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Items: 36


Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR.

Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24.


A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.

Trenner A, Godau J, Sartori AA.

Mol Cancer Ther. 2018 Jul;17(7):1392-1404. doi: 10.1158/1535-7163.MCT-17-1156. Epub 2018 Apr 13.


Author Correction: FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.

Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J.

Nat Commun. 2017 Dec 21;8(1):2285. doi: 10.1038/s41467-017-02130-x.


FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2.

Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, Ma Y, Nagasawa K, Sartori AA, Jiricny J.

Nat Commun. 2017 Oct 20;8(1):1073. doi: 10.1038/s41467-017-01074-6. Erratum in: Nat Commun. 2017 Dec 21;8(1):2285.


Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells.

Peña-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Borán M, Castor D, Lopes M, Sartori AA, Jiricny J.

Mol Cell. 2017 Jul 6;67(1):162. doi: 10.1016/j.molcel.2017.06.026. No abstract available.


Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells.

Mordasini V, Ueda S, Aslandogmus R, Berger C, Gysin C, Hühn D, Sartori AA, Bernasconi M, Nadal D.

Oncotarget. 2017 Jan 24;8(4):6461-6474. doi: 10.18632/oncotarget.14120.


Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO.

Himmels SF, Sartori AA.

Front Genet. 2016 Aug 23;7:152. doi: 10.3389/fgene.2016.00152. eCollection 2016. Review.


Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.

Ferretti LP, Himmels SF, Trenner A, Walker C, von Aesch C, Eggenschwiler A, Murina O, Enchev RI, Peter M, Freire R, Porro A, Sartori AA.

Nat Commun. 2016 Aug 26;7:12628. doi: 10.1038/ncomms12628.


The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection.

Lafranchi L, Sartori AA.

Mol Cell Oncol. 2015 Jan 23;2(4):e1000696. doi: 10.1080/23723556.2014.1000696. eCollection 2015 Oct-Dec.


Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation.

Fontana AO, Augsburger MA, Grosse N, Guckenberger M, Lomax AJ, Sartori AA, Pruschy MN.

Radiother Oncol. 2015 Sep;116(3):374-80. doi: 10.1016/j.radonc.2015.08.014. Epub 2015 Aug 25.


APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.

Lafranchi L, de Boer HR, de Vries EG, Ong SE, Sartori AA, van Vugt MA.

EMBO J. 2014 Dec 1;33(23):2860-79. doi: 10.15252/embj.201489017. Epub 2014 Oct 27.


miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP.

Hühn D, Kousholt AN, Sørensen CS, Sartori AA.

Oncogene. 2015 Jul 23;34(30):3977-84. doi: 10.1038/onc.2014.329. Epub 2014 Oct 13.


FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks.

Murina O, von Aesch C, Karakus U, Ferretti LP, Bolck HA, Hänggi K, Sartori AA.

Cell Rep. 2014 May 22;7(4):1030-8. doi: 10.1016/j.celrep.2014.03.069. Epub 2014 May 1.


Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation.

Grosse N, Fontana AO, Hug EB, Lomax A, Coray A, Augsburger M, Paganetti H, Sartori AA, Pruschy M.

Int J Radiat Oncol Biol Phys. 2014 Jan 1;88(1):175-81. doi: 10.1016/j.ijrobp.2013.09.041. Epub 2013 Nov 13.


HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.

Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V, Skehel JM, Stamp G, D'Andrea A, Sartori AA, Swanton C, Boulton SJ.

Nature. 2013 Oct 17;502(7471):381-4. doi: 10.1038/nature12565. Epub 2013 Sep 4.


Prolyl isomerization: a new PIN code for DSB repair.

Sartori AA, Steger M.

Cell Cycle. 2013 Sep 1;12(17):2717-8. doi: 10.4161/cc.26077. Epub 2013 Aug 19. No abstract available.


Targeting DNA double-strand break signalling and repair: recent advances in cancer therapy.

Hühn D, Bolck HA, Sartori AA.

Swiss Med Wkly. 2013 Jul 29;143:w13837. doi: 10.4414/smw.2013.13837. eCollection 2013. Review.


Controlling DNA-end resection: a new task for CDKs.

Ferretti LP, Lafranchi L, Sartori AA.

Front Genet. 2013 Jun 3;4:99. doi: 10.3389/fgene.2013.00099. eCollection 2013.


Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.

Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA.

Mol Cell. 2013 May 9;50(3):333-43. doi: 10.1016/j.molcel.2013.03.023. Epub 2013 Apr 25.


RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ.

Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17.


Noncanonical mismatch repair as a source of genomic instability in human cells.

Peña-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Borán M, Castor D, Lopes M, Sartori AA, Jiricny J.

Mol Cell. 2012 Sep 14;47(5):669-80. doi: 10.1016/j.molcel.2012.07.006. Epub 2012 Aug 2.


CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.

Kousholt AN, Fugger K, Hoffmann S, Larsen BD, Menzel T, Sartori AA, Sørensen CS.

J Cell Biol. 2012 Jun 25;197(7):869-76. doi: 10.1083/jcb.201111065.


γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.

Sharma A, Bode B, Wenger RH, Lehmann K, Sartori AA, Moch H, Knuth A, Boehmer Lv, Broek Mv.

PLoS One. 2011;6(11):e28217. doi: 10.1371/journal.pone.0028217. Epub 2011 Nov 29.


Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, Stucki M, Kalali B, Gerhard M, Sartori AA, Lopes M, Müller A.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14944-9. doi: 10.1073/pnas.1100959108. Epub 2011 Sep 6.


DNA end resection by CtIP and exonuclease 1 prevents genomic instability.

Eid W, Steger M, El-Shemerly M, Ferretti LP, Peña-Diaz J, König C, Valtorta E, Sartori AA, Ferrari S.

EMBO Rep. 2010 Dec;11(12):962-8. doi: 10.1038/embor.2010.157. Epub 2010 Nov 5.


Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

Kratz K, Schöpf B, Kaden S, Sendoel A, Eberhard R, Lademann C, Cannavó E, Sartori AA, Hengartner MO, Jiricny J.

Cell. 2010 Jul 9;142(1):77-88. doi: 10.1016/j.cell.2010.06.022.


MRE11 complex links RECQ5 helicase to sites of DNA damage.

Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P.

Nucleic Acids Res. 2009 May;37(8):2645-57. doi: 10.1093/nar/gkp147. Epub 2009 Mar 6.


CDK targets Sae2 to control DNA-end resection and homologous recombination.

Huertas P, Cortés-Ledesma F, Sartori AA, Aguilera A, Jackson SP.

Nature. 2008 Oct 2;455(7213):689-92. doi: 10.1038/nature07215. Epub 2008 Aug 20.


Human CtIP promotes DNA end resection.

Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP.

Nature. 2007 Nov 22;450(7169):509-14. Epub 2007 Oct 28.


A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure.

Lingaraju GM, Sartori AA, Kostrewa D, Prota AE, Jiricny J, Winkler FK.

Structure. 2005 Jan;13(1):87-98.


Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases.

Sartori AA, Lingaraju GM, Hunziker P, Winkler FK, Jiricny J.

Nucleic Acids Res. 2004 Dec 16;32(22):6531-9. Print 2004.


Enzymology of base excision repair in the hyperthermophilic archaeon Pyrobaculum aerophilum.

Sartori AA, Jiricny J.

J Biol Chem. 2003 Jul 4;278(27):24563-76. Epub 2003 Apr 30.


A novel uracil-DNA glycosylase with broad substrate specificity and an unusual active site.

Sartori AA, Fitz-Gibbon S, Yang H, Miller JH, Jiricny J.

EMBO J. 2002 Jun 17;21(12):3182-91.


Direct interaction between uracil-DNA glycosylase and a proliferating cell nuclear antigen homolog in the crenarchaeon Pyrobaculum aerophilum.

Yang H, Chiang JH, Fitz-Gibbon S, Lebel M, Sartori AA, Jiricny J, Slupska MM, Miller JH.

J Biol Chem. 2002 Jun 21;277(25):22271-8. Epub 2002 Apr 1.


An iron-sulfur cluster in the family 4 uracil-DNA glycosylases.

Hinks JA, Evans MC, De Miguel Y, Sartori AA, Jiricny J, Pearl LH.

J Biol Chem. 2002 May 10;277(19):16936-40. Epub 2002 Feb 27.


Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.

Sartori AA, Schär P, Fitz-Gibbon S, Miller JH, Jiricny J.

J Biol Chem. 2001 Aug 10;276(32):29979-86. Epub 2001 Jun 8.

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