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Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity.

Matsuda K, Ihara M, Sattelle DB.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:241-255. doi: 10.1146/annurev-pharmtox-010818-021747.


C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

Faravelli G, Raimondi S, Marchese L, Partridge FA, Soria C, Mangione PP, Canetti D, Perni M, Aprile FA, Zorzoli I, Di Schiavi E, Lomas DA, Bellotti V, Sattelle DB, Giorgetti S.

Sci Rep. 2019 Dec 27;9(1):19960. doi: 10.1038/s41598-019-56498-5.


Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.

Malintan NT, Buckingham SD, Lomas DA, Sattelle DB.

Sci Rep. 2019 Nov 21;9(1):17293. doi: 10.1038/s41598-019-53535-1.


Combined effects of mutations in loop C and the loop D-E-G triangle on neonicotinoid interactions with Drosophila Dα1/chicken β2 hybrid nAChRs.

Hikida M, Shimada S, Kurata R, Shigetou S, Ihara M, Sattelle DB, Matsuda K.

Pestic Biochem Physiol. 2018 Oct;151:47-52. doi: 10.1016/j.pestbp.2018.03.008. Epub 2018 Mar 27.


Editorial overview: Insect neuroreceptors and ion channels - roles as targets in the control of insect vectors and pests.

Sattelle DB, Matsuda K.

Curr Opin Insect Sci. 2018 Dec;30:iii-v. doi: 10.1016/j.cois.2018.10.002. Epub 2018 Oct 15. No abstract available.


Insect toxins - selective pharmacological tools and drug/chemical leads.

Kachel HS, Buckingham SD, Sattelle DB.

Curr Opin Insect Sci. 2018 Dec;30:93-98. doi: 10.1016/j.cois.2018.10.001. Epub 2018 Oct 9. Review.


Improved reference genome of Aedes aegypti informs arbovirus vector control.

Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipović I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC 4th, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB.

Nature. 2018 Nov;563(7732):501-507. doi: 10.1038/s41586-018-0692-z. Epub 2018 Nov 14.


2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm.

Partridge FA, Forman R, Willis NJ, Bataille CJR, Murphy EA, Brown AE, Heyer-Chauhan N, Marinič B, Sowood DJC, Wynne GM, Else KJ, Russell AJ, Sattelle DB.

PLoS Negl Trop Dis. 2018 Jul 11;12(7):e0006487. doi: 10.1371/journal.pntd.0006487. eCollection 2018 Jul.


The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.

Furutani S, Ihara M, Lees K, Buckingham SD, Partridge FA, David JA, Patel R, Warchal S, Mellor IR, Matsuda K, Sattelle DB.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):350-360. doi: 10.1016/j.ijpddr.2018.06.001. Epub 2018 Jun 4.


An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.

Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA, Sattelle DB.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):8-21. doi: 10.1016/j.ijpddr.2017.11.004. Epub 2017 Dec 2.


An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.

Furutani S, Okuhara D, Hashimoto A, Ihara M, Kai K, Hayashi H, Sattelle DB, Matsuda K.

Biosci Biotechnol Biochem. 2017 Oct;81(10):1861-1867. doi: 10.1080/09168451.2017.1359487. Epub 2017 Aug 21.


Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.

Ihara M, Hikida M, Matsushita H, Yamanaka K, Kishimoto Y, Kubo K, Watanabe S, Sakamoto M, Matsui K, Yamaguchi A, Okuhara D, Furutani S, Sattelle DB, Matsuda K.

Br J Pharmacol. 2018 Jun;175(11):1999-2012. doi: 10.1111/bph.13914. Epub 2017 Aug 24.


Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.

Buckingham SD, Ihara M, Sattelle DB, Matsuda K.

Curr Med Chem. 2017;24(27):2935-2945. doi: 10.2174/0929867324666170613075736. Review.


Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.

Partridge FA, Murphy EA, Willis NJ, Bataille CJ, Forman R, Heyer-Chauhan N, Marinič B, Sowood DJ, Wynne GM, Else KJ, Russell AJ, Sattelle DB.

PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005359. doi: 10.1371/journal.pntd.0005359. eCollection 2017 Feb.


Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors.

Ihara M, Buckingham SD, Matsuda K, Sattelle DB.

Curr Med Chem. 2017;24(27):2925-2934. doi: 10.2174/0929867324666170206142019. Review.


Tick Genome Assembled: New Opportunities for Research on Tick-Host-Pathogen Interactions.

de la Fuente J, Waterhouse RM, Sonenshine DE, Roe RM, Ribeiro JM, Sattelle DB, Hill CA.

Front Cell Infect Microbiol. 2016 Sep 15;6:103. eCollection 2016.


Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori.

Furutani S, Ihara M, Kai K, Tanaka K, Sattelle DB, Hayashi H, Matsuda K.

Neurotoxicology. 2017 May;60:240-244. doi: 10.1016/j.neuro.2016.05.002. Epub 2016 May 3.


Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J, Ribeiro JM, Megy K, Thimmapuram J, Miller JR, Walenz BP, Koren S, Hostetler JB, Thiagarajan M, Joardar VS, Hannick LI, Bidwell S, Hammond MP, Young S, Zeng Q, Abrudan JL, Almeida FC, Ayllón N, Bhide K, Bissinger BW, Bonzon-Kulichenko E, Buckingham SD, Caffrey DR, Caimano MJ, Croset V, Driscoll T, Gilbert D, Gillespie JJ, Giraldo-Calderón GI, Grabowski JM, Jiang D, Khalil SMS, Kim D, Kocan KM, Koči J, Kuhn RJ, Kurtti TJ, Lees K, Lang EG, Kennedy RC, Kwon H, Perera R, Qi Y, Radolf JD, Sakamoto JM, Sánchez-Gracia A, Severo MS, Silverman N, Šimo L, Tojo M, Tornador C, Van Zee JP, Vázquez J, Vieira FG, Villar M, Wespiser AR, Yang Y, Zhu J, Arensburger P, Pietrantonio PV, Barker SC, Shao R, Zdobnov EM, Hauser F, Grimmelikhuijzen CJP, Park Y, Rozas J, Benton R, Pedra JHF, Nelson DR, Unger MF, Tubio JMC, Tu Z, Robertson HM, Shumway M, Sutton G, Wortman JR, Lawson D, Wikel SK, Nene VM, Fraser CM, Collins FH, Birren B, Nelson KE, Caler E, Hill CA.

Nat Commun. 2016 Feb 9;7:10507. doi: 10.1038/ncomms10507.


Probing new components (loop G and the α-α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors.

Ihara M, Sattelle DB, Matsuda K.

Pestic Biochem Physiol. 2015 Jun;121:47-52. doi: 10.1016/j.pestbp.2015.02.011. Epub 2015 Feb 28. Review.


Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics.

Buckingham SD, Partridge FA, Sattelle DB.

Int J Parasitol Drugs Drug Resist. 2014 Oct 30;4(3):226-32. doi: 10.1016/j.ijpddr.2014.10.004. eCollection 2014 Dec. Review.


Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment.

Scott JG, Warren WC, Beukeboom LW, Bopp D, Clark AG, Giers SD, Hediger M, Jones AK, Kasai S, Leichter CA, Li M, Meisel RP, Minx P, Murphy TD, Nelson DR, Reid WR, Rinkevich FD, Robertson HM, Sackton TB, Sattelle DB, Thibaud-Nissen F, Tomlinson C, van de Zande L, Walden KK, Wilson RK, Liu N.

Genome Biol. 2014;15(10):466.


Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions.

Ihara M, Okajima T, Yamashita A, Oda T, Asano T, Matsui M, Sattelle DB, Matsuda K.

Mol Pharmacol. 2014 Dec;86(6):736-46. doi: 10.1124/mol.114.094698. Epub 2014 Sep 29.


An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro.

Hurst RJ, Hopwood T, Gallagher AL, Partridge FA, Burgis T, Sattelle DB, Else KJ.

BMC Infect Dis. 2014 Sep 27;14:520. doi: 10.1186/1471-2334-14-520.


Exon 3 splicing and mutagenesis identify residues influencing cell surface density of heterologously expressed silkworm (Bombyx mori) glutamate-gated chloride channels.

Furutani S, Ihara M, Nishino Y, Akamatsu M, Jones AK, Sattelle DB, Matsuda K.

Mol Pharmacol. 2014 Dec;86(6):686-95. doi: 10.1124/mol.114.095869. Epub 2014 Sep 26. Erratum in: Mol Pharmacol. 2015 Jan;87(1):141.


The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

Khabirova E, Moloney A, Marciniak SJ, Williams J, Lomas DA, Oliver SG, Favrin G, Sattelle DB, Crowther DC.

PLoS One. 2014 Jul 31;9(7):e102985. doi: 10.1371/journal.pone.0102985. eCollection 2014.


A single amino acid polymorphism in the Drosophila melanogaster Dα1 (ALS) subunit enhances neonicotinoid efficacy at Dα1-chicken β2 hybrid nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes.

Ihara M, Shimazu N, Utsunomiya M, Akamatsu M, Sattelle DB, Matsuda K.

Biosci Biotechnol Biochem. 2014;78(4):543-9. doi: 10.1080/09168451.2014.891928. Epub 2014 May 30.


Functional characterisation of a nicotinic acetylcholine receptor α subunit from the brown dog tick, Rhipicephalus sanguineus.

Lees K, Jones AK, Matsuda K, Akamatsu M, Sattelle DB, Woods DJ, Bowman AS.

Int J Parasitol. 2014 Jan;44(1):75-81. doi: 10.1016/j.ijpara.2013.11.002. Epub 2013 Dec 1.


Dr. Kathleen Drew-Baker, "Mother of the Sea", a Manchester scientist celebrated each year for half a century in Japan.

Harris C, Matsuda K, Sattelle DB.

Bioessays. 2013 Sep;35(9):838-9. doi: 10.1002/bies.201300061.


Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.

Bennett HM, Lees K, Harper KM, Jones AK, Sattelle DB, Wonnacott S, Wolstenholme AJ.

J Neurochem. 2012 Dec;123(6):911-8. doi: 10.1111/jnc.12013. Epub 2012 Oct 10.


Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.

Grice SJ, Sleigh JN, Liu JL, Sattelle DB.

Bioessays. 2011 Dec;33(12):956-65. doi: 10.1002/bies.201100082. Epub 2011 Oct 18. Review.


Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans.

Glendinning SK, Buckingham SD, Sattelle DB, Wonnacott S, Wolstenholme AJ.

PLoS One. 2011;6(7):e22390. doi: 10.1371/journal.pone.0022390. Epub 2011 Jul 26.


Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.

Echeverria V, Zeitlin R, Burgess S, Patel S, Barman A, Thakur G, Mamcarz M, Wang L, Sattelle DB, Kirschner DA, Mori T, Leblanc RM, Prabhakar R, Arendash GW.

J Alzheimers Dis. 2011;24(4):817-35. doi: 10.3233/JAD-2011-102136.


A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function.

Jones AK, Rayes D, Al-Diwani A, Maynard TP, Jones R, Hernando G, Buckingham SD, Bouzat C, Sattelle DB.

J Biol Chem. 2011 Jan 28;286(4):2550-8. doi: 10.1074/jbc.M110.177238. Epub 2010 Oct 21.


A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds.

Sleigh JN, Buckingham SD, Esmaeili B, Viswanathan M, Cuppen E, Westlund BM, Sattelle DB.

Hum Mol Genet. 2011 Jan 15;20(2):245-60. doi: 10.1093/hmg/ddq459. Epub 2010 Oct 20.


Diversity of insect nicotinic acetylcholine receptor subunits.

Jones AK, Sattelle DB.

Adv Exp Med Biol. 2010;683:25-43.


Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons.

Jones AK, Buckingham SD, Sattelle DB.

Trends Pharmacol Sci. 2010 Oct;31(10):455-62. doi: 10.1016/ Epub 2010 Jul 30. Review.


Identification of ion channel genes in the Acyrthosiphon pisum genome.

Dale RP, Jones AK, Tamborindeguy C, Davies TG, Amey JS, Williamson S, Wolstenholme A, Field LM, Williamson MS, Walsh TK, Sattelle DB.

Insect Mol Biol. 2010 Mar;19 Suppl 2:141-53. doi: 10.1111/j.1365-2583.2009.00975.x.


The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis.

Jones AK, Bera AN, Lees K, Sattelle DB.

Heredity (Edinb). 2010 Mar;104(3):247-59. doi: 10.1038/hdy.2009.97. Epub 2010 Jan 20.


Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.

Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK; Nasonia Genome Working Group, Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK, Beukeboom LW, Desplan C, Elsik CG, Grimmelikhuijzen CJ, Kitts P, Lynch JA, Murphy T, Oliveira DC, Smith CD, van de Zande L, Worley KC, Zdobnov EM, Aerts M, Albert S, Anaya VH, Anzola JM, Barchuk AR, Behura SK, Bera AN, Berenbaum MR, Bertossa RC, Bitondi MM, Bordenstein SR, Bork P, Bornberg-Bauer E, Brunain M, Cazzamali G, Chaboub L, Chacko J, Chavez D, Childers CP, Choi JH, Clark ME, Claudianos C, Clinton RA, Cree AG, Cristino AS, Dang PM, Darby AC, de Graaf DC, Devreese B, Dinh HH, Edwards R, Elango N, Elhaik E, Ermolaeva O, Evans JD, Foret S, Fowler GR, Gerlach D, Gibson JD, Gilbert DG, Graur D, Gründer S, Hagen DE, Han Y, Hauser F, Hultmark D, Hunter HC 4th, Hurst GD, Jhangian SN, Jiang H, Johnson RM, Jones AK, Junier T, Kadowaki T, Kamping A, Kapustin Y, Kechavarzi B, Kim J, Kim J, Kiryutin B, Koevoets T, Kovar CL, Kriventseva EV, Kucharski R, Lee H, Lee SL, Lees K, Lewis LR, Loehlin DW, Logsdon JM Jr, Lopez JA, Lozado RJ, Maglott D, Maleszka R, Mayampurath A, Mazur DJ, McClure MA, Moore AD, Morgan MB, Muller J, Munoz-Torres MC, Muzny DM, Nazareth LV, Neupert S, Nguyen NB, Nunes FM, Oakeshott JG, Okwuonu GO, Pannebakker BA, Pejaver VR, Peng Z, Pratt SC, Predel R, Pu LL, Ranson H, Raychoudhury R, Rechtsteiner A, Reese JT, Reid JG, Riddle M, Robertson HM, Romero-Severson J, Rosenberg M, Sackton TB, Sattelle DB, Schlüns H, Schmitt T, Schneider M, Schüler A, Schurko AM, Shuker DM, Simões ZL, Sinha S, Smith Z, Solovyev V, Souvorov A, Springauf A, Stafflinger E, Stage DE, Stanke M, Tanaka Y, Telschow A, Trent C, Vattathil S, Verhulst EC, Viljakainen L, Wanner KW, Waterhouse RM, Whitfield JB, Wilkes TE, Williamson M, Willis JH, Wolschin F, Wyder S, Yamada T, Yi SV, Zecher CN, Zhang L, Gibbs RA.

Science. 2010 Jan 15;327(5963):343-8. doi: 10.1126/science.1178028. Erratum in: Science. 2010 Mar 26;327(5973):1577.


Alzheimer's disease: insights from Drosophila melanogaster models.

Moloney A, Sattelle DB, Lomas DA, Crowther DC.

Trends Biochem Sci. 2010 Apr;35(4):228-35. doi: 10.1016/j.tibs.2009.11.004. Epub 2009 Dec 25. Review.


Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone.

Buckingham SD, Higashino Y, Sattelle DB.

Invert Neurosci. 2009 Nov;9(2):85-9. doi: 10.1007/s10158-009-0091-0. Epub 2009 Oct 22.


Alternative splicing of the Anopheles gambiae nicotinic acetylcholine receptor, Agamalphabeta9, generates both alpha and beta subunits.

Jones AK, Buckingham SD, Brown LA, Sattelle DB.

Invert Neurosci. 2009 Nov;9(2):77-84. doi: 10.1007/s10158-009-0089-7. Epub 2009 Aug 11.


Fast, automated measurement of nematode swimming (thrashing) without morphometry.

Buckingham SD, Sattelle DB.

BMC Neurosci. 2009 Jul 20;10:84. doi: 10.1186/1471-2202-10-84.


The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits.

Williamson SM, Robertson AP, Brown L, Williams T, Woods DJ, Martin RJ, Sattelle DB, Wolstenholme AJ.

PLoS Pathog. 2009 Jul;5(7):e1000517. doi: 10.1371/journal.ppat.1000517. Epub 2009 Jul 17.


Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.

Sattelle DB, Buckingham SD, Akamatsu M, Matsuda K, Pienaar IS, Jones AK, Sattelle BM, Almond A, Blundell CD.

Biochem Pharmacol. 2009 Oct 1;78(7):836-43. doi: 10.1016/j.bcp.2009.06.020. Epub 2009 Jun 21. Erratum in: Biochem Pharmacol. 2010 May 1;79(9):1372. Pienaar, Ilse [corrected to Pienaar, Ilse S].


Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency.

Jones AK, Buckingham SD, Papadaki M, Yokota M, Sattelle BM, Matsuda K, Sattelle DB.

J Neurosci. 2009 Apr 1;29(13):4287-92. doi: 10.1523/JNEUROSCI.5251-08.2009.


Diverse actions and target-site selectivity of neonicotinoids: structural insights.

Matsuda K, Kanaoka S, Akamatsu M, Sattelle DB.

Mol Pharmacol. 2009 Jul;76(1):1-10. doi: 10.1124/mol.109.055186. Epub 2009 Mar 25. Review.


Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

Buckingham SD, Jones AK, Brown LA, Sattelle DB.

Pharmacol Rev. 2009 Mar;61(1):39-61. doi: 10.1124/pr.108.000562. Epub 2009 Mar 16. Review.


Edited GluR2, a gatekeeper for motor neurone survival?

Buckingham SD, Kwak S, Jones AK, Blackshaw SE, Sattelle DB.

Bioessays. 2008 Nov;30(11-12):1185-92. doi: 10.1002/bies.20836. Review.


Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan.

Briese M, Esmaeili B, Fraboulet S, Burt EC, Christodoulou S, Towers PR, Davies KE, Sattelle DB.

Hum Mol Genet. 2009 Jan 1;18(1):97-104. doi: 10.1093/hmg/ddn320. Epub 2008 Oct 1.

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