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Items: 35

1.

Variable cellular decision-making behavior in a constant synthetic network topology.

Shah NA, Sarkar CA.

BMC Bioinformatics. 2019 May 14;20(1):237. doi: 10.1186/s12859-019-2866-6.

2.

Towards a Quantitative Understanding of Cell Identity.

Ye Z, Sarkar CA.

Trends Cell Biol. 2018 Dec;28(12):1030-1048. doi: 10.1016/j.tcb.2018.09.002. Epub 2018 Oct 8. Review.

PMID:
30309735
3.

RNA Thermometers for the PURExpress System.

Sadler FW, Dodevski I, Sarkar CA.

ACS Synth Biol. 2018 Jan 19;7(1):292-296. doi: 10.1021/acssynbio.7b00294. Epub 2017 Dec 22.

4.

Toward Bioremediation of Methylmercury Using Silica Encapsulated Escherichia coli Harboring the mer Operon.

Kane AL, Al-Shayeb B, Holec PV, Rajan S, Le Mieux NE, Heinsch SC, Psarska S, Aukema KG, Sarkar CA, Nater EA, Gralnick JA.

PLoS One. 2016 Jan 13;11(1):e0147036. doi: 10.1371/journal.pone.0147036. eCollection 2016.

5.

Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue.

Shah NA, Levesque MJ, Raj A, Sarkar CA.

J Cell Sci. 2015 Nov 1;128(21):4024. doi: 10.1242/jcs.180653. No abstract available.

6.

Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue.

Shah NA, Levesque MJ, Raj A, Sarkar CA.

J Cell Sci. 2015 Aug 15;128(16):3009-17. doi: 10.1242/jcs.158436. Epub 2015 Jul 9. Erratum in: J Cell Sci. 2015 Nov 1;128(21):4024.

7.

Conceptual and methodological advances in cell-free directed evolution.

Dodevski I, Markou GC, Sarkar CA.

Curr Opin Struct Biol. 2015 Aug;33:1-7. doi: 10.1016/j.sbi.2015.04.008. Epub 2015 Jun 18. Review.

8.

Computationally guided design of robust gene circuits.

Shah NA, Sarkar CA.

Methods Mol Biol. 2015;1244:167-78. doi: 10.1007/978-1-4939-1878-2_8.

PMID:
25487097
9.

Engineering Escherichia coli for light-activated cytolysis of mammalian cells.

Magaraci MS, Veerakumar A, Qiao P, Amurthur A, Lee JY, Miller JS, Goulian M, Sarkar CA.

ACS Synth Biol. 2014 Dec 19;3(12):944-8. doi: 10.1021/sb400174s. Epub 2014 Jan 14.

10.

NP-Sticky: a web server for optimizing DNA ligation with non-palindromic sticky ends.

Ng DT, Sarkar CA.

J Mol Biol. 2014 Apr 17;426(8):1861-9. doi: 10.1016/j.jmb.2014.02.003. Epub 2014 Feb 9.

PMID:
24518657
11.

Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.

Mehta HM, Futami M, Glaubach T, Lee DW, Andolina JR, Yang Q, Whichard Z, Quinn M, Lu HF, Kao WM, Przychodzen B, Sarkar CA, Minella A, Maciejewski JP, Corey SJ.

Leukemia. 2014 May;28(5):1041-51. doi: 10.1038/leu.2013.321. Epub 2013 Oct 30.

12.

Cell signaling. Concentrating (on) native proteins to control cell fate.

Sarkar CA.

Science. 2013 Sep 20;341(6152):1349-51. doi: 10.1126/science.1243994. No abstract available.

PMID:
24052296
13.

Evidence for context-dependent complementarity of non-Shine-Dalgarno ribosome binding sites to Escherichia coli rRNA.

Barendt PA, Shah NA, Barendt GA, Kothari PA, Sarkar CA.

ACS Chem Biol. 2013 May 17;8(5):958-66. doi: 10.1021/cb3005726. Epub 2013 Mar 7.

14.

Streamlined protocol for mRNA display.

Barendt PA, Ng DT, McQuade CN, Sarkar CA.

ACS Comb Sci. 2013 Feb 11;15(2):77-81. doi: 10.1021/co300135r. Epub 2013 Jan 25.

15.

Engineering signal peptides for enhanced protein secretion from Lactococcus lactis.

Ng DT, Sarkar CA.

Appl Environ Microbiol. 2013 Jan;79(1):347-56. doi: 10.1128/AEM.02667-12. Epub 2012 Nov 2.

16.

Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.

Jung ST, Kelton W, Kang TH, Ng DT, Andersen JT, Sandlie I, Sarkar CA, Georgiou G.

ACS Chem Biol. 2013 Feb 15;8(2):368-75. doi: 10.1021/cb300455f. Epub 2012 Oct 11.

PMID:
23030766
17.

Transient noise amplification and gene expression synchronization in a bistable mammalian cell-fate switch.

Palani S, Sarkar CA.

Cell Rep. 2012 Mar 29;1(3):215-24. doi: 10.1016/j.celrep.2012.01.007. Epub 2012 Mar 15.

18.

Model-guided ligation strategy for optimal assembly of DNA libraries.

Ng DT, Sarkar CA.

Protein Eng Des Sel. 2012 Oct;25(10):669-78. Epub 2012 Apr 27.

PMID:
22543356
19.

Broad-specificity mRNA-rRNA complementarity in efficient protein translation.

Barendt PA, Shah NA, Barendt GA, Sarkar CA.

PLoS Genet. 2012;8(3):e1002598. doi: 10.1371/journal.pgen.1002598. Epub 2012 Mar 22.

20.

Analyzing and engineering cell signaling modules with synthetic biology.

O'Shaughnessy EC, Sarkar CA.

Curr Opin Biotechnol. 2012 Oct;23(5):785-90. doi: 10.1016/j.copbio.2012.01.004. Epub 2012 Feb 8. Review.

PMID:
22325791
21.

Robust network topologies for generating switch-like cellular responses.

Shah NA, Sarkar CA.

PLoS Comput Biol. 2011 Jun;7(6):e1002085. doi: 10.1371/journal.pcbi.1002085. Epub 2011 Jun 23.

22.

Synthetic conversion of a graded receptor signal into a tunable, reversible switch.

Palani S, Sarkar CA.

Mol Syst Biol. 2011 Mar 29;7:480. doi: 10.1038/msb.2011.13.

23.

Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000.

Ng DT, Sarkar CA.

Biotechnol Bioeng. 2011 Aug;108(8):1987-96. doi: 10.1002/bit.23130. Epub 2011 Mar 29.

PMID:
21391210
24.

Tunable signal processing in synthetic MAP kinase cascades.

O'Shaughnessy EC, Palani S, Collins JJ, Sarkar CA.

Cell. 2011 Jan 7;144(1):119-31. doi: 10.1016/j.cell.2010.12.014.

25.

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution.

Zahnd C, Sarkar CA, Plückthun A.

Protein Eng Des Sel. 2010 Apr;23(4):175-84. doi: 10.1093/protein/gzp087. Epub 2010 Feb 3.

26.

Hematopoiesis and its disorders: a systems biology approach.

Whichard ZL, Sarkar CA, Kimmel M, Corey SJ.

Blood. 2010 Mar 25;115(12):2339-47. doi: 10.1182/blood-2009-08-215798. Epub 2010 Jan 26. Review.

27.

Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors.

Palani S, Sarkar CA.

PLoS Comput Biol. 2009 Sep;5(9):e1000518. doi: 10.1371/journal.pcbi.1000518. Epub 2009 Sep 25.

28.

Selection and characterization of DARPins specific for the neurotensin receptor 1.

Milovnik P, Ferrari D, Sarkar CA, Plückthun A.

Protein Eng Des Sel. 2009 Jun;22(6):357-66. doi: 10.1093/protein/gzp011. Epub 2009 Apr 22.

29.

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity.

Sarkar CA, Dodevski I, Kenig M, Dudli S, Mohr A, Hermans E, Plückthun A.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14808-13. doi: 10.1073/pnas.0803103105. Epub 2008 Sep 23.

30.

Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch.

Palani S, Sarkar CA.

Biophys J. 2008 Aug;95(4):1575-89. doi: 10.1529/biophysj.107.120600. Epub 2008 May 9.

31.

Protein PEGylation decreases observed target association rates via a dual blocking mechanism.

Kubetzko S, Sarkar CA, Plückthun A.

Mol Pharmacol. 2005 Nov;68(5):1439-54. Epub 2005 Aug 12.

PMID:
16099846
32.

Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues.

Sarkar CA, Lowenhaupt K, Wang PJ, Horan T, Lauffenburger DA.

Biotechnol Prog. 2003 May-Jun;19(3):955-64.

PMID:
12790662
33.

pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.

Ricci MS, Sarkar CA, Fallon EM, Lauffenburger DA, Brems DN.

Protein Sci. 2003 May;12(5):1030-8.

34.
35.

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".

Sarkar CA, Lowenhaupt K, Horan T, Boone TC, Tidor B, Lauffenburger DA.

Nat Biotechnol. 2002 Sep;20(9):908-13. Epub 2002 Aug 5.

PMID:
12161759

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