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Items: 1 to 50 of 199

1.

A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice.

Takagahara S, Shinohara H, Itokawa S, Satomi Y, Ando A, Yamamoto T, Suzuki H, Fujimoto T, Kubo K, Ikeda S.

J Pharmacol Exp Ther. 2019 Nov;371(2):290-298. doi: 10.1124/jpet.119.259846. Epub 2019 Sep 5.

PMID:
31488602
2.

Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice.

Ando A, Oka M, Satomi Y.

Cell Biosci. 2019 Aug 5;9:61. doi: 10.1186/s13578-019-0324-9. eCollection 2019.

3.

MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes.

Huang HJ, Holub C, Rolzin P, Bilakovics J, Fanjul A, Satomi Y, Plonowski A, Larson CJ, Farrell PJ.

J Biol Chem. 2019 Jun 14;294(24):9567-9575. doi: 10.1074/jbc.RA118.007302. Epub 2019 May 2.

PMID:
31048375
4.

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.

Nakamura A, Nambu T, Ebara S, Hasegawa Y, Toyoshima K, Tsuchiya Y, Tomita D, Fujimoto J, Kurasawa O, Takahara C, Ando A, Nishigaki R, Satomi Y, Hata A, Hara T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785. doi: 10.1073/pnas.1805523115. Epub 2018 Jul 30.

5.

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.

Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong TT, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S.

Bioorg Med Chem. 2018 May 15;26(9):2452-2465. doi: 10.1016/j.bmc.2018.04.008. Epub 2018 Apr 4.

PMID:
29669694
6.
7.

Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.

Mizojiri R, Asano M, Tomita D, Banno H, Nii N, Sasaki M, Sumi H, Satoh Y, Yamamoto Y, Moriya T, Satomi Y, Maezaki H.

J Med Chem. 2018 Feb 8;61(3):1098-1117. doi: 10.1021/acs.jmedchem.7b01547. Epub 2018 Jan 5.

PMID:
29232514
8.

Metabolomics of postprandial plasma alterations: a comprehensive Japanese study.

Moriya T, Satomi Y, Kobayashi H.

J Biochem. 2018 Feb 1;163(2):113-121. doi: 10.1093/jb/mvx066.

PMID:
29040577
9.

One-step lipid extraction for plasma lipidomics analysis by liquid chromatography mass spectrometry.

Satomi Y, Hirayama M, Kobayashi H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:93-100. doi: 10.1016/j.jchromb.2017.08.020. Epub 2017 Aug 19.

PMID:
28850891
10.

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.

Imamura K, Tomita N, Kawakita Y, Ito Y, Ono K, Nii N, Miyazaki T, Yonemori K, Tawada M, Sumi H, Satoh Y, Yamamoto Y, Miyahisa I, Sasaki M, Satomi Y, Hirayama M, Nishigaki R, Maezaki H.

Bioorg Med Chem. 2017 Jul 15;25(14):3768-3779. doi: 10.1016/j.bmc.2017.05.016. Epub 2017 May 11.

PMID:
28571972
11.

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions.

Murai S, Ando A, Ebara S, Hirayama M, Satomi Y, Hara T.

Oncogenesis. 2017 May 8;6(5):e329. doi: 10.1038/oncsis.2017.34.

12.

In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor.

Nishizawa S, Sumi H, Satoh Y, Yamamoto Y, Kitazawa S, Honda K, Araki H, Kakoi K, Imamura K, Sasaki M, Miyahisa I, Satomi Y, Nishigaki R, Hirayama M, Aoyama K, Maezaki H, Hara T.

Eur J Pharmacol. 2017 Jul 15;807:21-31. doi: 10.1016/j.ejphar.2017.03.064. Epub 2017 Apr 22.

PMID:
28442322
13.

Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.

Kitazawa S, Ebara S, Ando A, Baba Y, Satomi Y, Soga T, Hara T.

Oncotarget. 2017 Apr 25;8(17):28922-28938. doi: 10.18632/oncotarget.15959.

14.

Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors.

Okegawa T, Morimoto M, Nishizawa S, Kitazawa S, Honda K, Araki H, Tamura T, Ando A, Satomi Y, Nutahara K, Hara T.

EBioMedicine. 2017 May;19:31-38. doi: 10.1016/j.ebiom.2017.04.009. Epub 2017 Apr 6.

15.

Antitumor and Cancer-preventative Function of Fucoxanthin: A Marine Carotenoid.

Satomi Y.

Anticancer Res. 2017 Apr;37(4):1557-1562. Review.

PMID:
28373414
16.
17.

Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase.

Yaguchi M, Shibata S, Satomi Y, Hirayama M, Adachi R, Asano Y, Kojima T, Hirata Y, Mizutani A, Kiba A, Sagiya Y.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):493-500. doi: 10.1016/j.bbrc.2017.01.075. Epub 2017 Jan 17.

PMID:
28108287
18.

A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.

Kawata Y, Okuda S, Hotta N, Igawa H, Takahashi M, Ikoma M, Kasai S, Ando A, Satomi Y, Nishida M, Nakayama M, Yamamoto S, Nagisa Y, Takekawa S.

Eur J Pharmacol. 2017 Feb 5;796:45-53. doi: 10.1016/j.ejphar.2016.12.018. Epub 2016 Dec 13.

PMID:
27986627
19.

Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.

Gopalan V, Michael N, Ishino S, Lee SS, Yang AY, Bhanu Prakash KN, Yaligar J, Sadananthan SA, Kaneko M, Zhou Z, Satomi Y, Hirayama M, Kamiguchi H, Zhu B, Horiguchi T, Nishimoto T, Velan SS.

Sci Rep. 2016 May 20;6:26445. doi: 10.1038/srep26445.

20.

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.

Take K, Mochida T, Maki T, Satomi Y, Hirayama M, Nakakariya M, Amano N, Adachi R, Sato K, Kitazaki T, Takekawa S.

PLoS One. 2016 Mar 3;11(3):e0150976. doi: 10.1371/journal.pone.0150976. eCollection 2016.

21.

Differential effect of cholesterol on type I and II feline coronavirus infection.

Takano T, Satomi Y, Oyama Y, Doki T, Hohdatsu T.

Arch Virol. 2016 Jan;161(1):125-33. doi: 10.1007/s00705-015-2655-0. Epub 2015 Oct 29.

PMID:
26514843
22.

Efficient gene-targeting in rat embryonic stem cells by CRISPR/Cas and generation of human kynurenine aminotransferase II (KAT II) knock-in rat.

Yamamoto S, Ooshima Y, Nakata M, Yano T, Nishimura N, Nishigaki R, Satomi Y, Matsumoto H, Matsumoto Y, Takeyama M.

Transgenic Res. 2015 Dec;24(6):991-1001. doi: 10.1007/s11248-015-9909-1. Epub 2015 Oct 10.

PMID:
26454650
23.
24.

Clinical outcomes of prostate cancer patients in Yokosuka City, Japan: A comparative study between cases detected by prostate-specific antigen-based screening in Yokosuka and those detected by other means.

Sakai N, Taguri M, Kobayashi K, Noguchi S, Ikeda S, Koh H, Satomi Y, Furuhata A.

Int J Urol. 2015 Aug;22(8):747-52. doi: 10.1111/iju.12806. Epub 2015 May 23.

25.
26.

Chronic inflammation-derived nitric oxide causes conversion of human colonic adenoma cells into adenocarcinoma cells.

Tazawa H, Kawaguchi T, Kobayashi T, Kuramitsu Y, Wada S, Satomi Y, Nishino H, Kobayashi M, Kanda Y, Osaki M, Kitagawa T, Hosokawa M, Okada F.

Exp Cell Res. 2013 Nov 1;319(18):2835-44. doi: 10.1016/j.yexcr.2013.08.006. Epub 2013 Aug 13.

PMID:
23948305
28.

Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.

Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Yanagisawa S, Furusawa M, Uno Y, Yamasaki M, Satomi Y, Ichinose M.

Respirology. 2012 Apr;17(3):533-40. doi: 10.1111/j.1440-1843.2012.02136.x.

PMID:
22295989
29.

[Pancreatic metastasis from renal cell carcinoma 25 years after radical nephrectomy].

Yokonishi T, Ito Y, Osaka K, Komiya A, Kobayashi K, Sakai N, Noguchi S, Kishi H, Satomi Y, Mogaki M, Tsuura Y, Mizuno N, Ikeda I.

Hinyokika Kiyo. 2010 Nov;56(11):629-33. Review. Japanese.

30.

A screen for potential ferredoxin electron transfer partners uncovers new, redox dependent interactions.

Hanke GT, Satomi Y, Shinmura K, Takao T, Hase T.

Biochim Biophys Acta. 2011 Feb;1814(2):366-74. doi: 10.1016/j.bbapap.2010.09.011. Epub 2010 Sep 22.

PMID:
20869472
31.

Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.

Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N.

J Neurochem. 2010 Aug;114(4):1097-106. doi: 10.1111/j.1471-4159.2010.06827.x. Epub 2010 May 26.

32.
33.

Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.

Yoshitane H, Takao T, Satomi Y, Du NH, Okano T, Fukada Y.

Mol Cell Biol. 2009 Jul;29(13):3675-86. doi: 10.1128/MCB.01864-08. Epub 2009 May 4.

34.

Snapshot peptidomics of the regulated secretory pathway.

Sasaki K, Satomi Y, Takao T, Minamino N.

Mol Cell Proteomics. 2009 Jul;8(7):1638-47. doi: 10.1074/mcp.M900044-MCP200. Epub 2009 Mar 31.

35.

The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation.

Hanada T, Satomi Y, Takao T, Ohsumi Y.

FEBS Lett. 2009 Apr 2;583(7):1078-83. doi: 10.1016/j.febslet.2009.03.009. Epub 2009 Mar 13.

36.

[Multi-center trial on the early effects of silodosin on lower urinary tract symptoms associated with benign prostatic hyperplasia].

Ogawa T, Uemura H, Sano F, Hoshino K, Kita K, Hayashi N, Kagota M, Murakami T, Makiyama K, Miyoshii Y, Nakaigawa N, Yao M, Shimura H, Furuhata A, Fujikawa N, Shioi K, Ueki T, Hara Y, Saitou K, Kawakami S, Satomi Y, Hattori Y, Teranishi J, Kondo K, Kishida T, Saito K, Noguchi K, Fuji H, Yamaguchi T, Kinoshita Y, Nomura S, Yoshida M, Sakai N, Terao H, Matsumoto T, Umemoto S, Ogo Y, Kobayashi K, Noguchi S, Asakura T, Kohdaira T, Iguchi K, Izumi K, Hirano M, Kanno H, Takahashi T, Nukui F, Mokuo Y, Muraoka K, Osada Y, Funahashi M, Kitami K, Sugiura S, Ohta J, Miura T, Ishibashi Y, Masuda M, Komiya A, Suwa Y, Hashiba T, Mitaka K, Kobayashi M, Ohsaka K, Futoshi T, Tsuchiya T, Iwasaki A, Yamashita Y, Matsuzaki J, Kubota Y.

Hinyokika Kiyo. 2008 Dec;54(12):757-64. Japanese.

37.

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.

Nat Cell Biol. 2009 Feb;11(2):123-32. doi: 10.1038/ncb1821. Epub 2009 Jan 11.

PMID:
19136968
38.

Cancer prevention by carotenoids.

Nishino H, Murakoshi M, Tokuda H, Satomi Y.

Arch Biochem Biophys. 2009 Mar 15;483(2):165-8. doi: 10.1016/j.abb.2008.09.011. Epub 2008 Sep 30. Review.

PMID:
18848517
39.

Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head.

Kuribayashi M, Fujioka M, Takahashi KA, Arai Y, Hirata T, Nakajima S, Yoshimura N, Satomi Y, Nishino H, Kondo K, Fukushima W, Hirota Y, Kubo T.

J Orthop Sci. 2008 Jul;13(4):297-303. doi: 10.1007/s00776-008-1244-4. Epub 2008 Aug 13.

PMID:
18696186
40.
41.

[Splenosis mimicking local recurrence after radical nephrectomy: a report of two cases].

Onuki T, Terao H, Muraoka K, Nakamura M, Kobayashi K, Oogo Y, Noguchi S, Kishi H, Satomi Y, Fukuda M.

Hinyokika Kiyo. 2008 May;54(5):353-6. Review. Japanese.

42.

[Five-year results of prostate specific antigen (PSA) screening in Yokosuka City--comparative study between PSA-screened group and non-screened group].

Noguchi S, Satomi Y, Sakai N, Takemura H, Ikeda S, Okui N, Kobayashi M, Fukuoka H, Furuhata A.

Hinyokika Kiyo. 2008 Mar;54(3):197-201. Japanese.

44.

Cancer control by phytochemicals.

Nishino H, Satomi Y, Tokuda H, Masuda M.

Curr Pharm Des. 2007;13(33):3394-9. Review.

PMID:
18045193
45.

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.

Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y.

J Biol Chem. 2007 Dec 28;282(52):37298-302. Epub 2007 Nov 6.

46.

A sequential program of dual phosphorylation of KaiC as a basis for circadian rhythm in cyanobacteria.

Nishiwaki T, Satomi Y, Kitayama Y, Terauchi K, Kiyohara R, Takao T, Kondo T.

EMBO J. 2007 Sep 5;26(17):4029-37. Epub 2007 Aug 23.

47.

Clinical anatomical study of pedicled vascularised scapular bone graft using the angular branch.

Satomi Y, Shimizu H, Beppu M, Hirata K, Takahashi T.

Hand Surg. 2007;12(1):19-28.

PMID:
17613180
48.

Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2.

Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, González LJ, Shioda S, Takao T, Nakazato M, Minamino N.

J Biol Chem. 2007 Sep 7;282(36):26354-60. Epub 2007 Jul 3.

49.

Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand.

Yoshida T, Maoka T, Das SK, Kanazawa K, Horinaka M, Wakada M, Satomi Y, Nishino H, Sakai T.

Mol Cancer Res. 2007 Jun;5(6):615-25.

50.

ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantation.

Hirata T, Fujioka M, Takahashi KA, Arai Y, Asano T, Ishida M, Kuribayashi M, Akioka K, Okamoto M, Yoshimura N, Satomi Y, Nishino H, Fukushima W, Hirota Y, Nakajima S, Kato S, Kubo T.

J Orthop Sci. 2007 May;12(3):199-206. Epub 2007 May 31.

PMID:
17530370

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