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An acute immune response underlies the benefit of cardiac stem-cell therapy.

Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AK, Schwanekamp JA, York AJ, Huang V, Nahrendorf M, Sadayappan S, Molkentin JD.

Nature. 2019 Nov 27. doi: 10.1038/s41586-019-1802-2. [Epub ahead of print]


Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.

Karch J, Bround MJ, Khalil H, Sargent MA, Latchman N, Terada N, Peixoto PM, Molkentin JD.

Sci Adv. 2019 Aug 28;5(8):eaaw4597. doi: 10.1126/sciadv.aaw4597. eCollection 2019 Aug.


Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex 1 deficiency.

Apatean D, Rakic B, Brunel-Guitton C, Hendson G, Bai R, Sargent MA, Lavoie PM, Patel M, Stockler-Ipsiroglu S.

Mol Genet Metab Rep. 2019 Apr 30;19:100472. doi: 10.1016/j.ymgmr.2019.100472. eCollection 2019 Jun.


Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.

Brody MJ, Vanhoutte D, Bakshi CV, Liu R, Correll RN, Sargent MA, Molkentin JD.

J Biol Chem. 2019 May 31;294(22):8918-8929. doi: 10.1074/jbc.RA119.007585. Epub 2019 Apr 21.


ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.

Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD.

JCI Insight. 2019 Apr 9;5. pii: 127356. doi: 10.1172/jci.insight.127356.


Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex I deficiency.

Apatean D, Rakic B, Brunel-Guitton C, Hendson G, Bai R, Sargent MA, Lavoie PM, Patel M, Stockler-Ipsiroglu S.

Mol Genet Metab Rep. 2019 Jan 18;18:32-38. doi: 10.1016/j.ymgmr.2018.12.006. eCollection 2019 Mar.


Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.

Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD.

Nat Commun. 2019 Jan 8;10(1):76. doi: 10.1038/s41467-018-08026-8.


Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling.

Bhandary B, Meng Q, James J, Osinska H, Gulick J, Valiente-Alandi I, Sargent MA, Bhuiyan MS, Blaxall BC, Molkentin JD, Robbins J.

J Am Heart Assoc. 2018 Oct 16;7(20):e010013. doi: 10.1161/JAHA.118.010013.


Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart.

Vagnozzi RJ, Sargent MA, Lin SJ, Palpant NJ, Murry CE, Molkentin JD.

Circulation. 2018 Dec 18;138(25):2931-2939. doi: 10.1161/CIRCULATIONAHA.118.035210. Erratum in: Circulation. 2018 Oct 9;138(15):e424.


Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.

Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, Molkentin JD.

Mol Cell Biol. 2018 Jun 28;38(14). pii: e00114-18. doi: 10.1128/MCB.00114-18. Print 2018 Jul 15.


Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.

Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD.

J Clin Invest. 2018 May 1;128(5):2127-2143. doi: 10.1172/JCI98215. Epub 2018 Apr 16.


Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.

Valiente-Alandi I, Potter SJ, Salvador AM, Schafer AE, Schips T, Carrillo-Salinas F, Gibson AM, Nieman ML, Perkins C, Sargent MA, Huo J, Lorenz JN, DeFalco T, Molkentin JD, Alcaide P, Blaxall BC.

Circulation. 2018 Sep 18;138(12):1236-1252. doi: 10.1161/CIRCULATIONAHA.118.034609.


Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.

Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, Molkentin JD.

Elife. 2017 Nov 17;6. pii: e30543. doi: 10.7554/eLife.30543.


Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.

Travers JG, Kamal FA, Valiente-Alandi I, Nieman ML, Sargent MA, Lorenz JN, Molkentin JD, Blaxall BC.

J Am Coll Cardiol. 2017 Aug 22;70(8):958-971. doi: 10.1016/j.jacc.2017.06.049.


TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

Schwanekamp JA, Lorts A, Sargent MA, York AJ, Grimes KM, Fischesser DM, Gokey JJ, Whitsett JA, Conway SJ, Molkentin JD.

PLoS One. 2017 Jul 27;12(7):e0181945. doi: 10.1371/journal.pone.0181945. eCollection 2017.


Central adrenal insufficiency following traumatic brain injury: a missed diagnosis in the critically injured.

Fan E, Skippen PW, Sargent MA, Cochrane DD, Chanoine JP.

Childs Nerv Syst. 2017 Dec;33(12):2205-2207. doi: 10.1007/s00381-017-3536-5. Epub 2017 Jul 18.


Mitsugumin 29 regulates t-tubule architecture in the failing heart.

Correll RN, Lynch JM, Schips TG, Prasad V, York AJ, Sargent MA, Brochet DXP, Ma J, Molkentin JD.

Sci Rep. 2017 Jul 13;7(1):5328. doi: 10.1038/s41598-017-05284-2.


Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Correll RN, Makarewich CA, Zhang H, Zhang C, Sargent MA, York AJ, Berretta RM, Chen X, Houser SR, Molkentin JD.

Cardiovasc Res. 2017 Jun 1;113(7):749-759. doi: 10.1093/cvr/cvx046.


Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.

Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis J.

Circulation. 2017 Aug 8;136(6):549-561. doi: 10.1161/CIRCULATIONAHA.116.026238. Epub 2017 Mar 29.


Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.

Liu R, Khalil H, Lin SJ, Sargent MA, York AJ, Molkentin JD.

PLoS One. 2016 Oct 20;11(10):e0164897. doi: 10.1371/journal.pone.0164897. eCollection 2016.


Thrombospondin expression in myofibers stabilizes muscle membranes.

Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD.

Elife. 2016 Sep 26;5. pii: e17589. doi: 10.7554/eLife.17589.


Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice.

Tjondrokoesoemo A, Schips TG, Sargent MA, Vanhoutte D, Kanisicak O, Prasad V, Lin SC, Maillet M, Molkentin JD.

J Biol Chem. 2016 May 6;291(19):9920-8. doi: 10.1074/jbc.M116.719054. Epub 2016 Mar 10.


Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.

Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent MA, Molkentin JD.

Hum Mol Genet. 2016 Mar 15;25(6):1192-202. doi: 10.1093/hmg/ddw005. Epub 2016 Jan 6.


Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.

Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V, Molkentin JD.

Mol Cell Biol. 2015 Oct 12;36(1):2-12. doi: 10.1128/MCB.00607-15. Print 2016 Jan 1.


Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD.

J Mol Cell Cardiol. 2015 Oct;87:204-13. doi: 10.1016/j.yjmcc.2015.08.018. Epub 2015 Aug 31.


STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy.

Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD.

J Mol Cell Cardiol. 2015 Oct;87:38-47. doi: 10.1016/j.yjmcc.2015.07.032. Epub 2015 Aug 1.


The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.

Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD.

Cell Rep. 2015 Jul 7;12(1):15-22. doi: 10.1016/j.celrep.2015.06.002. Epub 2015 Jun 25.


Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD.

PLoS One. 2015 Jun 10;10(6):e0130520. doi: 10.1371/journal.pone.0130520. eCollection 2015.


Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling.

Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, Rabinowitz JE, Leask A, Molkentin JD.

Mol Cell Biol. 2015 Jun;35(12):2154-64. doi: 10.1128/MCB.00199-15. Epub 2015 Apr 13.


Radiological prevalence of superior and posterior semicircular canal dehiscence in children.

Saxby AJ, Gowdy C, Fandiño M, Chadha NK, Kozak FK, Sargent MA, Lea J.

Int J Pediatr Otorhinolaryngol. 2015 Mar;79(3):411-8. doi: 10.1016/j.ijporl.2015.01.001. Epub 2015 Jan 14.


P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.

Wissing ER, Boyer JG, Kwong JQ, Sargent MA, Karch J, McNally EM, Otsu K, Molkentin JD.

Hum Mol Genet. 2014 Oct 15;23(20):5452-63. doi: 10.1093/hmg/ddu270. Epub 2014 May 29.


Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.

Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD.

Mol Cell Biol. 2014 Jun;34(11):1991-2002. doi: 10.1128/MCB.00339-14. Epub 2014 Mar 24.


Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy.

Kwong JQ, Davis J, Baines CP, Sargent MA, Karch J, Wang X, Huang T, Molkentin JD.

Cell Death Differ. 2014 Aug;21(8):1209-17. doi: 10.1038/cdd.2014.36. Epub 2014 Mar 21.


Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD.

Hum Mol Genet. 2014 Jul 15;23(14):3706-15. doi: 10.1093/hmg/ddu079. Epub 2014 Feb 20.


MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy.

Gano D, Sargent MA, Miller SP, Connolly MB, Wong P, Glass HC, Poskitt KJ, Chau V.

Pediatr Neurol. 2013 Dec;49(6):401-5. doi: 10.1016/j.pediatrneurol.2013.08.007. Epub 2013 Oct 2.


Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.

Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD.

Elife. 2013 Aug 27;2:e00772. doi: 10.7554/eLife.00772.


Fetal progeria: prenatal sonographic findings in petty syndrome.

Pugash D, Schrader KA, Dunham CP, Popescu OE, Sargent MA, Lehman AM, Yong SL, Clarke LA.

J Ultrasound Med. 2013 May;32(5):881-3. doi: 10.7863/ultra.32.5.881. No abstract available.


Does optic nerve sheath diameter on MRI decrease with clinically improved pediatric hydrocephalus?

Singhal A, Yang MM, Sargent MA, Cochrane DD.

Childs Nerv Syst. 2013 Feb;29(2):269-74. doi: 10.1007/s00381-012-1937-z. Epub 2012 Oct 27. Review.


A thrombospondin-dependent pathway for a protective ER stress response.

Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD.

Cell. 2012 Jun 8;149(6):1257-68. doi: 10.1016/j.cell.2012.03.050.


Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.

Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD.

J Clin Invest. 2012 Jan;122(1):280-90. doi: 10.1172/JCI58227. Epub 2011 Dec 1.


Ophthalmic complications of otitis media in children.

Pollock TJ, Kim P, Sargent MA, Aroichane M, Lyons CJ, Gardiner JA.

J AAPOS. 2011 Jun;15(3):272-5. doi: 10.1016/j.jaapos.2010.12.018.


Expanding the clinical phenotype of the mitochondrial m.13513G>A mutation with the first report of a fatal neonatal presentation.

Van Karnebeek CD, Waters PJ, Sargent MA, Mezei MM, Wong LJ, Wang J, Stöckler-Ipsiroglu S.

Dev Med Child Neurol. 2011 Jun;53(6):565-8. doi: 10.1111/j.1469-8749.2010.03907.x. Epub 2011 Apr 19. Erratum in: Dev Med Child Neurol. 2011 Aug;53(8):767. Mezey, Michelle M [corrected to Mezei, Michelle M].


Third ventricular shape: a predictor of endoscopic third ventriculostomy success in pediatric patients.

Foroughi M, Wong A, Steinbok P, Singhal A, Sargent MA, Cochrane DD.

J Neurosurg Pediatr. 2011 Apr;7(4):389-96. doi: 10.3171/2011.1.PEDS10461.


Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas--possible role of Cannabis inhalation.

Foroughi M, Hendson G, Sargent MA, Steinbok P.

Childs Nerv Syst. 2011 Apr;27(4):671-9. doi: 10.1007/s00381-011-1410-4. Epub 2011 Feb 20.


Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.

Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD.

J Clin Invest. 2011 Mar;121(3):1044-52. doi: 10.1172/JCI43844.


Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.

Millay DP, Goonasekera SA, Sargent MA, Maillet M, Aronow BJ, Molkentin JD.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19023-8. doi: 10.1073/pnas.0906591106. Epub 2009 Oct 28.


Calcineurin protects the heart in a murine model of dilated cardiomyopathy.

Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD.

J Mol Cell Cardiol. 2010 Jun;48(6):1080-7. doi: 10.1016/j.yjmcc.2009.10.012. Epub 2009 Oct 22.


Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy.

Millay DP, Maillet M, Roche JA, Sargent MA, McNally EM, Bloch RJ, Molkentin JD.

Am J Pathol. 2009 Nov;175(5):1817-23. doi: 10.2353/ajpath.2009.090107. Epub 2009 Oct 15.


ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice.

Liu Q, Sargent MA, York AJ, Molkentin JD.

Circ Res. 2009 Nov 20;105(11):1110-7. doi: 10.1161/CIRCRESAHA.109.200741. Epub 2009 Oct 8.


Effect of chorioamnionitis on brain development and injury in premature newborns.

Chau V, Poskitt KJ, McFadden DE, Bowen-Roberts T, Synnes A, Brant R, Sargent MA, Soulikias W, Miller SP.

Ann Neurol. 2009 Aug;66(2):155-64. doi: 10.1002/ana.21713.


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