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Items: 1 to 50 of 82

1.

New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an in vivo BRET-based discovery platform.

Sartini S, Levati E, Maccesi M, Guerra M, Spadoni G, Bach S, Benincasa M, Scocchi M, Ottonello S, Rivara S, Montanini B.

ACS Chem Biol. 2019 Jul 16. doi: 10.1021/acschembio.9b00178. [Epub ahead of print]

PMID:
31310497
2.

Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation.

Quattrini L, Coviello V, Sartini S, Di Desidero T, Orlandi P, Ke YY, Liu KL, Hsieh HP, Bocci G, La Motta C.

Sci Rep. 2019 Jul 9;9(1):9943. doi: 10.1038/s41598-019-46287-5.

3.

Muscle activity prevents the uncoupling of mitochondria from Ca2+ Release Units induced by ageing and disuse.

Pietrangelo L, Michelucci A, Ambrogini P, Sartini S, Guarnier FA, Fusella A, Zamparo I, Mammucari C, Protasi F, Boncompagni S.

Arch Biochem Biophys. 2019 Mar 15;663:22-33. doi: 10.1016/j.abb.2018.12.017. Epub 2018 Dec 20.

4.

Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors.

Balestri F, Quattrini L, Coviello V, Sartini S, Da Settimo F, Cappiello M, Moschini R, Del Corso A, Mura U, La Motta C.

Cell Chem Biol. 2018 Nov 15;25(11):1414-1418.e3. doi: 10.1016/j.chembiol.2018.07.008. Epub 2018 Aug 16.

PMID:
30122369
5.

Microcirculatory Impairment Is Associated With Multiple Organ Dysfunction Following Traumatic Hemorrhagic Shock: The MICROSHOCK Study.

Hutchings SD, Naumann DN, Hopkins P, Mellis C, Riozzi P, Sartini S, Mamuza J, Harris T, Midwinter MJ, Wendon J.

Crit Care Med. 2018 Sep;46(9):e889-e896. doi: 10.1097/CCM.0000000000003275.

PMID:
29957708
6.

Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.

La Pietra V, Sartini S, Botta L, Antonelli A, Ferrari SM, Fallahi P, Moriconi A, Coviello V, Quattrini L, Ke YY, Hsing-Pang H, Da Settimo F, Novellino E, La Motta C, Marinelli L.

Eur J Med Chem. 2018 Apr 25;150:491-505. doi: 10.1016/j.ejmech.2018.02.080. Epub 2018 Mar 2.

PMID:
29549836
7.

An undefined acute respiratory failure: a peculiar case of lymphoma presentation.

Sartini S, Aspesi G, Segalerba MP, Bertin A, Murialdo G.

Intern Emerg Med. 2018 Mar;13(2):291-292. doi: 10.1007/s11739-017-1733-6. Epub 2017 Aug 11. No abstract available.

PMID:
28801745
8.

Correlates of frailty phenotype and frailty index and their associations with clinical outcomes.

Guaraldi G, Malagoli A, Theou O, Brothers TD, Wallace L, Torelli R, Mussini C, Sartini S, Kirkland SA, Rockwood K.

HIV Med. 2017 Nov;18(10):764-771. doi: 10.1111/hiv.12527. Epub 2017 Jul 24.

PMID:
28737297
9.

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold.

Digiacomo M, Sartini S, Nesi G, Sestito S, Coviello V, La Motta C, Rapposelli S.

Open Med Chem J. 2017 Jan 31;11:9-23. doi: 10.2174/1874104501711010009. eCollection 2017.

10.

Potential Roles of Kleinhovia hospita L. Leaf Extract in Reducing Doxorubicin Acute Hepatic, Cardiac and Renal Toxicities in Rats.

Djabir YY, Arsyad MA, Sartini S, Lallo S.

Pharmacognosy Res. 2017 Apr-Jun;9(2):168-173. doi: 10.4103/pr.pr_129_16.

11.

Cyclodextrin-based nanosponges for the targeted delivery of the anti-restenotic agent DB103: A novel opportunity for the local therapy of vessels wall subjected to percutaneous intervention.

Coviello V, Sartini S, Quattrini L, Baraldi C, Gamberini MC, La Motta C.

Eur J Pharm Biopharm. 2017 Aug;117:276-285. doi: 10.1016/j.ejpb.2017.04.028. Epub 2017 Apr 26.

PMID:
28456606
12.

N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.

Nencetti S, La Motta C, Rossello A, Sartini S, Nuti E, Ciccone L, Orlandini E.

Bioorg Med Chem. 2017 Jun 15;25(12):3068-3076. doi: 10.1016/j.bmc.2017.03.056. Epub 2017 Mar 28.

PMID:
28392277
13.

Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)-Based Assay in Yeast.

Corbel C, Sartini S, Levati E, Colas P, Maillet L, Couturier C, Montanini B, Bach S.

SLAS Discov. 2017 Jul;22(6):751-759. doi: 10.1177/2472555216689530. Epub 2017 Jan 31.

PMID:
28346092
14.

FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells.

Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I.

Cancer Res. 2016 Dec 15;76(24):7219-7230. Epub 2016 Aug 28.

15.

Dry and wet approaches for genome-wide functional annotation of conventional and unconventional transcriptional activators.

Levati E, Sartini S, Ottonello S, Montanini B.

Comput Struct Biotechnol J. 2016 Jun 29;14:262-70. doi: 10.1016/j.csbj.2016.06.004. eCollection 2016. Review.

16.

Which method is best for an early accurate diagnosis of acute heart failure? Comparison between lung ultrasound, chest X-ray and NT pro-BNP performance: a prospective study.

Sartini S, Frizzi J, Borselli M, Sarcoli E, Granai C, Gialli V, Cevenini G, Guazzi G, Bruni F, Gonnelli S, Pastorelli M.

Intern Emerg Med. 2017 Sep;12(6):861-869. doi: 10.1007/s11739-016-1498-3. Epub 2016 Jul 11.

PMID:
27401330
17.

Effect of Different Exercise Intensities on the Myotendinous Junction Plasticity.

Curzi D, Sartini S, Guescini M, Lattanzi D, Di Palma M, Ambrogini P, Savelli D, Stocchi V, Cuppini R, Falcieri E.

PLoS One. 2016 Jun 23;11(6):e0158059. doi: 10.1371/journal.pone.0158059. eCollection 2016.

18.

1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.

Coviello V, Marchi B, Sartini S, Quattrini L, Marini AM, Simorini F, Taliani S, Salerno S, Orlandi P, Fioravanti A, Desidero TD, Vullo D, Da Settimo F, Supuran CT, Bocci G, La Motta C.

J Med Chem. 2016 Jul 14;59(13):6547-52. doi: 10.1021/acs.jmedchem.6b00616. Epub 2016 Jun 27.

PMID:
27305384
19.

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis.

Consalvi S, Poce G, Ragno R, Sabatino M, La Motta C, Sartini S, Calderone V, Martelli A, Ghelardini C, Di Cesare Mannelli L, Biava M.

ChemMedChem. 2016 Aug 19;11(16):1804-11. doi: 10.1002/cmdc.201600086. Epub 2016 May 27.

PMID:
27229194
20.

Moonlighting transcriptional activation function of a fungal sulfur metabolism enzyme.

Levati E, Sartini S, Bolchi A, Ottonello S, Montanini B.

Sci Rep. 2016 Apr 28;6:25165. doi: 10.1038/srep25165.

21.

Duplex ultrasound in the early diagnosis of acute mesenteric ischemia: a longitudinal cohort multicentric study.

Sartini S, Calosi G, Granai C, Harris T, Bruni F, Pastorelli M.

Eur J Emerg Med. 2017 Dec;24(6):e21-e26. doi: 10.1097/MEJ.0000000000000378.

PMID:
26891086
22.

Effects of the New Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m on High Glucose Induced Prolongation of Cardiac QT Interval and Increase of Coronary Perfusion Pressure.

Di Filippo C, Ferraro B, Maisto R, Trotta MC, Di Carluccio N, Sartini S, La Motta C, Ferraraccio F, Rossi F, D'Amico M.

J Diabetes Res. 2016;2016:5281267. doi: 10.1155/2016/5281267. Epub 2015 Dec 29.

23.

Nanostructured ultra-thin patches for ultrasound-modulated delivery of anti-restenotic drug.

Vannozzi L, Ricotti L, Filippeschi C, Sartini S, Coviello V, Piazza V, Pingue P, La Motta C, Dario P, Menciassi A.

Int J Nanomedicine. 2015 Dec 23;11:69-91. doi: 10.2147/IJN.S92031. eCollection 2016.

24.

New insights into the trophic and cytoprotective effects of creatine in in vitro and in vivo models of cell maturation.

Sestili P, Ambrogini P, Barbieri E, Sartini S, Fimognari C, Calcabrini C, Diaz AR, Guescini M, Polidori E, Luchetti F, Canonico B, Lattanzi D, Cuppini R, Papa S, Stocchi V.

Amino Acids. 2016 Aug;48(8):1897-911. doi: 10.1007/s00726-015-2161-4. Epub 2016 Jan 2. Review.

PMID:
26724921
25.

Maternal creatine supplementation affects the morpho-functional development of hippocampal neurons in rat offspring.

Sartini S, Lattanzi D, Ambrogini P, Di Palma M, Galati C, Savelli D, Polidori E, Calcabrini C, Rocchi MB, Sestili P, Cuppini R.

Neuroscience. 2016 Jan 15;312:120-9. doi: 10.1016/j.neuroscience.2015.11.017. Epub 2015 Nov 17.

PMID:
26592720
26.

Pyrazolopyrimidine Derivatives as Antineoplastic Agents: with a Special Focus on Thyroid Cancer.

Ferrari SM, La Motta C, Sartini S, Baldini E, Materazzi G, Politti U, Ruffilli I, Ulisse S, Miccoli P, Antonelli A, Fallahi P.

Mini Rev Med Chem. 2016;16(2):86-93. Review.

PMID:
26471970
27.

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

Salerno S, Marini AM, Fornaciari G, Simorini F, La Motta C, Taliani S, Sartini S, Da Settimo F, García-Argáez AN, Gia O, Cosconati S, Novellino E, D'Ocon P, Fioravanti A, Orlandi P, Bocci G, Dalla Via L.

Eur J Med Chem. 2015 Oct 20;103:29-43. doi: 10.1016/j.ejmech.2015.08.027. Epub 2015 Aug 14.

PMID:
26318056
28.

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.

Consalvi S, Alfonso S, Di Capua A, Poce G, Pirolli A, Sabatino M, Ragno R, Anzini M, Sartini S, La Motta C, Di Cesare Mannelli L, Ghelardini C, Biava M.

Bioorg Med Chem. 2015 Feb 15;23(4):810-20. doi: 10.1016/j.bmc.2014.12.041. Epub 2014 Dec 26.

PMID:
25596758
29.

Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements.

Del Turco S, Sartini S, Cigni G, Sentieri C, Sbrana S, Battaglia D, Papa A, Da Settimo F, La Motta C, Basta G.

Food Chem. 2015 May 15;175:494-9. doi: 10.1016/j.foodchem.2014.12.005. Epub 2014 Dec 16.

PMID:
25577111
30.

Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis.

Di Filippo C, Zippo MV, Maisto R, Trotta MC, Siniscalco D, Ferraro B, Ferraraccio F, La Motta C, Sartini S, Cosconati S, Novellino E, Gesualdo C, Simonelli F, Rossi S, D'Amico M.

Mediators Inflamm. 2014;2014:857958. doi: 10.1155/2014/857958. Epub 2014 Nov 11.

31.

CLM29, a multi-target pyrazolopyrimidine derivative, has anti-neoplastic activity in medullary thyroid cancer in vitro and in vivo.

Antonelli A, Bocci G, La Motta C, Ferrari SM, Fallahi P, Corrado A, Fioravanti A, Sartini S, Orlandi P, Piaggi S, Corti A, Materazzi G, Galleri D, Ulisse S, Fontanini G, Danesi R, Da Settimo F, Miccoli P.

Mol Cell Endocrinol. 2014 Aug 5;393(1-2):56-64. doi: 10.1016/j.mce.2014.06.002. Epub 2014 Jun 12.

PMID:
24931161
32.

An alarming deterioration of neurological status.

Frizzi J, Bocchi V, Sartini S, Borselli M, Romano D, Gonnelli S, Bruni F, Pastorelli M.

Intern Emerg Med. 2014 Sep;9(6):661-4. doi: 10.1007/s11739-014-1084-5. Epub 2014 May 23. No abstract available.

PMID:
24852064
33.

Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.

Sartini S, Coviello V, Bruno A, La Pietra V, Marinelli L, Simorini F, Taliani S, Salerno S, Marini AM, Fioravanti A, Orlandi P, Antonelli A, Da Settimo F, Novellino E, Bocci G, La Motta C.

J Med Chem. 2014 Feb 27;57(4):1225-35. doi: 10.1021/jm401358b. Epub 2014 Feb 5.

PMID:
24447248
34.

CLM3, a multitarget tyrosine kinase inhibitor with antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.

Antonelli A, Bocci G, Fallahi P, La Motta C, Ferrari SM, Mancusi C, Fioravanti A, Di Desidero T, Sartini S, Corti A, Piaggi S, Materazzi G, Spinelli C, Fontanini G, Danesi R, Da Settimo F, Miccoli P.

J Clin Endocrinol Metab. 2014 Apr;99(4):E572-81. doi: 10.1210/jc.2013-2321. Epub 2014 Jan 1.

PMID:
24423321
35.

A novel 2,3-diphenyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative inhibits endothelial cell dysfunction and smooth muscle cell proliferation/activation.

Del Turco S, Sartini S, Sentieri C, Saponaro C, Navarra T, Dario B, Da Settimo F, La Motta C, Basta G.

Eur J Med Chem. 2014 Jan 24;72:102-9. doi: 10.1016/j.ejmech.2013.11.021. Epub 2013 Dec 1.

PMID:
24361522
36.

Genetic basis of congenital upper limb anomalies: analysis of 487 cases of a specialized clinic.

Carli D, Fairplay T, Ferrari P, Sartini S, Lando M, Garagnani L, Di Gennaro GL, Di Pancrazio L, Bianconi G, Elmakky A, Bernasconi S, Landi A, Percesepe A.

Birth Defects Res A Clin Mol Teratol. 2013 Dec;97(12):798-805. doi: 10.1002/bdra.23212.

PMID:
24343878
37.

PMMA/polysaccharides nanofilm loaded with adenosine deaminase inhibitor for targeted anti-inflammatory drug delivery.

Redolfi Riva E, Desii A, Sartini S, La Motta C, Mazzolai B, Mattoli V.

Langmuir. 2013 Oct 29;29(43):13190-7. doi: 10.1021/la402229k. Epub 2013 Oct 14.

PMID:
24073802
38.

A new approach to control the enigmatic activity of aldose reductase.

Del-Corso A, Balestri F, Di Bugno E, Moschini R, Cappiello M, Sartini S, La-Motta C, Da-Settimo F, Mura U.

PLoS One. 2013 Sep 3;8(9):e74076. doi: 10.1371/journal.pone.0074076. eCollection 2013.

39.

Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).

Perspicace E, Jouan-Hureaux V, Ragno R, Ballante F, Sartini S, La Motta C, Da Settimo F, Chen B, Kirsch G, Schneider S, Faivre B, Hesse S.

Eur J Med Chem. 2013 May;63:765-81. doi: 10.1016/j.ejmech.2013.03.022. Epub 2013 Mar 19.

PMID:
23583911
40.

Microvascular abnormalities in Rett syndrome.

Bianciardi G, Acampa M, Lamberti I, Sartini S, Servi M, Biagi F, Bocchi V, Hayek J, Pastorelli M.

Clin Hemorheol Microcirc. 2013 Jan 1;54(1):109-13. doi: 10.3233/CH-131707.

PMID:
23481597
41.

Effectiveness of cast immobilization in comparison to the gold-standard self-removal orthotic intervention for closed mallet fingers: a randomized clinical trial.

Tocco S, Boccolari P, Landi A, Leonelli C, Mercanti C, Pogliacomi F, Sartini S, Zingarello L, Nedelec B.

J Hand Ther. 2013 Jul-Sep;26(3):191-200; quiz 201. doi: 10.1016/j.jht.2013.01.004. Epub 2013 Feb 27.

PMID:
23453367
42.

Motor activity affects adult skeletal muscle re-innervation acting via tyrosine kinase receptors.

Sartini S, Bartolini F, Ambrogini P, Betti M, Ciuffoli S, Lattanzi D, Di Palma M, Cuppini R.

Eur J Neurosci. 2013 May;37(9):1394-403. doi: 10.1111/ejn.12130. Epub 2013 Feb 3.

PMID:
23373744
43.

Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.

Sartini S, Cosconati S, Marinelli L, Barresi E, Di Maro S, Simorini F, Taliani S, Salerno S, Marini AM, Da Settimo F, Novellino E, La Motta C.

J Med Chem. 2012 Dec 13;55(23):10523-31. doi: 10.1021/jm301124s. Epub 2012 Nov 20.

PMID:
23134227
44.

Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.

Ramunno A, Cosconati S, Sartini S, Maglio V, Angiuoli S, La Pietra V, Di Maro S, Giustiniano M, La Motta C, Da Settimo F, Marinelli L, Novellino E.

Eur J Med Chem. 2012 May;51:216-26. doi: 10.1016/j.ejmech.2012.02.045. Epub 2012 Mar 5.

PMID:
22436396
45.

[Scaphoidectomy (instead of trapezectomy) in the treatment of rhizoarthrosis. Report of a case].

Marcuzzi A, Lando M, Sartini S, Petit A.

Chir Main. 2012 Feb;31(1):30-3. doi: 10.1016/j.main.2012.01.007. Epub 2012 Feb 3. French.

PMID:
22365318
46.

CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.

Antonelli A, Bocci G, La Motta C, Ferrari SM, Fallahi P, Ruffilli I, Di Domenicantonio A, Fioravanti A, Sartini S, Minuto M, Piaggi S, Corti A, Alì G, Di Desidero T, Berti P, Fontanini G, Danesi R, Da Settimo F, Miccoli P.

J Clin Endocrinol Metab. 2012 Apr;97(4):E528-36. doi: 10.1210/jc.2011-1987. Epub 2012 Jan 25.

PMID:
22278419
47.

Sampling protein motion and solvent effect during ligand binding.

Limongelli V, Marinelli L, Cosconati S, La Motta C, Sartini S, Mugnaini L, Da Settimo F, Novellino E, Parrinello M.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1467-72. doi: 10.1073/pnas.1112181108. Epub 2012 Jan 11.

48.

Geometrically constrained derivatives of indolylglyoxylamides as ligands binding the GABAA/BzR complex.

Sartini S, Morelli M, Simorini F, Taliani S, Salerno S, Marini AM, Da Settimo F, La Motta C.

Curr Top Med Chem. 2012;12(4):312-20. Review.

PMID:
22204489
49.

Creatine affects in vitro electrophysiological maturation of neuroblasts and protects them from oxidative stress.

Sartini S, Sestili P, Colombo E, Martinelli C, Bartolini F, Ciuffoli S, Lattanzi D, Sisti D, Cuppini R.

J Neurosci Res. 2012 Feb;90(2):435-46. doi: 10.1002/jnr.22762. Epub 2011 Sep 21.

PMID:
21948019
50.

Receptor tyrosine kinase kit and gastrointestinal stromal tumours: an overview.

Sartini S, Dario B, Morelli M, Da Settimo F, La Motta C.

Curr Med Chem. 2011;18(19):2893-903. Review.

PMID:
21651490

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