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Items: 35


DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Mäki-Nevala S, Valo S, Ristimäki A, Sarhadi V, Knuutila S, Nyström M, Renkonen-Sinisalo L, Lepistö A, Mecklin JP, Peltomäki P.

EBioMedicine. 2019 Jan;39:280-291. doi: 10.1016/j.ebiom.2018.12.018. Epub 2018 Dec 18.


Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.

Youssef O, Knuuttila A, Piirilä P, Böhling T, Sarhadi V, Knuutila S.

Anticancer Res. 2018 Oct;38(10):5627-5634. doi: 10.21873/anticanres.12897.


Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms.

Youssef O, Lahti L, Kokkola A, Karla T, Tikkanen M, Ehsan H, Carpelan-Holmström M, Koskensalo S, Böhling T, Rautelin H, Puolakkainen P, Knuutila S, Sarhadi V.

Dig Dis Sci. 2018 Nov;63(11):2950-2958. doi: 10.1007/s10620-018-5190-5. Epub 2018 Jul 11.


Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing.

Youssef O, Sarhadi V, Ehsan H, Böhling T, Carpelan-Holmström M, Koskensalo S, Puolakkainen P, Kokkola A, Knuutila S.

World J Gastroenterol. 2017 Dec 21;23(47):8291-8299. doi: 10.3748/wjg.v23.i47.8291.


Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia.

Benard-Slagter A, Zondervan I, de Groot K, Ghazavi F, Sarhadi V, Van Vlierberghe P, De Moerloose B, Schwab C, Vettenranta K, Harrison CJ, Knuutila S, Schouten J, Lammens T, Savola S.

J Mol Diagn. 2017 Sep;19(5):659-672. doi: 10.1016/j.jmoldx.2017.05.004. Epub 2017 Jul 19.


Aberrant expression of ALK and EZH2 in Merkel cell carcinoma.

Veija T, Koljonen V, Bohling T, Kero M, Knuutila S, Sarhadi VK.

BMC Cancer. 2017 Mar 31;17(1):236. doi: 10.1186/s12885-017-3233-5.


Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination.

Mosakhani N, Sarhadi V, Panula P, Partinen M, Knuutila S.

Acta Neurol Scand. 2017 Nov;136(5):462-469. doi: 10.1111/ane.12749. Epub 2017 Mar 1.


Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.

Youssef O, Knuuttila A, Piirilä P, Böhling T, Sarhadi V, Knuutila S.

Oncotarget. 2017 Mar 14;8(11):18166-18176. doi: 10.18632/oncotarget.15233.


Validation of 34betaE12 immunoexpression in clear cell papillary renal cell carcinoma as a sensitive biomarker.

Martignoni G, Brunelli M, Segala D, Munari E, Gobbo S, Cima L, Borze I, Wirtanen T, Sarhadi VK, Atanesyan L, Savola S, Barzon L, Masi G, Fassan M, Eble JN, Bohling T, Cheng L, Delahunt B, Knuutila S.

Pathology. 2017 Jan;49(1):10-18. doi: 10.1016/j.pathol.2016.05.014. Epub 2016 Dec 4.


Hot spot mutations in Finnish non-small cell lung cancers.

Mäki-Nevala S, Sarhadi VK, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, Knuuttila A, Knuutila S.

Lung Cancer. 2016 Sep;99:102-10. doi: 10.1016/j.lungcan.2016.06.024. Epub 2016 Jun 27.


Exhaled breath condensate as a source of biomarkers for lung carcinomas. A focus on genetic and epigenetic markers-A mini-review.

Youssef O, Sarhadi VK, Armengol G, Piirilä P, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2016 Dec;55(12):905-914. doi: 10.1002/gcc.22399. Epub 2016 Aug 13. Review.


Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing.

Armengol G, Sarhadi VK, Ghanbari R, Doghaei-Moghaddam M, Ansari R, Sotoudeh M, Puolakkainen P, Kokkola A, Malekzadeh R, Knuutila S.

J Mol Diagn. 2016 Jul;18(4):471-9. doi: 10.1016/j.jmoldx.2016.01.008. Epub 2016 May 4.


Simultaneous Underexpression of let-7a-5p and let-7f-5p microRNAs in Plasma and Stool Samples from Early Stage Colorectal Carcinoma.

Ghanbari R, Mosakhani N, Sarhadi VK, Armengol G, Nouraee N, Mohammadkhani A, Khorrami S, Arefian E, Paryan M, Malekzadeh R, Knuutila S.

Biomark Cancer. 2016 Jan 12;7(Suppl 1):39-48. doi: 10.4137/BIC.S25252. eCollection 2015.


Hotspot mutations in polyomavirus positive and negative Merkel cell carcinomas.

Veija T, Sarhadi VK, Koljonen V, Bohling T, Knuutila S.

Cancer Genet. 2016 Jan-Feb;209(1-2):30-5. doi: 10.1016/j.cancergen.2015.11.006. Epub 2015 Dec 4.


Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.

Mäki-Nevala S, Sarhadi VK, Knuuttila A, Scheinin I, Ellonen P, Lagström S, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, Knuutila S.

Lung. 2016 Feb;194(1):125-35.


Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement.

Sarhadi VK, Parkkinen J, Reito A, Nieminen J, Porkka N, Wirtanen T, Laitinen M, Eskelinen A, Knuutila S.

Mutat Res. 2015 Nov;781:1-6. doi: 10.1016/j.mrfmmm.2015.08.006. Epub 2015 Aug 29.


Driver gene mutations of non-small-cell lung cancer are rare in primary carcinoids of the lung: NGS study by ion Torrent.

Armengol G, Sarhadi VK, Rönty M, Tikkanen M, Knuuttila A, Knuutila S.

Lung. 2015 Apr;193(2):303-8. doi: 10.1007/s00408-015-9690-1. Epub 2015 Feb 14.


ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients.

Tuononen K, Kero M, Mäki-Nevala S, Sarhadi VK, Tikkanen M, Wirtanen T, Rönty M, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2014 Nov;53(11):895-901. doi: 10.1002/gcc.22198. Epub 2014 Jun 19.


Epidermal growth factor receptor mutations in 510 Finnish non--small-cell lung cancer patients.

Mäki-Nevala S, Rönty M, Morel M, Gomez M, Dawson Z, Sarhadi VK, Telaranta-Keerie A, Knuuttila A, Knuutila S.

J Thorac Oncol. 2014 Jun;9(6):886-91. doi: 10.1097/JTO.0000000000000132.


Hsa-miR-31-3p expression is linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy.

Manceau G, Imbeaud S, Thiébaut R, Liébaert F, Fontaine K, Rousseau F, Génin B, Le Corre D, Didelot A, Vincent M, Bachet JB, Chibaudel B, Bouché O, Landi B, Bibeau F, Leroy K, Penault-Llorca F, Van Laethem JL, Demetter P, Tejpar S, Rossi S, Mosakhani N, Osterlund P, Ristamäki R, Sarhadi V, Knuutila S, Boige V, André T, Laurent-Puig P.

Clin Cancer Res. 2014 Jun 15;20(12):3338-47. doi: 10.1158/1078-0432.CCR-13-2750. Epub 2014 Apr 25.


Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.

Sarhadi VK, Lahti L, Scheinin I, Ellonen P, Kettunen E, Serra M, Scotlandi K, Picci P, Knuutila S.

Genes Chromosomes Cancer. 2014 Jul;53(7):579-88. doi: 10.1002/gcc.22168. Epub 2014 Mar 24.


Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods.

Tuononen K, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Knuuttila A, Remes S, Telaranta-Keerie AI, Bloor S, Ellonen P, Knuutila S.

Biomed Res Int. 2013;2013:757490. doi: 10.1155/2013/757490. Epub 2013 Jan 20.


Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

Tuononen K, Mäki-Nevala S, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Andrews JM, Telaranta-Keerie AI, Hannula S, Lagström S, Ellonen P, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2013 May;52(5):503-11. doi: 10.1002/gcc.22047. Epub 2013 Jan 30.


Targeted resequencing of 9p in acute lymphoblastic leukemia yields concordant results with array CGH and reveals novel genomic alterations.

Sarhadi VK, Lahti L, Scheinin I, Tyybäkinoja A, Savola S, Usvasalo A, Räty R, Elonen E, Ellonen P, Saarinen-Pihkala UM, Knuutila S.

Genomics. 2013 Sep;102(3):182-8. doi: 10.1016/j.ygeno.2013.01.001. Epub 2013 Jan 16.


MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF.

Mosakhani N, Lahti L, Borze I, Karjalainen-Lindsberg ML, Sundström J, Ristamäki R, Osterlund P, Knuutila S, Sarhadi VK.

Cancer Genet. 2012 Nov;205(11):545-51. doi: 10.1016/j.cancergen.2012.08.003. Epub 2012 Oct 23.


MicroRNA profiling in pediatric acute lymphoblastic leukemia: novel prognostic tools.

Mosakhani N, Sarhadi VK, Usvasalo A, Karjalainen-Lindsberg ML, Lahti L, Tuononen K, Saarinen-Pihkala UM, Knuutila S.

Leuk Lymphoma. 2012 Dec;53(12):2517-20. doi: 10.3109/10428194.2012.685731. Epub 2012 May 22. No abstract available.


The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas--correlation with array comparative genome hybridization results and IDH1 mutation.

Tuononen K, Tynninen O, Sarhadi VK, Tyybäkinoja A, Lindlöf M, Antikainen M, Näpänkangas J, Hirvonen A, Mäenpää H, Paetau A, Knuutila S.

Genes Chromosomes Cancer. 2012 Jan;51(1):20-9. doi: 10.1002/gcc.20927. Epub 2011 Sep 15.


MicroRNA profiling differentiates colorectal cancer according to KRAS status.

Mosakhani N, Sarhadi VK, Borze I, Karjalainen-Lindsberg ML, Sundström J, Ristamäki R, Osterlund P, Knuutila S.

Genes Chromosomes Cancer. 2012 Jan;51(1):1-9. doi: 10.1002/gcc.20925. Epub 2011 Sep 15.


Pathways affected by asbestos exposure in normal and tumour tissue of lung cancer patients.

Ruosaari S, Hienonen-Kempas T, Puustinen A, Sarhadi VK, Hollmén J, Knuutila S, Saharinen J, Wikman H, Anttila S.

BMC Med Genomics. 2008 Nov 11;1:55. doi: 10.1186/1755-8794-1-55.


Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer.

Wikman H, Ruosaari S, Nymark P, Sarhadi VK, Saharinen J, Vanhala E, Karjalainen A, Hollmén J, Knuutila S, Anttila S.

Oncogene. 2007 Jul 12;26(32):4730-7. Epub 2007 Feb 12.


Increased expression of high mobility group A proteins in lung cancer.

Sarhadi VK, Wikman H, Salmenkivi K, Kuosma E, Sioris T, Salo J, Karjalainen A, Knuutila S, Anttila S.

J Pathol. 2006 Jun;209(2):206-12.


Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays.

Wikman H, Seppänen JK, Sarhadi VK, Kettunen E, Salmenkivi K, Kuosma E, Vainio-Siukola K, Nagy B, Karjalainen A, Sioris T, Salo J, Hollmén J, Knuutila S, Anttila S.

J Pathol. 2004 May;203(1):584-93.


Genomic diversities and affinities among four endogamous groups of Punjab (India) based on autosomal and mitochondrial DNA polymorphisms.

Kaur I, Roy S, Chakrabarti S, Sarhadi VK, Majumder PP, Bhanwer AJ, Singh JR.

Hum Biol. 2002 Dec;74(6):819-36.


A unique form of autosomal dominant cataract explained by gene conversion between beta-crystallin B2 and its pseudogene.

Vanita, Sarhadi V, Reis A, Jung M, Singh D, Sperling K, Singh JR, Bürger J.

J Med Genet. 2001 Jun;38(6):392-6. No abstract available.


A novel form of "central pouchlike" cataract, with sutural opacities, maps to chromosome 15q21-22.

Vanita, Singh JR, Sarhadi VK, Singh D, Reis A, Rueschendorf F, Becker-Follmann J, Jung M, Sperling K.

Am J Hum Genet. 2001 Feb;68(2):509-14. Epub 2000 Dec 21.

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