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Items: 1 to 50 of 135

1.

New geldanamycin derivatives with anti Hsp properties by mutasynthesis.

Hermane J, Eichner S, Mancuso L, Schröder B, Sasse F, Zeilinger C, Kirschning A.

Org Biomol Chem. 2019 May 29;17(21):5269-5278. doi: 10.1039/c9ob00892f.

PMID:
31089638
2.

The intriguing chemistry and biology of soraphens.

Naini A, Sasse F, Brönstrup M.

Nat Prod Rep. 2019 Oct 1;36(10):1394-1411. doi: 10.1039/c9np00008a. Epub 2019 Apr 5.

PMID:
30950477
3.

xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery.

Franke R, Hinkelmann B, Fetz V, Stradal T, Sasse F, Klawonn F, Brönstrup M.

SLAS Discov. 2019 Mar;24(3):213-223. doi: 10.1177/2472555218819459. Epub 2019 Jan 25.

PMID:
30681906
4.

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria.

Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R, Büssow K, van den Heuvel J, Brönstrup M, Taylor RE, Laschat S, Sasse F.

PLoS One. 2018 Jul 31;13(7):e0201605. doi: 10.1371/journal.pone.0201605. eCollection 2018.

5.

Spectral and spatial information from a novel dual-wavelength full-waveform terrestrial laser scanner for forest ecology.

Mark Danson F, Sasse F, Schofield LA.

Interface Focus. 2018 Apr 6;8(2):20170049. doi: 10.1098/rsfs.2017.0049. Epub 2018 Feb 16.

6.

Heat Shock Proteins Revisited: Using a Mutasynthetically Generated Reblastatin Library to Compare the Inhibition of Human and Leishmania Hsp90s.

Mohammadi-Ostad-Kalayeh S, Stahl F, Scheper T, Kock K, Herrmann C, Heleno Batista FA, Borges JC, Sasse F, Eichner S, Ongouta J, Zeilinger C, Kirschning A.

Chembiochem. 2018 Mar 16;19(6):562-574. doi: 10.1002/cbic.201700616. Epub 2018 Feb 19.

PMID:
29265716
7.

Coprinuslactone protects the edible mushroom Coprinus comatus against biofilm infections by blocking both quorum-sensing and MurA.

de Carvalho MP, Gulotta G, do Amaral MW, Lünsdorf H, Sasse F, Abraham WR.

Environ Microbiol. 2016 Nov;18(11):4254-4264. doi: 10.1111/1462-2920.13560. Epub 2016 Oct 24.

PMID:
27696655
8.

Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives.

Busch T, Dräger G, Kunst E, Benson H, Sasse F, Siems K, Kirschning A.

Org Biomol Chem. 2016 Oct 14;14(38):9040-5. doi: 10.1039/c6ob01697a. Epub 2016 Sep 7.

PMID:
27604289
9.

Screening and characterization of molecules that modulate the biological activity of IFNs-I.

Bürgi M, Zapol'skii VA, Hinkelmann B, Köster M, Kaufmann DE, Sasse F, Hauser H, Etcheverrigaray M, Kratje R, Bollati-Fogolín M, Oggero M.

J Biotechnol. 2016 Sep 10;233:6-16. doi: 10.1016/j.jbiotec.2016.06.021. Epub 2016 Jun 23.

PMID:
27346232
10.

The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function.

Pfeffer TJ, Sasse F, Schmidt CF, Lakämper S, Kirschning A, Scholz T.

Eur J Med Chem. 2016 Apr 13;112:164-170. doi: 10.1016/j.ejmech.2016.02.022. Epub 2016 Feb 8.

PMID:
26896705
11.

Target identification by image analysis.

Fetz V, Prochnow H, Brönstrup M, Sasse F.

Nat Prod Rep. 2016 May 4;33(5):655-67. doi: 10.1039/c5np00113g. Review.

PMID:
26777141
12.

Synthesis of the AB ring system of clifednamide utilizing Claisen rearrangement and Diels-Alder reaction as key steps.

Loke I, Bentzinger G, Holz J, Raja A, Bhasin A, Sasse F, Köhn A, Schobert R, Laschat S.

Org Biomol Chem. 2016 Jan 21;14(3):884-94. doi: 10.1039/c5ob01491c. Epub 2015 Nov 24.

PMID:
26599642
13.

Paleo-soraphens: chemical total syntheses and biological studies.

Lu HH, Hinkelmann B, Tautz T, Li J, Sasse F, Franke R, Kalesse M.

Org Biomol Chem. 2015 Aug 7;13(29):8029-36. doi: 10.1039/c5ob01249j. Epub 2015 Jun 29.

PMID:
26119264
14.

The synthesis and biological evaluation of desepoxyisotedanolide and a comparison with desepoxytedanolide.

Naini A, Muthukumar Y, Raja A, Franke R, Harrier I, Smith AB 3rd, Lee D, Taylor RE, Sasse F, Kalesse M.

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6935-9. doi: 10.1002/anie.201501526. Epub 2015 Apr 27.

PMID:
25914374
15.

Design, synthesis, and biological evaluation of simplified side chain hybrids of the potent actin binding polyketides rhizopodin and bistramide.

Herkommer D, Dreisigacker S, Sergeev G, Sasse F, Gohlke H, Menche D.

ChemMedChem. 2015 Mar;10(3):470-89. doi: 10.1002/cmdc.201402508. Epub 2015 Jan 29.

PMID:
25641798
16.

New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.

Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A.

Chembiochem. 2015 Jan 19;16(2):302-11. doi: 10.1002/cbic.201402375. Epub 2015 Jan 8.

PMID:
25572106
17.

Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.

Mancuso L, Knobloch T, Buchholz J, Hartwig J, Möller L, Seidel K, Collisi W, Sasse F, Kirschning A.

Chemistry. 2014 Dec 22;20(52):17541-51. doi: 10.1002/chem.201404502. Epub 2014 Oct 24.

PMID:
25346489
18.

Antiviral drug discovery: broad-spectrum drugs from nature.

Martinez JP, Sasse F, Brönstrup M, Diez J, Meyerhans A.

Nat Prod Rep. 2015 Jan;32(1):29-48. doi: 10.1039/c4np00085d. Review.

PMID:
25315648
19.

Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.

Rahioui I, Eyraud V, Karaki L, Sasse F, Carre-Pierrat M, Qin A, Zheng MH, Toepfer S, Sivignon C, Royer C, Da Silva P, Gressent F.

Toxicon. 2014 Oct;89:67-76. doi: 10.1016/j.toxicon.2014.07.004. Epub 2014 Jul 23.

PMID:
25064271
20.

Sulfur, selenium and tellurium pseudopeptides: synthesis and biological evaluation.

Shaaban S, Sasse F, Burkholz T, Jacob C.

Bioorg Med Chem. 2014 Jul 15;22(14):3610-9. doi: 10.1016/j.bmc.2014.05.019. Epub 2014 May 21.

PMID:
24890655
21.

SAR studies on hydropentalene derivatives--Important core units of biologically active tetramic acid macrolactams and ptychanolides.

Lutz V, Mannchen F, Krebs M, Park N, Krüger C, Raja A, Sasse F, Baro A, Laschat S.

Bioorg Med Chem. 2014 Jul 1;22(13):3252-61. doi: 10.1016/j.bmc.2014.04.063. Epub 2014 May 9.

PMID:
24856181
22.

Preparative mass-spectrometry profiling of bioactive metabolites in Saudi-Arabian propolis fractionated by high-speed countercurrent chromatography and off-line atmospheric pressure chemical ionization mass-spectrometry injection.

Jerz G, Elnakady YA, Braun A, Jäckel K, Sasse F, Al Ghamdi AA, Omar MO, Winterhalter P.

J Chromatogr A. 2014 Jun 20;1347:17-29. doi: 10.1016/j.chroma.2014.04.068. Epub 2014 Apr 28.

PMID:
24831423
23.

Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential.

Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R.

ChemMedChem. 2014 Jun;9(6):1195-204. doi: 10.1002/cmdc.201400049. Epub 2014 Mar 19.

PMID:
24648184
24.

Preparation of new alkyne-modified ansamitocins by mutasynthesis.

Harmrolfs K, Mancuso L, Drung B, Sasse F, Kirschning A.

Beilstein J Org Chem. 2014 Mar 3;10:535-43. doi: 10.3762/bjoc.10.49. eCollection 2014.

25.

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.

Fleta-Soriano E, Martinez JP, Hinkelmann B, Gerth K, Washausen P, Diez J, Frank R, Sasse F, Meyerhans A.

Microb Cell Fact. 2014 Jan 29;13:17. doi: 10.1186/1475-2859-13-17.

26.

Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology.

Martínez JP, Pérez-Vilaró G, Muthukumar Y, Scheller N, Hirsch T, Diestel R, Steinmetz H, Jansen R, Frank R, Sasse F, Meyerhans A, Díez J.

RNA Biol. 2013 Nov;10(11):1661-9. doi: 10.4161/rna.26851.

27.

Synthesis and biological evaluation of paleo-soraphens.

Lu HH, Raja A, Franke R, Landsberg D, Sasse F, Kalesse M.

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13549-52. doi: 10.1002/anie.201305331. Epub 2013 Nov 7.

PMID:
24346938
28.

Total synthesis and biological evaluation of jerantinine E.

Frei R, Staedler D, Raja A, Franke R, Sasse F, Gerber-Lemaire S, Waser J.

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13373-6. doi: 10.1002/anie.201305533. Epub 2013 Oct 14. No abstract available.

PMID:
24127420
29.

Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay.

Martinez JP, Hinkelmann B, Fleta-Soriano E, Steinmetz H, Jansen R, Diez J, Frank R, Sasse F, Meyerhans A.

Microb Cell Fact. 2013 Sep 24;12:85. doi: 10.1186/1475-2859-12-85.

30.

Bioreduction of aryl azides during mutasynthesis of new ansamitocins.

Mancuso L, Jürjens G, Hermane J, Harmrolfs K, Eichner S, Fohrer J, Collisi W, Sasse F, Kirschning A.

Org Lett. 2013 Sep 6;15(17):4442-5. doi: 10.1021/ol401989e. Epub 2013 Aug 27.

PMID:
23981134
31.

Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A.

Adla SK, Sasse F, Kelter G, Fiebig HH, Lindel T.

Org Biomol Chem. 2013 Sep 28;11(36):6119-30. doi: 10.1039/c3ob40896e.

PMID:
23925418
32.

Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from Myxobacteria.

Irschik H, Washausen P, Sasse F, Fohrer J, Huch V, Müller R, Prusov EV.

Angew Chem Int Ed Engl. 2013 May 10;52(20):5402-5. doi: 10.1002/anie.201210113. Epub 2013 Apr 16. No abstract available.

PMID:
23592574
33.

Synthesis of penicillenol C1 and of a bis-azide analogue for photoaffinity labeling.

Kempf K, Raja A, Sasse F, Schobert R.

J Org Chem. 2013 Mar 15;78(6):2455-61. doi: 10.1021/jo3026737. Epub 2013 Mar 1.

PMID:
23438295
34.

The marine polyketide myriaporone 3/4 stalls translation by targeting the elongation phase.

Muthukumar Y, Roy M, Raja A, Taylor RE, Sasse F.

Chembiochem. 2013 Jan 21;14(2):260-4. doi: 10.1002/cbic.201200522. Epub 2013 Jan 9.

PMID:
23303710
35.

Synergistic "gold effects" of anti-vascular 4,5-diarylimidazol-2-ylidene gold(I) carbene complexes.

Münzner J, Biersack B, Kaps L, Mahal K, Schobert R, Sasse F.

Int J Clin Pharmacol Ther. 2013 Jan;51(1):44-6. No abstract available.

36.

Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.

Altendorfer M, Raja A, Sasse F, Irschik H, Menche D.

Org Biomol Chem. 2013 Apr 7;11(13):2116-39. doi: 10.1039/c2ob26906f.

PMID:
23196931
37.

Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents.

Shaaban S, Diestel R, Hinkelmann B, Muthukumar Y, Verma RP, Sasse F, Jacob C.

Eur J Med Chem. 2012 Dec;58:192-205. doi: 10.1016/j.ejmech.2012.09.033. Epub 2012 Oct 4.

PMID:
23124216
38.

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.

Knobloch T, Dräger G, Collisi W, Sasse F, Kirschning A.

Beilstein J Org Chem. 2012;8:861-9. Epub 2012 Jun 11.

39.

Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.

Höfle G, Gerth K, Reichenbach H, Kunze B, Sasse F, Forche E, Prusov EV.

Chemistry. 2012 Sep 3;18(36):11362-70. doi: 10.1002/chem.201201879. Epub 2012 Aug 13.

PMID:
22890974
40.

Fluorescent analogs of the marine natural product psammaplin A: synthesis and biological activity.

Hentschel F, Sasse F, Lindel T.

Org Biomol Chem. 2012 Sep 21;10(35):7120-33. doi: 10.1039/c2ob25909e. Epub 2012 Aug 7.

PMID:
22872318
41.

Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".

Plaza A, Garcia R, Bifulco G, Martinez JP, Hüttel S, Sasse F, Meyerhans A, Stadler M, Müller R.

Org Lett. 2012 Jun 1;14(11):2854-7. doi: 10.1021/ol3011002. Epub 2012 May 22.

PMID:
22616796
42.

Myxobacteria: natural pharmaceutical factories.

Diez J, Martinez JP, Mestres J, Sasse F, Frank R, Meyerhans A.

Microb Cell Fact. 2012 Apr 30;11:52. doi: 10.1186/1475-2859-11-52.

43.

An improved route to (+)-tedanolide and analysis of its subtle effects controlling conformation and biological behaviour.

Diaz N, Zhu M, Ehrlich G, Eggert U, Muthukumar Y, Sasse F, Kalesse M.

Chemistry. 2012 Apr 16;18(16):4946-52. doi: 10.1002/chem.201103038. Epub 2012 Mar 5.

PMID:
22392854
44.

Synthesis of simplified tedanolide analogues--connecting tedanolide to myriaporone and gephyronic acid.

Diaz N, Naini A, Muthukumar Y, Sasse F, Kalesse M.

ChemMedChem. 2012 May;7(5):771-5. doi: 10.1002/cmdc.201100576. Epub 2012 Mar 1.

PMID:
22383258
45.

The myxobacterial compounds spirangien a and spirangien M522 are potent inhibitors of IL-8 expression.

Reboll MR, Ritter B, Sasse F, Niggemann J, Frank R, Nourbakhsh M.

Chembiochem. 2012 Feb 13;13(3):409-15. doi: 10.1002/cbic.201100635. Epub 2012 Jan 23.

PMID:
22271561
46.

Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility.

Knobloch T, Harmrolfs K, Taft F, Thomaszewski B, Sasse F, Kirschning A.

Chembiochem. 2011 Mar 7;12(4):540-7. doi: 10.1002/cbic.201000608. Epub 2011 Jan 27.

PMID:
22238146
47.

Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.

Taft F, Harmrolfs K, Nickeleit I, Heutling A, Kiene M, Malek N, Sasse F, Kirschning A.

Chemistry. 2012 Jan 16;18(3):880-6. doi: 10.1002/chem.201101640. Epub 2011 Dec 14.

PMID:
22170289
48.

Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.

Eichner S, Eichner T, Floss HG, Fohrer J, Hofer E, Sasse F, Zeilinger C, Kirschning A.

J Am Chem Soc. 2012 Jan 25;134(3):1673-9. doi: 10.1021/ja2087147. Epub 2012 Jan 10.

49.

The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.

Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A.

Angew Chem Int Ed Engl. 2012 Jan 16;51(3):752-7. doi: 10.1002/anie.201106249. Epub 2011 Dec 1. No abstract available.

PMID:
22135226
50.

Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.

Garcia J, Barluenga S, Gorska K, Sasse F, Winssinger N.

Bioorg Med Chem. 2012 Jan 15;20(2):672-80. doi: 10.1016/j.bmc.2011.09.064. Epub 2011 Oct 8.

PMID:
22037048

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