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Items: 35


Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States.

Viskaitis P, Irvine EE, Smith MA, Choudhury AI, Alvarez-Curto E, Glegola JA, Hardy DG, Pedroni SMA, Paiva Pessoa MR, Fernando ABP, Katsouri L, Sardini A, Ungless MA, Milligan G, Withers DJ.

Cell Rep. 2017 Dec 19;21(12):3559-3572. doi: 10.1016/j.celrep.2017.11.089.


Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AG.

Cell Rep. 2017 Jan 31;18(5):1090-1099. doi: 10.1016/j.celrep.2017.01.010.


Time-lapse 3-D measurements of a glucose biosensor in multicellular spheroids by light sheet fluorescence microscopy in commercial 96-well plates.

Maioli V, Chennell G, Sparks H, Lana T, Kumar S, Carling D, Sardini A, Dunsby C.

Sci Rep. 2016 Nov 25;6:37777. doi: 10.1038/srep37777.


Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM.

Chennell G, Willows RJ, Warren SC, Carling D, French PM, Dunsby C, Sardini A.

Sensors (Basel). 2016 Aug 19;16(8). pii: E1312. doi: 10.3390/s16081312.


Analysis of DNA binding and nucleotide flipping kinetics using two-color two-photon fluorescence lifetime imaging microscopy.

Robinson T, Valluri P, Kennedy G, Sardini A, Dunsby C, Neil MA, Baldwin GS, French PM, de Mello AJ.

Anal Chem. 2014 Nov 4;86(21):10732-40. doi: 10.1021/ac502732s. Epub 2014 Oct 20.


C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.

Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto M.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8. doi: 10.1073/pnas.1316877111. Epub 2014 Jan 13.


Fluorescence lifetime readouts of Troponin-C-based calcium FRET sensors: a quantitative comparison of CFP and mTFP1 as donor fluorophores.

Laine R, Stuckey DW, Manning H, Warren SC, Kennedy G, Carling D, Dunsby C, Sardini A, French PM.

PLoS One. 2012;7(11):e49200. doi: 10.1371/journal.pone.0049200. Epub 2012 Nov 9.


Förster resonance energy transfer imaging in vivo with approximated radiative transfer equation.

Soloviev VY, McGinty J, Stuckey DW, Laine R, Wylezinska-Arridge M, Wells DJ, Sardini A, Hajnal JV, French PM, Arridge SR.

Appl Opt. 2011 Dec 20;50(36):6583-90. doi: 10.1364/AO.50.006583.


In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse.

McGinty J, Stuckey DW, Soloviev VY, Laine R, Wylezinska-Arridge M, Wells DJ, Arridge SR, French PM, Hajnal JV, Sardini A.

Biomed Opt Express. 2011 Jul 1;2(7):1907-17. doi: 10.1364/BOE.2.001907. Epub 2011 Jun 10.


FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ.

Kumar S, Alibhai D, Margineanu A, Laine R, Kennedy G, McGinty J, Warren S, Kelly D, Alexandrov Y, Munro I, Talbot C, Stuckey DW, Kimberly C, Viellerobe B, Lacombe F, Lam EW, Taylor H, Dallman MJ, Stamp G, Murray EJ, Stuhmeier F, Sardini A, Katan M, Elson DS, Neil MA, Dunsby C, French PM.

Chemphyschem. 2011 Feb 25;12(3):609-26. doi: 10.1002/cphc.201000874. Epub 2011 Feb 17.


Three-dimensional imaging of Förster resonance energy transfer in heterogeneous turbid media by tomographic fluorescent lifetime imaging.

McGinty J, Soloviev VY, Tahir KB, Laine R, Stuckey DW, Hajnal JV, Sardini A, French PM, Arridge SR.

Opt Lett. 2009 Sep 15;34(18):2772-4. doi: 10.1364/OL.34.002772.


Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression.

Thornton C, Sardini A, Carling D.

J Biol Chem. 2008 Jun 20;283(25):17116-22. doi: 10.1074/jbc.M708987200. Epub 2008 Apr 24.


Lifespan regulation of conventional protein kinase C isotypes.

Carmena D, Sardini A.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1043-5. Review.


Fluorescence lifetime tomography of live cells expressing enhanced green fluorescent protein embedded in a scattering medium exhibiting background autofluorescence.

Soloviev VY, McGinty J, Tahir KB, Neil MA, Sardini A, Hajnal JV, Arridge SR, French PM.

Opt Lett. 2007 Jul 15;32(14):2034-6.


ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment.

Weylandt KH, Nebrig M, Jansen-Rosseck N, Amey JS, Carmena D, Wiedenmann B, Higgins CF, Sardini A.

Mol Cancer Ther. 2007 Mar;6(3):979-86. Erratum in: Mol Cancer Ther. 2008 Jul;7(7):2261.


Agonist-dependent internalization of D2 receptors: Imaging quantification by confocal microscopy.

Goggi JL, Sardini A, Egerton A, Strange PG, Grasby PM.

Synapse. 2007 Apr;61(4):231-41.


The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.

Okkenhaug H, Weylandt KH, Carmena D, Wells DJ, Higgins CF, Sardini A.

FASEB J. 2006 Nov;20(13):2390-2. Epub 2006 Oct 3.


Phosphatidylserine exposure in B lymphocytes: a role for lipid packing.

Elliott JI, Sardini A, Cooper JC, Alexander DR, Davanture S, Chimini G, Higgins CF.

Blood. 2006 Sep 1;108(5):1611-7. Epub 2006 May 9.


A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF.

Blood. 2005 Jul 15;106(2):542-9. Epub 2005 Mar 24.


ABCA1 expression in carotid atherosclerotic plaques.

Albrecht C, Soumian S, Amey JS, Sardini A, Higgins CF, Davies AH, Gibbs RG.

Stroke. 2004 Dec;35(12):2801-6. Epub 2004 Nov 4.


Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell).

Nobles M, Higgins CF, Sardini A.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1426-35. Epub 2004 Aug 11.


Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.

Albrecht C, Baynes K, Sardini A, Schepelmann S, Eden ER, Davies SW, Higgins CF, Feher MD, Owen JS, Soutar AK.

Biochim Biophys Acta. 2004 May 24;1689(1):47-57.


Cell volume regulation and swelling-activated chloride channels.

Sardini A, Amey JS, Weylandt KH, Nobles M, Valverde MA, Higgins CF.

Biochim Biophys Acta. 2003 Dec 30;1618(2):153-62. Review.


An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.

Serero A, Giglione C, Sardini A, Martinez-Sanz J, Meinnel T.

J Biol Chem. 2003 Dec 26;278(52):52953-63. Epub 2003 Oct 7.


P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation.

Yague E, Armesilla AL, Harrison G, Elliott J, Sardini A, Higgins CF, Raguz S.

J Biol Chem. 2003 Mar 21;278(12):10344-52. Epub 2003 Jan 13.


Functional analysis of candidate ABC transporter proteins for sitosterol transport.

Albrecht C, Elliott JI, Sardini A, Litman T, Stieger B, Meier PJ, Higgins CF.

Biochim Biophys Acta. 2002 Dec 23;1567(1-2):133-42.


Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation.

Weylandt KH, Valverde MA, Nobles M, Raguz S, Amey JS, Diaz M, Nastrucci C, Higgins CF, Sardini A.

J Biol Chem. 2001 May 18;276(20):17461-7. Epub 2001 Feb 22.


Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat.

Cesare P, Dekker LV, Sardini A, Parker PJ, McNaughton PA.

Neuron. 1999 Jul;23(3):617-24.


A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene.

van Veen HW, Callaghan R, Soceneantu L, Sardini A, Konings WN, Higgins CF.

Nature. 1998 Jan 15;391(6664):291-5.


Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein.

Goodfellow HR, Sardini A, Ruetz S, Callaghan R, Gros P, McNaughton PA, Higgins CF.

J Biol Chem. 1996 Jun 7;271(23):13668-74.


Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

Sardini A, Mintenig GM, Valverde MA, Sepúlveda FV, Gill DR, Hyde SC, Higgins CF, McNaughton PA.

J Cell Sci. 1994 Dec;107 ( Pt 12):3281-90.


Modulation of drug-induced cytotoxicity by a bispecific monoclonal antibody that recognizes the epidermal growth factor receptor and doxorubicin.

Morelli D, Sardini A, Villa E, Villa ML, Ménard S, Colnaghi MI, Balsari A.

Cancer Immunol Immunother. 1994 Mar;38(3):171-7.


Increase in the therapeutic effect of doxorubicin induced by monoclonal antibodies raised against this drug.

Villa E, Balsari A, Sardini A, Morelli D, Ménard S, Colnaghi MI.

Pharmacol Res. 1992 Sep;26 Suppl 2:141-3. No abstract available.


An anti-doxorubicin monoclonal antibody modulates kinetic and dynamic characteristics of the drug.

Sardini A, Villa E, Morelli D, Ghione M, Ménard S, Colnaghi MI, Balsari A.

Int J Cancer. 1992 Feb 20;50(4):617-20.


Properties of acetylcholine-receptor activation in human Duchenne muscular dystrophy myotubes.

Mancinelli E, Sardini A, D'Aumiller A, Meola G, Martucci G, Cossu G, Wanke E.

Proc R Soc Lond B Biol Sci. 1989 Jul 22;237(1287):247-57.


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