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Items: 39

1.

Cell-based assays as an alternative for the study of aquatic toxicity of pharmaceuticals.

Rodrigues ET, Varela AT, Pardal MA, Sardão VA.

Environ Sci Pollut Res Int. 2019 Dec 27. doi: 10.1007/s11356-019-07384-0. [Epub ahead of print]

PMID:
31883075
2.

A Mitochondrial Approach to Cardiovascular Risk and Disease.

Veloso CD, Belew GD, Ferreira LL, Grilo LF, Jones JG, Portincasa P, Sardão VA, Oliveira PJ.

Curr Pharm Des. 2019;25(29):3175-3194. doi: 10.2174/1389203720666190830163735.

PMID:
31470786
3.

Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin.

Grasselli E, Baldini F, Vecchione G, Oliveira PJ, Sardão VA, Voci A, Portincasa P, Vergani L.

Int J Mol Med. 2019 Aug;44(2):705-712. doi: 10.3892/ijmm.2019.4234. Epub 2019 Jun 6.

PMID:
31173180
4.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J.

Cell Metab. 2019 Feb 5;29(2):399-416.e10. doi: 10.1016/j.cmet.2018.10.014. Epub 2018 Nov 15.

5.

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavan B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR.

Int Rev Cell Mol Biol. 2018;340:209-344. doi: 10.1016/bs.ircmb.2018.05.006. Epub 2018 Jun 22. Review.

PMID:
30072092
6.

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative.

Teixeira J, Amorim R, Santos K, Soares P, Datta S, Cortopassi GA, Serafim TL, Sardão VA, Garrido J, Borges F, Oliveira PJ.

Toxicology. 2018 Jan 15;393:123-139. doi: 10.1016/j.tox.2017.11.014. Epub 2017 Nov 12.

PMID:
29141199
7.

The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression.

Vecchione G, Grasselli E, Cioffi F, Baldini F, Oliveira PJ, Sardão VA, Cortese K, Lanni A, Voci A, Portincasa P, Vergani L.

Front Nutr. 2017 Sep 19;4:42. doi: 10.3389/fnut.2017.00042. eCollection 2017.

8.

Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway.

Wojtala A, Karkucinska-Wieckowska A, Sardao VA, Szczepanowska J, Kowalski P, Pronicki M, Duszynski J, Wieckowski MR.

Mitochondrion. 2017 Nov;37:62-79. doi: 10.1016/j.mito.2017.07.002. Epub 2017 Jul 21.

PMID:
28739512
9.

Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells.

Deus CM, Serafim TL, Magalhães-Novais S, Vilaça A, Moreira AC, Sardão VA, Cardoso SM, Oliveira PJ.

Arch Toxicol. 2017 Mar;91(3):1261-1278. doi: 10.1007/s00204-016-1784-x. Epub 2016 Jun 29.

PMID:
27358235
10.

Ketogenic diets: from cancer to mitochondrial diseases and beyond.

Branco AF, Ferreira A, Simões RF, Magalhães-Novais S, Zehowski C, Cope E, Silva AM, Pereira D, Sardão VA, Cunha-Oliveira T.

Eur J Clin Invest. 2016 Mar;46(3):285-98. doi: 10.1111/eci.12591. Review.

PMID:
26782788
11.

Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.

Jiménez-Chillarón JC, Nijland MJ, Ascensão AA, Sardão VA, Magalhães J, Hitchler MJ, Domann FE, Oliveira PJ.

Epigenetics. 2015;10(4):259-73. doi: 10.1080/15592294.2015.1020267. Epub 2015 Mar 16. Review.

12.

Role of mtDNA-related mitoepigenetic phenomena in cancer.

Ferreira A, Serafim TL, Sardão VA, Cunha-Oliveira T.

Eur J Clin Invest. 2015 Jan;45 Suppl 1:44-9. doi: 10.1111/eci.12359. Review.

PMID:
25524586
13.

Analysis of pro-apoptotic protein trafficking to and from mitochondria.

Vega-Naredo I, Cunha-Oliveira T, Serafim TL, Sardao VA, Oliveira PJ.

Methods Mol Biol. 2015;1241:163-80. doi: 10.1007/978-1-4939-1875-1_14.

PMID:
25308496
14.

Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

Moreira AC, Branco AF, Sampaio SF, Cunha-Oliveira T, Martins TR, Holy J, Oliveira PJ, Sardão VA.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2468-78. doi: 10.1016/j.bbadis.2014.09.015. Epub 2014 Oct 2.

15.

β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?

Branco AF, Moreira AC, Cunha-Oliveira T, Couto R, Sardao VA, Rizvanov AA, Palotas A, Oliveira PJ.

Curr Drug Targets. 2014;15(10):956-64. Review.

PMID:
25182471
16.

Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown.

Moreira AC, Silva AM, Santos MS, Sardão VA.

J Steroid Biochem Mol Biol. 2014 Sep;143:61-71. doi: 10.1016/j.jsbmb.2014.01.016. Epub 2014 Feb 28. Review.

PMID:
24583026
17.

Mitochondrial disruption occurs downstream from β-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: differential activation of stress and survival pathways.

Branco AF, Sampaio SF, Wieckowski MR, Sardão VA, Oliveira PJ.

Int J Biochem Cell Biol. 2013 Nov;45(11):2379-91. doi: 10.1016/j.biocel.2013.08.006. Epub 2013 Aug 16.

PMID:
23958426
18.

Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: investigation of the role of gender.

Moreira AC, Silva AM, Santos MS, Sardão VA.

Food Chem Toxicol. 2013 Mar;53:18-26. doi: 10.1016/j.fct.2012.11.031. Epub 2012 Nov 29.

PMID:
23200887
19.

Differentiation-dependent doxorubicin toxicity on H9c2 cardiomyoblasts.

Branco AF, Sampaio SF, Moreira AC, Holy J, Wallace KB, Baldeiras I, Oliveira PJ, Sardão VA.

Cardiovasc Toxicol. 2012 Dec;12(4):326-40. doi: 10.1007/s12012-012-9177-8.

PMID:
22744233
20.

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

Oliveira PJ, Carvalho RA, Portincasa P, Bonfrate L, Sardao VA.

J Lipids. 2012;2012:365798. doi: 10.1155/2012/365798. Epub 2012 Feb 1.

21.

Mitochondrial and liver oxidative stress alterations induced by N-butyl-N-(4-hydroxybutyl)nitrosamine: relevance for hepatotoxicity.

Oliveira MM, Teixeira JC, Vasconcelos-Nóbrega C, Felix LM, Sardão VA, Colaço AA, Oliveira PA, Peixoto FP.

J Appl Toxicol. 2013 Jun;33(6):434-43. doi: 10.1002/jat.1763. Epub 2011 Nov 16.

PMID:
22095756
22.

Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion.

Alves MG, Machado NG, Sardão VA, Carvalho RA, Oliveira PJ.

J Cell Biochem. 2011 Dec;112(12):3872-81. doi: 10.1002/jcb.23320.

PMID:
21866562
23.

Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line.

Branco AF, Pereira SL, Moreira AC, Holy J, Sardão VA, Oliveira PJ.

Cardiovasc Toxicol. 2011 Sep;11(3):191-203. doi: 10.1007/s12012-011-9111-5. Erratum in: Cardiovasc Toxicol. 2011 Sep;11(3):284.

PMID:
21455642
24.

Metabolic remodeling during H9c2 myoblast differentiation: relevance for in vitro toxicity studies.

Pereira SL, Ramalho-Santos J, Branco AF, Sardão VA, Oliveira PJ, Carvalho RA.

Cardiovasc Toxicol. 2011 Jun;11(2):180-90. doi: 10.1007/s12012-011-9112-4.

PMID:
21431998
25.

Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats.

Ascensão A, Lumini-Oliveira J, Machado NG, Ferreira RM, Gonçalves IO, Moreira AC, Marques F, Sardão VA, Oliveira PJ, Magalhães J.

Clin Sci (Lond). 2011 Jan;120(1):37-49. doi: 10.1042/CS20100254.

PMID:
20666733
26.

Nitrogen compounds prevent h9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death.

Silva JP, Sardão VA, Coutinho OP, Oliveira PJ.

Cardiovasc Toxicol. 2010 Mar;10(1):51-65. doi: 10.1007/s12012-010-9062-2. Erratum in: Cardiovasc Toxicol. 2010 Jun;10(2):152. Olveira, Paulo J [corrected to Oliveira, Paulo J].

PMID:
20119745
27.

Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB.

Cancer Chemother Pharmacol. 2009 Sep;64(4):811-27. doi: 10.1007/s00280-009-0932-x. Epub 2009 Jan 30.

PMID:
19184017
28.

Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?

Pereira CV, Moreira AC, Pereira SP, Machado NG, Carvalho FS, Sardão VA, Oliveira PJ.

Curr Drug Saf. 2009 Jan;4(1):34-54. Review.

PMID:
19149524
29.

Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects.

Serafim TL, Matos JA, Sardão VA, Pereira GC, Branco AF, Pereira SL, Parke D, Perkins EL, Moreno AJ, Holy J, Oliveira PJ.

Biochem Pharmacol. 2008 Dec 1;76(11):1459-75. doi: 10.1016/j.bcp.2008.07.013. Epub 2008 Jul 19.

PMID:
18692024
30.

Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB.

Cell Biol Toxicol. 2009 Jun;25(3):227-43. doi: 10.1007/s10565-008-9070-1. Epub 2008 Apr 3.

PMID:
18386138
31.

Drug-induced mitochondrial dysfunction in cardiac and skeletal muscle injury.

Sardão VA, Pereira SL, Oliveira PJ.

Expert Opin Drug Saf. 2008 Mar;7(2):129-46. doi: 10.1517/14740338.7.2.129 . Review.

PMID:
18324876
32.

Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ.

J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17.

PMID:
17704354
33.

Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line.

Serafim TL, Oliveira PJ, Sardao VA, Perkins E, Parke D, Holy J.

Cancer Chemother Pharmacol. 2008 May;61(6):1007-18. Epub 2007 Jul 28.

PMID:
17661039
34.

Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death.

Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB.

BMC Cell Biol. 2007 Mar 16;8:11.

35.

Vitamin E or coenzyme Q10 administration is not fully advantageous for heart mitochondrial function in diabetic goto kakizaki rats.

Oliveira PJ, Seica R, Santos DL, Rolo AP, Sardao VA, Ferreira FM, Palmeira CM, Santos MS, Moreno AJ.

Mitochondrion. 2004 May;3(6):337-45.

PMID:
16120365
36.

Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?

Ferreira M, Coxito PM, Sardão VA, Palmeira CM, Oliveira PJ.

Cardiovasc Toxicol. 2005;5(1):63-73.

PMID:
15738586
37.

Advantages in the use of carvedilol versus propranolol for the protection of cardiac mitochondrial function.

Oliveira PJ, Rolo AP, Sardão VA, Monteiro P, Gonçalves L, Providência LA, Palmeira CM, Moreno AJ.

Rev Port Cardiol. 2004 Oct;23(10):1291-8.

PMID:
15641294
38.

Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: relevance for caffeine toxicity.

Sardão VA, Oliveira PJ, Moreno AJ.

Toxicol Appl Pharmacol. 2002 Feb 15;179(1):50-6.

PMID:
11884236
39.

Carvedilol in heart mitochondria: protonophore or opener of the mitochondrial K(ATP) channels?

Oliveira PJ, Rolo AP, Sardão VA, Coxito PM, Palmeira CM, Moreno AJ.

Life Sci. 2001 Jun 1;69(2):123-32.

PMID:
11441902

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