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The design of the perfect pediatric supraglottic airway device.

Huang AS, Sarver A, Widing A, Hajduk J, Jagannathan N.

Paediatr Anaesth. 2019 Dec 14. doi: 10.1111/pan.13785. [Epub ahead of print]


Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment.

Langsten KL, Kim JH, Sarver AL, Dewhirst M, Modiano JF.

Front Oncol. 2019 Nov 7;9:1185. doi: 10.3389/fonc.2019.01185. eCollection 2019. Review.


Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia.

Sachs K, Sarver AL, Noble-Orcutt KE, LaRue RS, Antony ML, Chang D, Lee Y, Navis CM, Hillesheim AL, Nykaza IR, Ha NA, Hansen CJ, Karadag FK, Bergerson RJ, Verneris MR, Meredith MM, Schomaker ML, Linden MA, Myers CL, Largaespada DA, Sachs Z.

Cancer Res. 2019 Nov 29. pii: canres.2932.2018. doi: 10.1158/0008-5472.CAN-18-2932. [Epub ahead of print]


Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.

Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, Scott MC, Schulte AJ, Borst L, Tonomura N, Alfoldi J, Painter C, Thomas R, Karlsson EK, Breen M, Modiano JF, Elvers I, Lindblad-Toh K.

Mol Cancer Res. 2019 Dec;17(12):2410-2421. doi: 10.1158/1541-7786.MCR-19-0221. Epub 2019 Sep 30.


Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review.

Makielski KM, Mills LJ, Sarver AL, Henson MS, Spector LG, Naik S, Modiano JF.

Vet Sci. 2019 May 25;6(2). pii: E48. doi: 10.3390/vetsci6020048. Review.


Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.

Loeb KR, Hughes BT, Fissel BM, Osteen NJ, Knoblaugh SE, Grim JE, Drury LJ, Sarver A, Dupuy AJ, Clurman BE.

Sci Rep. 2019 Apr 2;9(1):5488. doi: 10.1038/s41598-019-41805-x.


Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma.

Olin MR, Ampudia-Mesias E, Pennell CA, Sarver A, Chen CC, Moertel CL, Hunt MA, Pluhar GE.

Cancers (Basel). 2019 Jan 24;11(2). pii: E137. doi: 10.3390/cancers11020137.


Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors.

Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA.

Cancer Res. 2019 Mar 1;79(5):905-917. doi: 10.1158/0008-5472.CAN-18-1261. Epub 2019 Jan 23.


Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer.

Silberman A, Goldman O, Boukobza Assayag O, Jacob A, Rabinovich S, Adler L, Lee JS, Keshet R, Sarver A, Frug J, Stettner N, Galai S, Persi E, Halpern KB, Zaltsman-Amir Y, Pode-Shakked B, Eilam R, Anikster Y, Nagamani SCS, Ulitsky I, Ruppin E, Erez A.

Cancer Res. 2019 Feb 1;79(3):518-533. doi: 10.1158/0008-5472.CAN-18-1062. Epub 2018 Dec 20.


Identification of Cancer Genes Based on De Novo Transposon Insertion Site Analysis Using RNA and DNA Sequencing.

Sarver A.

Methods Mol Biol. 2019;1907:73-79. doi: 10.1007/978-1-4939-8967-6_5.


OMCD: OncomiR Cancer Database.

Sarver AL, Sarver AE, Yuan C, Subramanian S.

BMC Cancer. 2018 Dec 6;18(1):1223. doi: 10.1186/s12885-018-5085-z.


Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer.

Stettner N, Rosen C, Bernshtein B, Gur-Cohen S, Frug J, Silberman A, Sarver A, Carmel-Neiderman NN, Eilam R, Biton I, Pevsner-Fischer M, Zmora N, Brandis A, Bahar Halpern K, Mazkereth R, di Bernardo D, Brunetti-Pierri N, Premkumar MH, Dank G, Nagamani SCS, Jung S, Harmelin A, Erez A.

Cell Rep. 2018 May 15;23(7):1962-1976. doi: 10.1016/j.celrep.2018.04.053.


Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers.

Kim JH, Frantz AM, Sarver AL, Gorden Klukas BH, Lewellen M, O'Brien TD, Dickerson EB, Modiano JF.

Vet Comp Oncol. 2018 Mar;16(1):E176-E184. doi: 10.1111/vco.12368. Epub 2017 Nov 20. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.


Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL.

Cancer Res. 2018 Jan 15;78(2):326-337. doi: 10.1158/0008-5472.CAN-17-0576. Epub 2017 Oct 24.


Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.


Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.

Xie C, Freeman MJ, Lu H, Wang X, Forster CL, Sarver AL, Hallstrom TC.

Oncotarget. 2017 Jun 13;8(24):38084-38098. doi: 10.18632/oncotarget.16970.


Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.

Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.


Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.

Buzaglo-Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman SL, Bassat E, Michailovici I, Sarver A, Tzahor E, Haran M, Vernochet C, Gross A.

Cell Rep. 2017 Jan 31;18(5):1335-1336. doi: 10.1016/j.celrep.2017.01.046. No abstract available.


Comprehensive analysis of microRNA signature of mouse pancreatic acini: overexpression of miR-21-3p in acute pancreatitis.

Dixit AK, Sarver AE, Yuan Z, George J, Barlass U, Cheema H, Sareen A, Banerjee S, Dudeja V, Dawra R, Subramanian S, Saluja AK.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G974-G980. doi: 10.1152/ajpgi.00191.2016. Epub 2016 Sep 29.


Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.

Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH.

Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658.


Imprinting defects in osteosarcoma: DNA- and chromatin-modifying drugs hold promise for osteosarcoma therapy.

Sarver AE, Subramanian S.

Epigenomics. 2016 Jul;8(7):885-8. doi: 10.2217/epi-2016-0046. Epub 2016 Jul 1. No abstract available.


MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells.

Dileepan M, Sarver AE, Rao SP, Panettieri RA Jr, Subramanian S, Kannan MS.

PLoS One. 2016 Mar 21;11(3):e0150842. doi: 10.1371/journal.pone.0150842. eCollection 2016.


Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

Becker MA, Ibrahim YH, Oh AS, Fagan DH, Byron SA, Sarver AL, Lee AV, Shaw LM, Fan C, Perou CM, Yee D.

PLoS One. 2016 Mar 18;11(3):e0150564. doi: 10.1371/journal.pone.0150564. eCollection 2016.


Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.

Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MM.

Haematologica. 2016 Jun;101(6):e232-6. doi: 10.3324/haematol.2015.139527. Epub 2016 Mar 4. No abstract available.


MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer.

Sarver AL, Murray CD, Temiz NA, Tseng YY, Bagchi A.

Cell Cycle. 2016;15(7):881-5. doi: 10.1080/15384101.2016.1149660.


Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity.

Buzaglo-Azriel L, Kuperman Y, Tsoory M, Zaltsman Y, Shachnai L, Zaidman SL, Bassat E, Michailovici I, Sarver A, Tzahor E, Haran M, Vernochet C, Gross A.

Cell Rep. 2016 Feb 23;14(7):1602-1610. doi: 10.1016/j.celrep.2016.01.046. Epub 2016 Feb 11. Erratum in: Cell Rep. 2017 Jan 31;18(5):1335-1336.


Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma.

Shu J, Li L, Sarver AE, Pope EA, Varshney J, Thayanithy V, Spector L, Largaespada DA, Steer CJ, Subramanian S.

Oncotarget. 2016 Apr 19;7(16):21298-314. doi: 10.18632/oncotarget.6965.


microRNAs in the Malignant Transformation Process.

Sarver AE, Li L, Kartha RV, Subramanian S.

Adv Exp Med Biol. 2015;889:1-21. doi: 10.1007/978-3-319-23730-5_1.


Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D, Korman S, Itzkovitz S, Dimmock D, Ulitsky I, Nagamani SC, Ruppin E, Erez A.

Nature. 2015 Nov 19;527(7578):379-383. doi: 10.1038/nature15529. Epub 2015 Nov 11.


RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens.

Temiz NA, Moriarity BS, Wolf NK, Riordan JD, Dupuy AJ, Largaespada DA, Sarver AL.

Genome Res. 2016 Jan;26(1):119-29. doi: 10.1101/gr.188649.114. Epub 2015 Nov 9.


Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.

Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26.


Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma.

Scott MC, Sarver AL, Tomiyasu H, Cornax I, Van Etten J, Varshney J, O'Sullivan MG, Subramanian S, Modiano JF.

J Biol Chem. 2015 Nov 20;290(47):28070-83. doi: 10.1074/jbc.M115.679696. Epub 2015 Sep 16.


MicroRNAs in the pathobiology of sarcomas.

Sarver AE, Subramanian S.

Lab Invest. 2015 Sep;95(9):987-94. doi: 10.1038/labinvest.2015.81. Epub 2015 Jun 29. Review.


Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors.

Sarver AE, Sarver AL, Thayanithy V, Subramanian S.

Lab Invest. 2015 Sep;95(9):1077-88. doi: 10.1038/labinvest.2015.80. Epub 2015 Jun 29.


Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK.

Mol Cancer Res. 2015 Aug;13(8):1238-47. doi: 10.1158/1541-7786.MCR-14-0674-T. Epub 2015 May 20.


A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.


Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.

PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 May;11(5):e1005339.


A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A.

Nat Genet. 2015 Jan;47(1):47-56. doi: 10.1038/ng.3164. Epub 2014 Dec 8.


NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.

Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA.

Blood. 2014 Nov 20;124(22):3274-83. doi: 10.1182/blood-2013-08-521708. Epub 2014 Oct 14.


Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma.

Li L, Sarver AL, Khatri R, Hajeri PB, Kamenev I, French AJ, Thibodeau SN, Steer CJ, Subramanian S.

J Pathol. 2014 Dec;234(4):488-501. doi: 10.1002/path.4407. Epub 2014 Oct 1.


Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.

Been RA, Linden MA, Hager CJ, DeCoursin KJ, Abrahante JE, Landman SR, Steinbach M, Sarver AL, Largaespada DA, Starr TK.

PLoS One. 2014 May 14;9(5):e97280. doi: 10.1371/journal.pone.0097280. eCollection 2014.


Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

Gorden BH, Kim JH, Sarver AL, Frantz AM, Breen M, Lindblad-Toh K, O'Brien TD, Sharkey LC, Modiano JF, Dickerson EB.

Am J Pathol. 2014 Apr;184(4):985-995. doi: 10.1016/j.ajpath.2013.12.025. Epub 2014 Feb 11. Erratum in: Am J Pathol. 2019 Mar;189(3):699-700.


Lats2 is critical for the pluripotency and proper differentiation of stem cells.

Aylon Y, Sarver A, Tovy A, Ainbinder E, Oren M.

Cell Death Differ. 2014 Apr;21(4):624-33. doi: 10.1038/cdd.2013.188. Epub 2014 Jan 10.


The role of KCNQ1 in mouse and human gastrointestinal cancers.

Than BL, Goos JA, Sarver AL, O'Sullivan MG, Rod A, Starr TK, Fijneman RJ, Meijer GA, Zhao L, Zhang Y, Largaespada DA, Scott PM, Cormier RT.

Oncogene. 2014 Jul 17;33(29):3861-8. doi: 10.1038/onc.2013.350. Epub 2013 Aug 26.


Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA.

Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19.


Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.

MacKenzie TN, Mujumdar N, Banerjee S, Sangwan V, Sarver A, Vickers S, Subramanian S, Saluja AK.

Mol Cancer Ther. 2013 Jul;12(7):1266-75. doi: 10.1158/1535-7163.MCT-12-1231. Epub 2013 May 1.


BRCA1 is a negative modulator of the PRC2 complex.

Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H.

EMBO J. 2013 May 29;32(11):1584-97. doi: 10.1038/emboj.2013.95. Epub 2013 Apr 26.


Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model.

Stessman HA, Baughn LB, Sarver A, Xia T, Deshpande R, Mansoor A, Walsh SA, Sunderland JJ, Dolloff NG, Linden MA, Zhan F, Janz S, Myers CL, Van Ness BG.

Mol Cancer Ther. 2013 Jun;12(6):1140-50. doi: 10.1158/1535-7163.MCT-12-1151. Epub 2013 Mar 27.


Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA.

Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27.


Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.

Krentz AD, Murphy MW, Zhang T, Sarver AL, Jain S, Griswold MD, Bardwell VJ, Zarkower D.

Dev Biol. 2013 May 1;377(1):67-78. doi: 10.1016/j.ydbio.2013.02.014. Epub 2013 Mar 6.

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