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Items: 1 to 50 of 439

1.

Evolutionary basis of HLA-DPB1 alleles affects acute GVHD in unrelated donor stem cell transplantation.

Morishima S, Shiina T, Suzuki S, Ogawa S, Sato-Otsubo A, Kashiwase K, Azuma F, Yabe T, Satake M, Kato S, Kodera Y, Sasazuki T, Morishima Y; Japan Marrow Donor Program.

Blood. 2018 Feb 15;131(7):808-817. doi: 10.1182/blood-2017-08-801449. Epub 2017 Dec 15.

2.

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.

Yoo BH, Khan IA, Koomson A, Gowda P, Sasazuki T, Shirasawa S, Gujar S, Rosen KV.

Autophagy. 2018;14(1):134-151. doi: 10.1080/15548627.2017.1370171. Epub 2017 Dec 21.

3.

MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers.

Radhakrishnan H, Ilm K, Walther W, Shirasawa S, Sasazuki T, Daniel PT, Gillissen B, Stein U.

Cancer Lett. 2017 Sep 10;403:231-245. doi: 10.1016/j.canlet.2017.06.020. Epub 2017 Jun 23.

PMID:
28649004
4.

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.

Toda K, Kawada K, Iwamoto M, Inamoto S, Sasazuki T, Shirasawa S, Hasegawa S, Sakai Y.

Neoplasia. 2016 Nov;18(11):654-665. doi: 10.1016/j.neo.2016.09.004. Epub 2016 Oct 18.

5.

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis.

Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike K, Kurosaki M, Izumi N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto T, Tokunaga K, Mizokami M.

Sci Rep. 2016 Apr 19;6:24767. doi: 10.1038/srep24767.

6.

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.

Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, Zografos G, Oikonomou E, Pintzas A.

Oncotarget. 2016 Feb 23;7(8):9188-221. doi: 10.18632/oncotarget.6942.

7.

Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation.

Sasazuki T, Inoko H, Morishima S, Morishima Y.

Adv Immunol. 2016;129:175-249. doi: 10.1016/bs.ai.2015.08.003. Epub 2015 Dec 1. Review.

PMID:
26791860
8.

High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation.

Morishima S, Kashiwase K, Matsuo K, Azuma F, Yabe T, Sato-Otsubo A, Ogawa S, Shiina T, Satake M, Saji H, Kato S, Kodera Y, Sasazuki T, Morishima Y; Japan Marrow Donor Program.

Haematologica. 2016 Apr;101(4):491-8. doi: 10.3324/haematol.2015.136903. Epub 2016 Jan 14.

9.

Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.

Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami M.

Tissue Antigens. 2015 Dec;86(6):406-12. doi: 10.1111/tan.12684. Epub 2015 Oct 9.

PMID:
26449183
10.

Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation.

Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S; Japan Marrow Donor Program.

Blood. 2015 Dec 17;126(25):2752-63. doi: 10.1182/blood-2015-03-630707. Epub 2015 Oct 2.

11.

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.

Dunne PD, Dasgupta S, Blayney JK, McArt DG, Redmond KL, Weir JA, Bradley CA, Sasazuki T, Shirasawa S, Wang T, Srivastava S, Ong CW, Arthur K, Salto-Tellez M, Wilson RH, Johnston PG, Van Schaeybroeck S.

Clin Cancer Res. 2016 Jan 1;22(1):230-242. doi: 10.1158/1078-0432.CCR-15-0603. Epub 2015 Aug 17.

12.

Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells.

Yoo BH, Zagryazhskaya A, Li Y, Koomson A, Khan IA, Sasazuki T, Shirasawa S, Rosen KV.

Autophagy. 2015;11(8):1230-46. doi: 10.1080/15548627.2015.1056968.

13.

Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.

Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S.

J Struct Funct Genomics. 2015 Jun;16(2):55-65. doi: 10.1007/s10969-015-9196-3. Epub 2015 Mar 24.

14.

β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome.

Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.

Blood. 2015 Apr 30;125(18):2835-44. doi: 10.1182/blood-2014-08-593624. Epub 2015 Mar 2.

15.

Biological significance of HLA locus matching in unrelated donor bone marrow transplantation.

Morishima Y, Kashiwase K, Matsuo K, Azuma F, Morishima S, Onizuka M, Yabe T, Murata M, Doki N, Eto T, Mori T, Miyamura K, Sao H, Ichinohe T, Saji H, Kato S, Atsuta Y, Kawa K, Kodera Y, Sasazuki T; Japan Marrow Donor Program.

Blood. 2015 Feb 12;125(7):1189-97. doi: 10.1182/blood-2014-10-604785. Epub 2014 Dec 17.

16.

Regulation of 18F-FDG accumulation in colorectal cancer cells with mutated KRAS.

Iwamoto M, Kawada K, Nakamoto Y, Itatani Y, Inamoto S, Toda K, Kimura H, Sasazuki T, Shirasawa S, Okuyama H, Inoue M, Hasegawa S, Togashi K, Sakai Y.

J Nucl Med. 2014 Dec;55(12):2038-44. doi: 10.2967/jnumed.114.142927. Epub 2014 Nov 5.

17.

Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.

Oryoji D, Ueda S, Yamamoto K, Yoshimura Noh J, Okamura K, Noda M, Watanabe N, Yoshihara A, Ito K, Sasazuki T.

J Clin Endocrinol Metab. 2015 Feb;100(2):E319-24. doi: 10.1210/jc.2014-3431. Epub 2014 Nov 27.

PMID:
25429627
18.

Associations of HLA class I alleles in Japanese patients with Crohn's disease.

Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S, Yamamoto K, Matsumoto T, Watanabe M, Hibi T, Sasazuki T.

Genes Immun. 2015 Jan-Feb;16(1):54-6. doi: 10.1038/gene.2014.61. Epub 2014 Nov 6.

PMID:
25373727
19.

Competition between human cells by entosis.

Sun Q, Luo T, Ren Y, Florey O, Shirasawa S, Sasazuki T, Robinson DN, Overholtzer M.

Cell Res. 2014 Nov;24(11):1299-310. doi: 10.1038/cr.2014.138. Epub 2014 Oct 24.

20.

Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5.

Kusano S, Kukimoto-Niino M, Satta Y, Ohsawa N, Uchikubo-Kamo T, Wakiyama M, Ikeda M, Terada T, Yamamoto K, Nishimura Y, Shirouzu M, Sasazuki T, Yokoyama S.

J Mol Biol. 2014 Aug 26;426(17):3016-27. doi: 10.1016/j.jmb.2014.06.020. Epub 2014 Jul 11.

21.

ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.

Van Schaeybroeck S, Kalimutho M, Dunne PD, Carson R, Allen W, Jithesh PV, Redmond KL, Sasazuki T, Shirasawa S, Blayney J, Michieli P, Fenning C, Lenz HJ, Lawler M, Longley DB, Johnston PG.

Cell Rep. 2014 Jun 26;7(6):1940-55. doi: 10.1016/j.celrep.2014.05.032. Epub 2014 Jun 12.

22.

Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.

Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3787-92. doi: 10.1073/pnas.1401105111. Epub 2014 Feb 24.

23.

NKG2D⁺ IFN-γ⁺ CD8⁺ T cells are responsible for palladium allergy.

Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.

PLoS One. 2014 Feb 12;9(2):e86810. doi: 10.1371/journal.pone.0086810. eCollection 2014.

24.

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.

Organ SL, Hai J, Radulovich N, Marshall CB, Leung L, Sasazuki T, Shirasawa S, Zhu CQ, Navab R, Ikura M, Tsao MS.

PLoS One. 2014 Jan 21;9(1):e86103. doi: 10.1371/journal.pone.0086103. eCollection 2014.

25.

Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.

Ueda S, Oryoji D, Yamamoto K, Noh JY, Okamura K, Noda M, Kashiwase K, Kosuga Y, Sekiya K, Inoue K, Yamada H, Oyamada A, Nishimura Y, Yoshikai Y, Ito K, Sasazuki T.

J Clin Endocrinol Metab. 2014 Feb;99(2):E379-83. doi: 10.1210/jc.2013-2841. Epub 2013 Nov 27.

PMID:
24285682
26.

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S.

PLoS One. 2013 Oct 3;8(10):e76254. doi: 10.1371/journal.pone.0076254. eCollection 2013.

27.

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

Vartanian S, Bentley C, Brauer MJ, Li L, Shirasawa S, Sasazuki T, Kim JS, Haverty P, Stawiski E, Modrusan Z, Waldman T, Stokoe D.

J Biol Chem. 2013 Jan 25;288(4):2403-13. doi: 10.1074/jbc.M112.394130. Epub 2012 Nov 27.

28.

Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus.

Fukushi M, Yoshinaka Y, Matsuoka Y, Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki T, Miyoshi-Akiyama T.

J Virol. 2012 Nov;86(21):11745-53. doi: 10.1128/JVI.01250-12. Epub 2012 Aug 22.

29.

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.

Doi K, Fujimoto T, Okamura T, Ogawa M, Tanaka Y, Mototani Y, Goto M, Ota T, Matsuzaki H, Kuroki M, Tsunoda T, Sasazuki T, Shirasawa S.

Biochem Biophys Res Commun. 2012 Aug 17;425(1):107-12. doi: 10.1016/j.bbrc.2012.07.065. Epub 2012 Jul 22.

PMID:
22828507
30.

Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.

Ikonomou G, Kostourou V, Shirasawa S, Sasazuki T, Samiotaki M, Panayotou G.

J Proteomics. 2012 Sep 18;75(17):5356-69. doi: 10.1016/j.jprot.2012.06.038. Epub 2012 Jul 16.

PMID:
22800643
31.

Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA.

Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T, Evers BM.

Carcinogenesis. 2012 Sep;33(9):1782-90. doi: 10.1093/carcin/bgs203. Epub 2012 Jun 13.

32.

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.

Yuen HF, Abramczyk O, Montgomery G, Chan KK, Huang YH, Sasazuki T, Shirasawa S, Gopesh S, Chan KW, Fennell D, Janne P, El-Tanani M, Murray JT.

Biosci Rep. 2012 Aug;32(4):413-22. doi: 10.1042/BSR20120050.

33.

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.

Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, Pintzas A.

Mol Cancer. 2011 Sep 23;10:118. doi: 10.1186/1476-4598-10-118.

34.

Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.

Yoo BH, Wang Y, Erdogan M, Sasazuki T, Shirasawa S, Corcos L, Sabapathy K, Rosen KV.

J Biol Chem. 2011 Nov 11;286(45):38894-903. doi: 10.1074/jbc.M111.290692. Epub 2011 Sep 8.

35.

Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.

Nakabayashi K, Tajima A, Yamamoto K, Takahashi A, Hata K, Takashima Y, Koyanagi M, Nakaoka H, Akamizu T, Ishikawa N, Kubota S, Maeda S, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Sasazuki T, Shirasawa S.

J Hum Genet. 2011 Nov;56(11):772-8. doi: 10.1038/jhg.2011.99. Epub 2011 Sep 8.

PMID:
21900946
36.

KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines.

Yoshida Y, Tsunoda T, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Takashima Y, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S.

Anticancer Res. 2011 Jul;31(7):2535-9.

PMID:
21873171
37.

Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells.

Tsunoda T, Takashima Y, Yoshida Y, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Kuroki M, Sasazuki T, Shirasawa S.

Anticancer Res. 2011 Jul;31(7):2453-9.

PMID:
21873159
38.

Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model.

Miyoshi-Akiyama T, Ishida I, Fukushi M, Yamaguchi K, Matsuoka Y, Ishihara T, Tsukahara M, Hatakeyama S, Itoh N, Morisawa A, Yoshinaka Y, Yamamoto N, Lianfeng Z, Chuan Q, Kirikae T, Sasazuki T.

J Infect Dis. 2011 Jun 1;203(11):1574-81. doi: 10.1093/infdis/jir084.

PMID:
21592986
39.

Significantly increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis.

Noto H, Tsujimoto T, Sasazuki T, Noda M.

Endocr Pract. 2011 Jul-Aug;17(4):616-28. doi: 10.4158/EP10357.RA. Review.

PMID:
21454235
40.

ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts.

Doi K, Fujimoto T, Koyanagi M, Tsunoda T, Tanaka Y, Yoshida Y, Takashima Y, Kuroki M, Sasazuki T, Shirasawa S.

Cell Mol Biol Lett. 2011 Mar;16(1):89-100. doi: 10.2478/s11658-010-0041-1. Epub 2010 Dec 27.

41.

Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.

Van Schaeybroeck S, Kyula JN, Fenton A, Fenning CS, Sasazuki T, Shirasawa S, Longley DB, Johnston PG.

Cancer Res. 2011 Feb 1;71(3):1071-80. doi: 10.1158/0008-5472.CAN-10-0714. Epub 2010 Dec 10.

42.

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus.

Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, Russo M, Cancelliere C, Zecchin D, Mazzucchelli L, Sasazuki T, Shirasawa S, Geuna M, Frattini M, Baselga J, Gallicchio M, Biffo S, Bardelli A.

J Clin Invest. 2010 Aug;120(8):2858-66. doi: 10.1172/JCI37539. Epub 2010 Jul 26.

43.

Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.

Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, Shirasawa S.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14199-204. doi: 10.1073/pnas.1002494107. Epub 2010 Jul 26.

44.

Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan.

Noto H, Osame K, Sasazuki T, Noda M.

J Diabetes Complications. 2010 Sep-Oct;24(5):345-53. doi: 10.1016/j.jdiacomp.2010.06.004. Epub 2010 Jul 24. Review.

PMID:
20656522
45.

ZFAT is essential for endothelial cell assembly and the branch point formation of capillary-like structures in an angiogenesis model.

Yoshida Y, Tsunoda T, Takashima Y, Fujimoto T, Doi K, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S.

Cell Mol Biol Lett. 2010 Dec;15(4):541-50. doi: 10.2478/s11658-010-0028-y. Epub 2010 Jul 19.

46.

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.

She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, Solit DB, Rosen N.

Cancer Cell. 2010 Jul 13;18(1):39-51. doi: 10.1016/j.ccr.2010.05.023.

47.

Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model.

Tsunoda T, Takashima Y, Fujimoto T, Koyanagi M, Yoshida Y, Doi K, Tanaka Y, Kuroki M, Sasazuki T, Shirasawa S.

Neoplasia. 2010 May;12(5):397-404.

48.

Nomenclature for factors of the HLA system, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Tissue Antigens. 2010 Apr;75(4):291-455. doi: 10.1111/j.1399-0039.2010.01466.x. Review. No abstract available.

49.

An update to HLA nomenclature, 2010.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J.

Bone Marrow Transplant. 2010 May;45(5):846-8. doi: 10.1038/bmt.2010.79. Epub 2010 Mar 29.

PMID:
20348972
50.

Impact of highly conserved HLA haplotype on acute graft-versus-host disease.

Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, Morishima Y; Japan Marrow Donor Program.

Blood. 2010 Jun 10;115(23):4664-70. doi: 10.1182/blood-2009-10-251157. Epub 2010 Mar 24.

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