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Items: 1 to 50 of 196

1.

Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani.

Zahid MSH, Johnson MM, Tokarski RJ 2nd, Satoskar AR, Fuchs JR, Bachelder EM, Ainslie KM.

Int J Parasitol Drugs Drug Resist. 2019 Aug;10:125-132. doi: 10.1016/j.ijpddr.2019.08.004. Epub 2019 Aug 21.

2.

Host-directed therapies for parasitic diseases.

Singh B, Varikuti S, Halsey G, Volpedo G, Hamza OM, Satoskar AR.

Future Med Chem. 2019 Aug;11(15):1999-2018. doi: 10.4155/fmc-2018-0439. Epub 2019 Aug 8.

PMID:
31390889
3.

Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses.

Oghumu S, Varikuti S, Stock JC, Volpedo G, Saljoughian N, Terrazas CA, Satoskar AR.

J Immunol. 2019 Aug 15;203(4):789-794. doi: 10.4049/jimmunol.1800931. Epub 2019 Jun 28.

PMID:
31253729
4.

Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages.

Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI.

J Immunol Res. 2019 May 14;2019:2946713. doi: 10.1155/2019/2946713. eCollection 2019.

5.

MicroRNA 155 Contributes to Host Immunity against Leishmania donovani but Is Not Essential for Resolution of Infection.

Varikuti S, Natarajan G, Volpedo G, Singh B, Hamza O, Messick GV, Guerau-de-Arellano M, Papenfuss TL, Oghumu S, Satoskar AR.

Infect Immun. 2019 Jul 23;87(8). pii: e00307-19. doi: 10.1128/IAI.00307-19. Print 2019 Aug.

PMID:
31182615
6.

Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis.

Howait M, Albassam A, Yamada C, Sasaki H, Bahammam L, Azuma MM, Cintra LTA, Satoskar AR, Yamada S, White R, Kawai T, Movila A.

J Immunol. 2019 Apr 1;202(7):2035-2043. doi: 10.4049/jimmunol.1801161. Epub 2019 Feb 8.

PMID:
30737274
7.

Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis.

Afzal I, Sarwar HS, Sohail MF, Varikuti S, Jahan S, Akhtar S, Yasinzai M, Satoskar AR, Shahnaz G.

Nanomedicine (Lond). 2019 Feb;14(4):387-406. doi: 10.2217/nnm-2018-0038. Epub 2019 Jan 28.

PMID:
30688557
8.

Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites.

Varikuti S, Jha BK, Volpedo G, Ryan NM, Halsey G, Hamza OM, McGwire BS, Satoskar AR.

Front Microbiol. 2018 Nov 30;9:2655. doi: 10.3389/fmicb.2018.02655. eCollection 2018. Review.

9.

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion.

Ghose J, Viola D, Terrazas C, Caserta E, Troadec E, Khalife J, Gunes EG, Sanchez J, McDonald T, Marcucci G, Kaur B, Rosenzweig M, Keats J, Rosen S, Krishnan A, Satoskar AR, Hofmeister CC, Pichiorri F.

Oncoimmunology. 2018 Jul 23;7(10):e1486948. doi: 10.1080/2162402X.2018.1486948. eCollection 2018.

10.

The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani.

Varikuti S, Volpedo G, Saljoughian N, Hamza OM, Halsey G, Ryan NM, Sedmak BE, Seidler GR, Papenfuss TL, Oghumu S, Satoskar AR.

J Infect Dis. 2019 Jan 29;219(4):599-608. doi: 10.1093/infdis/jiy552.

PMID:
30239895
11.

Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development.

Leon-Cabrera S, Vázquez-Sandoval A, Molina-Guzman E, Delgado-Ramirez Y, Delgado-Buenrostro NL, Callejas BE, Chirino YI, Pérez-Plasencia C, Rodríguez-Sosa M, Olguín JE, Salinas C, Satoskar AR, Terrazas LI.

Cancers (Basel). 2018 Sep 19;10(9). pii: E341. doi: 10.3390/cancers10090341.

12.

Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy.

Kim E, Lembert M, Fallata GM, Rowe JC, Martin TL, Satoskar AR, Reo NV, Paliy O, Cormet-Boyaka E, Boyaka PN.

Front Immunol. 2018 Aug 3;9:1692. doi: 10.3389/fimmu.2018.01692. eCollection 2018.

13.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR.

Int Immunol. 2018 Jul 24;30(8):385. doi: 10.1093/intimm/dxy037. No abstract available.

14.

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation.

Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK.

Oncogene. 2018 Aug;37(32):4428-4442. doi: 10.1038/s41388-018-0263-7. Epub 2018 May 3.

PMID:
29720724
15.

Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.

Attia Z, Rowe JC, Kim E, Varikuti S, Steiner HE, Zaghawa A, Hassan H, Cormet-Boyaka E, Satoskar AR, Boyaka PN.

Eur J Immunol. 2018 Aug;48(8):1295-1301. doi: 10.1002/eji.201747264. Epub 2018 Jul 5.

16.

IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy.

Zhu J, Liu JQ, Shi M, Cheng X, Ding M, Zhang JC, Davis JP, Varikuti S, Satoskar AR, Lu L, Pan X, Zheng P, Liu Y, Bai XF.

JCI Insight. 2018 Apr 5;3(7). pii: 98745. doi: 10.1172/jci.insight.98745. eCollection 2018 Apr 5.

17.

Editorial: Cell Signaling in Host-Pathogen Interactions: The Host Point of View.

Bahia D, Satoskar AR, Dussurget O.

Front Immunol. 2018 Feb 19;9:221. doi: 10.3389/fimmu.2018.00221. eCollection 2018. No abstract available.

18.

Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis.

Sarwar HS, Sohail MF, Saljoughian N, Rehman AU, Akhtar S, Nadhman A, Yasinzai M, Gendelman HE, Satoskar AR, Shahnaz G.

Artif Cells Nanomed Biotechnol. 2018;46(sup1):521-531. doi: 10.1080/21691401.2018.1430699. Epub 2018 Jan 31.

PMID:
29385910
19.

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.

Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, Sill JM, Christman JW, Satoskar AR, Zhao X.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):756-766. doi: 10.1165/rcmb.2017-0236OC.

20.

STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Varikuti S, Oghumu S, Elbaz M, Volpedo G, Ahirwar DK, Alarcon PC, Sperling RH, Moretti E, Pioso MS, Kimble J, Nasser MW, Ganju RK, Terrazas C, Satoskar AR.

Oncoimmunology. 2017 Aug 14;6(11):e1361088. doi: 10.1080/2162402X.2017.1361088. eCollection 2017.

21.

Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection.

Terrazas C, Varikuti S, Oghumu S, Steinkamp HM, Ardic N, Kimble J, Nakhasi H, Satoskar AR.

Sci Rep. 2017 Oct 31;7(1):14693. doi: 10.1038/s41598-017-14935-3.

22.

MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment.

Kim B, Kusibati R, Heisler-Taylor T, Mantopoulos D, Ding J, Abdel-Rahman MH, Satoskar AR, Godbout JP, Bhattacharya SK, Cebulla CM.

Sci Rep. 2017 Oct 30;7(1):14336. doi: 10.1038/s41598-017-14298-9.

23.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR.

J Nat Prod. 2017 Sep 22;80(9):2515-2523. doi: 10.1021/acs.jnatprod.7b00445. Epub 2017 Sep 6.

24.

Efficacy, Safety and Cost-Effectiveness of Thermotherapy in the Treatment of Leishmania donovani-Induced Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial.

Refai WF, Madarasingha NP, Sumanasena B, Weerasingha S, De Silva A, Fernandopulle R, Satoskar AR, Karunaweera ND.

Am J Trop Med Hyg. 2017 Oct;97(4):1120-1126. doi: 10.4269/ajtmh.16-0879. Epub 2017 Aug 18.

25.

Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes in vivo.

Liu Z, Wu L, Zhu J, Zhu X, Zhu J, Liu JQ, Zhang J, Davis JP, Varikuti S, Satoskar AR, Zhou J, Li MS, Bai XF.

Immunology. 2017 Dec;152(4):638-647. doi: 10.1111/imm.12805. Epub 2017 Aug 23.

26.

Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana.

Varikuti S, Oghumu S, Saljoughian N, Pioso MS, Sedmak BE, Khamesipour A, Satoskar AR.

Acta Trop. 2017 Sep;173:102-108. doi: 10.1016/j.actatropica.2017.06.004. Epub 2017 Jun 9.

27.

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani.

Manamperi NH, Oghumu S, Pathirana N, de Silva MV, Abeyewickreme W, Satoskar AR, Karunaweera ND.

Parasite Immunol. 2017 Mar;39(3). doi: 10.1111/pim.12413.

28.

Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis.

Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S.

Sci Rep. 2017 Jan 17;7:40814. doi: 10.1038/srep40814.

29.

Granuloma formation in leishmaniasis: A mathematical model.

Siewe N, Yakubu AA, Satoskar AR, Friedman A.

J Theor Biol. 2017 Jan 7;412:48-60. doi: 10.1016/j.jtbi.2016.10.004. Epub 2016 Oct 18.

PMID:
27769685
30.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR.

Int Immunol. 2016 Nov;28(11):565-570. Epub 2016 Aug 30. Erratum in: Int Immunol. 2018 Jul 24;30(8):385.

31.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.

32.

Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

Varikuti S, Natarajan G, Oghumu S, Sperling RH, Moretti E, Stock J, Papenfuss TL, Satoskar AR.

Cell Immunol. 2016 Nov;309:61-68. doi: 10.1016/j.cellimm.2016.08.016. Epub 2016 Sep 6.

33.

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Natarajan G, Oghumu S, Terrazas C, Varikuti S, Byrd JC, Satoskar AR.

Oncoimmunology. 2016 Mar 10;5(6):e1151592. doi: 10.1080/2162402X.2016.1151592. eCollection 2016 Jun.

34.

Pediatric Cutaneous Leishmaniasis in an Endemic Region in Turkey: A Retrospective Analysis of 8786 Cases during 1998-2014.

Aksoy M, Doni N, Ozkul HU, Yesilova Y, Ardic N, Yesilova A, Ahn-Jarvis J, Oghumu S, Terrazas C, Satoskar AR.

PLoS Negl Trop Dis. 2016 Jul 14;10(7):e0004835. doi: 10.1371/journal.pntd.0004835. eCollection 2016 Jul.

35.

Differential gene expression pattern in biopsies with renal allograft pyelonephritis and allograft rejection.

Oghumu S, Nori U, Bracewell A, Zhang J, Bott C, Nadasdy GM, Brodsky SV, Pelletier R, Satoskar AR, Nadasdy T, Satoskar AA.

Clin Transplant. 2016 Sep;30(9):1115-33. doi: 10.1111/ctr.12795. Epub 2016 Aug 8.

36.

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

Yang S, He P, Wang J, Schetter A, Tang W, Funamizu N, Yanaga K, Uwagawa T, Satoskar AR, Gaedcke J, Bernhardt M, Ghadimi BM, Gaida MM, Bergmann F, Werner J, Ried T, Hanna N, Alexander HR, Hussain SP.

Cancer Res. 2016 Jul 1;76(13):3838-50. doi: 10.1158/0008-5472.CAN-15-2841. Epub 2016 Apr 20.

37.

Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Oghumu S, Knobloch TJ, Terrazas C, Varikuti S, Ahn-Jarvis J, Bollinger CE, Iwenofu H, Weghorst CM, Satoskar AR.

Int J Cancer. 2016 Sep 15;139(6):1379-90. doi: 10.1002/ijc.30177. Epub 2016 Jun 16.

38.

MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C(high) Monocytes into TipDCs during Murine Toxoplasmosis.

Ruiz-Rosado Jde D, Olguín JE, Juárez-Avelar I, Saavedra R, Terrazas LI, Robledo-Avila FH, Vazquez-Mendoza A, Fernández J, Satoskar AR, Partida-Sánchez S, Rodriguez-Sosa M.

Mediators Inflamm. 2016;2016:9101762. doi: 10.1155/2016/9101762. Epub 2016 Feb 29.

39.

Immune response to infection by Leishmania: A mathematical model.

Siewe N, Yakubu AA, Satoskar AR, Friedman A.

Math Biosci. 2016 Jun;276:28-43. doi: 10.1016/j.mbs.2016.02.015. Epub 2016 Mar 14.

PMID:
26987853
40.

Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells.

Natarajan G, Terrazas C, Oghumu S, Varikuti S, Dubovsky JA, Byrd JC, Satoskar AR.

Oncoimmunology. 2015 Jun 9;5(1):e1057385. eCollection 2016.

41.

Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.

Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD.

J Nat Prod. 2016 Mar 25;79(3):598-606. doi: 10.1021/acs.jnatprod.5b01131. Epub 2016 Feb 23.

42.

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis.

Zhao H, Ahirwar DK, Oghumu S, Wilkie T, Powell CA, Nasser MW, Satoskar AR, Li DY, Ganju RK.

Mol Oncol. 2016 Feb;10(2):272-81. doi: 10.1016/j.molonc.2015.10.007. Epub 2015 Oct 28.

43.

IL-17A promotes susceptibility during experimental visceral leishmaniasis caused by Leishmania donovani.

Terrazas C, Varikuti S, Kimble J, Moretti E, Boyaka PN, Satoskar AR.

FASEB J. 2016 Mar;30(3):1135-43. doi: 10.1096/fj.15-277202. Epub 2015 Nov 18.

44.

Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis.

Yesilova Y, Surucu HA, Ardic N, Aksoy M, Yesilova A, Oghumu S, Satoskar AR.

J Dermatolog Treat. 2016;27(1):83-7. doi: 10.3109/09546634.2015.1054778. Epub 2015 Jun 24.

45.

Extraintestinal Helminth Infection Limits Pathology and Proinflammatory Cytokine Expression during DSS-Induced Ulcerative Colitis: A Role for Alternatively Activated Macrophages and Prostaglandins.

Ledesma-Soto Y, Callejas BE, Terrazas CA, Reyes JL, Espinoza-Jiménez A, González MI, León-Cabrera S, Morales R, Olguín JE, Saavedra R, Oghumu S, Satoskar AR, Terrazas LI.

Biomed Res Int. 2015;2015:563425. doi: 10.1155/2015/563425. Epub 2015 May 18.

46.

Immunology and Cell Biology of Parasitic Diseases 2014.

Terrazas LI, Satoskar AR, Rodriguez-Sosa M, Landa-Piedra A.

Biomed Res Int. 2015;2015:101025. doi: 10.1155/2015/101025. Epub 2015 May 20. No abstract available.

47.

A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis.

Turan E, Yeşilova Y, Sürücü HA, Ardic N, Doni N, Aksoy M, Yesilova A, Oghumu S, Varikuti S, Satoskar AR.

Am J Trop Med Hyg. 2015 Sep;93(3):559-63. doi: 10.4269/ajtmh.15-0090. Epub 2015 Jun 15.

48.

Uncovering Leishmania-macrophage interplay using imaging flow cytometry.

Terrazas C, Oghumu S, Varikuti S, Martinez-Saucedo D, Beverley SM, Satoskar AR.

J Immunol Methods. 2015 Aug;423:93-8. doi: 10.1016/j.jim.2015.04.022. Epub 2015 May 9.

49.

Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha.

da Costa-Silva TA, Grecco SS, de Sousa FS, Lago JH, Martins EG, Terrazas CA, Varikuti S, Owens KL, Beverley SM, Satoskar AR, Tempone AG.

J Nat Prod. 2015 Apr 24;78(4):653-7. doi: 10.1021/np500809a. Epub 2015 Apr 2.

50.

Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar AR, Shilo K, Carson WE 3rd, Ganju RK.

Mol Oncol. 2015 Apr;9(4):906-19. doi: 10.1016/j.molonc.2014.12.010. Epub 2015 Jan 19.

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