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Items: 1 to 50 of 119

1.

A Case for Bond-Network Analysis in Bridged Polycyclic Complex Molecule Synthesis: Hetidine and Hetisine Diterpenoid Alkaloids.

Doering NA, Sarpong R, Hoffmann RW.

Angew Chem Int Ed Engl. 2019 Dec 5. doi: 10.1002/anie.201909656. [Epub ahead of print]

PMID:
31808282
2.

Bio-inspired synthesis of xishacorenes A, B, and C, and a new congener from fuscol.

Rovira AR, Müller N, Deng W, Ndubaku C, Sarpong R.

Chem Sci. 2019 Jul 3;10(33):7788-7791. doi: 10.1039/c9sc02572c. eCollection 2019 Sep 7.

3.

Calyciphylline B-type Alkaloids: Evolution of a Synthetic Strategy to (-)-Daphlongamine H.

Hugelshofer CL, Palani V, Sarpong R.

J Org Chem. 2019 Nov 1;84(21):14069-14091. doi: 10.1021/acs.joc.9b02223. Epub 2019 Oct 2.

PMID:
31533427
4.

Enantiospecific Entry to a Common Decalin Intermediate for the Syntheses of Highly Oxygenated Terpenoids.

Nagasawa S, Jones KE, Sarpong R.

J Org Chem. 2019 Sep 20;84(18):12209-12215. doi: 10.1021/acs.joc.9b01937. Epub 2019 Sep 11.

PMID:
31454485
5.

A Unified Strategy for the Enantiospecific Total Synthesis of Delavatine A and Formal Synthesis of Incarviatone A.

Palani V, Hugelshofer CL, Sarpong R.

J Am Chem Soc. 2019 Sep 11;141(36):14421-14432. doi: 10.1021/jacs.9b07693. Epub 2019 Sep 3.

PMID:
31433634
6.

Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti-Fungal Properties.

Pfaffenbach M, Bakanas I, O'Connor NR, Herrick JL, Sarpong R.

Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15304-15308. doi: 10.1002/anie.201908399. Epub 2019 Sep 12.

PMID:
31419367
7.

Total Synthesis of the Diterpenoid Alkaloid Arcutinidine Using a Strategy Inspired by Chemical Network Analysis.

Owens KR, McCowen SV, Blackford KA, Ueno S, Hirooka Y, Weber M, Sarpong R.

J Am Chem Soc. 2019 Sep 4;141(35):13713-13717. doi: 10.1021/jacs.9b05815. Epub 2019 Aug 21.

PMID:
31276621
8.

Copper-Catalyzed [4+2] Cycloaddition of 9 H-Cyclohepta[ b]pyridine-9-one and Electron-Rich Alkenes.

Gritsch PJ, Gimenez-Nueno I, Wonilowicz L, Sarpong R.

J Org Chem. 2019 Jul 5;84(13):8717-8723. doi: 10.1021/acs.joc.9b00899. Epub 2019 Jun 20.

PMID:
31244151
9.

Calyciphylline B-Type Alkaloids: Total Syntheses of (-)-Daphlongamine H and (-)-Isodaphlongamine H.

Hugelshofer CL, Palani V, Sarpong R.

J Am Chem Soc. 2019 May 29;141(21):8431-8435. doi: 10.1021/jacs.9b03576. Epub 2019 May 16.

10.

A Late-Stage Functionalization Approach to Derivatives of the Pyrano[3,2- a]carbazole Natural Products.

Norseeda K, Gasser V, Sarpong R.

J Org Chem. 2019 May 3;84(9):5965-5973. doi: 10.1021/acs.joc.9b00631. Epub 2019 Apr 17.

PMID:
30969773
11.

Charting a course for chemistry.

Aspuru-Guzik A, Baik MH, Balasubramanian S, Banerjee R, Bart S, Borduas-Dedekind N, Chang S, Chen P, Corminboeuf C, Coudert FX, Cronin L, Crudden C, Cuk T, Doyle AG, Fan C, Feng X, Freedman D, Furukawa S, Ghosh S, Glorius F, Jeffries-El M, Katsonis N, Li A, Linse SS, Marchesan S, Maulide N, Milo A, Narayan ARH, Naumov P, Nevado C, Nyokong T, Palacin R, Reid M, Robinson C, Robinson G, Sarpong R, Schindler C, Schlau-Cohen GS, Schmidt TW, Sessoli R, Shao-Horn Y, Sleiman H, Sutherland J, Taylor A, Tezcan A, Tortosa M, Walsh A, Watson AJB, Weckhuysen BM, Weiss E, Wilson D, Yam VW, Yang X, Ying JY, Yoon T, You SL, Zarbin AJG, Zhang H.

Nat Chem. 2019 Apr;11(4):286-294. doi: 10.1038/s41557-019-0236-7. No abstract available.

PMID:
30903035
12.

Total Synthesis of Pentacyclic (-)-Ambiguine P Using Sequential Indole Functionalizations.

Johnson RE, Ree H, Hartmann M, Lang L, Sawano S, Sarpong R.

J Am Chem Soc. 2019 Feb 13;141(6):2233-2237. doi: 10.1021/jacs.8b13388. Epub 2019 Feb 4.

13.

Mixed-methods approach to exploring patients' perspectives on the acceptability of a urinary biomarker test in replacing cystoscopy for bladder cancer surveillance.

Tan WS, Teo CH, Chan D, Heinrich M, Feber A, Sarpong R, Allan J, Williams N, Brew-Graves C, Ng CJ, Kelly JD; DETECT II trial collaborators.

BJU Int. 2019 Sep;124(3):408-417. doi: 10.1111/bju.14690. Epub 2019 Mar 4.

14.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

15.

A Short Synthesis of Delavatine A Unveils New Insights into Site-Selective Cross-Coupling of 3,5-Dibromo-2-pyrone.

Palani V, Hugelshofer CL, Kevlishvili I, Liu P, Sarpong R.

J Am Chem Soc. 2019 Feb 13;141(6):2652-2660. doi: 10.1021/jacs.8b13012. Epub 2019 Jan 30.

16.

Deconstructive diversification of cyclic amines.

Roque JB, Kuroda Y, Göttemann LT, Sarpong R.

Nature. 2018 Dec;564(7735):244-248. doi: 10.1038/s41586-018-0700-3. Epub 2018 Oct 31.

17.

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids.

Doering NA, Kou KGM, Norseeda K, Lee JC, Marth CJ, Gallego GM, Sarpong R.

J Org Chem. 2018 Oct 19;83(20):12911-12920. doi: 10.1021/acs.joc.8b01967. Epub 2018 Sep 28.

18.

Correction to "Generality and Strength of Transition Metal β-Effects".

Haines BE, Sarpong R, Musaev DG.

J Am Chem Soc. 2018 Sep 26;140(38):12308. doi: 10.1021/jacs.8b09704. Epub 2018 Sep 14. No abstract available.

PMID:
30216057
19.

Robot-assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy (iROC): protocol for a randomised controlled trial with internal feasibility study.

Catto JWF, Khetrapal P, Ambler G, Sarpong R, Khan MS, Tan M, Feber A, Dixon S, Goodwin L, Williams NR, McGrath J, Rowe E, Koupparis A, Brew-Graves C, Kelly JD.

BMJ Open. 2018 Aug 8;8(8):e020500. doi: 10.1136/bmjopen-2017-020500. Erratum in: BMJ Open. 2019 Aug 15;9(8):e020500corr1.

20.

Isolation, synthesis and bioactivity studies of phomactin terpenoids.

Kuroda Y, Nicacio KJ, da Silva-Jr IA, Leger PR, Chang S, Gubiani JR, Deflon VM, Nagashima N, Rode A, Blackford K, Ferreira AG, Sette LD, Williams DE, Andersen RJ, Jancar S, Berlinck RGS, Sarpong R.

Nat Chem. 2018 Sep;10(9):938-945. doi: 10.1038/s41557-018-0084-x. Epub 2018 Jul 30.

PMID:
30061613
21.

Generality and Strength of Transition Metal β-Effects.

Haines BE, Sarpong R, Musaev DG.

J Am Chem Soc. 2018 Aug 22;140(33):10612-10618. doi: 10.1021/jacs.8b06817. Epub 2018 Aug 7. Erratum in: J Am Chem Soc. 2018 Sep 26;140(38):12308.

PMID:
30051713
22.

Total Synthesis of (-)-Xishacorene B from ( R)-Carvone Using a C-C Activation Strategy.

Kerschgens I, Rovira AR, Sarpong R.

J Am Chem Soc. 2018 Aug 8;140(31):9810-9813. doi: 10.1021/jacs.8b05832. Epub 2018 Jul 25.

PMID:
30032603
23.

Does urinary cytology have a role in haematuria investigations?

Tan WS, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Watson D, Rane A, Hicks J, Hellawell G, Davies M, Srirangam SJ, Dawson L, Payne D, Williams N, Brew-Graves C, Feber A, Kelly JD; DETECT I trial collaborators.

BJU Int. 2019 Jan;123(1):74-81. doi: 10.1111/bju.14459. Epub 2018 Aug 29.

24.

Deconstructive fluorination of cyclic amines by carbon-carbon cleavage.

Roque JB, Kuroda Y, Göttemann LT, Sarpong R.

Science. 2018 Jul 13;361(6398):171-174. doi: 10.1126/science.aat6365.

25.

Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity.

Blümel M, Nagasawa S, Blackford K, Hare SR, Tantillo DJ, Sarpong R.

J Am Chem Soc. 2018 Jul 25;140(29):9291-9298. doi: 10.1021/jacs.8b05804. Epub 2018 Jul 13.

PMID:
29968475
26.

A Benzyne Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine).

Kou KGM, Pflueger JJ, Kiho T, Morrill LC, Fisher EL, Clagg K, Lebold TP, Kisunzu JK, Sarpong R.

J Am Chem Soc. 2018 Jul 5;140(26):8105-8109. doi: 10.1021/jacs.8b05043. Epub 2018 Jun 19.

27.

Multidomain Quantitative Recovery Following Radical Cystectomy for Patients Within the Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion Versus Open Radical Cystectomy Randomised Controlled Trial: The First 30 Patients.

Catto JWF, Khetrapal P, Ambler G, Sarpong R, Potyka I, Khan MS, Tan M, Feber A, Bourke L, Noon AP, Dixon S, Goodwin L, Williams NR, Rowe E, Kouparis A, McGrath J, Brew-Graves C, Kelly JD.

Eur Urol. 2018 Oct;74(4):531-534. doi: 10.1016/j.eururo.2018.05.008. Epub 2018 May 21. No abstract available.

PMID:
29793815
28.

Can Renal and Bladder Ultrasound Replace Computerized Tomography Urogram in Patients Investigated for Microscopic Hematuria?

Tan WS, Sarpong R, Khetrapal P, Rodney S, Mostafid H, Cresswell J, Hicks J, Rane A, Henderson A, Watson D, Cherian J, Williams N, Brew-Graves C, Feber A, Kelly JD; DETECT I Trial Collaborators.

J Urol. 2018 Nov;200(5):973-980. doi: 10.1016/j.juro.2018.04.065. Epub 2018 Apr 24.

29.

Oxazaborinines from Vinylogous N-Allylic Amides: Reactivities of Underexplored Heterocyclic Building Blocks.

Hugelshofer CL, Palani V, Sarpong R.

Org Lett. 2018 May 4;20(9):2649-2653. doi: 10.1021/acs.orglett.8b00859. Epub 2018 Apr 18.

PMID:
29667837
30.

Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients.

Tan WS, Feber A, Sarpong R, Khetrapal P, Rodney S, Jalil R, Mostafid H, Cresswell J, Hicks J, Rane A, Henderson A, Watson D, Cherian J, Williams N, Brew-Graves C, Kelly JD; DETECT I trial collaborators.

Eur Urol. 2018 Jul;74(1):10-14. doi: 10.1016/j.eururo.2018.03.008. Epub 2018 Apr 10.

PMID:
29653885
31.

Bioinspired chemical synthesis of monomeric and dimeric stephacidin A congeners.

Mukai K, de Sant'Ana DP, Hirooka Y, Mercado-Marin EV, Stephens DE, Kou KGM, Richter SC, Kelley N, Sarpong R.

Nat Chem. 2018 Jan;10(1):38-44. doi: 10.1038/nchem.2862. Epub 2017 Sep 18.

32.

Isocanthine Synthesis via Rh(III)-Catalyzed Intramolecular C-H Functionalization.

Chen AY, Lu Q, Fu Y, Sarpong R, Stoltz BM, Zhang H.

J Org Chem. 2018 Jan 5;83(1):330-337. doi: 10.1021/acs.joc.7b02731. Epub 2017 Dec 8.

PMID:
29182872
33.

DETECT I & DETECT II: a study protocol for a prospective multicentre observational study to validate the UroMark assay for the detection of bladder cancer from urinary cells.

Tan WS, Feber A, Dong L, Sarpong R, Rezaee S, Rodney S, Khetrapal P, de Winter P, Ocampo F, Jalil R, Williams NR, Brew-Graves C, Kelly JD.

BMC Cancer. 2017 Nov 15;17(1):767. doi: 10.1186/s12885-017-3758-7.

34.

Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme.

de Rond T, Stow P, Eigl I, Johnson RE, Chan LJG, Goyal G, Baidoo EEK, Hillson NJ, Petzold CJ, Sarpong R, Keasling JD.

Nat Chem Biol. 2017 Nov;13(11):1155-1157. doi: 10.1038/nchembio.2471. Epub 2017 Sep 11.

35.
36.

A Unifying Synthesis Approach to the C18-, C19-, and C20-Diterpenoid Alkaloids.

Kou KGM, Kulyk S, Marth CJ, Lee JC, Doering NA, Li BX, Gallego GM, Lebold TP, Sarpong R.

J Am Chem Soc. 2017 Oct 4;139(39):13882-13896. doi: 10.1021/jacs.7b07706. Epub 2017 Sep 20.

37.

Magnesiate Addition/Ring-Expansion Strategy To Access the 6-7-6 Tricyclic Core of Hetisine-Type C20-Diterpenoid Alkaloids.

Pflueger JJ, Morrill LC, deGruyter JN, Perea MA, Sarpong R.

Org Lett. 2017 Sep 1;19(17):4632-4635. doi: 10.1021/acs.orglett.7b02260. Epub 2017 Aug 18.

38.

Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb GP, Watts KR, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH.

J Am Chem Soc. 2017 Aug 30;139(34):12060-12068. doi: 10.1021/jacs.7b06773. Epub 2017 Aug 21.

39.

Total Synthesis of Terpenoids Employing a "Benzannulation of Carvone" Strategy: Synthesis of (-)-Crotogoudin.

Finkbeiner P, Murai K, Röpke M, Sarpong R.

J Am Chem Soc. 2017 Aug 23;139(33):11349-11352. doi: 10.1021/jacs.7b06823. Epub 2017 Aug 15.

40.

Mechanism of a No-Metal-Added Heterocycloisomerization of Alkynylcyclopropylhydrazones: Synthesis of Cycloheptane-Fused Aminopyrroles Facilitated by Copper Salts at Trace Loadings.

Wilkerson-Hill SM, Yu D, Painter PP, Fisher EL, Tantillo DJ, Sarpong R, Hein JE.

J Am Chem Soc. 2017 Aug 2;139(30):10569-10577. doi: 10.1021/jacs.7b06007. Epub 2017 Jul 20.

PMID:
28683552
41.

C-H Functionalization/activation in organic synthesis.

Sarpong R.

Beilstein J Org Chem. 2016 Nov 3;12:2315-2316. doi: 10.3762/bjoc.12.224. eCollection 2016. No abstract available.

42.

β-Carboline Amides as Intrinsic Directing Groups for C(sp2)-H Functionalization.

Viart HM, Bachmann A, Kayitare W, Sarpong R.

J Am Chem Soc. 2017 Jan 25;139(3):1325-1329. doi: 10.1021/jacs.6b12569. Epub 2017 Jan 12.

PMID:
28040899
43.

Bis(1-cyanovinyl acetate) Is a Linear Precursor to 3-Oxidopyrylium Ions.

Wilkerson-Hill SM, Sawano S, Sarpong R.

J Org Chem. 2016 Nov 18;81(22):11132-11144. Epub 2016 Nov 1.

PMID:
27740750
44.

Application of a Palladium-Catalyzed C-H Functionalization/Indolization Method to Syntheses of cis-Trikentrin A and Herbindole B.

Leal RA, Bischof C, Lee YV, Sawano S, McAtee CC, Latimer LN, Russ ZN, Dueber JE, Yu JQ, Sarpong R.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):11824-8. doi: 10.1002/anie.201605475. Epub 2016 Aug 29.

PMID:
27570932
45.

Syntheses of Denudatine Diterpenoid Alkaloids: Cochlearenine, N-Ethyl-1α-hydroxy-17-veratroyldictyzine, and Paniculamine.

Kou KG, Li BX, Lee JC, Gallego GM, Lebold TP, DiPasquale AG, Sarpong R.

J Am Chem Soc. 2016 Aug 31;138(34):10830-3. doi: 10.1021/jacs.6b07268. Epub 2016 Aug 22.

46.

Network-analysis-guided synthesis of weisaconitine D and liljestrandinine.

Marth CJ, Gallego GM, Lee JC, Lebold TP, Kulyk S, Kou KG, Qin J, Lilien R, Sarpong R.

Nature. 2015 Dec 24;528(7583):493-8. doi: 10.1038/nature16440.

47.

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C-C Bond Cleavage/Arylation Reaction.

Weber M, Owens K, Masarwa A, Sarpong R.

Org Lett. 2015 Nov 6;17(21):5432-5. doi: 10.1021/acs.orglett.5b02797. Epub 2015 Oct 20.

PMID:
26485318
48.
49.

One-pot Unsymmetrical Ketone Synthesis Employing a Pyrrole-Bearing Formal Carbonyl Dication Linchpin Reagent.

Heller ST, Newton JN, Fu T, Sarpong R.

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9839-43. doi: 10.1002/anie.201502894. Epub 2015 Jul 3.

PMID:
26138029
50.

Synthesis of Cycloprodigiosin Identifies the Natural Isolate as a Scalemic Mixture.

Johnson RE, de Rond T, Lindsay VN, Keasling JD, Sarpong R.

Org Lett. 2015 Jul 17;17(14):3474-7. doi: 10.1021/acs.orglett.5b01527. Epub 2015 Jun 26.

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