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Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.

Kalbitz M, Fattahi F, Herron TJ, Grailer JJ, Jajou L, Lu H, Huber-Lang M, Zetoune FS, Sarma JV, Day SM, Russell MW, Jalife J, Ward PA.

J Immunol. 2016 Sep 15;197(6):2353-61. doi: 10.4049/jimmunol.1600091. Epub 2016 Aug 12.


Role of extracellular histones in the cardiomyopathy of sepsis.

Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA.

FASEB J. 2015 May;29(5):2185-93. doi: 10.1096/fj.14-268730. Epub 2015 Feb 13.


Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.

Bosmann M, Russkamp NF, Strobl B, Roewe J, Balouzian L, Pache F, Radsak MP, van Rooijen N, Zetoune FS, Sarma JV, Núñez G, Müller M, Murray PJ, Ward PA.

J Immunol. 2014 Dec 1;193(11):5668-77. doi: 10.4049/jimmunol.1302280. Epub 2014 Oct 27.


Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury.

Sladojevic N, Stamatovic SM, Keep RF, Grailer JJ, Sarma JV, Ward PA, Andjelkovic AV.

Neurobiol Dis. 2014 Jul;67:57-70. doi: 10.1016/j.nbd.2014.03.010. Epub 2014 Mar 21.


Induction of M2 regulatory macrophages through the β2-adrenergic receptor with protection during endotoxemia and acute lung injury.

Grailer JJ, Haggadone MD, Sarma JV, Zetoune FS, Ward PA.

J Innate Immun. 2014;6(5):607-18. doi: 10.1159/000358524. Epub 2014 Mar 14.


Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury.

Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA.

FASEB J. 2013 Dec;27(12):5010-21. doi: 10.1096/fj.13-236380. Epub 2013 Aug 27.


New developments in C5a receptor signaling.

Sarma JV, Ward PA.

Cell Health Cytoskelet. 2012 Jul 1;4:73-82. Epub 2012 Jul 31.


The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation.

Bosmann M, Haggadone MD, Zetoune FS, Sarma JV, Ward PA.

Eur J Immunol. 2013 Jul;43(7):1907-13. doi: 10.1002/eji.201243075. Epub 2013 May 13.


Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice.

Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA.

Am J Pathol. 2013 Apr;182(4):1124-30. doi: 10.1016/j.ajpath.2013.01.005.


CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.

Bosmann M, Grailer JJ, Russkamp NF, Ruemmler R, Zetoune FS, Sarma JV, Ward PA.

Shock. 2013 May;39(5):447-52. doi: 10.1097/SHK.0b013e31828f9c92.


Changes and regulation of the C5a receptor on neutrophils during septic shock in humans.

Unnewehr H, Rittirsch D, Sarma JV, Zetoune F, Flierl MA, Perl M, Denk S, Weiss M, Schneider ME, Monk PN, Neff T, Mihlan M, Barth H, Gebhard F, Ward PA, Huber-Lang M.

J Immunol. 2013 Apr 15;190(8):4215-25. doi: 10.4049/jimmunol.1200534. Epub 2013 Mar 11.


Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria.

Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME, Sled J, Fletcher JF, Rogerson S, Kain KC.

Cell Host Microbe. 2013 Feb 13;13(2):215-26. doi: 10.1016/j.chom.2013.01.010.


Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.

Bosmann M, Haggadone MD, Hemmila MR, Zetoune FS, Sarma JV, Ward PA.

J Immunol. 2012 May 15;188(10):5086-93. doi: 10.4049/jimmunol.1102914. Epub 2012 Apr 9.


Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury.

Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA.

FASEB J. 2012 May;26(5):2137-44. doi: 10.1096/fj.11-201640. Epub 2012 Feb 7.


Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.

Bosmann M, Sarma JV, Atefi G, Zetoune FS, Ward PA.

FASEB J. 2012 Apr;26(4):1640-51. doi: 10.1096/fj.11-199216. Epub 2011 Dec 27.


MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.

Bosmann M, Patel VR, Russkamp NF, Pache F, Zetoune FS, Sarma JV, Ward PA.

FASEB J. 2011 Dec;25(12):4222-32. doi: 10.1096/fj.11-191205. Epub 2011 Aug 22.


An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation.

Tang H, Yan C, Cao J, Sarma JV, Haura EB, Wu M, Gao H.

FASEB J. 2011 Dec;25(12):4292-300. doi: 10.1096/fj.11-187955. Epub 2011 Aug 22.


Oxidants and redox signaling in acute lung injury.

Sarma JV, Ward PA.

Compr Physiol. 2011 Jul;1(3):1365-81. doi: 10.1002/cphy.c100068. Review.


The outcome of polymicrobial sepsis is independent of T and B cells.

Bosmann M, Russkamp NF, Patel VR, Zetoune FS, Sarma JV, Ward PA.

Shock. 2011 Oct;36(4):396-401. doi: 10.1097/SHK.0b013e3182295f5f.


Complement dependency of cardiomyocyte release of mediators during sepsis.

Atefi G, Zetoune FS, Herron TJ, Jalife J, Bosmann M, Al-Aref R, Sarma JV, Ward PA.

FASEB J. 2011 Jul;25(7):2500-8. doi: 10.1096/fj.11-183236. Epub 2011 Apr 8.


The complement system.

Sarma JV, Ward PA.

Cell Tissue Res. 2011 Jan;343(1):227-35. doi: 10.1007/s00441-010-1034-0. Epub 2010 Sep 14. Review.


Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells.

Sun L, Guo RF, Gao H, Sarma JV, Zetoune FS, Ward PA.

FASEB J. 2009 Nov;23(11):3808-18. doi: 10.1096/fj.09-133694. Epub 2009 Jul 20.


Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways.

Rittirsch D, Flierl MA, Day DE, Nadeau BA, Zetoune FS, Sarma JV, Werner CM, Wanner GA, Simmen HP, Huber-Lang MS, Ward PA.

PLoS Pathog. 2009 Jun;5(6):e1000464. doi: 10.1371/journal.ppat.1000464. Epub 2009 Jun 5.


Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response.

Flierl MA, Rittirsch D, Nadeau BA, Sarma JV, Day DE, Lentsch AB, Huber-Lang MS, Ward PA.

PLoS One. 2009;4(2):e4414. doi: 10.1371/journal.pone.0004414. Epub 2009 Feb 12.


Activation by C5a of endothelial cell caspase 8 and cFLIP.

Albrecht EA, Sarma JV, Ward PA.

Inflamm Res. 2009 Jan;58(1):30-7. doi: 10.1007/s00011-008-8156-9.


Adrenergic regulation of complement-induced acute lung injury.

Flierl MA, Rittirsch D, Sarma JV, Huber-Lang M, Ward PA.

Adv Exp Med Biol. 2008;632:93-103. Review.


The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis.

Flierl MA, Rittirsch D, Chen AJ, Nadeau BA, Day DE, Sarma JV, Huber-Lang MS, Ward PA.

PLoS One. 2008 Jul 2;3(7):e2560. doi: 10.1371/journal.pone.0002560.


Functions of the complement components C3 and C5 during sepsis.

Flierl MA, Rittirsch D, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ward PA.

FASEB J. 2008 Oct;22(10):3483-90. doi: 10.1096/fj.08-110595. Epub 2008 Jun 27.


Acute lung injury induced by lipopolysaccharide is independent of complement activation.

Rittirsch D, Flierl MA, Day DE, Nadeau BA, McGuire SR, Hoesel LM, Ipaktchi K, Zetoune FS, Sarma JV, Leng L, Huber-Lang MS, Neff TA, Bucala R, Ward PA.

J Immunol. 2008 Jun 1;180(11):7664-72.


Functional roles for C5a receptors in sepsis.

Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Köhl J, Gerard C, Sarma JV, Ward PA.

Nat Med. 2008 May;14(5):551-7. doi: 10.1038/nm1753. Epub 2008 May 4.


C5 deficiency and C5a or C5aR blockade protects against cerebral malaria.

Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC.

J Exp Med. 2008 May 12;205(5):1133-43. doi: 10.1084/jem.20072248. Epub 2008 Apr 21.


Adverse functions of IL-17A in experimental sepsis.

Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA.

FASEB J. 2008 Jul;22(7):2198-205. doi: 10.1096/fj.07-105221. Epub 2008 Feb 25.


Ability of antioxidant liposomes to prevent acute and progressive pulmonary injury.

Hoesel LM, Flierl MA, Niederbichler AD, Rittirsch D, McClintock SD, Reuben JS, Pianko MJ, Stone W, Yang H, Smith M, Sarma JV, Ward PA.

Antioxid Redox Signal. 2008 May;10(5):973-81. doi: 10.1089/ars.2007.1878.


Molecular events in the cardiomyopathy of sepsis.

Flierl MA, Rittirsch D, Huber-Lang MS, Sarma JV, Ward PA.

Mol Med. 2008 May-Jun;14(5-6):327-36. doi: 10.2119/2007-00130.Flierl. Review.


Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?

Flierl MA, Rittirsch D, Huber-Lang M, Sarma JV, Ward PA.

Mol Med. 2008 Mar-Apr;14(3-4):195-204. Review.


Phagocyte-derived catecholamines enhance acute inflammatory injury.

Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Van Rooijen N, Huber-Lang MS, Neubig RR, Ward PA.

Nature. 2007 Oct 11;449(7163):721-5. Epub 2007 Sep 30.


In vivo biological responses in the presence or absence of C3.

Sarma JV, Ward PA.

Adv Exp Med Biol. 2007;598:240-50. Review. No abstract available.


C5a-blockade improves burn-induced cardiac dysfunction.

Hoesel LM, Niederbichler AD, Schaefer J, Ipaktchi KR, Gao H, Rittirsch D, Pianko MJ, Vogt PM, Sarma JV, Su GL, Arbabi S, Westfall MV, Wang SC, Hemmila MR, Ward PA.

J Immunol. 2007 Jun 15;178(12):7902-10.


Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury.

Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA.

J Immunol. 2006 Jul 1;177(1):612-20.


Generation of C5a in the absence of C3: a new complement activation pathway.

Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA.

Nat Med. 2006 Jun;12(6):682-7. Epub 2006 May 21.


Drusen complement components C3a and C5a promote choroidal neovascularization.

Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2328-33. Epub 2006 Feb 1.


An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction.

Niederbichler AD, Hoesel LM, Westfall MV, Gao H, Ipaktchi KR, Sun L, Zetoune FS, Su GL, Arbabi S, Sarma JV, Wang SC, Hemmila MR, Ward PA.

J Exp Med. 2006 Jan 23;203(1):53-61. Epub 2005 Dec 27.


Harmful and protective roles of neutrophils in sepsis.

Hoesel LM, Neff TA, Neff SB, Younger JG, Olle EW, Gao H, Pianko MJ, Bernacki KD, Sarma JV, Ward PA.

Shock. 2005 Jul;24(1):40-7.


Complement C5 and early oxygen kinetics during murine sepsis.

Valencia G, Sarma JV, Younger JG.

Acad Emerg Med. 2005 Apr;12(4):275-81.


Evidence for a functional role of the second C5a receptor C5L2.

Gao H, Neff TA, Guo RF, Speyer CL, Sarma JV, Tomlins S, Man Y, Riedemann NC, Hoesel LM, Younkin E, Zetoune FS, Ward PA.

FASEB J. 2005 Jun;19(8):1003-5. Epub 2005 Mar 22.


Regulatory effects of estrogen on acute lung inflammation in mice.

Speyer CL, Rancilio NJ, McClintock SD, Crawford JD, Gao H, Sarma JV, Ward PA.

Am J Physiol Cell Physiol. 2005 Apr;288(4):C881-90.


Relationship of acute lung inflammatory injury to Fas/FasL system.

Neff TA, Guo RF, Neff SB, Sarma JV, Speyer CL, Gao H, Bernacki KD, Huber-Lang M, McGuire S, Hoesel LM, Riedemann NC, Beck-Schimmer B, Zetoune FS, Ward PA.

Am J Pathol. 2005 Mar;166(3):685-94.


Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.

Huber-Lang M, Sarma JV, Rittirsch D, Schreiber H, Weiss M, Flierl M, Younkin E, Schneider M, Suger-Wiedeck H, Gebhard F, McClintock SD, Neff T, Zetoune F, Bruckner U, Guo RF, Monk PN, Ward PA.

J Immunol. 2005 Jan 15;174(2):1104-10.


Novel chemokine responsiveness and mobilization of neutrophils during sepsis.

Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA.

Am J Pathol. 2004 Dec;165(6):2187-96.


Stat3 activation in acute lung injury.

Gao H, Guo RF, Speyer CL, Reuben J, Neff TA, Hoesel LM, Riedemann NC, McClintock SD, Sarma JV, Van Rooijen N, Zetoune FS, Ward PA.

J Immunol. 2004 Jun 15;172(12):7703-12.

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