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Items: 1 to 50 of 245

1.

Wildfire effects on two freshwater producers: Combining in-situ and laboratory bioassays.

Ré A, Campos I, Saraiva MJ, Puga J, Keizer JJ, Gonçalves FJM, Pereira JL, Abrantes N.

Ecotoxicol Environ Saf. 2020 May;194:110361. doi: 10.1016/j.ecoenv.2020.110361. Epub 2020 Feb 29.

PMID:
32126411
2.

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy.

Maia LF, Maceski A, Conceição I, Obici L, Magalhães R, Cortese A, Leppert D, Merlini G, Kuhle J, Saraiva MJ.

Amyloid. 2020 Jan 6:1-6. doi: 10.1080/13506129.2019.1708716. [Epub ahead of print]

PMID:
31906707
3.

Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.

Moreira J, Saraiva M, Saraiva MJ.

Amyloid. 2019;26(sup1):63-64. doi: 10.1080/13506129.2019.1585342. No abstract available.

PMID:
31343320
4.

Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous.

Bezerra F, Simões CJV, Beirão JM, Saraiva MJ, Brito RMM, Almeida MR.

Amyloid. 2019;26(sup1):73-74. doi: 10.1080/13506129.2019.1583193. No abstract available.

PMID:
31343304
5.

Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS.

Simões CJV, Almeida ZL, Cardoso AL, Bezerra F, Almeida MR, Beirão J, Pinho E Melo TMVD, Saraiva MJ, Brito RMM.

Amyloid. 2019;26(sup1):77-78. doi: 10.1080/13506129.2019.1583195. No abstract available.

PMID:
31343302
6.

Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis.

Ferreira N, Saraiva MJ, Almeida MR.

Int J Mol Sci. 2019 Mar 14;20(6). pii: E1287. doi: 10.3390/ijms20061287. Review.

7.

Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.

Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P.

Amyloid. 2018 Dec;25(4):215-219. doi: 10.1080/13506129.2018.1549825. Epub 2019 Jan 7.

PMID:
30614283
8.

Anti-TTR Nanobodies Allow the Identification of TTR Neuritogenic Epitope Associated with TTR-Megalin Neurotrophic Activities.

Gomes JR, Sárkány Z, Teixeira A, Nogueira R, Cabrito I, Soares H, Wittelsberger A, Stortelers C, Macedo-Ribeiro S, Vanlandschoot P, Saraiva MJ.

ACS Chem Neurosci. 2019 Jan 16;10(1):704-715. doi: 10.1021/acschemneuro.8b00502. Epub 2018 Oct 23.

PMID:
30346709
9.

Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons.

Gomes JR, Cabrito I, Soares HR, Costelha S, Teixeira A, Wittelsberger A, Stortelers C, Vanlandschoot P, Saraiva MJ.

J Neurochem. 2018 Jun;145(5):393-408. doi: 10.1111/jnc.14332. Epub 2018 May 9.

10.

MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy.

Martins D, Moreira J, Gonçalves NP, Saraiva MJ.

Dis Model Mech. 2017 Oct 1;10(10):1253-1260. doi: 10.1242/dmm.028571.

11.

Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.

Pansieri J, Plissonneau M, Stransky-Heilkron N, Dumoulin M, Heinrich-Balard L, Rivory P, Morfin JF, Toth E, Saraiva MJ, Allémann E, Tillement O, Forge V, Lux F, Marquette C.

Nanomedicine (Lond). 2017 Jul;12(14):1675-1687. doi: 10.2217/nnm-2017-0079. Epub 2017 Jun 21.

12.

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system.

Gonçalves NP, Moreira J, Martins D, Vieira P, Obici L, Merlini G, Saraiva M, Saraiva MJ.

J Neuroinflammation. 2017 Jun 6;14(1):115. doi: 10.1186/s12974-017-0891-9.

13.

Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model.

Teixeira C, Costelha S, Martins HS, Teixeira A, Saraiva MJ.

Amyloid. 2017 Mar;24(sup1):80. doi: 10.1080/13506129.2016.1277695. No abstract available.

PMID:
28434372
14.

Efficiency of siRNA for removal of transthyretin V30M in a TTR leptomeningeal animal model.

Gonçalves P, Martins H, Costelha S, Saraiva MJ.

Amyloid. 2017 Mar;24(sup1):38-39. doi: 10.1080/13506129.2016.1272452. No abstract available.

PMID:
28434297
15.

The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers.

Gonçalves NP, Martins D, Saraiva MJ.

Amyloid. 2017 Mar;24(sup1):83-84. doi: 10.1080/13506129.2016.1278362. No abstract available.

PMID:
28434291
16.

C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy.

Panayiotou E, Fella E, Papacharalambous R, Malas S, Saraiva MJ, Kyriakides T.

PLoS One. 2017 Apr 13;12(4):e0175767. doi: 10.1371/journal.pone.0175767. eCollection 2017.

17.

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.

Sant'Anna R, Almeida MR, Varejāo N, Gallego P, Esperante S, Ferreira P, Pereira-Henriques A, Palhano FL, de Carvalho M, Foguel D, Reverter D, Saraiva MJ, Ventura S.

Sci Rep. 2017 Mar 24;7:44709. doi: 10.1038/srep44709.

18.

BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.

Lopes CDF, Gonçalves NP, Gomes CP, Saraiva MJ, Pêgo AP.

Biomaterials. 2017 Mar;121:83-96. doi: 10.1016/j.biomaterials.2016.12.025. Epub 2016 Dec 24.

PMID:
28081461
19.

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines.

Sipe JD, Benson MD, Buxbaum JN, Ikeda SI, Merlini G, Saraiva MJ, Westermark P.

Amyloid. 2016 Dec;23(4):209-213. Epub 2016 Nov 24.

PMID:
27884064
20.

Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model.

Gonçalves P, Martins H, Costelha S, Maia LF, Saraiva MJ.

Amyloid. 2016 Dec;23(4):249-253. Epub 2016 Nov 24.

PMID:
27884058
21.

Force spectroscopy reveals the presence of structurally modified dimers in transthyretin amyloid annular oligomers.

Pires RH, Saraiva MJ, Damas AM, Kellermayer MS.

J Mol Recognit. 2017 Mar;30(3). doi: 10.1002/jmr.2587. Epub 2016 Nov 3.

PMID:
27808434
22.

Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model.

Gonçalves NP, Gonçalves P, Magalhães J, Ventosa M, Coelho AV, Saraiva MJ.

Neurobiol Aging. 2016 Nov;47:91-101. doi: 10.1016/j.neurobiolaging.2016.07.020. Epub 2016 Aug 1.

PMID:
27568093
23.

Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia.

Gomes JR, Nogueira RS, Vieira M, Santos SD, Ferraz-Nogueira JP, Relvas JB, Saraiva MJ.

Cell Death Differ. 2016 Nov 1;23(11):1749-1764. doi: 10.1038/cdd.2016.64. Epub 2016 Aug 12.

24.

Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.

Plissonneau M, Pansieri J, Heinrich-Balard L, Morfin JF, Stransky-Heilkron N, Rivory P, Mowat P, Dumoulin M, Cohen R, Allémann É, Tόth É, Saraiva MJ, Louis C, Tillement O, Forge V, Lux F, Marquette C.

J Nanobiotechnology. 2016 Jul 25;14(1):60. doi: 10.1186/s12951-016-0212-y.

25.

Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin.

Teixeira CA, Almeida Mdo R, Saraiva MJ.

Clin Sci (Lond). 2016 Sep 1;130(18):1665-75. doi: 10.1042/CS20160075. Epub 2016 Jul 6.

PMID:
27382986
26.

Overexpression of Protocadherin-10 in Transthyretin-Related Familial Amyloidotic Polyneuropathy.

Gonçalves NP, Martins D, Saraiva MJ.

Am J Pathol. 2016 Jul;186(7):1913-24. doi: 10.1016/j.ajpath.2016.02.020.

27.

Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis.

Ferreira N, Gonçalves NP, Saraiva MJ, Almeida MR.

Sci Rep. 2016 May 20;6:26623. doi: 10.1038/srep26623.

28.

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.

Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, Manoharan M, Fitzgerald K, Meyers RE, Nochur SV, Saraiva MJ, Zimmermann TS.

Amyloid. 2016 Jun;23(2):109-18. doi: 10.3109/13506129.2016.1160882. Epub 2016 Mar 31.

29.

A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition.

Simões CJV, Almeida ZL, Costa D, Jesus CSH, Cardoso AL, Almeida MR, Saraiva MJ, Pinho E Melo TMVD, Brito RMM.

Eur J Med Chem. 2016 Oct 4;121:823-840. doi: 10.1016/j.ejmech.2016.02.074. Epub 2016 Mar 3.

PMID:
27020050
30.

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

Alemi M, Gaiteiro C, Ribeiro CA, Santos LM, Gomes JR, Oliveira SM, Couraud PO, Weksler B, Romero I, Saraiva MJ, Cardoso I.

Sci Rep. 2016 Feb 3;6:20164. doi: 10.1038/srep20164.

31.

Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor.

Vieira M, Leal SS, Gomes CM, Saraiva MJ.

Biochim Biophys Acta. 2016 Apr;1862(4):797-804. doi: 10.1016/j.bbadis.2016.01.008. Epub 2016 Jan 12.

32.

Homozygosity for the E526V Mutation in Fibrinogen A Alpha-Chain Amyloidosis: The First Report.

Tavares I, Lobato L, Matos C, Santos J, Moreira P, Saraiva MJ, Castro Henriques A.

Case Rep Nephrol. 2015;2015:919763. doi: 10.1155/2015/919763. Epub 2015 Jun 23.

33.

Protective role of anakinra against transthyretin-mediated axonal loss and cell death in a mouse model of familial amyloidotic polyneuropathy.

Gonçalves NP, Teixeira-Coelho M, Saraiva MJ.

J Neuropathol Exp Neurol. 2015 Mar;74(3):203-17. doi: 10.1097/NEN.0000000000000164.

PMID:
25668561
34.

Glial cells in familial amyloidotic polyneuropathy.

Gonçalves NP, Costelha S, Saraiva MJ.

Acta Neuropathol Commun. 2014 Dec 18;2:177. doi: 10.1186/s40478-014-0177-8.

35.

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

Conejos-Sánchez I, Cardoso I, Oteo-Vives M, Romero-Sanz E, Paul A, Sauri AR, Morcillo MA, Saraiva MJ, Vicent MJ.

J Control Release. 2015 Jan 28;198:80-90. doi: 10.1016/j.jconrel.2014.12.003. Epub 2014 Dec 4.

PMID:
25481444
36.

Transthyretin: a multifaceted protein.

Vieira M, Saraiva MJ.

Biomol Concepts. 2014 Mar;5(1):45-54. doi: 10.1515/bmc-2013-0038. Review.

PMID:
25372741
37.

Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model.

Batista AR, Gianni D, Ventosa M, Coelho AV, Almeida MR, Sena-Esteves M, Saraiva MJ.

Gene Ther. 2014 Dec;21(12):1041-50. doi: 10.1038/gt.2014.86. Epub 2014 Oct 2. Erratum in: Gene Ther. 2014 Dec;21(12):1065.

PMID:
25273354
38.

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis.

Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, Westermark P.

Amyloid. 2014 Dec;21(4):221-4. doi: 10.3109/13506129.2014.964858. Epub 2014 Sep 29. No abstract available.

39.

Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus.

Vieira M, Gomes JR, Saraiva MJ.

Mol Neurobiol. 2015;51(3):1468-79. doi: 10.1007/s12035-014-8824-4. Epub 2014 Aug 2.

40.

Interleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis.

Gonçalves NP, Vieira P, Saraiva MJ.

Amyloid. 2014 Sep;21(3):175-84. doi: 10.3109/13506129.2014.927759. Epub 2014 Jun 11.

41.

The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model.

Gonçalves NP, Teixeira-Coelho M, Saraiva MJ.

Exp Neurol. 2014 Jul;257:76-87. doi: 10.1016/j.expneurol.2014.04.030. Epub 2014 May 5.

PMID:
24800914
42.

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

Conejos-Sánchez I, Cardoso I, Saraiva MJ, Vicent MJ.

J Control Release. 2014 Mar 28;178:95-100. doi: 10.1016/j.jconrel.2014.01.019. Epub 2014 Jan 31.

PMID:
24486260
43.

Molecular tweezers targeting transthyretin amyloidosis.

Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR.

Neurotherapeutics. 2014 Apr;11(2):450-61. doi: 10.1007/s13311-013-0256-8.

44.

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.

Ribeiro CA, Oliveira SM, Guido LF, Magalhães A, Valencia G, Arsequell G, Saraiva MJ, Cardoso I.

J Alzheimers Dis. 2014;39(2):357-70. doi: 10.3233/JAD-131355.

PMID:
24169237
45.

Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis.

Petrakis I, Mavroeidi V, Stylianou K, Andronikidi E, Lioudaki E, Perakis K, Stratigis S, Vardaki E, Zafeiri M, Giannakakis K, Plaitakis A, Amoiridis G, Saraiva MJ, Daphnis E.

Amyloid. 2013 Sep;20(3):164-72. doi: 10.3109/13506129.2013.814046. Epub 2013 Jul 5.

PMID:
23829269
46.

Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis.

Misumi Y, Ando Y, Gonçalves NP, Saraiva MJ.

Lab Invest. 2013 Aug;93(8):911-20. doi: 10.1038/labinvest.2013.83. Epub 2013 Jul 1.

47.

Hepatic production of transthyretin L12P leads to intracellular lysosomal aggregates in a new somatic transgenic mouse model.

Batista AR, Sena-Esteves M, Saraiva MJ.

Biochim Biophys Acta. 2013 Aug;1832(8):1183-93. doi: 10.1016/j.bbadis.2013.04.001. Epub 2013 Apr 8.

48.

Transthyretin regulates hippocampal 14-3-3ζ protein levels.

Vieira M, Saraiva MJ.

FEBS Lett. 2013 May 21;587(10):1482-8. doi: 10.1016/j.febslet.2013.03.011. Epub 2013 Mar 21.

49.

Presence of N-glycosylated transthyretin in plasma of V30M carriers in familial amyloidotic polyneuropathy: an escape from ERAD.

Teixeira AC, Saraiva MJ.

J Cell Mol Med. 2013 Mar;17(3):429-35. doi: 10.1111/jcmm.12024. Epub 2013 Feb 7.

50.

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis.

Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, Westermark P; Nomenclature Committee of the International Society of Amyloidosis.

Amyloid. 2012 Dec;19(4):167-70. doi: 10.3109/13506129.2012.734345. Epub 2012 Nov 1.

PMID:
23113696

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