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Items: 1 to 50 of 67

1.

Correction of hypomagnesemia by dapagliflozin in patients with type 2 diabetes: A post hoc analysis of 10 randomized, placebo-controlled trials.

Toto RD, Goldenberg R, Chertow GM, Cain V, Stefánsson BV, Sjöström CD, Sartipy P.

J Diabetes Complications. 2019 Jul 2:107402. doi: 10.1016/j.jdiacomp.2019.06.007. [Epub ahead of print]

PMID:
31375422
2.

Reduction in albuminuria with dapagliflozin cannot be predicted by baseline clinical characteristics or changes in most other risk markers.

Heerspink HJL, Sjöström CD, Inzucchi SE, Hallow MK, Cain VA, Rossing P, Stefansson BV, Sartipy P.

Diabetes Obes Metab. 2019 Mar;21(3):720-725. doi: 10.1111/dom.13579. Epub 2018 Dec 11.

3.

Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models.

Granéli C, Hicks R, Brolén G, Synnergren J, Sartipy P.

Stem Cell Rev. 2019 Feb;15(1):13-22. doi: 10.1007/s12015-018-9858-1. Review.

4.

Efficacy and safety of dapagliflozin in patients with type 2 diabetes and moderate renal impairment (chronic kidney disease stage 3A): The DERIVE Study.

Fioretto P, Del Prato S, Buse JB, Goldenberg R, Giorgino F, Reyner D, Langkilde AM, Sjöström CD, Sartipy P; DERIVE Study Investigators.

Diabetes Obes Metab. 2018 Nov;20(11):2532-2540. doi: 10.1111/dom.13413. Epub 2018 Jul 10. Erratum in: Diabetes Obes Metab. 2019 Jan;21(1):203.

5.

Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data.

Holmgren G, Sartipy P, Andersson CX, Lindahl A, Synnergren J.

Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.

PMID:
29385562
6.

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue.

Ghosheh N, Küppers-Munther B, Asplund A, Edsbagge J, Ulfenborg B, Andersson TB, Björquist P, Andersson CX, Carén H, Simonsson S, Sartipy P, Synnergren J.

Physiol Genomics. 2017 Aug 1;49(8):430-446. doi: 10.1152/physiolgenomics.00007.2017. Epub 2017 Jul 10.

7.

A data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells.

Ulfenborg B, Karlsson A, Riveiro M, Améen C, Åkesson K, Andersson CX, Sartipy P, Synnergren J.

PLoS One. 2017 Jun 27;12(6):e0179613. doi: 10.1371/journal.pone.0179613. eCollection 2017.

8.

Dapagliflozin in patients with type II diabetes mellitus, with and without elevated triglyceride and reduced high-density lipoprotein cholesterol levels.

Bays HE, Sartipy P, Xu J, Sjöström CD, Underberg JA.

J Clin Lipidol. 2017 Mar - Apr;11(2):450-458.e1. doi: 10.1016/j.jacl.2017.01.018. Epub 2017 Feb 10.

PMID:
28502502
9.

Comparative transcriptomic analysis identifies genes differentially expressed in human epicardial progenitors and hiPSC-derived cardiac progenitors.

Synnergren J, Drowley L, Plowright AT, Brolén G, Goumans MJ, Gittenberger-de Groot AC, Sartipy P, Wang QD.

Physiol Genomics. 2016 Nov 1;48(11):771-784. doi: 10.1152/physiolgenomics.00064.2016. Epub 2016 Sep 2.

10.

MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.

Holmgren G, Synnergren J, Andersson CX, Lindahl A, Sartipy P.

Toxicol In Vitro. 2016 Aug;34:26-34. doi: 10.1016/j.tiv.2016.03.009. Epub 2016 Apr 6.

PMID:
27033315
11.

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.

Ghosheh N, Olsson B, Edsbagge J, Küppers-Munther B, Van Giezen M, Asplund A, Andersson TB, Björquist P, Carén H, Simonsson S, Sartipy P, Synnergren J.

Stem Cells Int. 2016;2016:8648356. doi: 10.1155/2016/8648356. Epub 2016 Feb 1.

12.

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis.

Pradip A, Steel D, Jacobsson S, Holmgren G, Ingelman-Sundberg M, Sartipy P, Björquist P, Johansson I, Edsbagge J.

Stem Cells Int. 2016;2016:2475631. doi: 10.1155/2016/2475631. Epub 2016 Jan 5.

13.

One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells.

Asplund A, Pradip A, van Giezen M, Aspegren A, Choukair H, Rehnström M, Jacobsson S, Ghosheh N, El Hajjam D, Holmgren S, Larsson S, Benecke J, Butron M, Wigander A, Noaksson K, Sartipy P, Björquist P, Edsbagge J, Küppers-Munther B.

Stem Cell Rev. 2016 Feb;12(1):90-104. doi: 10.1007/s12015-015-9621-9.

PMID:
26385115
14.

Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters.

Kunze A, Steel D, Dahlenborg K, Sartipy P, Svedhem S.

PLoS One. 2015 May 11;10(5):e0125540. doi: 10.1371/journal.pone.0125540. eCollection 2015.

15.

Identification of stable reference genes in differentiating human pluripotent stem cells.

Holmgren G, Ghosheh N, Zeng X, Bogestål Y, Sartipy P, Synnergren J.

Physiol Genomics. 2015 Jun;47(6):232-9. doi: 10.1152/physiolgenomics.00130.2014. Epub 2015 Apr 7.

PMID:
25852171
16.

Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells.

Holmgren G, Synnergren J, Bogestål Y, Améen C, Åkesson K, Holmgren S, Lindahl A, Sartipy P.

Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.

17.

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes.

Holmgren G, Sjögren AK, Barragan I, Sabirsh A, Sartipy P, Synnergren J, Björquist P, Ingelman-Sundberg M, Andersson TB, Edsbagge J.

Drug Metab Dispos. 2014 Sep;42(9):1401-6. doi: 10.1124/dmd.114.059154. Epub 2014 Jun 30.

PMID:
24980256
18.

Employment of the Triple Helix concept for development of regenerative medicine applications based on human pluripotent stem cells.

Sartipy P, Björquist P.

Clin Transl Med. 2014 May 9;3:9. doi: 10.1186/2001-1326-3-9. eCollection 2014. Review.

19.

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip.

Kaneko T, Nomura F, Hamada T, Abe Y, Takamori H, Sakakura T, Takasuna K, Sanbuissho A, Hyllner J, Sartipy P, Yasuda K.

Sci Rep. 2014 Apr 22;4:4670. doi: 10.1038/srep04670.

20.

Can stem-cell-derived models revolutionize drug discovery?

Landgren H, Sartipy P.

Expert Opin Drug Discov. 2014 Jan;9(1):9-13. doi: 10.1517/17460441.2014.867945. Epub 2013 Dec 6.

PMID:
24308376
21.

A novel 3D label-free monitoring system of hES-derived cardiomyocyte clusters: a step forward to in vitro cardiotoxicity testing.

Jahnke HG, Steel D, Fleischer S, Seidel D, Kurz R, Vinz S, Dahlenborg K, Sartipy P, Robitzki AA.

PLoS One. 2013 Jul 8;8(7):e68971. doi: 10.1371/journal.pone.0068971. Print 2013.

22.

Advancing pluripotent stem cell culture: it is a matter of setting the standard.

Sartipy P.

Stem Cells Dev. 2013 Apr 15;22(8):1159-61. doi: 10.1089/scd.2012.0668. Epub 2013 Jan 18.

23.

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.

Jonsson MK, Vos MA, Mirams GR, Duker G, Sartipy P, de Boer TP, van Veen TA.

J Mol Cell Cardiol. 2012 May;52(5):998-1008. doi: 10.1016/j.yjmcc.2012.02.002. Epub 2012 Feb 14.

PMID:
22353256
24.

Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue.

Synnergren J, Améen C, Jansson A, Sartipy P.

Physiol Genomics. 2012 Feb 27;44(4):245-58. doi: 10.1152/physiolgenomics.00118.2011. Epub 2011 Dec 13.

PMID:
22166955
25.

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.

Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.

Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x.

26.

Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment.

Sartipy P, Björquist P.

Stem Cells. 2011 May;29(5):744-8. doi: 10.1002/stem.631. Review.

27.

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.

Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, Asp J, Arain S, Kraushaar U, Bremer S, Class R, Sartipy P.

J Appl Toxicol. 2011 Apr;31(3):191-205. doi: 10.1002/jat.1663. Epub 2011 Feb 16. Review.

PMID:
21328588
28.

Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissue.

Synnergren J, Améen C, Lindahl A, Olsson B, Sartipy P.

Physiol Genomics. 2011 May 1;43(10):581-94. doi: 10.1152/physiolgenomics.00074.2010. Epub 2010 Sep 14.

PMID:
20841501
29.

Cardiomyocyte clusters derived from human embryonic stem cells share similarities with human heart tissue.

Asp J, Steel D, Jonsson M, Améen C, Dahlenborg K, Jeppsson A, Lindahl A, Sartipy P.

J Mol Cell Biol. 2010 Oct;2(5):276-83. doi: 10.1093/jmcb/mjq022. Epub 2010 Aug 27.

PMID:
20802012
30.

Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells.

Andersson H, Steel D, Asp J, Dahlenborg K, Jonsson M, Jeppsson A, Lindahl A, Kågedal B, Sartipy P, Mandenius CF.

J Biotechnol. 2010 Oct 1;150(1):175-81. doi: 10.1016/j.jbiotec.2010.06.023. Epub 2010 Jul 13.

PMID:
20633583
31.

Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.

Jonsson MK, Duker G, Tropp C, Andersson B, Sartipy P, Vos MA, van Veen TA.

Stem Cell Res. 2010 May;4(3):189-200. doi: 10.1016/j.scr.2010.02.001. Epub 2010 Feb 17.

32.

Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications.

Vidarsson H, Hyllner J, Sartipy P.

Stem Cell Rev. 2010 Mar;6(1):108-20. doi: 10.1007/s12015-010-9113-x. Review.

PMID:
20091143
33.

Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further toward the hepatic lineage.

Synnergren J, Heins N, Brolén G, Eriksson G, Lindahl A, Hyllner J, Olsson B, Sartipy P, Björquist P.

Stem Cells Dev. 2010 Jul;19(7):961-78. doi: 10.1089/scd.2009.0220.

PMID:
19757991
34.

Regulation of 'stemness' and stem cell differentiation by microRNAs.

Sartipy P, Olsson B, Hyllner J, Synnergren J.

IDrugs. 2009 Aug;12(8):492-6. Review.

PMID:
19629883
35.

Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes.

Jonsson MK, van Veen TA, Goumans MJ, Vos MA, Duker G, Sartipy P.

Expert Opin Drug Discov. 2009 Apr;4(4):357-72. doi: 10.1517/17460440902794912.

PMID:
23485039
36.

Cardiomyocytes derived from human embryonic stem cells - characteristics and utility for drug discovery.

Steel D, Hyllner J, Sartipy P.

Curr Opin Drug Discov Devel. 2009 Jan;12(1):133-40. Review.

PMID:
19152222
37.

Low molecular weight compounds for in vitro fate determination of human embryonic stem cells.

Sartipy P, Strehl R, Björquist P, Hyllner J.

Pharmacol Res. 2008 Aug;58(2):152-7. doi: 10.1016/j.phrs.2008.06.002. Epub 2008 Jun 8. Review.

PMID:
18586099
38.

Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells.

Synnergren J, Akesson K, Dahlenborg K, Vidarsson H, Améen C, Steel D, Lindahl A, Olsson B, Sartipy P.

Stem Cells. 2008 Jul;26(7):1831-40. doi: 10.1634/stemcells.2007-1033. Epub 2008 Apr 24.

39.

Cardiomyogenic gene expression profiling of differentiating human embryonic stem cells.

Synnergren J, Adak S, Englund MC, Giesler TL, Noaksson K, Lindahl A, Nilsson P, Nelson D, Abbot S, Olsson B, Sartipy P.

J Biotechnol. 2008 Mar 20;134(1-2):162-70. doi: 10.1016/j.jbiotec.2007.11.011. Epub 2007 Dec 14.

PMID:
18241947
40.

The application of human embryonic stem cell technologies to drug discovery.

Sartipy P, Björquist P, Strehl R, Hyllner J.

Drug Discov Today. 2007 Sep;12(17-18):688-99. Epub 2007 Aug 30. Review.

PMID:
17826681
41.

New cell models and assays in cardiac safety profiling.

Meyer T, Sartipy P, Blind F, Leisgen C, Guenther E.

Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):507-17. Review.

PMID:
17696802
42.

Human embryonic stem cells: current technologies and emerging industrial applications.

Améen C, Strehl R, Björquist P, Lindahl A, Hyllner J, Sartipy P.

Crit Rev Oncol Hematol. 2008 Jan;65(1):54-80. Epub 2007 Aug 6. Review.

PMID:
17689256
43.

Differentiating human embryonic stem cells express a unique housekeeping gene signature.

Synnergren J, Giesler TL, Adak S, Tandon R, Noaksson K, Lindahl A, Nilsson P, Nelson D, Olsson B, Englund MC, Abbot S, Sartipy P.

Stem Cells. 2007 Feb;25(2):473-80.

44.

Molecular and pharmacological properties of human embryonic stem cell-derived cardiomyocytes.

Norström A, Akesson K, Hardarson T, Hamberger L, Björquist P, Sartipy P.

Exp Biol Med (Maywood). 2006 Dec;231(11):1753-62.

PMID:
17138763
45.

Pluripotent human stem cells as novel tools in drug discovery and toxicity testing.

Sartipy P, Bjorquist P, Strehl R, Hyllner J.

IDrugs. 2006 Oct;9(10):702-5.

PMID:
17016777
46.

Human embryonic stem cells have a unique epigenetic signature.

Bibikova M, Chudin E, Wu B, Zhou L, Garcia EW, Liu Y, Shin S, Plaia TW, Auerbach JM, Arking DE, Gonzalez R, Crook J, Davidson B, Schulz TC, Robins A, Khanna A, Sartipy P, Hyllner J, Vanguri P, Savant-Bhonsale S, Smith AK, Chakravarti A, Maitra A, Rao M, Barker DL, Loring JF, Fan JB.

Genome Res. 2006 Sep;16(9):1075-83. Epub 2006 Aug 9.

47.

Stem cells and regenerative medicine 2006 -- first international meeting.

Sartipy P.

IDrugs. 2006 Mar;9(3):151-3. No abstract available.

PMID:
16523372
48.

Clonal derivation and characterization of human embryonic stem cell lines.

Heins N, Lindahl A, Karlsson U, Rehnström M, Caisander G, Emanuelsson K, Hanson C, Semb H, Björquist P, Sartipy P, Hyllner J.

J Biotechnol. 2006 Apr 20;122(4):511-20. Epub 2005 Dec 1.

PMID:
16324761
49.

Genomic alterations in cultured human embryonic stem cells.

Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui S, Carpenter M, Gazdar AF, Rao M, Chakravarti A.

Nat Genet. 2005 Oct;37(10):1099-103. Epub 2005 Sep 4.

PMID:
16142235
50.

Monitoring differentiation of human embryonic stem cells using real-time PCR.

Noaksson K, Zoric N, Zeng X, Rao MS, Hyllner J, Semb H, Kubista M, Sartipy P.

Stem Cells. 2005 Nov-Dec;23(10):1460-7. Epub 2005 Aug 4.

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