Ladell K, McLaren JE, Briceño O, Gostick E, Papagno L, Autran B, Sauce D, Price DA, Saez-Cirion A, Appay V.

AIDS. 2014 Feb 20;28(4):477-86. doi: 10.1097/QAD.0000000000000175.


[Influence of PD-1 on the immunological synapse: a facet of immune regulation ?].

Larsen M, Appay V, Sauce D.

Med Sci (Paris). 2013 Dec;29(12):1080-2. doi: 10.1051/medsci/20132912006. Epub 2013 Dec 20. French. No abstract available.


Differential impact of age and cytomegalovirus infection on the γδ T cell compartment.

Roux A, Mourin G, Larsen M, Fastenackels S, Urrutia A, Gorochov G, Autran B, Donner C, Sidi D, Sibony-Prat J, Marchant A, Stern M, Sauce D, Appay V.

J Immunol. 2013 Aug 1;191(3):1300-6. doi: 10.4049/jimmunol.1202940. Epub 2013 Jul 1.


CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.

Roux A, Mourin G, Fastenackels S, Almeida JR, Iglesias MC, Boyd A, Gostick E, Larsen M, Price DA, Sacre K, Douek DC, Autran B, Picard C, Miranda Sd, Sauce D, Stern M, Appay V.

Clin Immunol. 2013 Jul;148(1):16-26. doi: 10.1016/j.clim.2013.03.012. Epub 2013 Mar 29.


Monitoring cellular immune markers in HIV infection: from activation to exhaustion.

Sauce D, Elbim C, Appay V.

Curr Opin HIV AIDS. 2013 Mar;8(2):125-31. doi: 10.1097/COH.0b013e32835d08a9. Review.


Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults.

Sauce D, Larsen M, Fastenackels S, Roux A, Gorochov G, Katlama C, Sidi D, Sibony-Prat J, Appay V.

J Immunol. 2012 Dec 15;189(12):5541-8. doi: 10.4049/jimmunol.1201235. Epub 2012 Nov 7.


CMV and Immunosenescence: from basics to clinics.

Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G.

Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.


Evaluating cellular polyfunctionality with a novel polyfunctionality index.

Larsen M, Sauce D, Arnaud L, Fastenackels S, Appay V, Gorochov G.

PLoS One. 2012;7(7):e42403. doi: 10.1371/journal.pone.0042403. Epub 2012 Jul 30.


Report from the second cytomegalovirus and immunosenescence workshop.

Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, Goronzy J, Griffiths SJ, Henson S, Herndler-Brandstetter D, Hill A, Kern F, Klenerman P, Macallan D, Macualay R, Maier AB, Mason G, Melzer D, Morgan M, Moss P, Nikolich-Zugich J, Pachnio A, Riddell N, Roberts R, Sansoni P, Sauce D, Sinclair J, Solana R, Strindhall J, Trzonkowski P, van Lier R, Vescovini R, Wang G, Westendorp R, Pawelec G.

Immun Ageing. 2011 Oct 28;8(1):10. doi: 10.1186/1742-4933-8-10.


Exhausted cytotoxic control of Epstein-Barr virus in human lupus.

Larsen M, Sauce D, Deback C, Arnaud L, Mathian A, Miyara M, Boutolleau D, Parizot C, Dorgham K, Papagno L, Appay V, Amoura Z, Gorochov G.

PLoS Pathog. 2011 Oct;7(10):e1002328. doi: 10.1371/journal.ppat.1002328. Epub 2011 Oct 20.


Altered thymic activity in early life: how does it affect the immune system in young adults?

Sauce D, Appay V.

Curr Opin Immunol. 2011 Aug;23(4):543-8. doi: 10.1016/j.coi.2011.05.001. Review.


Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets.

Larsen M, Arnaud L, Hié M, Parizot C, Dorgham K, Shoukry M, Kemula M, Barete S, Derai D, Sauce D, Amoura Z, Pène J, Yssel H, Gorochov G.

Eur J Immunol. 2011 Sep;41(9):2596-605. doi: 10.1002/eji.201041131. Epub 2011 Aug 4.


HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis.

Sauce D, Larsen M, Fastenackels S, Pauchard M, Ait-Mohand H, Schneider L, Guihot A, Boufassa F, Zaunders J, Iguertsira M, Bailey M, Gorochov G, Duvivier C, Carcelain G, Kelleher AD, Simon A, Meyer L, Costagliola D, Deeks SG, Lambotte O, Autran B, Hunt PW, Katlama C, Appay V.

Blood. 2011 May 12;117(19):5142-51. doi: 10.1182/blood-2011-01-331306. Epub 2011 Mar 24.


Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients.

Appay V, Fastenackels S, Katlama C, Ait-Mohand H, Schneider L, Guihot A, Keller M, Grubeck-Loebenstein B, Simon A, Lambotte O, Hunt PW, Deeks SG, Costagliola D, Autran B, Sauce D.

AIDS. 2011 Sep 24;25(15):1813-22. doi: 10.1097/QAD.0b013e32834640e6.


[Thymectomy and viral infection in humans: evidence for the role of the thymus in adulthood].

Sauce D, Appay V.

Med Sci (Paris). 2010 Apr;26(4):347-9. doi: 10.1051/medsci/2010264347. French. No abstract available.


The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals.

Appay V, Sauce D, Prelog M.

Aging (Albany NY). 2010 Mar 20;2(2):78-81. Review.


Evidence of premature immune aging in patients thymectomized during early childhood.

Sauce D, Larsen M, Fastenackels S, Duperrier A, Keller M, Grubeck-Loebenstein B, Ferrand C, Debré P, Sidi D, Appay V.

J Clin Invest. 2009 Oct;119(10):3070-8. doi: 10.1172/JCI39269. Epub 2009 Sep 21.


Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.

Sauce D, Larsen M, Abbott RJ, Hislop AD, Leese AM, Khan N, Papagno L, Freeman GJ, Rickinson AB.

J Virol. 2009 Sep;83(18):9068-78. doi: 10.1128/JVI.00141-09. Epub 2009 Jul 15.


Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.

Almeida JR, Sauce D, Price DA, Papagno L, Shin SY, Moris A, Larsen M, Pancino G, Douek DC, Autran B, Sáez-Cirión A, Appay V.

Blood. 2009 Jun 18;113(25):6351-60. doi: 10.1182/blood-2009-02-206557. Epub 2009 Apr 23.


Functionally fused antibodies--a novel adjuvant fusion system.

Larsen M, Jensen KB, Christensen PA, Suarez E, Paris D, Sanz L, Ravn P, Sauce D, Saas P, Goletz S, Alvarez-Vallina L, Kristensen P.

J Immunol Methods. 2008 Dec 31;339(2):220-7. doi: 10.1016/j.jim.2008.09.015. Epub 2008 Oct 12.


Early immune response against retrovirally transduced herpes simplex virus thymidine kinase-expressing gene-modified T cells coinfused with a T cell-depleted marrow graft: an altered immune response?

Mercier-Letondal P, Deschamps M, Sauce D, Certoux JM, Milpied N, Lioure B, Cahn JY, Deconinck E, Ferrand C, Tiberghien P, Robinet E.

Hum Gene Ther. 2008 Sep;19(9):937-50.


Alloreactivity of ex vivo-expanded T cells is correlated with expansion and CD4/CD8 ratio.

Mercier-Letondal P, Montcuquet N, Sauce D, Certoux JM, Jeanningros S, Ferrand C, Bonyhadi M, Tiberghien P, Robinet E.

Cytotherapy. 2008;10(3):275-88. doi: 10.1080/14653240801927032.


Immune activation and inflammation in HIV-1 infection: causes and consequences.

Appay V, Sauce D.

J Pathol. 2008 Jan;214(2):231-41. Review.


Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.

Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, Asher TE, Samri A, Schnuriger A, Theodorou I, Costagliola D, Rouzioux C, Agut H, Marcelin AG, Douek D, Autran B, Appay V.

J Exp Med. 2007 Oct 1;204(10):2473-85. Epub 2007 Sep 24.


PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.

Sauce D, Almeida JR, Larsen M, Haro L, Autran B, Freeman GJ, Appay V.

AIDS. 2007 Oct 1;21(15):2005-13.


Transcriptome of retrovirally transduced CD8+ lymphocytes: influence of cell activation, transgene integration, and selection process.

Deschamps M, Robinet E, Certoux JM, Mercier P, Sauce D, De Vos J, Montcuquet N, Bonyhadi M, Rème T, Tiberghien P, Ferrand C.

Mol Immunol. 2008 Feb;45(4):1112-25. Epub 2007 Sep 10.


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