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Items: 1 to 50 of 182

1.

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.

Wong YH, Kumar A, Liew CW, Tharakaraman K, Srinivasaraghavan K, Sasisekharan R, Verma C, Lescar J.

Sci Rep. 2018 May 31;8(1):8449. doi: 10.1038/s41598-018-26800-y.

2.

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.

Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R.

Cell Host Microbe. 2018 May 9;23(5):618-627.e6. doi: 10.1016/j.chom.2018.04.004.

3.

An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein.

Quinlan DS, Raman R, Tharakaraman K, Subramanian V, Del Hierro G, Sasisekharan R.

Sci Rep. 2017 Apr 11;7:45886. doi: 10.1038/srep45886.

4.

AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures.

Raguram A, Sasisekharan V, Sasisekharan R.

Trends Microbiol. 2017 Jun;25(6):438-446. doi: 10.1016/j.tim.2016.12.007. Epub 2017 Jan 13. Review.

5.

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors.

Macchi E, Rudd TR, Raman R, Sasisekharan R, Yates EA, Naggi A, Guerrini M, Elli S.

Biochemistry. 2016 Dec 6;55(48):6605-6616. Epub 2016 Nov 23.

6.

Glycan-protein interactions in viral pathogenesis.

Raman R, Tharakaraman K, Sasisekharan V, Sasisekharan R.

Curr Opin Struct Biol. 2016 Oct;40:153-162. doi: 10.1016/j.sbi.2016.10.003. Epub 2016 Oct 25. Review.

7.

A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.

Ramakrishnan B, Viswanathan K, Tharakaraman K, Dančík V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R.

Trends Microbiol. 2016 Dec;24(12):933-943. doi: 10.1016/j.tim.2016.09.003. Epub 2016 Oct 14. Review.

8.

New England harbor seal H3N8 influenza virus retains avian-like receptor specificity.

Hussein IT, Krammer F, Ma E, Estrin M, Viswanathan K, Stebbins NW, Quinlan DS, Sasisekharan R, Runstadler J.

Sci Rep. 2016 Feb 18;6:21428. doi: 10.1038/srep21428.

9.

Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.

Zhu X, Viswanathan K, Raman R, Yu W, Sasisekharan R, Wilson IA.

Cell Rep. 2015 Nov 24;13(8):1683-91. doi: 10.1016/j.celrep.2015.10.027. Epub 2015 Nov 12.

10.

The soft palate is an important site of adaptation for transmissible influenza viruses.

Lakdawala SS, Jayaraman A, Halpin RA, Lamirande EW, Shih AR, Stockwell TB, Lin X, Simenauer A, Hanson CT, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das SR, Wentworth DE, Sasisekharan R, Subbarao K.

Nature. 2015 Oct 1;526(7571):122-5. doi: 10.1038/nature15379. Epub 2015 Sep 23.

11.

A broadly neutralizing human monoclonal antibody is effective against H7N9.

Tharakaraman K, Subramanian V, Viswanathan K, Sloan S, Yen HL, Barnard DL, Leung YH, Szretter KJ, Koch TJ, Delaney JC, Babcock GJ, Wogan GN, Sasisekharan R, Shriver Z.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10890-5. doi: 10.1073/pnas.1502374112. Epub 2015 Aug 17.

12.

Antibody-Based Strategies to Prevent and Treat Influenza.

Shriver Z, Trevejo JM, Sasisekharan R.

Front Immunol. 2015 Jul 13;6:315. doi: 10.3389/fimmu.2015.00315. eCollection 2015. Review.

13.

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.

Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan B, Myette JR, Babcock GJ, Sasisekharan V, Alonso S, Chen J, Lescar J, Shriver Z, Ooi EE, Sasisekharan R.

Cell. 2015 Jul 30;162(3):493-504. doi: 10.1016/j.cell.2015.06.057. Epub 2015 Jul 16.

14.

Influenza surveillance: 2014-2015 H1N1 "swine"-derived influenza viruses from India.

Tharakaraman K, Sasisekharan R.

Cell Host Microbe. 2015 Mar 11;17(3):279-282. doi: 10.1016/j.chom.2015.02.019.

15.

Glycan array data management at Consortium for Functional Glycomics.

Venkataraman M, Sasisekharan R, Raman R.

Methods Mol Biol. 2015;1273:181-90. doi: 10.1007/978-1-4939-2343-4_13.

PMID:
25753711
16.

Capillary electrophoretic analysis of isolated sulfated polysaccharides to characterize pharmaceutical products.

Shriver Z, Sasisekharan R.

Methods Mol Biol. 2015;1229:161-71. doi: 10.1007/978-1-4939-1714-3_15.

17.

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.

Raman R, Tharakaraman K, Shriver Z, Jayaraman A, Sasisekharan V, Sasisekharan R.

Trends Microbiol. 2014 Nov;22(11):632-41. doi: 10.1016/j.tim.2014.07.002. Epub 2014 Aug 6. Review.

18.

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

Elli S, Macchi E, Rudd TR, Raman R, Sassaki G, Viswanathan K, Yates EA, Shriver Z, Naggi A, Torri G, Sasisekharan R, Guerrini M.

Biochemistry. 2014 Jul 1;53(25):4122-35. doi: 10.1021/bi500338r. Epub 2014 Jun 20.

19.

Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species.

Chandramohanadas R, Basappa, Russell B, Liew K, Yau YH, Chong A, Liu M, Gunalan K, Raman R, Renia L, Nosten F, Shochat SG, Dao M, Sasisekharan R, Suresh S, Preiser P.

J Infect Dis. 2014 Nov 15;210(10):1616-26. doi: 10.1093/infdis/jiu296. Epub 2014 May 26.

20.

Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure.

Tharakaraman K, Subramanian V, Cain D, Sasisekharan V, Sasisekharan R.

Cell Host Microbe. 2014 May 14;15(5):644-51. doi: 10.1016/j.chom.2014.04.009.

21.

Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets.

Lakdawala SS, Shih AR, Jayaraman A, Lamirande EW, Moore I, Paskel M, Kenney H, Sasisekharan R, Subbarao K.

Virology. 2013 Nov;446(1-2):349-56. doi: 10.1016/j.virol.2013.08.011. Epub 2013 Sep 10. Erratum in: Virology. 2015 Dec;486():321. Kenney, Heather [Added].

22.

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution.

Sassaki GL, Elli S, Rudd TR, Macchi E, Yates EA, Naggi A, Shriver Z, Raman R, Sasisekharan R, Torri G, Guerrini M.

Biochemistry. 2013 Oct 15;52(41):7217-7230. doi: 10.1021/bi400677n. Epub 2013 Sep 27.

23.

Heparin sensing: blue-chip binding.

Shriver Z, Sasisekharan R.

Nat Chem. 2013 Aug;5(8):644-6. doi: 10.1038/nchem.1701. Epub 2013 Jul 7. No abstract available.

24.

Glycan receptor binding of the influenza A virus H7N9 hemagglutinin.

Tharakaraman K, Jayaraman A, Raman R, Viswanathan K, Stebbins NW, Johnson D, Shriver Z, Sasisekharan V, Sasisekharan R.

Cell. 2013 Jun 20;153(7):1486-93. doi: 10.1016/j.cell.2013.05.034. Epub 2013 Jun 6.

25.

Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity.

Tharakaraman K, Raman R, Viswanathan K, Stebbins NW, Jayaraman A, Krishnan A, Sasisekharan V, Sasisekharan R.

Cell. 2013 Jun 20;153(7):1475-85. doi: 10.1016/j.cell.2013.05.035. Epub 2013 Jun 6.

26.

N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses.

Sun X, Jayaraman A, Maniprasad P, Raman R, Houser KV, Pappas C, Zeng H, Sasisekharan R, Katz JM, Tumpey TM.

J Virol. 2013 Aug;87(15):8756-66. doi: 10.1128/JVI.00593-13. Epub 2013 Jun 5.

27.

Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles.

Artpradit C, Robinson LN, Gavrilov BK, Rurak TT, Ruchirawat M, Sasisekharan R.

Virus Res. 2013 Sep;176(1-2):69-77. doi: 10.1016/j.virusres.2013.04.017. Epub 2013 May 22.

28.

Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic.

Tharakaraman K, Raman R, Stebbins NW, Viswanathan K, Sasisekharan V, Sasisekharan R.

Sci Rep. 2013;3:1822. doi: 10.1038/srep01822.

29.

Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin.

Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R.

PLoS One. 2013 Apr 23;8(4):e59550. doi: 10.1371/journal.pone.0059550. Print 2013.

30.

Modular glycosphere assays for high-throughput functional characterization of influenza viruses.

Hobbie SN, Viswanathan K, Bachelet I, Aich U, Shriver Z, Subramanian V, Raman R, Sasisekharan R.

BMC Biotechnol. 2013 Apr 15;13:34. doi: 10.1186/1472-6750-13-34.

31.

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency.

Tharakaraman K, Robinson LN, Hatas A, Chen YL, Siyue L, Raguram S, Sasisekharan V, Wogan GN, Sasisekharan R.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1555-64. doi: 10.1073/pnas.1303645110. Epub 2013 Apr 8.

32.

Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin.

Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R.

PLoS One. 2013;8(2):e49597. doi: 10.1371/journal.pone.0049597. Epub 2013 Feb 20. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/c3b40a6f-a4be-4117-8ce2-a1b9b873e87c.

33.

Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors.

Jayaraman A, Koh X, Li J, Raman R, Viswanathan K, Shriver Z, Sasisekharan R.

Biochem J. 2012 Jun 15;444(3):429-35. doi: 10.1042/BJ20112101.

34.

Heparin and heparan sulfate: analyzing structure and microheterogeneity.

Shriver Z, Capila I, Venkataraman G, Sasisekharan R.

Handb Exp Pharmacol. 2012;(207):159-76. doi: 10.1007/978-3-642-23056-1_8. Review.

35.

Harnessing glycomics technologies: integrating structure with function for glycan characterization.

Robinson LN, Artpradit C, Raman R, Shriver ZH, Ruchirawat M, Sasisekharan R.

Electrophoresis. 2012 Mar;33(5):797-814. doi: 10.1002/elps.201100231. Review.

36.

Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract.

Jayaraman A, Chandrasekaran A, Viswanathan K, Raman R, Fox JG, Sasisekharan R.

PLoS One. 2012;7(2):e27517. doi: 10.1371/journal.pone.0027517. Epub 2012 Feb 16.

37.

Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation.

Soundararajan V, Zheng S, Patel N, Warnock K, Raman R, Wilson IA, Raguram S, Sasisekharan V, Sasisekharan R.

Sci Rep. 2011;1:200. doi: 10.1038/srep00200. Epub 2011 Dec 19.

38.

Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets.

Pearce MB, Jayaraman A, Pappas C, Belser JA, Zeng H, Gustin KM, Maines TR, Sun X, Raman R, Cox NJ, Sasisekharan R, Katz JM, Tumpey TM.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3944-9. doi: 10.1073/pnas.1119945109. Epub 2012 Feb 21.

39.

Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions.

Morris MK, Shriver Z, Sasisekharan R, Lauffenburger DA.

Biotechnol J. 2012 Mar;7(3):374-86. doi: 10.1002/biot.201100222. Epub 2012 Jan 10.

40.

Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus.

Belser JA, Jayaraman A, Raman R, Pappas C, Zeng H, Cox NJ, Katz JM, Sasisekharan R, Tumpey TM.

PLoS One. 2011;6(9):e25091. doi: 10.1371/journal.pone.0025091. Epub 2011 Sep 22.

41.

Competitive inhibition of heparinase by persulfonated glycosaminoglycans: a tool to detect heparin contamination.

Aich U, Shriver Z, Tharakaraman K, Raman R, Sasisekharan R.

Anal Chem. 2011 Oct 15;83(20):7815-22. doi: 10.1021/ac201498a. Epub 2011 Sep 19.

42.

Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay.

Aich U, Beckley N, Shriver Z, Raman R, Viswanathan K, Hobbie S, Sasisekharan R.

FEBS J. 2011 May;278(10):1699-712. doi: 10.1111/j.1742-4658.2011.08096.x. Epub 2011 Apr 20.

43.

A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets.

Jayaraman A, Pappas C, Raman R, Belser JA, Viswanathan K, Shriver Z, Tumpey TM, Sasisekharan R.

PLoS One. 2011 Mar 2;6(3):e17616. doi: 10.1371/journal.pone.0017616.

44.

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses.

Maines TR, Chen LM, Van Hoeven N, Tumpey TM, Blixt O, Belser JA, Gustin KM, Pearce MB, Pappas C, Stevens J, Cox NJ, Paulson JC, Raman R, Sasisekharan R, Katz JM, Donis RO.

Virology. 2011 Apr 25;413(1):139-47. doi: 10.1016/j.virol.2011.02.015. Epub 2011 Mar 23.

45.

A voxel-based Monte Carlo model of drug release from bulk eroding nanoparticles.

Eavarone DA, Soundararajan V, Haller T, Sasisekharan R.

J Nanosci Nanotechnol. 2010 Sep;10(9):5903-7.

46.

Determinants of glycan receptor specificity of H2N2 influenza A virus hemagglutinin.

Viswanathan K, Koh X, Chandrasekaran A, Pappas C, Raman R, Srinivasan A, Shriver Z, Tumpey TM, Sasisekharan R.

PLoS One. 2010 Oct 29;5(10):e13768. doi: 10.1371/journal.pone.0013768.

47.

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins.

Bosques CJ, Collins BE, Meador JW 3rd, Sarvaiya H, Murphy JL, Dellorusso G, Bulik DA, Hsu IH, Washburn N, Sipsey SF, Myette JR, Raman R, Shriver Z, Sasisekharan R, Venkataraman G.

Nat Biotechnol. 2010 Nov;28(11):1153-6. doi: 10.1038/nbt1110-1153. No abstract available. Erratum in: Nat Biotechnol. 2011 May;29(5):459.

48.

Glycans as receptors for influenza pathogenesis.

Viswanathan K, Chandrasekaran A, Srinivasan A, Raman R, Sasisekharan V, Sasisekharan R.

Glycoconj J. 2010 Aug;27(6):561-70. doi: 10.1007/s10719-010-9303-4. Epub 2010 Aug 24. Review.

49.

Glycomics: technologies taming a frontier omics field.

Turnbull JE, Sasisekharan R.

OMICS. 2010 Aug;14(4):385-7. doi: 10.1089/omi.2010.0067. No abstract available.

PMID:
20726798
50.

The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation.

Soundararajan V, Patel N, Subramanian V, Sasisekharan V, Sasisekharan R.

Innate Immun. 2011 Dec;17(6):548-57. doi: 10.1177/1753425910377099. Epub 2010 Aug 10.

PMID:
20699282

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