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Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?

Sasse P, Funken M, Beiert T, Bruegmann T.

Front Physiol. 2019 Jun 6;10:675. doi: 10.3389/fphys.2019.00675. eCollection 2019. Review.


Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia.

Funken M, Malan D, Sasse P, Bruegmann T.

Front Physiol. 2019 Apr 24;10:498. doi: 10.3389/fphys.2019.00498. eCollection 2019.


Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision.

Makowka P, Bruegmann T, Dusend V, Malan D, Beiert T, Hesse M, Fleischmann BK, Sasse P.

Nat Commun. 2019 Mar 20;10(1):1281. doi: 10.1038/s41467-019-09322-7.


Optical control of L-type Ca2+ channels using a diltiazem photoswitch.

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D.

Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16.


Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.

Roell W, Klein AM, Breitbach M, Becker TS, Parikh A, Lee J, Zimmermann K, Reining S, Gabris B, Ottersbach A, Doran R, Engelbrecht B, Schiffer M, Kimura K, Freitag P, Carls E, Geisen C, Duerr GD, Sasse P, Welz A, Pfeifer A, Salama G, Kotlikoff M, Fleischmann BK.

Sci Rep. 2018 May 8;8(1):7145. doi: 10.1038/s41598-018-25147-8.


Sympathetic control of cardiac output by noradrenaline: quasi-synaptic quantal release or interstitial diffusion and spillover?

Sasse P.

J Physiol. 2018 Jun;596(11):2031-2032. doi: 10.1113/JP276109. Epub 2018 May 10. No abstract available.


Optogenetic termination of atrial fibrillation in mice.

Bruegmann T, Beiert T, Vogt CC, Schrickel JW, Sasse P.

Cardiovasc Res. 2018 Apr 1;114(5):713-723. doi: 10.1093/cvr/cvx250.


Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation.

Rehnelt S, Malan D, Juhasz K, Wolters B, Doerr L, Beckler M, Kettenhofen R, Bohlen H, Bruegmann T, Sasse P.

Int J Mol Sci. 2017 Dec 6;18(12). pii: E2634. doi: 10.3390/ijms18122634.


Improved heart repair upon myocardial infarction: Combination of magnetic nanoparticles and tailored magnets strongly increases engraftment of myocytes.

Ottersbach A, Mykhaylyk O, Heidsieck A, Eberbeck D, Rieck S, Zimmermann K, Breitbach M, Engelbrecht B, Brügmann T, Hesse M, Welz A, Sasse P, Wenzel D, Plank C, Gleich B, Hölzel M, Bloch W, Pfeifer A, Fleischmann BK, Roell W.

Biomaterials. 2018 Feb;155:176-190. doi: 10.1016/j.biomaterials.2017.11.012. Epub 2017 Nov 15.


Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function.

van Bremen T, Send T, Sasse P, Bruegmann T.

J Muscle Res Cell Motil. 2017 Aug;38(3-4):331-337. doi: 10.1007/s10974-017-9481-9. Epub 2017 Sep 16.


Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.

Lapp H, Bruegmann T, Malan D, Friedrichs S, Kilgus C, Heidsieck A, Sasse P.

Sci Rep. 2017 Aug 29;7(1):9629. doi: 10.1038/s41598-017-09760-7.


Synchronization of excitable cardiac cultures of different origin.

Agladze NN, Halaidych OV, Tsvelaya VA, Bruegmann T, Kilgus C, Sasse P, Agladze KI.

Biomater Sci. 2017 Aug 22;5(9):1777-1785. doi: 10.1039/c7bm00171a.


EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival.

Jara-Avaca M, Kempf H, Rückert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Dräger G, Kirschning A, Martin U, Zweigerdt R.

Stem Cell Reports. 2017 Feb 14;8(2):305-317. doi: 10.1016/j.stemcr.2016.12.012. Epub 2017 Jan 12.


Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

Seemann WK, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, Warnken M, Sasse P, Klöckner J, Holzgrabe U, DeAmici M, Schlicker E, Racké K, Kostenis E, Meyer R, Fleischmann BK, Mohr K.

J Pharmacol Exp Ther. 2017 Feb;360(2):289-299. doi: 10.1124/jpet.116.237149. Epub 2016 Nov 15.


Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.

J Clin Invest. 2016 Oct 3;126(10):3894-3904. doi: 10.1172/JCI88950. Epub 2016 Sep 12.


Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Malan D, Zhang M, Stallmeyer B, Müller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B.

Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23.


Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.

Friedrichs S, Malan D, Voss Y, Sasse P.

J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102.


Optogenetic control of contractile function in skeletal muscle.

Bruegmann T, van Bremen T, Vogt CC, Send T, Fleischmann BK, Sasse P.

Nat Commun. 2015 Jun 2;6:7153. doi: 10.1038/ncomms8153.


Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B.

Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964.


Systemic gene transfer enables optogenetic pacing of mouse hearts.

Vogt CC, Bruegmann T, Malan D, Ottersbach A, Roell W, Fleischmann BK, Sasse P.

Cardiovasc Res. 2015 May 1;106(2):338-43. doi: 10.1093/cvr/cvv004. Epub 2015 Jan 12.


Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice.

Lübkemeier I, Bosen F, Kim JS, Sasse P, Malan D, Fleischmann BK, Willecke K.

Circ Cardiovasc Genet. 2015 Feb;8(1):21-9. doi: 10.1161/CIRCGENETICS.114.000793. Epub 2014 Dec 10.


Optogenetic cardiac pacemakers: science or fiction?

Bruegmann T, Sasse P.

Trends Cardiovasc Med. 2015 Feb;25(2):82-3. doi: 10.1016/j.tcm.2014.10.016. Epub 2014 Oct 30. No abstract available.


MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization.

Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T, Boettger T.

PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449. eCollection 2014.


Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling.

Kadari A, Mekala S, Wagner N, Malan D, Köth J, Doll K, Stappert L, Eckert D, Peitz M, Matthes J, Sasse P, Herzig S, Brüstle O, Ergün S, Edenhofer F.

Stem Cell Rev Rep. 2015 Aug;11(4):560-9. doi: 10.1007/s12015-014-9564-6.


Optogenetic activation of Gq signalling modulates pacemaker activity of cardiomyocytes.

Beiert T, Bruegmann T, Sasse P.

Cardiovasc Res. 2014 Jun 1;102(3):507-16. doi: 10.1093/cvr/cvu046. Epub 2014 Feb 27.


Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.

Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K.

Basic Res Cardiol. 2013 May;108(3):348. doi: 10.1007/s00395-013-0348-y. Epub 2013 Apr 5.


Modeling long QT syndromes using induced pluripotent stem cells: current progress and future challenges.

Friedrichs S, Malan D, Sasse P.

Trends Cardiovasc Med. 2013 May;23(4):91-8. doi: 10.1016/j.tcm.2012.09.006. Epub 2012 Dec 21. Review.


Local gene targeting and cell positioning using magnetic nanoparticles and magnetic tips: comparison of mathematical simulations with experiments.

Kilgus C, Heidsieck A, Ottersbach A, Roell W, Trueck C, Fleischmann BK, Gleich B, Sasse P.

Pharm Res. 2012 May;29(5):1380-91. doi: 10.1007/s11095-011-0647-7. Epub 2011 Dec 30.


Optical pacing of the heart: the long way to enlightenment.

Sasse P.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):598-600. doi: 10.1161/CIRCEP.111.965400. No abstract available.


Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro.

Malan D, Friedrichs S, Fleischmann BK, Sasse P.

Circ Res. 2011 Sep 30;109(8):841-7. doi: 10.1161/CIRCRESAHA.111.243139. Epub 2011 Jul 28.


Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart.

Frank M, Eiberger B, Janssen-Bienhold U, de Sevilla Müller LP, Tjarks A, Kim JS, Maschke S, Dobrowolski R, Sasse P, Weiler R, Fleischmann BK, Willecke K.

J Cell Sci. 2010 Oct 15;123(Pt 20):3605-15. doi: 10.1242/jcs.068668.


Optogenetic control of heart muscle in vitro and in vivo.

Bruegmann T, Malan D, Hesse M, Beiert T, Fuegemann CJ, Fleischmann BK, Sasse P.

Nat Methods. 2010 Nov;7(11):897-900. doi: 10.1038/nmeth.1512. Epub 2010 Oct 3.


Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice.

Schrickel JW, Stöckigt F, Krzyzak W, Paulin D, Li Z, Lübkemeier I, Fleischmann B, Sasse P, Linhart M, Lewalter T, Nickenig G, Lickfett L, Schröder R, Clemen CS.

J Interv Card Electrophysiol. 2010 Aug;28(2):71-80. doi: 10.1007/s10840-010-9482-8.


Enrichment and terminal differentiation of striated muscle progenitors in vitro.

Becher UM, Breitbach M, Sasse P, Garbe S, van der Ven PF, Fürst DO, Fleischmann BK.

Exp Cell Res. 2009 Oct 1;315(16):2741-51. doi: 10.1016/j.yexcr.2009.07.005. Epub 2009 Jul 15.


Induction of pluripotency in adult unipotent germline stem cells.

Ko K, Tapia N, Wu G, Kim JB, Bravo MJ, Sasse P, Glaser T, Ruau D, Han DW, Greber B, Hausdörfer K, Sebastiano V, Stehling M, Fleischmann BK, Brüstle O, Zenke M, Schöler HR.

Cell Stem Cell. 2009 Jul 2;5(1):87-96. doi: 10.1016/j.stem.2009.05.025.


beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway.

Wenzel D, Knies R, Matthey M, Klein AM, Welschoff J, Stolle V, Sasse P, Röll W, Breuer J, Fleischmann BK.

Hypertension. 2009 Jul;54(1):157-63. doi: 10.1161/HYPERTENSIONAHA.109.130468. Epub 2009 May 26.


Oct4-induced pluripotency in adult neural stem cells.

Kim JB, Sebastiano V, Wu G, Araúzo-Bravo MJ, Sasse P, Gentile L, Ko K, Ruau D, Ehrich M, van den Boom D, Meyer J, Hübner K, Bernemann C, Ortmeier C, Zenke M, Fleischmann BK, Zaehres H, Schöler HR.

Cell. 2009 Feb 6;136(3):411-9. doi: 10.1016/j.cell.2009.01.023.


Modulation of L-type Ca(2+) channel current density and inactivation by beta-adrenergic stimulation during murine cardiac embryogenesis.

Nguemo F, Sasse P, Fleischmann BK, Kamanyi A, Schunkert H, Hescheler J, Reppel M.

Basic Res Cardiol. 2009 May;104(3):295-306. doi: 10.1007/s00395-008-0755-7. Epub 2008 Oct 24.


Perlecan is critical for heart stability.

Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK.

Cardiovasc Res. 2008 Dec 1;80(3):435-44. doi: 10.1093/cvr/cvn225. Epub 2008 Aug 10.


Adult germ line stem cells as a source of functional neurons and glia.

Glaser T, Opitz T, Kischlat T, Konang R, Sasse P, Fleischmann BK, Engel W, Nayernia K, Brüstle O.

Stem Cells. 2008 Sep;26(9):2434-43. doi: 10.1634/stemcells.2008-0163. Epub 2008 Jul 17.


Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Nygren JM, Liuba K, Breitbach M, Stott S, Thorén L, Roell W, Geisen C, Sasse P, Kirik D, Björklund A, Nerlov C, Fleischmann BK, Jovinge S, Jacobsen SE.

Nat Cell Biol. 2008 May;10(5):584-92. doi: 10.1038/ncb1721. Epub 2008 Apr 20.


Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.

Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher UM, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Eiberger B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI, Fleischmann BK.

Nature. 2007 Dec 6;450(7171):819-24.


The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.

Dobrowolski R, Sasse P, Schrickel JW, Watkins M, Kim JS, Rackauskas M, Troatz C, Ghanem A, Tiemann K, Degen J, Bukauskas FF, Civitelli R, Lewalter T, Fleischmann BK, Willecke K.

Hum Mol Genet. 2008 Feb 15;17(4):539-54. Epub 2007 Nov 13.


Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.

Sasse P, Zhang J, Cleemann L, Morad M, Hescheler J, Fleischmann BK.

J Gen Physiol. 2007 Aug;130(2):133-44.


Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.

Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, Reetz K, Grohé C, Meyer R, Tiemann K, Schröder R, Bloch W, Nickenig G, Fleischmann BK, Noegel AA, Schwinger RH, Lewalter T.

Cardiovasc Res. 2007 Nov 1;76(2):257-68. Epub 2007 Jul 6.


Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.

Reppel M, Fleischmann BK, Reuter H, Sasse P, Schunkert H, Hescheler J.

Cardiovasc Res. 2007 Jul 1;75(1):99-108. Epub 2007 Mar 28.


NCX current in the murine embryonic heart: development-dependent regulation by Na+.

Reppel M, Reuter H, Sasse P, Hescheler J, Fleischmann BK.

Ann N Y Acad Sci. 2007 Mar;1099:175-82.


Functional expression of the Na+/Ca2+ exchanger in the embryonic mouse heart.

Reppel M, Sasse P, Malan D, Nguemo F, Reuter H, Bloch W, Hescheler J, Fleischmann BK.

J Mol Cell Cardiol. 2007 Jan;42(1):121-32. Epub 2006 Dec 8.


Diversity of Ca2+ signaling in developing cardiac cells.

Janowski E, Cleemann L, Sasse P, Morad M.

Ann N Y Acad Sci. 2006 Oct;1080:154-64. Review.


Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Kolossov E, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren JM, Sasse P, Rubenchik O, Fries JW, Wenzel D, Geisen C, Xia Y, Lu Z, Duan Y, Kettenhofen R, Jovinge S, Bloch W, Bohlen H, Welz A, Hescheler J, Jacobsen SE, Fleischmann BK.

J Exp Med. 2006 Oct 2;203(10):2315-27. Epub 2006 Sep 5.

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