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Items: 37

1.

The Detroit 562 Pharyngeal Immortalized Cell Line Model for the Assessment of Infectivity of Pathogenic Neisseria sp.

Kibble EA, Sarkar-Tyson M, Coombs GW, Kahler CM.

Methods Mol Biol. 2019;1969:123-133. doi: 10.1007/978-1-4939-9202-7_9.

PMID:
30877674
2.

Enzyme targets for drug design of new anti-virulence therapeutics.

Kahler CM, Sarkar-Tyson M, Kibble EA, Stubbs KA, Vrielink A.

Curr Opin Struct Biol. 2018 Dec;53:140-150. doi: 10.1016/j.sbi.2018.08.010. Epub 2018 Sep 14. Review.

PMID:
30223251
3.

Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses.

Aller S, Scott A, Sarkar-Tyson M, Soyer OS.

J R Soc Interface. 2018 Sep 12;15(146). pii: 20180125. doi: 10.1098/rsif.2018.0125.

4.

Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbB.

McMahon RM, Ireland PM, Sarovich DS, Petit G, Jenkins CH, Sarkar-Tyson M, Currie BJ, Martin JL.

Infect Immun. 2018 Apr 23;86(5). pii: e00938-17. doi: 10.1128/IAI.00938-17. Print 2018 May.

5.

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.

Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.

6.

A miniaturized peptidyl-prolyl isomerase enzyme assay.

Vivoli M, Renou J, Chevalier A, Norville IH, Diaz S, Juli C, Atkins H, Holzgrabe U, Renard PY, Sarkar-Tyson M, Harmer NJ.

Anal Biochem. 2017 Nov 1;536:59-68. doi: 10.1016/j.ab.2017.08.004. Epub 2017 Aug 11.

PMID:
28803887
7.

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.

Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, Atkins TP, Atkins HS, Soyer OS, Titball RW.

BMC Microbiol. 2017 Jul 21;17(1):163. doi: 10.1186/s12866-017-1073-8.

8.

A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis.

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PC, Atkins TP, Titball RW.

Sci Rep. 2017 Feb 6;7:41923. doi: 10.1038/srep41923.

9.

Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei.

Custódio R, McLean CJ, Scott AE, Lowther J, Kennedy A, Clarke DJ, Campopiano DJ, Sarkar-Tyson M, Brown AR.

Mol Microbiol. 2016 Dec;102(6):1004-1019. doi: 10.1111/mmi.13531. Epub 2016 Sep 26.

10.

Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei.

Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville IH, Sarkar-Tyson M, Marshall LE, Schweimer K, Bruhn H, Rösch P, Harmer NJ, Sotriffer CA, Holzgrabe U.

Bioorg Med Chem. 2016 Nov 1;24(21):5134-5147. doi: 10.1016/j.bmc.2016.08.025. Epub 2016 Aug 20.

PMID:
27591009
11.

Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity.

Reimer A, Seufert F, Weiwad M, Ebert J, Bzdyl NM, Kahler CM, Sarkar-Tyson M, Holzgrabe U, Rudel T, Kozjak-Pavlovic V.

Int J Antimicrob Agents. 2016 Oct;48(4):401-8. doi: 10.1016/j.ijantimicag.2016.06.020. Epub 2016 Aug 1.

PMID:
27516227
12.

Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.

Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A.

Virulence. 2017 Jan 2;8(1):30-40. doi: 10.1080/21505594.2016.1199316. Epub 2016 Jul 1.

13.

Survival protein A is essential for virulence in Yersinia pestis.

Southern SJ, Scott AE, Jenner DC, Ireland PM, Norville IH, Sarkar-Tyson M.

Microb Pathog. 2016 Mar;92:50-53. doi: 10.1016/j.micpath.2015.12.013. Epub 2015 Dec 25.

14.

Evaluating the role of phage-shock protein A in Burkholderia pseudomallei.

Southern SJ, Male A, Milne T, Sarkar-Tyson M, Tavassoli A, Oyston PC.

Microbiology. 2015 Nov;161(11):2192-203. doi: 10.1099/mic.0.000175. Epub 2015 Sep 14.

15.

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

Nandi T, Holden MT, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, Wang S, How LC, Sim B, Essex-Lopresti A, Sarkar-Tyson M, Nelson M, Smither S, Ong C, Aw LT, Hoon CH, Michell S, Studholme DJ, Titball R, Chen SL, Parkhill J, Tan P.

Genome Res. 2015 Apr;25(4):608. No abstract available.

16.

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

Nandi T, Holden MT, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, Wang S, How LC, Sim B, Essex-Lopresti A, Sarkar-Tyson M, Nelson M, Smither S, Ong C, Aw LT, Hoon CH, Michell S, Studholme DJ, Titball R, Chen SL, Parkhill J, Tan P.

Genome Res. 2015 Jan;25(1):129-41. doi: 10.1101/gr.177543.114. Epub 2014 Sep 18. Erratum in: Genome Res. 2015 Apr;25(4):608. Holden, Mathew T G [corrected to Holden, Matthew T G].

17.

The use of a three-dimensional cell culture model to investigate host-pathogen interactions of Francisella tularensis in human lung epithelial cells.

David J, Sayer NM, Sarkar-Tyson M.

Microbes Infect. 2014 Sep;16(9):735-45. doi: 10.1016/j.micinf.2014.04.001. Epub 2014 May 4.

PMID:
24796635
18.

Construction of an inducible system for the analysis of essential genes in Yersinia pestis.

Ford DC, Ireland PM, Bullifent HL, Saint RJ, McAlister EV, Sarkar-Tyson M, Oyston PC.

J Microbiol Methods. 2014 May;100:1-7. doi: 10.1016/j.mimet.2014.01.017. Epub 2014 Feb 11.

PMID:
24524852
19.

Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development.

Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PB, Titball RW, Cuccui J, Wren BW.

MBio. 2014 Feb 11;5(1):e00926-13. doi: 10.1128/mBio.00926-13.

20.

The serine protease inhibitor Ecotin is required for full virulence of Burkholderia pseudomallei.

Ireland PM, Marshall L, Norville I, Sarkar-Tyson M.

Microb Pathog. 2014 Feb-Mar;67-68:55-8. doi: 10.1016/j.micpath.2014.01.001. Epub 2014 Jan 23.

PMID:
24462575
21.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.

Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD.

Antimicrob Agents Chemother. 2014;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23.

22.

Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo.

Ireland PM, McMahon RM, Marshall LE, Halili M, Furlong E, Tay S, Martin JL, Sarkar-Tyson M.

Antioxid Redox Signal. 2014 Feb 1;20(4):606-17. doi: 10.1089/ars.2013.5375. Epub 2013 Sep 20.

23.

Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region.

Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, Prior JL.

Infect Immun. 2012 Mar;80(3):1209-21. doi: 10.1128/IAI.05805-11. Epub 2012 Jan 17.

24.

A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.

Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW.

Science. 2011 Nov 11;334(6057):821-4. doi: 10.1126/science.1211915.

25.

A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence.

Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW.

Infect Immun. 2011 Nov;79(11):4299-307. doi: 10.1128/IAI.00134-11. Epub 2011 Aug 22.

26.

Antimicrobials for bacterial bioterrorism agents.

Sarkar-Tyson M, Atkins HS.

Future Microbiol. 2011 Jun;6(6):667-76. doi: 10.2217/fmb.11.50. Review.

PMID:
21707313
27.

A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei.

Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I.

Microbiology. 2011 Sep;157(Pt 9):2629-38. doi: 10.1099/mic.0.049163-0. Epub 2011 Jun 16.

PMID:
21680634
28.

Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei.

Vanaporn M, Wand M, Michell SL, Sarkar-Tyson M, Ireland P, Goldman S, Kewcharoenwong C, Rinchai D, Lertmemongkolchai G, Titball RW.

Microbiology. 2011 Aug;157(Pt 8):2392-400. doi: 10.1099/mic.0.050823-0. Epub 2011 Jun 9.

PMID:
21659326
29.

The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.

Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ.

Biochem J. 2011 Aug 1;437(3):413-22. doi: 10.1042/BJ20110345.

30.

Progress toward development of vaccines against melioidosis: A review.

Sarkar-Tyson M, Titball RW.

Clin Ther. 2010 Aug;32(8):1437-45. doi: 10.1016/j.clinthera.2010.07.020. Review.

PMID:
20728758
31.

A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.

Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, Nilsson C, Ariyaratne P, Ronning C, Losada L, Ruan Y, Sung WK, Woods D, Titball RW, Beacham I, Peak I, Keim P, Nierman WC, Tan P.

PLoS Pathog. 2010 Apr 1;6(4):e1000845. doi: 10.1371/journal.ppat.1000845.

32.

Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders.

Sarkar-Tyson M, Smither SJ, Harding SV, Atkins TP, Titball RW.

Vaccine. 2009 Jul 16;27(33):4447-51. doi: 10.1016/j.vaccine.2009.05.040. Epub 2009 May 31.

PMID:
19490962
33.

Burkholderia pseudomallei: animal models of infection.

Titball RW, Russell P, Cuccui J, Easton A, Haque A, Atkins T, Sarkar-Tyson M, Harley V, Wren B, Bancroft GJ.

Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S111-6. doi: 10.1016/S0035-9203(08)70026-9.

PMID:
19121670
34.

Polysaccharides and virulence of Burkholderia pseudomallei.

Sarkar-Tyson M, Thwaite JE, Harding SV, Smither SJ, Oyston PC, Atkins TP, Titball RW.

J Med Microbiol. 2007 Aug;56(Pt 8):1005-10.

PMID:
17644705
35.

Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis.

Harland DN, Chu K, Haque A, Nelson M, Walker NJ, Sarkar-Tyson M, Atkins TP, Moore B, Brown KA, Bancroft G, Titball RW, Atkins HS.

Infect Immun. 2007 Aug;75(8):4173-80. Epub 2007 May 21.

36.

The identification of surface proteins of Burkholderia pseudomallei.

Harding SV, Sarkar-Tyson M, Smither SJ, Atkins TP, Oyston PC, Brown KA, Liu Y, Wait R, Titball RW.

Vaccine. 2007 Mar 30;25(14):2664-72. Epub 2006 Dec 26.

PMID:
17289218
37.

Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis.

Rodrigues F, Sarkar-Tyson M, Harding SV, Sim SH, Chua HH, Lin CH, Han X, Karuturi RK, Sung K, Yu K, Chen W, Atkins TP, Titball RW, Tan P.

J Bacteriol. 2006 Dec;188(23):8178-88. Epub 2006 Sep 22.

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