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Items: 23


Developing lipid nanoparticle-based siRNA therapeutics for hepatocellular carcinoma using an integrated approach.

Li L, Wang R, Wilcox D, Sarthy A, Lin X, Huang X, Tian L, Dande P, Hubbard RD, Hansen TM, Wada C, Zhao X, Kohlbrenner WM, Fesik SW, Shen Y.

Mol Cancer Ther. 2013 Nov;12(11):2308-18. doi: 10.1158/1535-7163.MCT-12-0983-T. Epub 2013 Aug 13.


Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

Morgan-Lappe SE, Tucker LA, Huang X, Zhang Q, Sarthy AV, Zakula D, Vernetti L, Schurdak M, Wang J, Fesik SW.

Cancer Res. 2007 May 1;67(9):4390-8.


Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, Warner RB, Ng SC, Fesik SW, Elmore SW, Rosenberg SH, Tse C.

Cancer Res. 2007 Feb 1;67(3):1176-83.


Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

Sarthy AV, Morgan-Lappe SE, Zakula D, Vernetti L, Schurdak M, Packer JC, Anderson MG, Shirasawa S, Sasazuki T, Fesik SW.

Mol Cancer Ther. 2007 Jan;6(1):269-76.


Specificity of short interfering RNA determined through gene expression signatures.

Semizarov D, Frost L, Sarthy A, Kroeger P, Halbert DN, Fesik SW.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6347-52. Epub 2003 May 13.


Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells.

Chen J, Jin S, Tahir SK, Zhang H, Liu X, Sarthy AV, McGonigal TP, Liu Z, Rosenberg SH, Ng SC.

J Biol Chem. 2003 Jan 3;278(1):486-90. Epub 2002 Nov 4.


Species specificity of amidine-based urokinase inhibitors.

Klinghofer V, Stewart K, McGonigal T, Smith R, Sarthy A, Nienaber V, Butler C, Dorwin S, Richardson P, Weitzberg M, Wendt M, Rockway T, Zhao X, Hulkower KI, Giranda VL.

Biochemistry. 2001 Aug 7;40(31):9125-31.


Antifungal rapamycin analogues with reduced immunosuppressive activity.

Dickman DA, Ding H, Li Q, Nilius AM, Balli DJ, Ballaron SJ, Trevillyan JM, Smith ML, Seif LS, Kim K, Sarthy A, Goldman RC, Plattner JJ, Bennani YL.

Bioorg Med Chem Lett. 2000 Jul 3;10(13):1405-8.


Domain structure analysis of elongation factor-3 from Saccharomyces cerevisiae by limited proteolysis and differential scanning calorimetry.

Ladror US, Egan DA, Snyder SW, Capobianco JO, Goldman RC, Dorwin SA, Johnson RW, Edalji R, Sarthy AV, McGonigal T, Walter KA, Holzman TF.

Protein Sci. 1998 Dec;7(12):2595-601.


Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae.

Sarthy AV, McGonigal T, Capobianco JO, Schmidt M, Green SR, Moehle CM, Goldman RC.

Yeast. 1998 Feb;14(3):239-53. Erratum in: Yeast 1998 Jun 15;14(8):792.


Construction of a sorbitol-based vector for expression of heterologous proteins in Saccharomyces cerevisiae.

McGonigal T, Bodelle P, Schopp C, Sarthy AV.

Appl Environ Microbiol. 1998 Feb;64(2):793-4.


High-level overexpression of yeast elongation factor 3 and detailed kinetic analysis using a coupled spectrophotometric assay.

Sarthy AV, McGonigal T, Capobianco JO, Holzman TH, Walter KA, Egan DA, Goldman RC.

Anal Biochem. 1997 Dec 15;254(2):288-90. No abstract available.


Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase.

Sarthy AV, McGonigal T, Coen M, Frost DJ, Meulbroek JA, Goldman RC.

Microbiology. 1997 Feb;143 ( Pt 2):367-76.


Identification of the gene encoding DNA topoisomerase I from Candida albicans.

Taylor A, Giles K, Sarthy AV, McGonigal T, Fostel J.

FEMS Microbiol Lett. 1996 May 1;138(2-3):113-21.


Construction of a human DNA library in a circular centromere-based yeast plasmid.

McGonigal T, Bodelle P, Schopp C, Sarthy AV.

Gene. 1995 Apr 3;155(2):267-71.


Expression of the Escherichia coli xylose isomerase gene in Saccharomyces cerevisiae.

Sarthy AV, McConaughy BL, Lobo Z, Sundstrom JA, Furlong CE, Hall BD.

Appl Environ Microbiol. 1987 Sep;53(9):1996-2000.


Xylose isomerase from Escherichia coli. Characterization of the protein and the structural gene.

Schellenberg GD, Sarthy A, Larson AE, Backer MP, Crabb JW, Lidstrom M, Hall BD, Furlong CE.

J Biol Chem. 1984 Jun 10;259(11):6826-32.


Regulation of metallothionein--thymidine kinase fusion plasmids injected into mouse eggs.

Brinster RL, Chen HY, Warren R, Sarthy A, Palmiter RD.

Nature. 1982 Mar 4;296(5852):39-42.


Deletion map of the Escherichia coli structural gene for alkaline phosphatase, phoA.

Sarthy A, Michaelis S, Beckwith J.

J Bacteriol. 1981 Jan;145(1):288-92.


Use of gene fusions to determine a partial signal sequence of alkaline phosphatase.

Sarthy A, Fowler A, Zabin I, Beckwith J.

J Bacteriol. 1979 Sep;139(3):932-9.

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