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Items: 1 to 50 of 306

1.

Yeast As a Chassis for Developing Functional Assays to Study Human P53.

Monti P, Bosco B, Gomes S, Saraiva L, Fronza G, Inga A.

J Vis Exp. 2019 Aug 4;(150). doi: 10.3791/59071.

PMID:
31424436
2.

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.

Gomes S, Bosco B, Loureiro JB, Ramos H, Raimundo L, Soares J, Nazareth N, Barcherini V, Domingues L, Oliveira C, Bisio A, Piazza S, Bauer MR, Brás JP, Almeida MI, Gomes C, Reis F, Fersht AR, Inga A, Santos MMM, Saraiva L.

Cancers (Basel). 2019 Aug 10;11(8). pii: E1151. doi: 10.3390/cancers11081151.

3.

A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans.

Saraiva LR, Riveros-McKay F, Mezzavilla M, Abou-Moussa EH, Arayata CJ, Makhlouf M, Trimmer C, Ibarra-Soria X, Khan M, Van Gerven L, Jorissen M, Gibbs M, O'Flynn C, McGrane S, Mombaerts P, Marioni JC, Mainland JD, Logan DW.

Sci Adv. 2019 Jul 31;5(7):eaax0396. doi: 10.1126/sciadv.aax0396. eCollection 2019 Jul.

4.

Metabolomics of Escherichia coli treated with the antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 reveals TCA cycle as major target.

Carvalho SM, Marques J, Romão CC, Saraiva LM.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00643-19. doi: 10.1128/AAC.00643-19. [Epub ahead of print]

PMID:
31332064
5.

A simple linearization method unveils hidden enzymatic assay interferences.

Pinto MF, Ripoll-Rozada J, Ramos H, Watson EE, Franck C, Payne RJ, Saraiva L, Pereira PJB, Pastore A, Rocha F, Martins PM.

Biophys Chem. 2019 Sep;252:106193. doi: 10.1016/j.bpc.2019.106193. Epub 2019 May 29.

PMID:
31195341
6.

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents.

Lemos A, Gomes AS, Loureiro JB, Brandão P, Palmeira A, Pinto MMM, Saraiva L, Sousa ME.

Molecules. 2019 May 22;24(10). pii: E1975. doi: 10.3390/molecules24101975.

7.

Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities.

Matias D, Nicolai M, Fernandes AS, Saraiva N, Almeida J, Saraiva L, Faustino C, Díaz-Lanza AM, Reis CP, Rijo P.

Biomolecules. 2019 May 8;9(5). pii: E179. doi: 10.3390/biom9050179.

8.

Bilirubin encephalopathy (kernicterus) in an adult cat.

Saraiva LH, Andrade MC, Moreira MV, Oliveira LB, Santos ÁF, Ferreira RS, Santos WH, Ecco R.

JFMS Open Rep. 2019 Mar 27;5(1):2055116919838874. doi: 10.1177/2055116919838874. eCollection 2019 Jan-Jun.

9.

Comparison of Volumetric and Bead-Based Counting of CD34 Cells by Single-Platform Flow Cytometry.

Saraiva L, Wang L, Kammel M, Kummrow A, Atkinson E, Lee JY, Yalcinkaya B, Akgöz M, Höckner J, Ruf A, Engel A, Zhang YZ, O'Shea O, Sassi MP, Divieto C, Lekishvili T, Campbell J, Liu Y, Wang J, Stebbings R, Gaigalas AK, Rigsby P, Neukammer J, Vessillier S.

Cytometry B Clin Cytom. 2019 Feb 20. doi: 10.1002/cyto.b.21773. [Epub ahead of print]

PMID:
30790450
10.

One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis.

Martins ES, César-Neto JB, Albuquerque-Souza E, Rebeis ES, Holzhausen M, Pannuti CM, Mayer MPA, Saraiva L.

Cytokine. 2019 Apr;116:27-37. doi: 10.1016/j.cyto.2018.12.019. Epub 2019 Jan 23.

PMID:
30684915
11.

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma.

Gomes S, Raimundo L, Soares J, Loureiro JB, Leão M, Ramos H, Monteiro MN, Lemos A, Moreira J, Pinto M, Chlapek P, Veselska R, Sousa E, Saraiva L.

Cancer Lett. 2019 Apr 1;446:90-102. doi: 10.1016/j.canlet.2019.01.014. Epub 2019 Jan 19.

PMID:
30664963
12.

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.

Moreira J, Ribeiro D, Silva PMA, Nazareth N, Monteiro M, Palmeira A, Saraiva L, Pinto M, Bousbaa H, Cidade H.

Molecules. 2018 Dec 31;24(1). pii: E129. doi: 10.3390/molecules24010129.

13.

Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin.

Sales KMO, Cavalcanti RF, Nobre E Souza MA, Saraiva LGM, Braga LLBC, de Castro M, Oliveira RB, Souza MHLP.

Dig Dis. 2019;37(3):226-233. doi: 10.1159/000494920. Epub 2019 Jan 2.

PMID:
30602159
14.

Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A. actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients.

Rebeis ES, Albuquerque-Souza E, Paulino da Silva M, Giudicissi M, Mayer MPA, Saraiva L.

Oral Dis. 2019 Mar;25(2):569-579. doi: 10.1111/odi.13010. Epub 2018 Dec 27.

PMID:
30506613
15.

Analysis of a new flavodiiron core structural arrangement in Flv1-ΔFlR protein from Synechocystis sp. PCC6803.

Borges PT, Romão CV, Saraiva LM, Gonçalves VL, Carrondo MA, Teixeira M, Frazão C.

J Struct Biol. 2019 Jan 1;205(1):91-102. doi: 10.1016/j.jsb.2018.11.004. Epub 2018 Nov 14.

PMID:
30447285
16.

Interspecific variation of olfactory preferences in flies, mice, and humans.

Manoel D, Makhlouf M, Scialdone A, Saraiva LR.

Chem Senses. 2019 Jan 1;44(1):7-9. doi: 10.1093/chemse/bjy074.

17.

Small Molecules Targeting Mutant P53: A Promising Approach For Cancer Treatment.

Lopes EA, Gomes S, Saraiva L, Santos M.

Curr Med Chem. 2018 Nov 16. doi: 10.2174/0929867325666181116124308. [Epub ahead of print]

PMID:
30444195
18.

West Nile virus associated with equid encephalitis in Brazil, 2018.

Silva ASG, Matos ACD, da Cunha MACR, Rehfeld IS, Galinari GCF, Marcelino SAC, Saraiva LHG, Martins NRDS, Maranhão RPA, Lobato ZIP, Pierezan F, Guedes MIMC, Costa EA.

Transbound Emerg Dis. 2019 Jan;66(1):445-453. doi: 10.1111/tbed.13043. Epub 2018 Nov 2.

PMID:
30318735
19.

The Di-iron RIC Protein (YtfE) of Escherichia coli Interacts with the DNA-Binding Protein from Starved Cells (Dps) To Diminish RIC Protein-Mediated Redox Stress.

Silva LSO, Baptista JM, Batley C, Andrews SC, Saraiva LM.

J Bacteriol. 2018 Nov 26;200(24). pii: e00527-18. doi: 10.1128/JB.00527-18. Print 2018 Dec 15.

20.

Improving anticancer activity towards colon cancer cells with a new p53-activating agent.

Raimundo L, Espadinha M, Soares J, Loureiro JB, Alves MG, Santos MMM, Saraiva L.

Br J Pharmacol. 2018 Oct;175(20):3947-3962. doi: 10.1111/bph.14468. Epub 2018 Sep 6.

PMID:
30076608
21.

Targeting the MDM2-p53 protein-protein interaction with prenylchalcones: Synthesis of a small library and evaluation of potential antitumor activity.

Brandão P, Loureiro JB, Carvalho S, Hamadou MH, Cravo S, Moreira J, Pereira D, Palmeira A, Pinto M, Saraiva L, Cidade H.

Eur J Med Chem. 2018 Aug 5;156:711-721. doi: 10.1016/j.ejmech.2018.07.037. Epub 2018 Jul 17.

PMID:
30041135
22.

Staphylococcus aureus haem biosynthesis and acquisition pathways are linked through haem monooxygenase IsdG.

Videira MAM, Lobo SAL, Silva LSO, Palmer DJ, Warren MJ, Prieto M, Coutinho A, Sousa FL, Fernandes F, Saraiva LM.

Mol Microbiol. 2018 Aug;109(3):385-400. doi: 10.1111/mmi.14060. Epub 2018 Aug 2.

PMID:
29989674
23.

Meglumine antimoniate intralesional infiltration for localised cutaneous leishmaniasis: a single arm, open label, phase II clinical trial.

Ramalho DB, Silva RED, Senna MCR, Moreira HSA, Pedras MJ, Avelar DM, Saraiva L, Rabello A, Cota G.

Mem Inst Oswaldo Cruz. 2018 Jun 21;113(9):e180200. doi: 10.1590/0074-02760180200.

24.

Natural Ecosystem Surrounding a Conventional Banana Crop Improves Plant Health and Fruit Quality.

Castelan FP, Castro-Alves VC, Saraiva LA, Nascimento TP, Cálhau MFNS, Dias CTS, Cordenunsi-Lysenko BR.

Front Plant Sci. 2018 Jun 7;9:759. doi: 10.3389/fpls.2018.00759. eCollection 2018.

25.

Immunological and microbiological periodontal profiles in isolated growth hormone deficiency.

Araújo IMP, Albuquerque-Souza E, Aguiar-Oliveira MH, Holzhausen M, Oliveira-Neto LA, Salvatori R, Saraiva L, Mayer MPA, Pannuti CM, Ribeiro AO, Romito GA, Pustiglioni FE.

J Periodontol. 2018 Nov;89(11):1351-1361. doi: 10.1002/JPER.17-0687. Epub 2018 Sep 11.

PMID:
29797719
26.

A systematic review and meta-analysis of the survival rate of implants placed in previously failed sites.

Gomes GH, Misawa MYO, Fernandes C, Pannuti CM, Saraiva L, Huynh-Ba G, Villar CC.

Braz Oral Res. 2018;32:e27. doi: 10.1590/1807-3107bor-2018.vol32.0027. Epub 2018 May 3. Review.

27.

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

Gomes AS, Trovão F, Andrade Pinheiro B, Freire F, Gomes S, Oliveira C, Domingues L, Romão MJ, Saraiva L, Carvalho AL.

Int J Mol Sci. 2018 Apr 13;19(4). pii: E1184. doi: 10.3390/ijms19041184.

28.

Orthodontic treatment in patients with aggressive periodontitis.

Carvalho CV, Saraiva L, Bauer FPF, Kimura RY, Souto MLS, Bernardo CC, Pannuti CM, Romito GA, Pustiglioni FE.

Am J Orthod Dentofacial Orthop. 2018 Apr;153(4):550-557. doi: 10.1016/j.ajodo.2017.08.018.

PMID:
29602347
29.

Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39.

Carvalho SM, Kloosterman TG, Manzoor I, Caldas J, Vinga S, Martinussen J, Saraiva LM, Kuipers OP, Neves AR.

Front Microbiol. 2018 Mar 6;9:321. doi: 10.3389/fmicb.2018.00321. eCollection 2018.

30.

The ideal time of systemic metronidazole and amoxicillin administration in the treatment of severe periodontitis: study protocol for a randomized controlled trial.

Feres M, Retamal-Valdes B, Mestnik MJ, de Figueiredo LC, Faveri M, Duarte PM, Fritoli A, Faustino E, Souto MLS, de Franco Rodrigues M, Giudicissi M, Nogueira BCL, Saraiva L, Romito GA, Pannuti CM.

Trials. 2018 Mar 27;19(1):201. doi: 10.1186/s13063-018-2540-8.

31.

p53 and glucose metabolism: an orchestra to be directed in cancer therapy.

Gomes AS, Ramos H, Soares J, Saraiva L.

Pharmacol Res. 2018 May;131:75-86. doi: 10.1016/j.phrs.2018.03.015. Epub 2018 Mar 23. Review.

PMID:
29580896
32.

Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life.

Llanos AH, Silva CGB, Ichimura KT, Rebeis ES, Giudicissi M, Romano MM, Saraiva L.

Braz Oral Res. 2018;32:e006. doi: 10.1590/1807-3107bor-2018.vol32.0006. Epub 2018 Feb 8.

33.

Thap Maeo bananas: Fast ripening and full ethylene perception at low doses.

Saraiva LA, Castelan FP, Gomes BL, Purgatto E, Cordenunsi-Lysenko BR.

Food Res Int. 2018 Mar;105:384-392. doi: 10.1016/j.foodres.2017.11.007. Epub 2017 Nov 10.

PMID:
29433227
34.

Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, Saraiva L.

Cell Death Dis. 2018 Jan 18;9(2):23. doi: 10.1038/s41419-017-0154-9.

35.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST.

J Biol Chem. 2018 Feb 9;293(6):1957-1975. doi: 10.1074/jbc.M117.807180. Epub 2017 Dec 28.

36.

Repair of Iron Centers RIC protein contributes to the virulence of Staphylococcus aureus.

Silva LO, Nobre LS, Mil-Homens D, Fialho A, Saraiva LM.

Virulence. 2018 Jan 1;9(1):312-317. doi: 10.1080/21505594.2017.1389829. Epub 2017 Dec 8.

37.

Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum.

Parente MR, Forte E, Falabella M, Boneca IG, Teixeira M, Giuffrè A, Saraiva LM.

Sci Rep. 2017 Aug 30;7(1):9909. doi: 10.1038/s41598-017-10375-1.

38.

Is periodontitis a risk factor for infections in cirrhotic patients?

Di Profio B, Villar CC, Saraiva L, Ortega KL, Pannuti CM.

Med Hypotheses. 2017 Sep;106:19-22. doi: 10.1016/j.mehy.2017.06.022. Epub 2017 Jun 30. No abstract available.

PMID:
28818265
39.

Peñaloza-Tranchesi sign secondary to ascending aortic aneurysm and not due to right atrium enlargement.

Santos ECL, Saraiva LR, Markman B, Lordsleem AB, Lima SG, de Souza Vasconcelos M, Dos Santos Filho EC, Holanda AC.

J Electrocardiol. 2017 Nov - Dec;50(6):960-963. doi: 10.1016/j.jelectrocard.2017.07.009. Epub 2017 Jul 12.

PMID:
28807354
40.

The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress.

Carvalho SM, de Jong A, Kloosterman TG, Kuipers OP, Saraiva LM.

Front Microbiol. 2017 Jul 11;8:1273. doi: 10.3389/fmicb.2017.01273. eCollection 2017.

41.

E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner.

Barisa M, Kramer AM, Majani Y, Moulding D, Saraiva L, Bajaj-Elliott M, Anderson J, Gustafsson K.

Sci Rep. 2017 Jun 5;7(1):2805. doi: 10.1038/s41598-017-02886-8.

42.

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH.

Mol Metab. 2017 Mar 1;6(5):383-392. doi: 10.1016/j.molmet.2017.02.007. eCollection 2017 May.

43.

Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.

Ibarra-Soria X, Nakahara TS, Lilue J, Jiang Y, Trimmer C, Souza MA, Netto PH, Ikegami K, Murphy NR, Kusma M, Kirton A, Saraiva LR, Keane TM, Matsunami H, Mainland J, Papes F, Logan DW.

Elife. 2017 Apr 25;6. pii: e21476. doi: 10.7554/eLife.21476.

44.

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, Woelk L, Fan H, Logan DW, Schürmann A, Saraiva LR, Schulz TJ.

Cell Stem Cell. 2017 Jun 1;20(6):771-784.e6. doi: 10.1016/j.stem.2017.02.009. Epub 2017 Mar 16.

45.

Seasonality of sand flies (Diptera: Psychodidae) and Leishmania DNA detection in vector species in an area with endemic visceral leishmaniasis.

Saraiva L, Leite CG, Lima AC, Carvalho LO, Pereira AA, Rugani JM, Rego FD, Gontijo CM, Andrade JD Filho.

Mem Inst Oswaldo Cruz. 2017 Apr;112(4):309-318. doi: 10.1590/0074-02760160438.

46.

Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology.

Whitfield SJC, Taylor C, Risdall JE, Griffiths GD, Jones JTA, Williamson ED, Rijpkema S, Saraiva L, Vessillier S, Green AC, Carter AJ.

J Immunol. 2017 May 15;198(10):3989-3998. doi: 10.4049/jimmunol.1601525. Epub 2017 Mar 20.

47.

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, Loureiro JB, Inga A, Reis F, Gomes C, Santos MMM, Saraiva L.

Mol Oncol. 2017 Jun;11(6):612-627. doi: 10.1002/1878-0261.12051. Epub 2017 May 2.

48.

Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity.

Flint A, Stintzi A, Saraiva LM.

FEMS Microbiol Rev. 2016 Nov 1;40(6):938-960. doi: 10.1093/femsre/fuw025.

49.

PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

Fukushima H, Alves VT, Carvalho VF, Ambrósio LM, Eichler RA, Carvalho MH, Saraiva L, Holzhausen M.

Braz Oral Res. 2017 Jan 26;31:e16. doi: 10.1590/1807-3107BOR-2017.vol31.0016.

50.

Effects of periodontal treatment on primary sjȫgren's syndrome symptoms.

Ambrósio LM, Rovai ES, França BN, Balzarini DA, Abreu IS, Lopes SB, Nunes TB, Lourenço SV, Pasoto SG, Saraiva L, Holzhausen M.

Braz Oral Res. 2017 Jan 16;31:e8. doi: 10.1590/1807-3107BOR-2017.vol31.0008.

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