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Items: 1 to 50 of 225

1.

Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.

Mózner O, Bartos Z, Zámbó B, Homolya L, Hegedűs T, Sarkadi B.

Cells. 2019 Oct 8;8(10). pii: E1215. doi: 10.3390/cells8101215. Review.

2.

Hereditary Diseases Predisposing to Pheochromocytoma (VHL, NF-1, Paraganglioma Syndromes, and Novel Genes).

Sarkadi B, Patócs A.

Exp Suppl. 2019;111:129-147. doi: 10.1007/978-3-030-25905-1_8. Review.

PMID:
31588531
3.

Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation.

Sarkadi B, Baghy K, Sápi Z, Nyirő G, Likó I, Patócs A.

Front Genet. 2019 Jun 11;10:544. doi: 10.3389/fgene.2019.00544. eCollection 2019.

4.

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter.

Zámbó B, Mózner O, Bartos Z, Török G, Várady G, Telbisz Á, Homolya L, Orbán TI, Sarkadi B.

Cell Mol Life Sci. 2019 Jun 28. doi: 10.1007/s00018-019-03186-2. [Epub ahead of print]

PMID:
31254042
5.

Hemodynamic characterization of a transgenic rat strain stably expressing the calcium sensor protein GCaMP2.

Oláh A, Ruppert M, Orbán TI, Apáti Á, Sarkadi B, Merkely B, Radovits T.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1224-H1228. doi: 10.1152/ajpheart.00074.2019. Epub 2019 Mar 15.

PMID:
30875251
6.

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2018 Dec 19;9(1):5398. doi: 10.1038/s41467-018-07917-0.

7.

Application of human pluripotent stem cells and pluripotent stem cell-derived cellular models for assessing drug toxicity.

Apáti Á, Varga N, Berecz T, Erdei Z, Homolya L, Sarkadi B.

Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):61-75. doi: 10.1080/17425255.2019.1558207. Epub 2018 Dec 17. Review.

PMID:
30526128
8.

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters.

Temesszentandrási-Ambrus C, Tóth S, Verma R, Bánhegyi P, Szabadkai I, Baska F, Szántai-Kis C, Hartkoorn RC, Lingerfelt MA, Sarkadi B, Szakács G, Őrfi L, Nagaraja V, Ekins S, Telbisz Á.

PLoS One. 2018 Sep 5;13(9):e0202749. doi: 10.1371/journal.pone.0202749. eCollection 2018.

9.

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.

Zámbó B, Bartos Z, Mózner O, Szabó E, Várady G, Poór G, Pálinkás M, Andrikovics H, Hegedűs T, Homolya L, Sarkadi B.

Sci Rep. 2018 May 10;8(1):7487. doi: 10.1038/s41598-018-25695-z.

10.

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells.

Erdei Z, Schamberger A, Török G, Szebényi K, Várady G, Orbán TI, Homolya L, Sarkadi B, Apáti Á.

PLoS One. 2018 Apr 12;13(4):e0194925. doi: 10.1371/journal.pone.0194925. eCollection 2018.

11.

[Evolution of molecular genetic methods in the clinical diagnosis of hereditary endocrine tumour syndromes].

Sarkadi B, Grolmusz VK, Butz H, Kövesdi A, Likó I, Nyirő G, Igaz P, Patócs A.

Orv Hetil. 2018 Feb;159(7):285-292. doi: 10.1556/650.2018.31036. Review. Hungarian.

PMID:
29429353
12.

Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein.

Vőfély G, Berecz T, Szabó E, Szebényi K, Hathy E, Orbán TI, Sarkadi B, Homolya L, Marchetto MC, Réthelyi JM, Apáti Á.

Mol Cell Neurosci. 2018 Apr;88:222-230. doi: 10.1016/j.mcn.2018.02.003. Epub 2018 Feb 6.

PMID:
29425968
13.

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions.

Szabó E, Türk D, Telbisz Á, Kucsma N, Horváth T, Szakács G, Homolya L, Sarkadi B, Várady G.

PLoS One. 2018 Jan 17;13(1):e0190629. doi: 10.1371/journal.pone.0190629. eCollection 2018.

14.

Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo.

Szabó Z, Héja L, Szalay G, Kékesi O, Füredi A, Szebényi K, Dobolyi Á, Orbán TI, Kolacsek O, Tompa T, Miskolczy Z, Biczók L, Rózsa B, Sarkadi B, Kardos J.

Sci Rep. 2017 Jul 20;7(1):6018. doi: 10.1038/s41598-017-06073-7.

15.

ABCMdb reloaded: updates on mutations in ATP binding cassette proteins.

Tordai H, Jakab K, Gyimesi G, András K, Brózik A, Sarkadi B, Hegedus T.

Database (Oxford). 2017 Jan 1;2017(1). doi: 10.1093/database/bax023.

16.

Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene.

Zámbó B, Várady G, Padányi R, Szabó E, Németh A, Langó T, Enyedi Á, Sarkadi B.

Cell Calcium. 2017 Jul;65:73-79. doi: 10.1016/j.ceca.2017.02.001. Epub 2017 Feb 3.

PMID:
28216081
17.

In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration.

Szepesi Á, Matula Z, Szigeti A, Várady G, Szalma J, Szabó G, Uher F, Sarkadi B, Német K.

Stem Cells Int. 2016;2016:3595941. doi: 10.1155/2016/3595941. Epub 2016 Nov 24.

18.

Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter.

László L, Sarkadi B, Hegedűs T.

PLoS One. 2016 Oct 14;11(10):e0164426. doi: 10.1371/journal.pone.0164426. eCollection 2016.

19.

Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level.

Nerada Z, Hegyi Z, Szepesi Á, Tóth S, Hegedüs C, Várady G, Matula Z, Homolya L, Sarkadi B, Telbisz Á.

Cytometry A. 2016 Sep;89(9):826-34. doi: 10.1002/cyto.a.22931. Epub 2016 Sep 7.

20.

Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury.

Pálóczi J, Varga ZV, Apáti Á, Szebényi K, Sarkadi B, Madonna R, De Caterina R, Csont T, Eschenhagen T, Ferdinandy P, Görbe A.

Oxid Med Cell Longev. 2016;2016:4298945. doi: 10.1155/2016/4298945. Epub 2016 Jun 15.

21.

Alterations of membrane protein expression in red blood cells of Alzheimer's disease patients.

Várady G, Szabó E, Fehér Á, Németh A, Zámbó B, Pákáski M, Janka Z, Sarkadi B.

Alzheimers Dement (Amst). 2015 Jul 21;1(3):334-8. doi: 10.1016/j.dadm.2015.06.007. eCollection 2015 Sep.

22.

Functional characterization of the ABCG2 5' non-coding exon variants: Stem cell specificity, translation efficiency and the influence of drug selection.

Sándor S, Jordanidisz T, Schamberger A, Várady G, Erdei Z, Apáti Á, Sarkadi B, Orbán TI.

Biochim Biophys Acta. 2016 Jul;1859(7):943-51. doi: 10.1016/j.bbagrm.2016.05.007. Epub 2016 May 15.

PMID:
27191194
23.

Calcium signaling in human pluripotent stem cells.

Apáti Á, Berecz T, Sarkadi B.

Cell Calcium. 2016 Mar;59(2-3):117-23. doi: 10.1016/j.ceca.2016.01.005. Epub 2016 Feb 17. Review.

PMID:
26922096
24.

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2016 Jan 8;7:10286. doi: 10.1038/ncomms10286. Erratum in: Nat Commun. 2018 Dec 19;9(1):5398.

25.

The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation.

Apáti Á, Szebényi K, Erdei Z, Várady G, Orbán TI, Sarkadi B.

Expert Opin Drug Metab Toxicol. 2016;12(1):77-92. doi: 10.1517/17425255.2016.1121382. Epub 2015 Dec 14. Review.

PMID:
26592535
26.

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling.

Szebényi K, Füredi A, Kolacsek O, Pergel E, Bősze Z, Bender B, Vajdovich P, Tóvári J, Homolya L, Szakács G, Héja L, Enyedi Á, Sarkadi B, Apáti Á, Orbán TI.

Sci Rep. 2015 Aug 3;5:12645. doi: 10.1038/srep12645.

27.

Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications.

Hegedűs T, Chaubey PM, Várady G, Szabó E, Sarankó H, Hofstetter L, Roschitzki B, Stieger B, Sarkadi B.

Database (Oxford). 2015 Jun 14;2015:bav056. doi: 10.1093/database/bav056. Print 2015.

28.

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells.

Erdélyi-Belle B, Török G, Apáti Á, Sarkadi B, Schaff Z, Kiss A, Homolya L.

Pathol Oncol Res. 2015 Sep;21(4):1059-70. doi: 10.1007/s12253-015-9936-5. Epub 2015 Apr 7.

PMID:
25845432
29.

Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells.

Bacskai I, Mázló A, Kis-Tóth K, Szabó A, Panyi G, Sarkadi B, Apáti Á, Rajnavölgyi É.

Stem Cells Dev. 2015 Aug 1;24(15):1805-16. doi: 10.1089/scd.2014.0509. Epub 2015 Apr 29.

PMID:
25808140
30.

Visualization of Calcium Dynamics in Kidney Proximal Tubules.

Szebényi K, Füredi A, Kolacsek O, Csohány R, Prókai Á, Kis-Petik K, Szabó A, Bősze Z, Bender B, Tóvári J, Enyedi Á, Orbán TI, Apáti Á, Sarkadi B.

J Am Soc Nephrol. 2015 Nov;26(11):2731-40. doi: 10.1681/ASN.2014070705. Epub 2015 Mar 18.

31.

A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system.

Tóth A, Brózik A, Szakács G, Sarkadi B, Hegedüs T.

PLoS One. 2015 Feb 20;10(2):e0115533. doi: 10.1371/journal.pone.0115533. eCollection 2015.

32.

Lipid regulation of the ABCB1 and ABCG2 multidrug transporters.

Hegedüs C, Telbisz Á, Hegedűs T, Sarkadi B, Özvegy-Laczka C.

Adv Cancer Res. 2015;125:97-137. doi: 10.1016/bs.acr.2014.10.004. Epub 2015 Jan 8. Review.

PMID:
25640268
33.

Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.

Gál Z, Hegedüs C, Szakács G, Váradi A, Sarkadi B, Özvegy-Laczka C.

Biochim Biophys Acta. 2015 Feb;1848(2):477-87. doi: 10.1016/j.bbamem.2014.11.006. Epub 2014 Nov 14.

34.

Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy individuals.

Koszarska M, Kucsma N, Kiss K, Varady G, Gera M, Antalffy G, Andrikovics H, Tordai A, Studzian M, Strapagiel D, Pulaski L, Tani Y, Sarkadi B, Szakacs G.

PLoS One. 2014 Oct 31;9(10):e111590. doi: 10.1371/journal.pone.0111590. eCollection 2014.

35.

ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells.

Szepesi Á, Matula Z, Szigeti A, Várady G, Szabó G, Uher F, Sarkadi B, Német K.

Stem Cells Dev. 2015 Jan 15;24(2):244-52. doi: 10.1089/scd.2014.0177.

36.

Excision efficiency is not strongly coupled to transgenic rate: cell type-dependent transposition efficiency of sleeping beauty and piggyBac DNA transposons.

Kolacsek O, Erdei Z, Apáti A, Sándor S, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI.

Hum Gene Ther Methods. 2014 Aug;25(4):241-52. doi: 10.1089/hgtb.2013.149.

37.

Efficient generation of human embryonic stem cell-derived cardiac progenitors based on tissue-specific enhanced green fluorescence protein expression.

Szebényi K, Péntek A, Erdei Z, Várady G, Orbán TI, Sarkadi B, Apáti Á.

Tissue Eng Part C Methods. 2015 Jan;21(1):35-45. doi: 10.1089/ten.TEC.2013.0646.

38.

Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives.

Erdei Z, Lőrincz R, Szebényi K, Péntek A, Varga N, Likó I, Várady G, Szakács G, Orbán TI, Sarkadi B, Apáti A.

Cytometry B Clin Cytom. 2014 Sep;86(5):299-310. doi: 10.1002/cyto.b.21168. Epub 2014 Apr 11.

39.

Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites.

Telbisz Á, Hegedüs C, Váradi A, Sarkadi B, Özvegy-Laczka C.

Drug Metab Dispos. 2014 Apr;42(4):575-85. doi: 10.1124/dmd.113.055731. Epub 2014 Jan 2.

40.

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity.

Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Di Pietro A.

Front Pharmacol. 2013 Nov 7;4:138. doi: 10.3389/fphar.2013.00138. eCollection 2013.

41.

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Winter E, Lecerf-Schmidt F, Gozzi G, Peres B, Lightbody M, Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Creczynski-Pasa TB, Boumendjel A, Di Pietro A.

J Med Chem. 2013 Dec 27;56(24):9849-60. doi: 10.1021/jm401649j. Epub 2013 Dec 13.

PMID:
24304387
42.

Cell surface membrane proteins as personalized biomarkers: where we stand and where we are headed.

Várady G, Cserepes J, Németh A, Szabó E, Sarkadi B.

Biomark Med. 2013 Oct;7(5):803-19. doi: 10.2217/bmm.13.90. Review.

PMID:
24044572
43.

Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein.

Sarankó H, Tordai H, Telbisz Á, Özvegy-Laczka C, Erdős G, Sarkadi B, Hegedűs T.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):140-5. doi: 10.1016/j.bbrc.2013.06.054. Epub 2013 Jun 22.

PMID:
23800412
44.

ABCC6 is a basolateral plasma membrane protein.

Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A.

Circ Res. 2013 May 24;112(11):e148-51. doi: 10.1161/CIRCRESAHA.111.300194. Epub 2013 Apr 26.

45.

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers.

Kolacsek O, Krízsik V, Schamberger A, Erdei Z, Apáti A, Várady G, Mátés L, Izsvák Z, Ivics Z, Sarkadi B, Orbán TI.

Mob DNA. 2013 Mar 15;4(1):11. doi: 10.1186/1759-8753-4-11. No abstract available.

46.

Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein.

Apáti Á, Pászty K, Hegedűs L, Kolacsek O, Orbán TI, Erdei Z, Szebényi K, Péntek A, Enyedi Á, Sarkadi B.

Cell Signal. 2013 Apr;25(4):752-9. doi: 10.1016/j.cellsig.2012.12.024. Epub 2013 Jan 7.

PMID:
23305950
47.

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells.

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvák Z, Sarkadi B, Ivics Z.

Nucleic Acids Res. 2013 Feb 1;41(3):1829-47. doi: 10.1093/nar/gks1305. Epub 2012 Dec 28.

48.

Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein.

Telbisz Á, Özvegy-Laczka C, Hegedűs T, Váradi A, Sarkadi B.

Biochem J. 2013 Mar 1;450(2):387-95. doi: 10.1042/BJ20121485.

PMID:
23205634
49.

Expression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variations.

Kasza I, Várady G, Andrikovics H, Koszarska M, Tordai A, Scheffer GL, Németh A, Szakács G, Sarkadi B.

PLoS One. 2012;7(11):e48423. doi: 10.1371/journal.pone.0048423. Epub 2012 Nov 15.

50.

Human mirtrons can express functional microRNAs simultaneously from both arms in a flanking exon-independent manner.

Schamberger A, Sarkadi B, Orban TI.

RNA Biol. 2012 Sep;9(9):1177-85. doi: 10.4161/rna.21359. Epub 2012 Sep 1.

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