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Items: 17

1.

Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System.

Bauer PO, Dunmore JH, Sasaguri H, Matoska V.

Front Neurosci. 2019 Sep 6;13:935. doi: 10.3389/fnins.2019.00935. eCollection 2019.

2.

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.

Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC.

J Biol Chem. 2019 Aug 23;294(34):12754-12765. doi: 10.1074/jbc.RA119.009487. Epub 2019 Jul 4.

PMID:
31273083
3.

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC.

Nat Commun. 2018 Jul 24;9(1):2892. doi: 10.1038/s41467-018-05262-w.

4.

APP mouse models for Alzheimer's disease preclinical studies.

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC.

EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1. Review.

5.

Cerebral infarction in right pons during the course of mobile mitral annular calcification-related calcified amorphous tumor during a long time hemodialysis.

Saito K, Doi M, Karikusa M, Sakata K, Sasaguri H, Toru S.

Rinsho Shinkeigaku. 2016 Aug 31;56(8):580-3. doi: 10.5692/clinicalneurol.cn-000895. Epub 2016 Jul 29. Japanese.

PMID:
27477571
6.

The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo.

Sasaguri H, Chew J, Xu YF, Gendron TF, Garrett A, Lee CW, Jansen-West K, Bauer PO, Perkerson EA, Tong J, Stetler C, Zhang YJ.

Brain Res. 2016 Sep 15;1647:57-64. doi: 10.1016/j.brainres.2016.04.069. Epub 2016 May 4. Review.

7.

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.

Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L.

Nat Neurosci. 2016 May;19(5):668-677. doi: 10.1038/nn.4272. Epub 2016 Mar 21.

8.

Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits.

Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ, Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME, Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN, Stetler C, Daughrity LM, Perkerson EA, Desaro P, Johnston A, Overstreet K, Edbauer D, Rademakers R, Boylan KB, Dickson DW, Fryer JD, Petrucelli L.

Science. 2015 Jun 5;348(6239):1151-4. doi: 10.1126/science.aaa9344. Epub 2015 May 14.

9.

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.

Zhang YJ, Jansen-West K, Xu YF, Gendron TF, Bieniek KF, Lin WL, Sasaguri H, Caulfield T, Hubbard J, Daughrity L, Chew J, Belzil VV, Prudencio M, Stankowski JN, Castanedes-Casey M, Whitelaw E, Ash PE, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L.

Acta Neuropathol. 2014 Oct;128(4):505-24. doi: 10.1007/s00401-014-1336-5. Epub 2014 Aug 31.

10.

Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.

Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer PO, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, Gao FB, Petrucelli L.

Hum Mol Genet. 2014 Mar 15;23(6):1467-78. doi: 10.1093/hmg/ddt534. Epub 2013 Oct 26.

11.

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Zhang YJ, Caulfield T, Xu YF, Gendron TF, Hubbard J, Stetler C, Sasaguri H, Whitelaw EC, Cai S, Lee WC, Petrucelli L.

Hum Mol Genet. 2013 Aug 1;22(15):3112-22. doi: 10.1093/hmg/ddt166. Epub 2013 Apr 10.

12.

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.

Uchida A, Sasaguri H, Kimura N, Tajiri M, Ohkubo T, Ono F, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Yamamoto M, Yokota S, Kubodera T, Tomori M, Sakaki K, Enomoto M, Hirai Y, Kumagai J, Yasutomi Y, Mochizuki H, Kuwabara S, Uchihara T, Mizusawa H, Yokota T.

Brain. 2012 Mar;135(Pt 3):833-46. doi: 10.1093/brain/awr348. Epub 2012 Jan 17.

13.

Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.

Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, Mizusawa H, Yokota T.

J Biol Chem. 2009 Nov 27;284(48):33400-8. doi: 10.1074/jbc.M109.054056. Epub 2009 Aug 13.

14.

Silencing efficiency differs among tissues and endogenous microRNA pathway is preserved in short hairpin RNA transgenic mice.

Sasaguri H, Mitani T, Anzai M, Kubodera T, Saito Y, Yamada H, Mizusawa H, Yokota T.

FEBS Lett. 2009 Jan 5;583(1):213-8. doi: 10.1016/j.febslet.2008.12.012. Epub 2008 Dec 11.

15.

Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.

Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S.

Cell Death Differ. 2007 Dec;14(12):2058-67. Epub 2007 Sep 21.

16.

Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.

Yokota T, Sasaguri H, Saito Y, Yamada H, Unno T, Yamamoto Y, Kubodera T, Anzai M, Mitani T, Mizusawa H.

Arch Neurol. 2007 Jan;64(1):145-6. No abstract available.

PMID:
17210827
17.

Slowly progressive Foix-Chavany-Marie syndrome associated with chronic herpes simplex encephalitis.

Sasaguri H, Sodeyama N, Maejima Y, Kanda T, Mizusawa H.

J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):203-4. No abstract available.

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