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Items: 26


TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase.

Sarathy JP, Ragunathan P, Shin J, Cooper CB, Upton AM, Grüber G, Dick T.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01191-19. doi: 10.1128/AAC.01191-19. Print 2019 Oct.


Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.

Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang HP, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02516-18. doi: 10.1128/AAC.02516-18. Print 2019 May.


Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.

Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, Richmann T, Gupta A, Singleton E, Verma S, Husain S, Soteropoulos P, Wang Z, Morris R, Porter G, Agnihotri G, Salgame P, Ekins S, Rhee KY, Connell N, Dartois V, Neiditch MB, Freundlich JS, Alland D.

MBio. 2018 Dec 18;9(6). pii: e02101-17. doi: 10.1128/mBio.02101-17.


Impact of immunopathology on the antituberculous activity of pyrazinamide.

Blanc L, Sarathy JP, Alvarez Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Sacchettini J, Savic RM, Gengenbacher M, Podell BK, Prideaux B, Ioerger T, Dick T, Dartois V.

J Exp Med. 2018 Aug 6;215(8):1975-1986. doi: 10.1084/jem.20180518. Epub 2018 Jul 17.


Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum.

Sarathy JP, Via LE, Weiner D, Blanc L, Boshoff H, Eugenin EA, Barry CE 3rd, Dartois VA.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02266-17. doi: 10.1128/AAC.02266-17. Print 2018 Feb.


Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

Gopal P, Nartey W, Ragunathan P, Sarathy J, Kaya F, Yee M, Setzer C, Manimekalai MSS, Dartois V, Grüber G, Dick T.

ACS Infect Dis. 2017 Nov 10;3(11):807-819. doi: 10.1021/acsinfecdis.7b00079. Epub 2017 Oct 18.


Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.

Pienaar E, Sarathy J, Prideaux B, Dietzold J, Dartois V, Kirschner DE, Linderman JJ.

PLoS Comput Biol. 2017 Aug 17;13(8):e1005650. doi: 10.1371/journal.pcbi.1005650. eCollection 2017 Aug.


Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.

Zimmerman M, Lestner J, Prideaux B, O'Brien P, Dias-Freedman I, Chen C, Dietzold J, Daudelin I, Kaya F, Blanc L, Chen PY, Park S, Salgame P, Sarathy J, Dartois V.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00924-17. doi: 10.1128/AAC.00924-17. Print 2017 Sep.


The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium.

Sarathy J, Detloff SJ, Ao M, Khan N, French S, Sirajuddin H, Nair T, Rao MC.

Physiol Rep. 2017 May;5(10):e13294. doi: 10.14814/phy2.13294.


An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions.

Sarathy JP, Liang HH, Weiner D, Gonzales J, Via LE, Dartois V.

J Vis Exp. 2017 May 8;(123). doi: 10.3791/55559.


In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.

Gopal P, Tasneen R, Yee M, Lanoix JP, Sarathy J, Rasic G, Li L, Dartois V, Nuermberger E, Dick T.

ACS Infect Dis. 2017 Jul 14;3(7):492-501. doi: 10.1021/acsinfecdis.7b00017. Epub 2017 Mar 16.


Chenodeoxycholic acid requires activation of EGFR, EPAC, and Ca2+ to stimulate CFTR-dependent Cl- secretion in human colonic T84 cells.

Domingue JC, Ao M, Sarathy J, Rao MC.

Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C777-C792. doi: 10.1152/ajpcell.00168.2016. Epub 2016 Aug 24.


Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis.

Gopal P, Yee M, Sarathy J, Low JL, Sarathy JP, Kaya F, Dartois V, Gengenbacher M, Dick T.

ACS Infect Dis. 2016 Sep 9;2(9):616-626. Epub 2016 Aug 8.


Prediction of Drug Penetration in Tuberculosis Lesions.

Sarathy JP, Zuccotto F, Hsinpin H, Sandberg L, Via LE, Marriner GA, Masquelin T, Wyatt P, Ray P, Dartois V.

ACS Infect Dis. 2016 Aug 12;2(8):552-63. doi: 10.1021/acsinfecdis.6b00051. Epub 2016 Jul 6.


High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.

Lanoix JP, Tasneen R, O'Brien P, Sarathy J, Safi H, Pinn M, Alland D, Dartois V, Nuermberger E.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4197-205. doi: 10.1128/AAC.03085-15. Print 2016 Jul.


Lithocholic acid attenuates cAMP-dependent Cl- secretion in human colonic epithelial T84 cells.

Ao M, Domingue JC, Khan N, Javed F, Osmani K, Sarathy J, Rao MC.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C1010-23. doi: 10.1152/ajpcell.00350.2015. Epub 2016 Apr 13.


The association between sterilizing activity and drug distribution into tuberculosis lesions.

Prideaux B, Via LE, Zimmerman MD, Eum S, Sarathy J, O'Brien P, Chen C, Kaya F, Weiner DM, Chen PY, Song T, Lee M, Shim TS, Cho JS, Kim W, Cho SN, Olivier KN, Barry CE 3rd, Dartois V.

Nat Med. 2015 Oct;21(10):1223-7. doi: 10.1038/nm.3937. Epub 2015 Sep 7.


HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl- transport.

Domingue JC, Ao M, Sarathy J, George A, Alrefai WA, Nelson DJ, Rao MC.

Physiol Rep. 2014 Sep 28;2(9). pii: e12158. doi: 10.14814/phy2.12158. Print 2014 Sep 1.


Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells.

Ao M, Sarathy J, Domingue J, Alrefai WA, Rao MC.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56. doi: 10.1152/ajpcell.00416.2012. Epub 2013 Jun 12.


Polyamines inhibit porin-mediated fluoroquinolone uptake in mycobacteria.

Sarathy JP, Lee E, Dartois V.

PLoS One. 2013 Jun 3;8(6):e65806. doi: 10.1371/journal.pone.0065806. Print 2013.


Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis.

Sarathy J, Dartois V, Dick T, Gengenbacher M.

Antimicrob Agents Chemother. 2013 Apr;57(4):1648-53. doi: 10.1128/AAC.02202-12. Epub 2013 Jan 18.


The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.

Sarathy JP, Dartois V, Lee EJ.

Pharmaceuticals (Basel). 2012 Nov 9;5(11):1210-35. doi: 10.3390/ph5111210.


Efficient performance optimization of SOA-MZI devices.

Wang JP, Robinson BS, Savage SJ, Hamilton SA, Ippen EP, Mu R, Wang H, Sarathy J, Stefanov BB.

Opt Express. 2008 Mar 3;16(5):3288-92.


Crystallographically limited submicrometer gratings in (100) and (211) silicon.

Sarathy J, Diaz DC, Campbell JC.

Opt Lett. 1995 May 15;20(10):1216-8.


Characteristics of crystallographic gratings.

Sarathy J, Diaz DC, Hartin OL, Campbell JC.

Opt Lett. 1995 Jan 15;20(2):228-30.


Normal-incidence grating couplers in Ge-Si.

Sarathy J, Mayer RA, Jung K, Unnikrishnan S, Kwong DL, Campbell JC.

Opt Lett. 1994 Jun 1;19(11):798-800.


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