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Items: 1 to 50 of 245

1.

A novel integrated molecular and serological analysis method to predict new cases of leprosy amongst household contacts.

Gama RS, Souza MLM, Sarno EN, Moraes MO, Gonçalves A, Stefani MMA, Garcia RMG, Fraga LAO.

PLoS Negl Trop Dis. 2019 Jun 10;13(6):e0007400. doi: 10.1371/journal.pntd.0007400. [Epub ahead of print]

2.

Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.

Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL.

JCI Insight. 2019 Apr 18;4(8). pii: 126955. doi: 10.1172/jci.insight.126955. eCollection 2019 Apr 18.

3.

Neutrophils in Leprosy.

Schmitz V, Tavares IF, Pignataro P, Machado AM, Pacheco FDS, Dos Santos JB, da Silva CO, Sarno EN.

Front Immunol. 2019 Mar 19;10:495. doi: 10.3389/fimmu.2019.00495. eCollection 2019. Review.

4.

IL-26 contributes to host defense against intracellular bacteria.

Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL.

J Clin Invest. 2019 Apr 2;130:1926-1939. doi: 10.1172/JCI99550. eCollection 2019 Apr 2.

5.

Involvement of TNF-Producing CD8+ Effector Memory T Cells with Immunopathogenesis of Erythema Nodosum Leprosum in Leprosy Patients.

Silva PHL, Santos LN, Mendes MA, Nery JAC, Sarno EN, Esquenazi D.

Am J Trop Med Hyg. 2019 Feb;100(2):377-385. doi: 10.4269/ajtmh.18-0517.

PMID:
30652669
6.

Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators.

de Macedo CS, de Carvalho FM, Amaral JJ, de Mendonça Ochs S, Assis EF, Sarno EN, Bozza PT, Pessolani MCV.

Cytokine. 2018 Dec;112:87-94. doi: 10.1016/j.cyto.2018.07.008. Epub 2018 Jul 14.

PMID:
30017389
7.

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

Díaz Acosta CC, Dias AA, Rosa TLSA, Batista-Silva LR, Rosa PS, Toledo-Pinto TG, Costa FDMR, Lara FA, Rodrigues LS, Mattos KA, Sarno EN, Bozza PT, Guilhot C, de Berrêdo-Pinho M, Pessolani MCV.

PLoS Pathog. 2018 Jul 6;14(7):e1007151. doi: 10.1371/journal.ppat.1007151. eCollection 2018 Jul.

8.

Autophagy Impairment Is Associated With Increased Inflammasome Activation and Reversal Reaction Development in Multibacillary Leprosy.

de Mattos Barbosa MG, de Andrade Silva BJ, Assis TQ, da Silva Prata RB, Ferreira H, Andrade PR, da Paixão de Oliveira JA, Sperandio da Silva GM, da Costa Nery JA, Sarno EN, Pinheiro RO.

Front Immunol. 2018 Jun 4;9:1223. doi: 10.3389/fimmu.2018.01223. eCollection 2018.

9.

Chemoprophylaxis of leprosy with rifampicin in contacts of multibacillary patients: study protocol for a randomized controlled trial.

Dos Santos DS, Duppre NC, Sarno EN, Pinheiro RO, Sales AM, Nery JADC, Moraes MO, Camacho LAB.

Trials. 2018 Apr 23;19(1):244. doi: 10.1186/s13063-018-2623-6.

10.

Innate Immune Responses in Leprosy.

Pinheiro RO, Schmitz V, Silva BJA, Dias AA, de Souza BJ, de Mattos Barbosa MG, de Almeida Esquenazi D, Pessolani MCV, Sarno EN.

Front Immunol. 2018 Mar 28;9:518. doi: 10.3389/fimmu.2018.00518. eCollection 2018. Review.

11.

Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain.

Giesel LM, Pitta IJR, da Silveira RC, Andrade LR, Vital RT, Nery JADC, Hacker MAVB, Sarno EN, Rodrigues MMJ.

Am J Trop Med Hyg. 2018 Jun;98(6):1609-1613. doi: 10.4269/ajtmh.17-0817. Epub 2018 Mar 29.

12.

High frequency of M. leprae DNA detection in asymptomatic household contacts.

Gama RS, Gomides TAR, Gama CFM, Moreira SJM, de Neves Manta FS, de Oliveira LBP, Marçal PHF, Sarno EN, Moraes MO, Garcia RMG, de Oliveira Fraga LA.

BMC Infect Dis. 2018 Apr 2;18(1):153. doi: 10.1186/s12879-018-3056-2.

13.

Blood coagulation abnormalities in multibacillary leprosy patients.

Silva DSD, Teixeira LAC, Beghini DG, Ferreira ATDS, Pinho MBM, Rosa PS, Ribeiro MR, Freire MDC, Hacker MA, Nery JADC, Pessolani MCV, Tovar AMF, Sarno EN, Perales J, Bozza FA, Esquenazi D, Monteiro RQ, Lara FA.

PLoS Negl Trop Dis. 2018 Mar 22;12(3):e0006214. doi: 10.1371/journal.pntd.0006214. eCollection 2018 Mar.

14.

Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy.

Marçal PHF, Fraga LAO, Mattos AMM, Menegati L, Coelho ADCO, Pinheiro RO, Sarno EN, Duthie MS, Teixeira HC.

Mem Inst Oswaldo Cruz. 2018;113(5):e170467. doi: 10.1590/0074-02760170467. Epub 2018 Feb 26.

15.

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.

Benjak A, Avanzi C, Singh P, Loiseau C, Girma S, Busso P, Fontes ANB, Miyamoto Y, Namisato M, Bobosha K, Salgado CG, da Silva MB, Bouth RC, Frade MAC, Filho FB, Barreto JG, Nery JAC, Bührer-Sékula S, Lupien A, Al-Samie AR, Al-Qubati Y, Alkubati AS, Bretzel G, Vera-Cabrera L, Sakho F, Johnson CR, Kodio M, Fomba A, Sow SO, Gado M, Konaté O, Stefani MMA, Penna GO, Suffys PN, Sarno EN, Moraes MO, Rosa PS, Baptista IMFD, Spencer JS, Aseffa A, Matsuoka M, Kai M, Cole ST.

Nat Commun. 2018 Jan 24;9(1):352. doi: 10.1038/s41467-017-02576-z.

16.

Elevated Pentraxin-3 Concentrations in Patients With Leprosy: Potential Biomarker of Erythema Nodosum Leprosum.

Mendes MA, de Carvalho DS, Amadeu TP, Silva BJA, Prata RBDS, da Silva CO, Ferreira H, Hacker MA, Nery JAC, Pinheiro RO, Sampaio EP, Sarno EN, Schmitz V.

J Infect Dis. 2017 Dec 19;216(12):1635-1643. doi: 10.1093/infdis/jix267.

PMID:
29272525
17.

Cross-cultural adaptation of the EMIC Stigma Scale for people with leprosy in Brazil.

Morgado FFDR, Silveira EMKXD, Sales AM, Nascimento LPRD, Sarno EN, Nery JADC, Oliveira AJ, Illarramendi X.

Rev Saude Publica. 2017 Sep 4;51:80. doi: 10.11606/S1518-8787.2017051000167. English, Portuguese.

18.

Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.

Sales-Marques C, Cardoso CC, Alvarado-Arnez LE, Illaramendi X, Sales AM, Hacker MA, Barbosa MGM, Nery JADC, Pinheiro RO, Sarno EN, Pacheco AG, Moraes MO.

PLoS Negl Trop Dis. 2017 Jul 17;11(7):e0005754. doi: 10.1371/journal.pntd.0005754. eCollection 2017 Jul.

19.

Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival.

de Mattos Barbosa MG, da Silva Prata RB, Andrade PR, Ferreira H, de Andrade Silva BJ, da Paixão de Oliveira JA, Assis TQ, de Toledo-Pinto TG, de Lima Bezerra OC, da Costa Nery JA, Rosa PS, Bozza MT, Lara FA, Moraes MO, Schmitz V, Sarno EN, Pinheiro RO.

Microbes Infect. 2017 Nov;19(11):505-514. doi: 10.1016/j.micinf.2017.06.006. Epub 2017 Jul 3.

PMID:
28684130
20.

Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens.

de Carvalho FM, Rodrigues LS, Duppre NC, Alvim IMP, Ribeiro-Alves M, Pinheiro RO, Sarno EN, Pessolani MCV, Pereira GMB.

PLoS Negl Trop Dis. 2017 May 3;11(5):e0005560. doi: 10.1371/journal.pntd.0005560. eCollection 2017 May.

21.

Multibacillary leprosy by population groups in Brazil: Lessons from an observational study.

Nobre ML, Illarramendi X, Dupnik KM, Hacker MA, Nery JA, Jerônimo SM, Sarno EN.

PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005364. doi: 10.1371/journal.pntd.0005364. eCollection 2017 Feb.

22.

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization.

Silva BJ, Barbosa MG, Andrade PR, Ferreira H, Nery JA, Côrte-Real S, da Silva GM, Rosa PS, Fabri M, Sarno EN, Pinheiro RO.

PLoS Pathog. 2017 Jan 5;13(1):e1006103. doi: 10.1371/journal.ppat.1006103. eCollection 2017 Jan.

23.

Type 1 Reaction in Patients With Leprosy Corresponds to a Decrease in Proresolving Lipid Mediators and an Increase in Proinflammatory Lipid Mediators.

Silva CA, Webb K, Andre BG, Marques MA, Carvalho FM, de Macedo CS, Pinheiro RO, Sarno EN, Pessolani MC, Belisle JT.

J Infect Dis. 2017 Feb 1;215(3):431-439. doi: 10.1093/infdis/jiw541.

PMID:
27932613
24.

Corticosteroid therapy in borderline tuberculoid leprosy patients co-infected with HIV undergoing reversal reaction: a clinical study.

Secchin-De-Andrade PJ, De Andrea Vilas-Boas Hacker M, Sales AM, Dalvi-Garcia F, Da Costa Nery JA, Menezes VM, Sarno EN.

Lepr Rev. 2016 Dec;87(4):516-25.

PMID:
30226355
25.

Response to Comment on "DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum".

Pereira GM, Pessolani MC, Sarno EN.

J Immunol. 2016 Dec 1;197(11):4184-4185. No abstract available.

26.

Subversion of Schwann cell glucose metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, de Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Nov 18;291(47):24803. No abstract available.

27.

Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients.

Dos Santos LN, da Silva PH, Alvim IM, Nery JA, Lara FA, Sarno EN, Esquenazi D.

PLoS One. 2016 Oct 20;11(10):e0164543. doi: 10.1371/journal.pone.0164543. eCollection 2016.

28.

Impact of a Reference Center on Leprosy Control under a Decentralized Public Health Care Policy in Brazil.

Barbieri RR, Sales AM, Hacker MA, Nery JA, Duppre NC, Machado AM, Moraes MO, Sarno EN.

PLoS Negl Trop Dis. 2016 Oct 12;10(10):e0005059. doi: 10.1371/journal.pntd.0005059. eCollection 2016 Oct.

29.

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL.

JCI Insight. 2016 Sep 22;1(15):e88843. doi: 10.1172/jci.insight.88843.

30.

Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum.

Schmitz V, Prata RB, Barbosa MG, Mendes MA, Brandão SS, Amadeu TP, Rodrigues LS, Ferreira H, Costa Fda M, Dos Santos JB, Pacheco Fdos S, Machado Ade M, Nery JA, Hacker Mde A, Sales AM, Pinheiro RO, Sarno EN.

PLoS Negl Trop Dis. 2016 Aug 24;10(8):e0004955. doi: 10.1371/journal.pntd.0004955. eCollection 2016 Aug.

31.

Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Oct 7;291(41):21375-21387. Epub 2016 Aug 23. Erratum in: J Biol Chem. 2016 Nov 18;291(47):24803.

32.

DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum.

Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, Lara FA, Machado AM, Nery JA, Sarno EN, Pereira GM, Pessolani MC.

J Immunol. 2016 Sep 1;197(5):1905-13. doi: 10.4049/jimmunol.1600042. Epub 2016 Jul 29.

33.

S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL.

PLoS Pathog. 2016 Jun 29;12(6):e1005705. doi: 10.1371/journal.ppat.1005705. eCollection 2016 Jun.

34.

Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages.

Batista-Silva LR, Rodrigues LS, Vivarini Ade C, Costa Fda M, Mattos KA, Costa MR, Rosa PS, Toledo-Pinto TG, Dias AA, Moura DF, Sarno EN, Lopes UG, Pessolani MC.

Sci Rep. 2016 Jun 10;6:27632. doi: 10.1038/srep27632.

35.

STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.

de Toledo-Pinto TG, Ferreira AB, Ribeiro-Alves M, Rodrigues LS, Batista-Silva LR, Silva BJ, Lemes RM, Martinez AN, Sandoval FG, Alvarado-Arnez LE, Rosa PS, Shannon EJ, Pessolani MC, Pinheiro RO, Antunes SL, Sarno EN, Lara FA, Williams DL, Ozório Moraes M.

J Infect Dis. 2016 Jul 15;214(2):311-20. doi: 10.1093/infdis/jiw144. Epub 2016 May 14.

PMID:
27190175
36.

Human migration, railways and the geographic distribution of leprosy in Rio Grande do Norte State--Brazil.

Nobre ML, Dupnik KM, Nobre PJ, Freitas De Souza MC, Dűppre NC, Sarno EN, Jerŏnimo SM.

Lepr Rev. 2015 Dec;86(4):335-44.

37.

Inflammatory Cytokines Are Involved in Focal Demyelination in Leprosy Neuritis.

Andrade PR, Jardim MR, da Silva AC, Manhaes PS, Antunes SL, Vital R, Prata RB, Petito RB, Pinheiro RO, Sarno EN.

J Neuropathol Exp Neurol. 2016 Mar;75(3):272-83. doi: 10.1093/jnen/nlv027. Epub 2016 Feb 17.

PMID:
26888306
38.

MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT).

de Macedo CS, Anderson DM, Pascarelli BM, Spraggins JM, Sarno EN, Schey KL, Pessolani MC.

J Mass Spectrom. 2015 Dec;50(12):1374-85. doi: 10.1002/jms.3708.

PMID:
26634971
39.

Downregulation of PHEX in multibacillary leprosy patients: observational cross-sectional study.

Silva SR, Illarramendi X, Tempone AJ, Silva PH, Nery JA, Monteiro AM, Pessolani MC, Boasquevisque E, Sarno EN, Pereira GM, Esquenazi D.

J Transl Med. 2015 Sep 11;13:296. doi: 10.1186/s12967-015-0651-5.

40.

Correction: Correlation between Central Memory T Cell Expression and Proinflammatory Cytokine Production with Clinical Presentation of Multibacillary Leprosy Relapse.

Esquenazi D, Alvim IM, Pinheiro RO, de Oliveira EB, Moreira Lde O, Sarno EN, da Costa Nery JA.

PLoS One. 2015 Aug 31;10(8):e0137445. doi: 10.1371/journal.pone.0137445. eCollection 2015. No abstract available.

41.

IL-27 Suppresses Antimicrobial Activity in Human Leprosy.

Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL.

J Invest Dermatol. 2015 Oct;135(10):2410-2417. doi: 10.1038/jid.2015.195. Epub 2015 Jun 1.

42.

Correlation between Central Memory T Cell Expression and Proinflammatory Cytokine Production with Clinical Presentation of Multibacillary Leprosy Relapse.

Esquenazi D, Alvim IM, Pinheiro RO, Oliveira EB, Moreira Lde O, Sarno EN, Nery JA.

PLoS One. 2015 May 19;10(5):e0127416. doi: 10.1371/journal.pone.0127416. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0137445.

43.

Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry.

Lima Ede O, de Macedo CS, Esteves CZ, de Oliveira DN, Pessolani MC, Nery JA, Sarno EN, Catharino RR.

Anal Chem. 2015 Apr 7;87(7):3585-92. doi: 10.1021/acs.analchem.5b00097. Epub 2015 Mar 25.

PMID:
25785304
44.

Type 1 reaction in leprosy: a model for a better understanding of tissue immunity under an immunopathological condition.

Andrade PR, Pinheiro RO, Sales AM, Illarramendi X, Barbosa MG, Moraes MO, Jardim MR, Nery JA, Sampaio EP, Sarno EN.

Expert Rev Clin Immunol. 2015 Mar;11(3):391-407. doi: 10.1586/1744666X.2015.1012501. Epub 2015 Feb 10. Review.

PMID:
25666357
45.

Leprosy neuropathy evaluated by NCS is independent of the patient's infectious state.

Jardim MR, Vital R, Hacker MA, Nascimento M, Balassiano SL, Sarno EN, Illarramendi X.

Clin Neurol Neurosurg. 2015 Apr;131:5-10. doi: 10.1016/j.clineuro.2015.01.008. Epub 2015 Jan 12.

PMID:
25655301
46.

Diagnostic challenges of single plaque-like lesion paucibacillary leprosy.

Barbieri RR, Sales AM, Illarramendi X, Moraes MO, Nery JA, Moreira SJ, Sarno EN, Machado Ade M, Bozza FA.

Mem Inst Oswaldo Cruz. 2014 Nov;109(7):944-7. Epub 2014 Oct 14.

47.

CD123, the plasmacytoid dendritic cell phenotypic marker, is abundant in leprosy type 1 reaction.

Andrade PR, Amadeu TP, Nery JA, Pinheiro RO, Sarno EN.

Br J Dermatol. 2015 Jan;172(1):268-71. doi: 10.1111/bjd.13430. Epub 2014 Dec 11. No abstract available.

PMID:
25256168
48.

CXCL10, MCP-1, and other immunologic markers involved in neural leprosy.

Medeiros MF, Rodrigues MM, Vital RT, da Costa Nery JA, Sales AM, de Andrea Hacker M, Ferreira H, Chimelli L, Sarno EN, Antunes SL.

Appl Immunohistochem Mol Morphol. 2015 Mar;23(3):220-9. doi: 10.1097/PAI.0000000000000074.

PMID:
25221954
49.

Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy.

Cezar-de-Mello PF, Toledo-Pinto TG, Marques CS, Arnez LE, Cardoso CC, Guerreiro LT, Antunes SL, Jardim MM, Covas Cde J, Illaramendi X, Dias-Baptista IM, Rosa PS, Durães SM, Pacheco AG, Ribeiro-Alves M, Sarno EN, Moraes MO.

PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3099. doi: 10.1371/journal.pntd.0003099. eCollection 2014 Sep.

50.

Effect of apoptotic cell recognition on macrophage polarization and mycobacterial persistence.

de Oliveira Fulco T, Andrade PR, de Mattos Barbosa MG, Pinto TG, Ferreira PF, Ferreira H, da Costa Nery JA, Real SC, Borges VM, Moraes MO, Sarno EN, Sampaio EP, Pinheiro RO.

Infect Immun. 2014 Sep;82(9):3968-78. doi: 10.1128/IAI.02194-14. Epub 2014 Jul 14.

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