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The Escherichia coli transcriptome mostly consists of independently regulated modules.

Sastry AV, Gao Y, Szubin R, Hefner Y, Xu S, Kim D, Choudhary KS, Yang L, King ZA, Palsson BO.

Nat Commun. 2019 Dec 4;10(1):5536. doi: 10.1038/s41467-019-13483-w.


Adaptive evolution reveals a tradeoff between growth rate and oxidative stress during naphthoquinone-based aerobic respiration.

Anand A, Chen K, Yang L, Sastry AV, Olson CA, Poudel S, Seif Y, Hefner Y, Phaneuf PV, Xu S, Szubin R, Feist AM, Palsson BO.

Proc Natl Acad Sci U S A. 2019 Nov 25. pii: 201909987. doi: 10.1073/pnas.1909987116. [Epub ahead of print]


OxyR is a convergent target for mutations acquired during adaptation to oxidative stress-prone metabolic states.

Anand A, Chen K, Catoiu E, Sastry AV, Olson CA, Sandberg TE, Seif Y, Xu S, Szubin R, Yang L, Feist AM, Palsson BO.

Mol Biol Evol. 2019 Oct 25. pii: msz251. doi: 10.1093/molbev/msz251. [Epub ahead of print]


Adaptive laboratory evolution of Escherichia coli under acid stress.

Du B, Olson CA, Sastry AV, Fang X, Phaneuf PV, Chen K, Wu M, Szubin R, Xu S, Gao Y, Hefner Y, Feist AM, Palsson BO.

Microbiology. 2019 Oct 18. doi: 10.1099/mic.0.000867. [Epub ahead of print]


Cellular responses to reactive oxygen species are predicted from molecular mechanisms.

Yang L, Mih N, Anand A, Park JH, Tan J, Yurkovich JT, Monk JM, Lloyd CJ, Sandberg TE, Seo SW, Kim D, Sastry AV, Phaneuf P, Gao Y, Broddrick JT, Chen K, Heckmann D, Szubin R, Hefner Y, Feist AM, Palsson BO.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14368-14373. doi: 10.1073/pnas.1905039116. Epub 2019 Jul 3.


Efficacy of a Laparoscopic Saline-Coupled Bipolar Sealer in Minimally Invasive Hepatobiliary Surgery.

Sastry A, Sulzer JK, Passeri M, Baker EH, Vrochides D, McKillop IH, Iannitti DA, Martinie JB.

Surg Innov. 2019 Dec;26(6):668-674. doi: 10.1177/1553350619855282. Epub 2019 Jun 19.


The trends in robotic-assisted knee arthroplasty: A statewide database study.

Naziri Q, Burekhovich SA, Mixa PJ, Pivec R, Newman JM, Shah NV, Patel PD, Sastry A.

J Orthop. 2019 May 3;16(3):298-301. doi: 10.1016/j.jor.2019.04.020. eCollection 2019 May-Jun.


Evaluation of performance of direct disk diffusion test from positively flagged blood culture broth: A large scale study from South India.

Rajshekar D, Chaudhari KV, Bhat P, Prakash SS, Raghvan R, Vasanth S, Jayakar S, Sugumaran R, Kannambath R, Chowdury S, Sneha R, Nair A, Greeshma V, Rajavelu D, Sastry AS.

J Lab Physicians. 2019 Apr-Jun;11(2):154-160. doi: 10.4103/JLP.JLP_137_18.


How I Do It: Robotic Pancreaticoduodenectomy.

Nagarkatti SS, Sastry AV, Vrochides D, Martinie JB.

J Gastrointest Surg. 2019 Aug;23(8):1672-1681. doi: 10.1007/s11605-019-04222-z. Epub 2019 May 31. No abstract available.


Making the transition from traditional to robotic-arm assisted TKA: What to expect? A single-surgeon comparative-analysis of the first-40 consecutive cases.

Naziri Q, Cusson BC, Chaudhri M, Shah NV, Sastry A.

J Orthop. 2019 Mar 22;16(4):364-368. doi: 10.1016/j.jor.2019.03.010. eCollection 2019 Jul-Aug.


BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data.

Lachance JC, Lloyd CJ, Monk JM, Yang L, Sastry AV, Seif Y, Palsson BO, Rodrigue S, Feist AM, King ZA, Jacques PÉ.

PLoS Comput Biol. 2019 Apr 22;15(4):e1006971. doi: 10.1371/journal.pcbi.1006971. eCollection 2019 Apr.


Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor.

Dorich V, Brugger C, Tripathi A, Hoskins JR, Tong S, Suhanovsky MM, Sastry A, Wickner S, Gottesman S, Deaconescu AM.

Genes Dev. 2019 Jun 1;33(11-12):718-732. doi: 10.1101/gad.320168.118. Epub 2019 Apr 11.


The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function.

Ghatak S, King ZA, Sastry A, Palsson BO.

Nucleic Acids Res. 2019 Mar 18;47(5):2446-2454. doi: 10.1093/nar/gkz030.


Pseudogene repair driven by selection pressure applied in experimental evolution.

Anand A, Olson CA, Yang L, Sastry AV, Catoiu E, Choudhary KS, Phaneuf PV, Sandberg TE, Xu S, Hefner Y, Szubin R, Feist AM, Palsson BO.

Nat Microbiol. 2019 Mar;4(3):386-389. doi: 10.1038/s41564-018-0340-2. Epub 2019 Jan 28.


Imminent Rupture of a Hepatoma.

Pickens RC, Sastry AV, Vrochides D, Iannitti DA.

Curr Probl Cancer. 2019 Dec;43(6):100451. doi: 10.1016/j.currproblcancer.2018.11.004. Epub 2018 Dec 3. No abstract available.


Robotic-assisted versus laparoscopic left pancreatectomy at a high-volume, minimally invasive center.

Lyman WB, Passeri M, Sastry A, Cochran A, Iannitti DA, Vrochides D, Baker EH, Martinie JB.

Surg Endosc. 2019 Sep;33(9):2991-3000. doi: 10.1007/s00464-018-6565-6. Epub 2018 Nov 12.


The impact of intraoperative goal-directed fluid therapy on complications after pancreaticoduodenectomy.

Sulzer JK, Sastry AV, Meyer LM, Cochran A, Buhrman WC, Baker EH, Martinie JB, Iannitti DA, Vrochides D.

Ann Med Surg (Lond). 2018 Oct 16;36:23-28. doi: 10.1016/j.amsu.2018.10.018. eCollection 2018 Dec.


Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655.

Gao Y, Yurkovich JT, Seo SW, Kabimoldayev I, Dräger A, Chen K, Sastry AV, Fang X, Mih N, Yang L, Eichner J, Cho BK, Kim D, Palsson BO.

Nucleic Acids Res. 2018 Nov 16;46(20):10682-10696. doi: 10.1093/nar/gky752.


Escherichia coli B2 strains prevalent in inflammatory bowel disease patients have distinct metabolic capabilities that enable colonization of intestinal mucosa.

Fang X, Monk JM, Mih N, Du B, Sastry AV, Kavvas E, Seif Y, Smarr L, Palsson BO.

BMC Syst Biol. 2018 Jun 11;12(1):66. doi: 10.1186/s12918-018-0587-5.


A multimodal intervention to improve hand hygiene compliance in a tertiary care center.

Laskar AM, R D, Bhat P, Pottakkat B, Narayan S, Sastry AS, Sneha R.

Am J Infect Control. 2018 Jul;46(7):775-780. doi: 10.1016/j.ajic.2017.12.017. Epub 2018 May 9.


A Complete Pathological Response to Pembrolizumab following ex vivo Liver Resection in a Patient with Colorectal Liver Metastases.

Baimas-George M, Baker E, Kamionek M, Salmon JS, Sastry A, Levi D, Vrochides D.

Chemotherapy. 2018 Apr 5;63(2):90-94. doi: 10.1159/000487814. [Epub ahead of print]


Robotic-Assisted and Computer-Navigated Unicompartmental Knee Arthroplasties: A Systematic Review.

Naziri Q, Mixa PJ, Murray DP, Abraham R, Zikria BA, Sastry A, Patel PD.

Surg Technol Int. 2018 Jun 1;32:271-278. Review.


Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Distal Common Bile Duct Arising from a Choledochal Cyst.

Siddiqui I, Kirks RC, Sastry AV, Baker EH, Vrochides D, Iannitti DA, Kamionek M, Martinie JB.

Am Surg. 2018 Feb 1;84(2):319-321. No abstract available.


Fellows' perspective of HPB training programs in North America: results of a survey.

Siddiqui IA, Sastry AV, Martinie JB, Vrochides D, Baker EH, Iannitti DA.

HPB (Oxford). 2018 Aug;20(8):695-701. doi: 10.1016/j.hpb.2018.01.012. Epub 2018 Mar 8.


Recon3D enables a three-dimensional view of gene variation in human metabolism.

Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlić A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO.

Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19.


ssbio: a Python framework for structural systems biology.

Mih N, Brunk E, Chen K, Catoiu E, Sastry A, Kavvas E, Monk JM, Zhang Z, Palsson BO.

Bioinformatics. 2018 Jun 15;34(12):2155-2157. doi: 10.1093/bioinformatics/bty077.


Leaf thermotolerance in dry tropical forest tree species: relationships with leaf traits and effects of drought.

Sastry A, Guha A, Barua D.

AoB Plants. 2017 Dec 11;10(1):plx070. doi: 10.1093/aobpla/plx070. eCollection 2018 Feb.


Mechanical thrombectomy in acute ischaemic stroke: a review of the different techniques.

Leung V, Sastry A, Srivastava S, Wilcock D, Parrott A, Nayak S.

Clin Radiol. 2018 May;73(5):428-438. doi: 10.1016/j.crad.2017.10.022. Epub 2018 Jan 9. Review.


iML1515, a knowledgebase that computes Escherichia coli traits.

Monk JM, Lloyd CJ, Brunk E, Mih N, Sastry A, King Z, Takeuchi R, Nomura W, Zhang Z, Mori H, Feist AM, Palsson BO.

Nat Biotechnol. 2017 Oct 11;35(10):904-908. doi: 10.1038/nbt.3956. No abstract available.


Care bundle approach to reduce device-associated infections in a tertiary care teaching hospital, South India.

Prakash SS, Rajshekar D, Cherian A, Sastry AS.

J Lab Physicians. 2017 Oct-Dec;9(4):273-278. doi: 10.4103/JLP.JLP_162_16.


A novel 3-dimensional electromagnetic guidance system increases intraoperative microwave antenna placement accuracy.

Sastry AV, Swet JH, Murphy KJ, Baker EH, Vrochides D, Martinie JB, McKillop IH, Iannitti DA.

HPB (Oxford). 2017 Dec;19(12):1066-1073. doi: 10.1016/j.hpb.2017.08.001. Epub 2017 Sep 13.


Global transcriptional regulatory network for Escherichia coli robustly connects gene expression to transcription factor activities.

Fang X, Sastry A, Mih N, Kim D, Tan J, Yurkovich JT, Lloyd CJ, Gao Y, Yang L, Palsson BO.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10286-10291. doi: 10.1073/pnas.1702581114. Epub 2017 Sep 5.


Machine learning in computational biology to accelerate high-throughput protein expression.

Sastry A, Monk J, Tegel H, Uhlen M, Palsson BO, Rockberg J, Brunk E.

Bioinformatics. 2017 Aug 15;33(16):2487-2495. doi: 10.1093/bioinformatics/btx207.


Antimicrobial Resistance Surveillance among Intensive Care Units of a Tertiary Care Hospital in Southern India.

Moolchandani K, Sastry AS, Deepashree R, Sistla S, Harish BN, Mandal J.

J Clin Diagn Res. 2017 Feb;11(2):DC01-DC07. doi: 10.7860/JCDR/2017/23717.9247. Epub 2017 Feb 1.


Impact of a hand hygiene audit on hand hygiene compliance in a tertiary care public sector teaching hospital in South India.

Sastry AS, R D, Bhat P.

Am J Infect Control. 2017 May 1;45(5):498-501. doi: 10.1016/j.ajic.2016.12.013. Epub 2017 Jan 25.


Multi-omic data integration enables discovery of hidden biological regularities.

Ebrahim A, Brunk E, Tan J, O'Brien EJ, Kim D, Szubin R, Lerman JA, Lechner A, Sastry A, Bordbar A, Feist AM, Palsson BO.

Nat Commun. 2016 Oct 26;7:13091. doi: 10.1038/ncomms13091.


The role of awake craniotomy in reducing intraoperative visual field deficits during tumor surgery.

Wolfson R, Soni N, Shah AH, Hosein K, Sastry A, Bregy A, Komotar RJ.

Asian J Neurosurg. 2015 Jul-Sep;10(3):139-44. doi: 10.4103/1793-5482.161189.


Implementation of a split-bolus single-pass CT protocol at a UK major trauma centre to reduce excess radiation dose in trauma pan-CT.

Leung V, Sastry A, Woo TD, Jones HR.

Clin Radiol. 2015 Oct;70(10):1110-5. doi: 10.1016/j.crad.2015.05.014. Epub 2015 Jul 4.


Dry eye specific quality of life in veterans using glaucoma drops.

Camp A, Wellik SR, Tzu JH, Feuer W, Arheart KL, Sastry A, Galor A.

Cont Lens Anterior Eye. 2015 Jun;38(3):220-5. doi: 10.1016/j.clae.2015.02.001. Epub 2015 Feb 24.


Three synchronous, sporadic and separate periampullary and pancreatic tumors: more than a coincidence?

Sastry A, Wayne M, Steele J, Iskandar M, Yuan S, Cooperman AM.

World J Surg Oncol. 2014 Dec 13;12:382. doi: 10.1186/1477-7819-12-382.


What is the incidence of biliary carcinoma in choledochal cysts, when do they develop, and how should it affect management?

Sastry AV, Abbadessa B, Wayne MG, Steele JG, Cooperman AM.

World J Surg. 2015 Feb;39(2):487-92. doi: 10.1007/s00268-014-2831-5. Review.


Effects of local pH on the formation and regulation of cristae morphologies.

Song DH, Park J, Philbert MA, Sastry AM, Lu W.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):022702. Epub 2014 Aug 5.


Overview of the US FDA medical device approval process.

Sastry A.

Curr Cardiol Rep. 2014;16(6):494. doi: 10.1007/s11886-014-0494-3. Review.


The perils of Passover: small bowel obstruction from a matzah bezoar.

Sastry A, Steele J, Cooperman A.

Isr Med Assoc J. 2014 Apr;16(4):255-6. No abstract available.


Prevalence of Invasive Aspergillosis Among (PTB) Patients in Kanchipuram, India.

S S, S S, C A, Sastry AS, Bhatt S, M S K, S K A.

J Clin Diagn Res. 2014 Mar;8(3):22-3. doi: 10.7860/JCDR/2014/7957.4094. Epub 2014 Mar 15.


Biophysical significance of the inner mitochondrial membrane structure on the electrochemical potential of mitochondria.

Song DH, Park J, Maurer LL, Lu W, Philbert MA, Sastry AM.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Dec;88(6):062723. Epub 2013 Dec 27.


Refractive outcomes of combined cataract and glaucoma surgery.

Tzu JH, Shah CT, Galor A, Junk AK, Sastry A, Wellik SR.

J Glaucoma. 2015 Feb;24(2):161-4. doi: 10.1097/01.ijg.0000435773.20279.56.


Recovery of atrioventricular conduction after pacemaker placement following cardiac valvular surgery.

Rene AG, Sastry A, Horowitz JM, Cheung J, Liu CF, Thomas G, Ip JE, Lerman BB, Markowitz SM.

J Cardiovasc Electrophysiol. 2013 Dec;24(12):1383-7. doi: 10.1111/jce.12260. Epub 2013 Sep 12.


Relationship of body fat and its distribution with bone mineral density in Indian population.

Marwaha RK, Garg MK, Tandon N, Mehan N, Sastry A, Bhadra K.

J Clin Densitom. 2013 Jul-Sep;16(3):353-359. doi: 10.1016/j.jocd.2012.08.074.


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