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The bystander effect contributes to the accumulation of senescent cells in vivo.

da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T.

Aging Cell. 2018 Nov 21:e12848. doi: 10.1111/acel.12848. [Epub ahead of print]


Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue.

Ishaq A, Dufour D, Cameron K, von Zglinicki T, Saretzki G.

Exp Gerontol. 2018 Nov;113:228-236. doi: 10.1016/j.exger.2018.10.008. Epub 2018 Oct 10.


Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.

Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1283-1296. doi: 10.1161/ATVBAHA.117.309940. Epub 2018 Mar 29.


Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey.

Ishaq A, Schröder J, Edwards N, von Zglinicki T, Saretzki G.

J Nutr Health Aging. 2018;22(4):555-561. doi: 10.1007/s12603-017-0968-2.


iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M.

Cell Death Dis. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1.


Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A > G mitochondrial DNA mutation.

Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L, Yu-Wai-Man P, Lako M, Steel DH.

Sci Rep. 2017 Sep 26;7(1):12320. doi: 10.1038/s41598-017-12396-2.


An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

Hallam D, Collin J, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyborski S, Alharthi S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M.

Stem Cells. 2017 Nov;35(11):2305-2320. doi: 10.1002/stem.2708. Epub 2017 Oct 9. Erratum in: Stem Cells. 2018 Apr;36(4):630.


Telomerase and mTOR in the brain: the mitochondria connection.

Miwa S, Saretzki G.

Neural Regen Res. 2017 Mar;12(3):358-361. doi: 10.4103/1673-5374.202922. Review.


Implications of telomeres and telomerase in endometrial pathology.

Hapangama DK, Kamal A, Saretzki G.

Hum Reprod Update. 2017 Mar 1;23(2):166-187. doi: 10.1093/humupd/dmw044. Review.


The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.

Zhu L, Gomez-Duran A, Saretzki G, Jin S, Tilgner K, Melguizo-Sanchis D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, Lako M, Armstrong L.

J Cell Biol. 2016 Oct 24;215(2):187-202. Epub 2016 Oct 17.


Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress.

Ashor AW, Chowdhury S, Oggioni C, Qadir O, Brandt K, Ishaq A, Mathers JC, Saretzki G, Siervo M.

J Nutr. 2016 Nov;146(11):2224-2232. Epub 2016 Oct 12.


Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria.

Miwa S, Czapiewski R, Wan T, Bell A, Hill KN, von Zglinicki T, Saretzki G.

Aging (Albany NY). 2016 Oct 22;8(10):2551-2567. doi: 10.18632/aging.101089.


Telomerase Activity is Downregulated Early During Human Brain Development.

Ishaq A, Hanson PS, Morris CM, Saretzki G.

Genes (Basel). 2016 Jun 16;7(6). pii: E27. doi: 10.3390/genes7060027.


Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.


Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis.

Valentijn AJ, Saretzki G, Tempest N, Critchley HO, Hapangama DK.

Hum Reprod. 2015 Dec;30(12):2816-28. doi: 10.1093/humrep/dev267. Epub 2015 Oct 25.


Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium.

Hallam D, Wan T, Saretzki G.

Exp Gerontol. 2015 Jul;67:72-9. doi: 10.1016/j.exger.2015.04.014. Epub 2015 Apr 30.


The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.

Spilsbury A, Miwa S, Attems J, Saretzki G.

J Neurosci. 2015 Jan 28;35(4):1659-74. doi: 10.1523/JNEUROSCI.2925-14.2015.


Improvement of biological age by physical activity.

Melk A, Tegtbur U, Hilfiker-Kleiner D, Eberhard J, Saretzki G, Eulert C, Kerling A, Nelius AK, Hömme M, Strunk D, Berliner D, Röntgen P, Kück M, Bauersachs J, Hilfiker A, Haverich A, Bara C, Stiesch M.

Int J Cardiol. 2014 Oct 20;176(3):1187-9. doi: 10.1016/j.ijcard.2014.07.236. Epub 2014 Aug 12. No abstract available.


Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.

Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I.

Atherosclerosis. 2014 Oct;236(2):312-20. doi: 10.1016/j.atherosclerosis.2014.07.020. Epub 2014 Aug 4.


Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.

Al-Ajmi N, Saretzki G, Miles C, Spyridopoulos I.

Exp Gerontol. 2014 Oct;58:113-9. doi: 10.1016/j.exger.2014.07.010. Epub 2014 Jul 17.


Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress.

Saretzki G.

Curr Pharm Des. 2014;20(41):6386-403. Review.


Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.


Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.

Miwa S, Jow H, Baty K, Johnson A, Czapiewski R, Saretzki G, Treumann A, von Zglinicki T.

Nat Commun. 2014 May 12;5:3837. doi: 10.1038/ncomms4837.


SSEA-1 isolates human endometrial basal glandular epithelial cells: phenotypic and functional characterization and implications in the pathogenesis of endometriosis.

Valentijn AJ, Palial K, Al-Lamee H, Tempest N, Drury J, Von Zglinicki T, Saretzki G, Murray P, Gargett CE, Hapangama DK.

Hum Reprod. 2013 Oct;28(10):2695-708. doi: 10.1093/humrep/det285. Epub 2013 Jul 11.


Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Stem Cells. 2013 Sep;31(9):2015-23. doi: 10.1002/stem.1456.


A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Cell Death Differ. 2013 Aug;20(8):1089-100. doi: 10.1038/cdd.2013.44. Epub 2013 May 31.


Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.

Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC.

PLoS One. 2013;8(1):e52989. doi: 10.1371/journal.pone.0052989. Epub 2013 Jan 9.


Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C, Saretzki G, Stojkovic M, Armstrong L, Przyborski S, Lako M.

Stem Cells. 2013 May;31(5):1022-9. doi: 10.1002/stem.1308.


The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult.

Tsolou A, Nelson G, Trachana V, Chondrogianni N, Saretzki G, von Zglinicki T, Gonos ES.

IUBMB Life. 2012 May;64(5):432-42. doi: 10.1002/iub.1018. Epub 2012 Mar 31.


A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.

Lawless C, Jurk D, Gillespie CS, Shanley D, Saretzki G, von Zglinicki T, Passos JF.

PLoS One. 2012;7(2):e32117. doi: 10.1371/journal.pone.0032117. Epub 2012 Feb 16.


Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, Browne C, Dewilton A, Przyborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L.

Stem Cells. 2012 Apr;30(4):599-611. doi: 10.1002/stem.1053.


Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism.

Gorowiec MR, Borthwick LA, Parker SM, Kirby JA, Saretzki GC, Fisher AJ.

Free Radic Biol Med. 2012 Mar 15;52(6):1024-32. doi: 10.1016/j.freeradbiomed.2011.12.020. Epub 2012 Jan 2.


Adult-onset, short-term dietary restriction reduces cell senescence in mice.

Wang C, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SA, Godschalk RW, Cameron K, von Zglinicki T.

Aging (Albany NY). 2010 Sep;2(9):555-66.


The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families.

Tuppen HA, Hogan VE, He L, Blakely EL, Worgan L, Al-Dosary M, Saretzki G, Alston CL, Morris AA, Clarke M, Jones S, Devlin AM, Mansour S, Chrzanowska-Lightowlers ZM, Thorburn DR, McFarland R, Taylor RW.

Brain. 2010 Oct;133(10):2952-63. doi: 10.1093/brain/awq232. Epub 2010 Sep 6.


Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts.

Daniels DJ, Clothier C, Swan DC, Saretzki G.

Biochem Biophys Res Commun. 2010 Aug 13;399(1):7-13. doi: 10.1016/j.bbrc.2010.07.018. Epub 2010 Jul 15.


Cellular senescence in the development and treatment of cancer.

Saretzki G.

Curr Pharm Des. 2010 Jan;16(1):79-100. Review.


Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T.

Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16.


Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M.

Stem Cells. 2010 Apr;28(4):661-73. doi: 10.1002/stem.307.


Well-known signaling proteins exert new functions in the nucleus and mitochondria.

Büchner N, Altschmied J, Jakob S, Saretzki G, Haendeler J.

Antioxid Redox Signal. 2010 Aug 15;13(4):551-8. doi: 10.1089/ars.2009.2994. Review.


Telomerase, mitochondria and oxidative stress.

Saretzki G.

Exp Gerontol. 2009 Aug;44(8):485-92. doi: 10.1016/j.exger.2009.05.004. Epub 2009 May 18. Review.


Airway epithelial cell senescence in the lung allograft.

Parker SM, Goriwiec MR, Borthwick LA, Johnson G, Ward C, Lordan JL, Corris PA, Saretzki GC, Fisher AJ.

Am J Transplant. 2008 Jul;8(7):1544-9. doi: 10.1111/j.1600-6143.2008.02284.x.


Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

Hapangama DK, Turner MA, Drury JA, Quenby S, Saretzki G, Martin-Ruiz C, Von Zglinicki T.

Hum Reprod. 2008 Jul;23(7):1511-9. doi: 10.1093/humrep/den172. Epub 2008 May 2.


Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.

Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G.

J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53. doi: 10.1242/jcs.019372. Epub 2008 Mar 11.


A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation.

Yang C, Przyborski S, Cooke MJ, Zhang X, Stewart R, Anyfantis G, Atkinson SP, Saretzki G, Armstrong L, Lako M.

Stem Cells. 2008 Apr;26(4):850-63. doi: 10.1634/stemcells.2007-0677. Epub 2008 Jan 17.


Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M.

Stem Cells. 2008 Feb;26(2):455-64. Epub 2007 Nov 29.


DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Passos JF, Saretzki G, von Zglinicki T.

Nucleic Acids Res. 2007;35(22):7505-13. Epub 2007 Nov 5. Review.


Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.

Ksiazek K, Passos JF, Olijslagers S, Saretzki G, Martin-Ruiz C, von Zglinicki T.

Biochem Biophys Res Commun. 2007 Oct 26;362(3):707-11. Epub 2007 Aug 20.


Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.

Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T.

PLoS Biol. 2007 May;5(5):e110.


TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts.

Richter T, Saretzki G, Nelson G, Melcher M, Olijslagers S, von Zglinicki T.

Mech Ageing Dev. 2007 Apr;128(4):340-5. Epub 2007 Mar 4.


Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart.

Serakinci N, Christensen R, Graakjaer J, Cairney CJ, Keith WN, Alsner J, Saretzki G, Kolvraa S.

Exp Cell Res. 2007 Mar 10;313(5):1056-67. Epub 2007 Jan 8.


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