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Items: 39


Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage.

Simonich CA, Doepker L, Ralph D, Williams JA, Dhar A, Yaffe Z, Gentles L, Small CT, Oliver B, Vigdorovich V, Mangala Prasad V, Nduati R, Sather DN, Lee KK, Matsen Iv FA, Overbaugh J.

Nat Commun. 2019 May 16;10(1):2190. doi: 10.1038/s41467-019-09481-7.


Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth.

Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, Kalams SA, Haigwood NL, Crowe JE Jr.

PLoS One. 2018 Dec 19;13(12):e0209437. doi: 10.1371/journal.pone.0209437. eCollection 2018.


A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry.

Swearingen KE, Eng JK, Shteynberg D, Vigdorovich V, Springer TA, Mendoza L, Sather DN, Deutsch EW, Kappe SHI, Moritz RL.

J Proteome Res. 2019 Feb 1;18(2):652-663. doi: 10.1021/acs.jproteome.8b00638. Epub 2018 Dec 21.


A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages.

Schafer C, Dambrauskas N, Steel RW, Carbonetti S, Chuenchob V, Flannery EL, Vigdorovich V, Oliver BG, Roobsoong W, Maher SP, Kyle D, Sattabongkot J, Kappe SHI, Mikolajczak SA, Sather DN.

Malar J. 2018 Oct 17;17(1):370. doi: 10.1186/s12936-018-2519-7.


B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques.

Yacoob C, Lange MD, Cohen K, Lathia K, Feng J, Glenn J, Carbonetti S, Oliver B, Vigdorovich V, Sather DN, Stamatatos L.

PLoS Pathog. 2018 Jun 22;14(6):e1007120. doi: 10.1371/journal.ppat.1007120. eCollection 2018 Jun.


Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.

Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A.

Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012.


cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M.

JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. eCollection 2018 Jan 25.


Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal.

Steel RWJ, Pei Y, Camargo N, Kaushansky A, Dankwa DA, Martinson T, Nguyen T, Betz W, Cardamone H, Vigdorovich V, Dambrauskas N, Carbonetti S, Vaughan AM, Sather DN, Kappe SHI.

Cell Microbiol. 2018 Apr;20(4). doi: 10.1111/cmi.12817. Epub 2018 Jan 12.


Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria.

Kessler A, Dankwa S, Bernabeu M, Harawa V, Danziger SA, Duffy F, Kampondeni SD, Potchen MJ, Dambrauskas N, Vigdorovich V, Oliver BG, Hochman SE, Mowrey WB, MacCormick IJC, Mandala WL, Rogerson SJ, Sather DN, Aitchison JD, Taylor TE, Seydel KB, Smith JD, Kim K.

Cell Host Microbe. 2017 Nov 8;22(5):601-614.e5. doi: 10.1016/j.chom.2017.09.009. Epub 2017 Oct 26.


A method for the isolation and characterization of functional murine monoclonal antibodies by single B cell cloning.

Carbonetti S, Oliver BG, Vigdorovich V, Dambrauskas N, Sack B, Bergl E, Kappe SHI, Sather DN.

J Immunol Methods. 2017 Sep;448:66-73. doi: 10.1016/j.jim.2017.05.010. Epub 2017 May 26.


In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases.

Carnes J, McDermott S, Anupama A, Oliver BG, Sather DN, Stuart K.

Nucleic Acids Res. 2017 May 5;45(8):4667-4686. doi: 10.1093/nar/gkx116.


Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection.

Sack B, Kappe SH, Sather DN.

Expert Rev Vaccines. 2017 May;16(5):403-414. doi: 10.1080/14760584.2017.1295853. Epub 2017 Mar 1. Review.


Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein.

Keitany GJ, Kim KS, Krishnamurty AT, Hondowicz BD, Hahn WO, Dambrauskas N, Sather DN, Vaughan AM, Kappe SHI, Pepper M.

Cell Rep. 2016 Dec 20;17(12):3193-3205. doi: 10.1016/j.celrep.2016.11.060.


Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.

Yacoob C, Pancera M, Vigdorovich V, Oliver BG, Glenn JA, Feng J, Sather DN, McGuire AT, Stamatatos L.

Cell Rep. 2016 Nov 1;17(6):1560-1570. doi: 10.1016/j.celrep.2016.10.017.


Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus macaques by next-generation sequencing.

Vigdorovich V, Oliver BG, Carbonetti S, Dambrauskas N, Lange MD, Yacoob C, Leahy W, Callahan J, Stamatatos L, Sather DN.

Clin Transl Immunology. 2016 Jul 22;5(7):e93. doi: 10.1038/cti.2016.42. eCollection 2016 Jul.


Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.

Hessell AJ, Malherbe DC, Pissani F, McBurney S, Krebs SJ, Gomes M, Pandey S, Sutton WF, Burwitz BJ, Gray M, Robins H, Park BS, Sacha JB, LaBranche CC, Fuller DH, Montefiori DC, Stamatatos L, Sather DN, Haigwood NL.

J Immunol. 2016 Apr 1;196(7):3064-78. doi: 10.4049/jimmunol.1500527. Epub 2016 Mar 4.


Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.

Kaushansky A, Douglass AN, Arang N, Vigdorovich V, Dambrauskas N, Kain HS, Austin LS, Sather DN, Kappe SH.

Science. 2015 Nov 27;350(6264):1089-92. doi: 10.1126/science.aad3318.


Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor.

Sampath S, Brazier AJ, Avril M, Bernabeu M, Vigdorovich V, Mascarenhas A, Gomes E, Sather DN, Esmon CT, Smith JD.

Cell Microbiol. 2015 Dec;17(12):1868-82. doi: 10.1111/cmi.12478. Epub 2015 Jul 16.


Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria.

Keitany GJ, Sack B, Smithers H, Chen L, Jang IK, Sebastian L, Gupta M, Sather DN, Vignali M, Vaughan AM, Kappe SH, Wang R.

Infect Immun. 2014 Dec;82(12):5143-53. doi: 10.1128/IAI.02320-14. Epub 2014 Sep 29.


Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.

Malherbe DC, Pissani F, Sather DN, Guo B, Pandey S, Sutton WF, Stuart AB, Robins H, Park B, Krebs SJ, Schuman JT, Kalams S, Hessell AJ, Haigwood NL.

J Virol. 2014 Nov;88(22):12949-67. doi: 10.1128/JVI.01812-14. Epub 2014 Sep 10.


SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility.

Harupa A, Sack BK, Lakshmanan V, Arang N, Douglass AN, Oliver BG, Stuart AB, Sather DN, Lindner SE, Hybiske K, Torii M, Kappe SH.

Infect Immun. 2014 Nov;82(11):4643-53. doi: 10.1128/IAI.01800-14. Epub 2014 Aug 25.


Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1.

Sather DN, Carbonetti S, Malherbe DC, Pissani F, Stuart AB, Hessell AJ, Gray MD, Mikell I, Kalams SA, Haigwood NL, Stamatatos L.

J Virol. 2014 Nov;88(22):12968-81. doi: 10.1128/JVI.01816-14. Epub 2014 Aug 13.


Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies.

Carbonetti S, Oliver BG, Glenn J, Stamatatos L, Sather DN.

PLoS One. 2014 Jan 23;9(1):e86905. doi: 10.1371/journal.pone.0086905. eCollection 2014.


Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.

Diskin R, Klein F, Horwitz JA, Halper-Stromberg A, Sather DN, Marcovecchio PM, Lee T, West AP Jr, Gao H, Seaman MS, Stamatatos L, Nussenzweig MC, Bjorkman PJ.

J Exp Med. 2013 Jun 3;210(6):1235-49. doi: 10.1084/jem.20130221. Epub 2013 May 27.


Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.

Hoot S, McGuire AT, Cohen KW, Strong RK, Hangartner L, Klein F, Diskin R, Scheid JF, Sather DN, Burton DR, Stamatatos L.

PLoS Pathog. 2013 Jan;9(1):e1003106. doi: 10.1371/journal.ppat.1003106. Epub 2013 Jan 3. Erratum in: PLoS Pathog. 2013 Jul;9(9). doi:10.1371/annotation/ed7c0148-97eb-4416-824d-6e6d1aaeceef.


Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus.

Sather DN, Carbonetti S, Kehayia J, Kraft Z, Mikell I, Scheid JF, Klein F, Stamatatos L.

J Virol. 2012 Dec;86(23):12676-85. doi: 10.1128/JVI.01893-12. Epub 2012 Sep 12.


Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.

Klein F, Gaebler C, Mouquet H, Sather DN, Lehmann C, Scheid JF, Kraft Z, Liu Y, Pietzsch J, Hurley A, Poignard P, Feizi T, Morris L, Walker BD, Fätkenheuer G, Seaman MS, Stamatatos L, Nussenzweig MC.

J Exp Med. 2012 Jul 30;209(8):1469-79. doi: 10.1084/jem.20120423. Epub 2012 Jul 23.


Measurements of immune responses for establishing correlates of vaccine protection against HIV.

Burgers WA, Manrique A, Masopust D, McKinnon LR, Reynolds MR, Rolland M, Blish C, Chege GK, Curran R, Fischer W, Herrera C, Sather DN.

AIDS Res Hum Retroviruses. 2012 Jul;28(7):641-8. doi: 10.1089/AID.2011.0239. Epub 2011 Sep 23.


Characteristics of the earliest cross-neutralizing antibody response to HIV-1.

Mikell I, Sather DN, Kalams SA, Altfeld M, Alter G, Stamatatos L.

PLoS Pathog. 2011 Jan 13;7(1):e1001251. doi: 10.1371/journal.ppat.1001251. Erratum in: PLoS Pathog. 2011 Mar;7(3). doi: 10.1371/annotation/8b3b24b5-d4ed-483a-b233-0a88513ad499.


Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope.

Correia BE, Ban YE, Holmes MA, Xu H, Ellingson K, Kraft Z, Carrico C, Boni E, Sather DN, Zenobia C, Burke KY, Bradley-Hewitt T, Bruhn-Johannsen JF, Kalyuzhniy O, Baker D, Strong RK, Stamatatos L, Schief WR.

Structure. 2010 Sep 8;18(9):1116-26. doi: 10.1016/j.str.2010.06.010.


Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects.

Sather DN, Stamatatos L.

Vaccine. 2010 May 26;28 Suppl 2:B8-12. doi: 10.1016/j.vaccine.2009.07.085.


Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism.

Sather DN, Jovanovic M, Golenberg EM.

BMC Plant Biol. 2010 Mar 12;10:46. doi: 10.1186/1471-2229-10-46.


Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopes.

Blish CA, Sather DN, Sellhorn G, Stamatatos L, Sun Y, Srivastava I, Barnett SW, Cleveland B, Overbaugh J, Hu SL.

J Virol. 2010 Mar;84(5):2573-84. doi: 10.1128/JVI.01687-09. Epub 2009 Dec 16.


Development of a gene silencing DNA vector derived from a broad host range geminivirus.

Golenberg EM, Sather DN, Hancock LC, Buckley KJ, Villafranco NM, Bisaro DM.

Plant Methods. 2009 Jul 2;5:9. doi: 10.1186/1746-4811-5-9.


Duplication of AP1 within the Spinacia oleracea L. AP1/FUL clade is followed by rapid amino acid and regulatory evolution.

Sather DN, Golenberg EM.

Planta. 2009 Feb;229(3):507-21. doi: 10.1007/s00425-008-0851-9. Epub 2008 Nov 13.


Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection.

Sather DN, Armann J, Ching LK, Mavrantoni A, Sellhorn G, Caldwell Z, Yu X, Wood B, Self S, Kalams S, Stamatatos L.

J Virol. 2009 Jan;83(2):757-69. doi: 10.1128/JVI.02036-08. Epub 2008 Nov 5. Erratum in: J Virol. 2009 May;83(9):4713-5.


Sequence evolution and sex-specific expression patterns of the C class floral identity gene, SpAGAMOUS, in dioecious Spinacia oleracea L.

Sather DN, York A, Pobursky KJ, Golenberg EM.

Planta. 2005 Oct;222(2):284-92. Epub 2005 Jun 7.


Characterization of SpAPETALA3 and SpPISTILLATA, B class floral identity genes in Spinacia oleracea, and their relationship to sexual dimorphism.

Pfent C, Pobursky KJ, Sather DN, Golenberg EM.

Dev Genes Evol. 2005 Mar;215(3):132-42. Epub 2005 Jan 20.


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