Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 55

1.

Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma.

Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, Scott MC, Graef AJ, Borst L, Tonomura N, Alfoldi J, Painter C, Thomas R, Karlsson EK, Breen M, Modiano JF, Elvers I, Lindblad-Toh K.

Mol Cancer Res. 2019 Sep 30. pii: molcanres.0221.2019. doi: 10.1158/1541-7786.MCR-19-0221. [Epub ahead of print]

PMID:
31570656
2.

Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review.

Makielski KM, Mills LJ, Sarver AL, Henson MS, Spector LG, Naik S, Modiano JF.

Vet Sci. 2019 May 25;6(2). pii: E48. doi: 10.3390/vetsci6020048. Review.

3.

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA.

Cancer Res. 2019 Mar 1;79(5):905-917. doi: 10.1158/0008-5472.CAN-18-1261. Epub 2019 Jan 23.

PMID:
30674530
4.

OMCD: OncomiR Cancer Database.

Sarver AL, Sarver AE, Yuan C, Subramanian S.

BMC Cancer. 2018 Dec 6;18(1):1223. doi: 10.1186/s12885-018-5085-z.

5.

Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers.

Kim JH, Frantz AM, Sarver AL, Gorden Klukas BH, Lewellen M, O'Brien TD, Dickerson EB, Modiano JF.

Vet Comp Oncol. 2018 Mar;16(1):E176-E184. doi: 10.1111/vco.12368. Epub 2017 Nov 20. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.

6.

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL.

Cancer Res. 2018 Jan 15;78(2):326-337. doi: 10.1158/0008-5472.CAN-17-0576. Epub 2017 Oct 24.

7.

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.

8.

Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.

Xie C, Freeman MJ, Lu H, Wang X, Forster CL, Sarver AL, Hallstrom TC.

Oncotarget. 2017 Jun 13;8(24):38084-38098. doi: 10.18632/oncotarget.16970.

9.

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.

Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.

10.

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.

Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH.

Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658.

11.

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

Becker MA, Ibrahim YH, Oh AS, Fagan DH, Byron SA, Sarver AL, Lee AV, Shaw LM, Fan C, Perou CM, Yee D.

PLoS One. 2016 Mar 18;11(3):e0150564. doi: 10.1371/journal.pone.0150564. eCollection 2016.

12.

Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.

Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MM.

Haematologica. 2016 Jun;101(6):e232-6. doi: 10.3324/haematol.2015.139527. Epub 2016 Mar 4. No abstract available.

13.

MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer.

Sarver AL, Murray CD, Temiz NA, Tseng YY, Bagchi A.

Cell Cycle. 2016;15(7):881-5. doi: 10.1080/15384101.2016.1149660.

14.

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL.

Genome Res. 2016 Jan;26(1):119-29. doi: 10.1101/gr.188649.114. Epub 2015 Nov 9.

15.

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.

Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.

16.

Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma.

Scott MC, Sarver AL, Tomiyasu H, Cornax I, Van Etten J, Varshney J, O'Sullivan MG, Subramanian S, Modiano JF.

J Biol Chem. 2015 Nov 20;290(47):28070-83. doi: 10.1074/jbc.M115.679696. Epub 2015 Sep 16.

17.

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors.

Sarver AE, Sarver AL, Thayanithy V, Subramanian S.

Lab Invest. 2015 Sep;95(9):1077-88. doi: 10.1038/labinvest.2015.80. Epub 2015 Jun 29.

18.

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK.

Mol Cancer Res. 2015 Aug;13(8):1238-47. doi: 10.1158/1541-7786.MCR-14-0674-T. Epub 2015 May 20.

19.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.

20.

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.

PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 May;11(5):e1005339.

21.

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.

Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA.

Blood. 2014 Nov 20;124(22):3274-83. doi: 10.1182/blood-2013-08-521708. Epub 2014 Oct 14.

22.

Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma.

Li L, Sarver AL, Khatri R, Hajeri PB, Kamenev I, French AJ, Thibodeau SN, Steer CJ, Subramanian S.

J Pathol. 2014 Dec;234(4):488-501. doi: 10.1002/path.4407. Epub 2014 Oct 1.

PMID:
25269767
23.

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.

Been RA, Linden MA, Hager CJ, DeCoursin KJ, Abrahante JE, Landman SR, Steinbach M, Sarver AL, Largaespada DA, Starr TK.

PLoS One. 2014 May 14;9(5):e97280. doi: 10.1371/journal.pone.0097280. eCollection 2014.

24.

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

Gorden BH, Kim JH, Sarver AL, Frantz AM, Breen M, Lindblad-Toh K, O'Brien TD, Sharkey LC, Modiano JF, Dickerson EB.

Am J Pathol. 2014 Apr;184(4):985-995. doi: 10.1016/j.ajpath.2013.12.025. Epub 2014 Feb 11. Erratum in: Am J Pathol. 2019 Mar;189(3):699-700.

25.

The role of KCNQ1 in mouse and human gastrointestinal cancers.

Than BL, Goos JA, Sarver AL, O'Sullivan MG, Rod A, Starr TK, Fijneman RJ, Meijer GA, Zhao L, Zhang Y, Largaespada DA, Scott PM, Cormier RT.

Oncogene. 2014 Jul 17;33(29):3861-8. doi: 10.1038/onc.2013.350. Epub 2013 Aug 26.

26.

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA.

Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27.

27.

Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.

Krentz AD, Murphy MW, Zhang T, Sarver AL, Jain S, Griswold MD, Bardwell VJ, Zarkower D.

Dev Biol. 2013 May 1;377(1):67-78. doi: 10.1016/j.ydbio.2013.02.014. Epub 2013 Mar 6.

28.

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.

Sarver AL, Thayanithy V, Scott MC, Cleton-Jansen AM, Hogendoorn PC, Modiano JF, Subramanian S.

Orphanet J Rare Dis. 2013 Jan 11;8:7. doi: 10.1186/1750-1172-8-7.

29.

Molecular profiling reveals prognostically significant subtypes of canine lymphoma.

Frantz AM, Sarver AL, Ito D, Phang TL, Karimpour-Fard A, Scott MC, Valli VE, Lindblad-Toh K, Burgess KE, Husbands BD, Henson MS, Borgatti A, Kisseberth WC, Hunter LE, Breen M, O'Brien TD, Modiano JF.

Vet Pathol. 2013 Jul;50(4):693-703. doi: 10.1177/0300985812465325. Epub 2012 Nov 2.

30.

Competing endogenous RNA database.

Sarver AL, Subramanian S.

Bioinformation. 2012;8(15):731-3. doi: 10.6026/97320630008731. Epub 2012 Aug 3.

31.

Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.

Thayanithy V, Park C, Sarver AL, Kartha RV, Korpela DM, Graef AJ, Steer CJ, Modiano JF, Subramanian S.

PLoS One. 2012;7(9):e43720. doi: 10.1371/journal.pone.0043720. Epub 2012 Sep 5.

32.

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

Keng VW, Sia D, Sarver AL, Tschida BR, Fan D, Alsinet C, Solé M, Lee WL, Kuka TP, Moriarity BS, Villanueva A, Dupuy AJ, Riordan JD, Bell JB, Silverstein KA, Llovet JM, Largaespada DA.

Hepatology. 2013 Jan;57(1):120-30. doi: 10.1002/hep.26004. Epub 2012 Oct 19.

33.

TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data.

Sarver AL, Erdman J, Starr T, Largaespada DA, Silverstein KA.

BMC Bioinformatics. 2012 Jun 29;13:154. doi: 10.1186/1471-2105-13-154.

34.

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.

Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA.

Nature. 2012 Apr 29;486(7402):266-70. doi: 10.1038/nature11114. Erratum in: Nature. 2013 Feb 21;494(7437):390. Scarlett, Christopher J [added]; Kaplan, Warren [added]; Scarpa, Aldo [added], Das, Amithabad [corrected to Das, Amitabha].

35.

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA.

Blood. 2012 May 10;119(19):4512-23. doi: 10.1182/blood-2010-04-281428. Epub 2012 Mar 16.

36.

Clonal selection drives genetic divergence of metastatic medulloblastoma.

Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD.

Nature. 2012 Feb 15;482(7386):529-33. doi: 10.1038/nature10825.

37.

Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma.

Li L, Sarver AL, Alamgir S, Subramanian S.

Lab Invest. 2012 Apr;92(4):571-83. doi: 10.1038/labinvest.2012.10. Epub 2012 Feb 13.

38.

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma.

Thayanithy V, Sarver AL, Kartha RV, Li L, Angstadt AY, Breen M, Steer CJ, Modiano JF, Subramanian S.

Bone. 2012 Jan;50(1):171-81. doi: 10.1016/j.bone.2011.10.012. Epub 2011 Oct 18.

39.

Oxygen is a master regulator of the immunogenicity of primary human glioma cells.

Olin MR, Andersen BM, Litterman AJ, Grogan PT, Sarver AL, Robertson PT, Liang X, Chen W, Parney IF, Hunt MA, Blazar BR, Ohlfest JR.

Cancer Res. 2011 Nov 1;71(21):6583-9. doi: 10.1158/0008-5472.CAN-11-1166. Epub 2011 Sep 9.

40.

DMRT1 prevents female reprogramming in the postnatal mammalian testis.

Matson CK, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D.

Nature. 2011 Jul 20;476(7358):101-4. doi: 10.1038/nature10239. Erratum in: Nature. 2011 Sep 8;477(7363):238.

41.

miRNA expression in colon polyps provides evidence for a multihit model of colon cancer.

Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, Smyrk TC, Asmann Y, Steer CJ, Thibodeau SN.

PLoS One. 2011;6(6):e20465. doi: 10.1371/journal.pone.0020465. Epub 2011 Jun 9.

42.

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach.

Scott MC, Sarver AL, Gavin KJ, Thayanithy V, Getzy DM, Newman RA, Cutter GR, Lindblad-Toh K, Kisseberth WC, Hunter LE, Subramanian S, Breen M, Modiano JF.

Bone. 2011 Sep;49(3):356-67. doi: 10.1016/j.bone.2011.05.008. Epub 2011 May 15.

43.

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.

Krentz AD, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D.

Dev Biol. 2011 Aug 1;356(1):63-70. doi: 10.1016/j.ydbio.2011.05.658. Epub 2011 May 20.

44.

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.

Billington CJ Jr, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A.

Dev Biol. 2011 Jul 1;355(1):21-31. doi: 10.1016/j.ydbio.2011.04.026. Epub 2011 Apr 28.

45.

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.

Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5765-70. doi: 10.1073/pnas.1018012108. Epub 2011 Mar 21.

46.

MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration.

Sarver AL, Li L, Subramanian S.

Cancer Res. 2010 Dec 1;70(23):9570-80. doi: 10.1158/0008-5472.CAN-10-2074. Epub 2010 Nov 30.

47.

Hepatic differentiation of liver-derived progenitor cells and their characterization by microRNA analysis.

Chen Y, Zhou H, Sarver AL, Zeng Y, Roy-Chowdhury J, Steer CJ, Sahin MB.

Liver Transpl. 2010 Sep;16(9):1086-97. doi: 10.1002/lt.22111.

48.

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.

Castro RE, Ferreira DM, Zhang X, Borralho PM, Sarver AL, Zeng Y, Steer CJ, Kren BT, Rodrigues CM.

Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G887-97. doi: 10.1152/ajpgi.00216.2010. Epub 2010 Aug 5.

49.

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis.

Murphy MW, Sarver AL, Rice D, Hatzi K, Ye K, Melnick A, Heckert LL, Zarkower D, Bardwell VJ.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13360-5. doi: 10.1073/pnas.1006243107. Epub 2010 Jul 7.

50.

Toward understanding the informatics and statistical aspects of micro-RNA profiling.

Sarver AL.

J Cardiovasc Transl Res. 2010 Jun;3(3):204-11. doi: 10.1007/s12265-010-9180-z. Epub 2010 May 4. Review.

PMID:
20560041

Supplemental Content

Loading ...
Support Center