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Items: 34


Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.

Wu KZL, Jones RA, Tachie-Menson T, Macartney TJ, Wood NT, Varghese J, Gourlay R, Soares RF, Smith JC, Sapkota GP.

Wellcome Open Res. 2019 Sep 9;4:133. doi: 10.12688/wellcomeopenres.15403.1. eCollection 2019.


FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.

Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP.

EMBO Rep. 2019 Sep;20(9):e47495. doi: 10.15252/embr.201847495. Epub 2019 Jul 24.


Advances in targeted degradation of endogenous proteins.

Röth S, Fulcher LJ, Sapkota GP.

Cell Mol Life Sci. 2019 Jul;76(14):2761-2777. doi: 10.1007/s00018-019-03112-6. Epub 2019 Apr 27. Review.


Generation of Endogenous BMP Transcriptional Reporter Cells Through CRISPR/Cas9 Genome Editing.

Hutchinson LD, Bozatzi P, Macartney T, Sapkota GP.

Methods Mol Biol. 2019;1891:29-35. doi: 10.1007/978-1-4939-8904-1_4.


The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms.

Bozatzi P, Sapkota GP.

Biochem Soc Trans. 2018 Jun 19;46(3):761-771. doi: 10.1042/BST20160277. Epub 2018 Jun 5. Review.


The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.

Fulcher LJ, Bozatzi P, Tachie-Menson T, Wu KZL, Cummins TD, Bufton JC, Pinkas DM, Dunbar K, Shrestha S, Wood NT, Weidlich S, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Dingwell KS, Smith JC, Bullock AN, Sapkota GP.

Sci Signal. 2018 May 22;11(531). pii: eaao2341. doi: 10.1126/scisignal.aao2341.


PAWS1 controls Wnt signalling through association with casein kinase 1α.

Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP.

EMBO Rep. 2018 Apr;19(4). pii: e44807. doi: 10.15252/embr.201744807. Epub 2018 Mar 7.


TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.

Ramachandran A, Vizán P, Das D, Chakravarty P, Vogt J, Rogers KW, Müller P, Hinck AP, Sapkota GP, Hill CS.

Elife. 2018 Jan 29;7. pii: e31756. doi: 10.7554/eLife.31756.


PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP.

Cummins TD, Wu KZL, Bozatzi P, Dingwell KS, Macartney TJ, Wood NT, Varghese J, Gourlay R, Campbell DG, Prescott A, Griffis E, Smith JC, Sapkota GP.

J Cell Sci. 2018 Jan 10;131(1). pii: jcs202390. doi: 10.1242/jcs.202390.


Characterization of Protein Complexes Using Chemical Cross-Linking Coupled Electrospray Mass Spectrometry.

Cummins TD, Sapkota GP.

Methods Mol Biol. 2018;1788:43-61. doi: 10.1007/7651_2017_85.


Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

Fernandez-Alonso R, Davidson L, Hukelmann J, Zengerle M, Prescott AR, Lamond A, Ciulli A, Sapkota GP, Findlay GM.

EMBO Rep. 2017 Jul;18(7):1108-1122. doi: 10.15252/embr.201643534. Epub 2017 Jun 6.


Targeting endogenous proteins for degradation through the affinity-directed protein missile system.

Fulcher LJ, Hutchinson LD, Macartney TJ, Turnbull C, Sapkota GP.

Open Biol. 2017 May;7(5). pii: 170066. doi: 10.1098/rsob.170066.


An affinity-directed protein missile system for targeted proteolysis.

Fulcher LJ, Macartney T, Bozatzi P, Hornberger A, Rojas-Fernandez A, Sapkota GP.

Open Biol. 2016 Oct;6(10). pii: 160255.


Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ.

Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493.


Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP.

Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811.


Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.

Herhaus L, Perez-Oliva AB, Cozza G, Gourlay R, Weidlich S, Campbell DG, Pinna LA, Sapkota GP.

Sci Signal. 2015 Apr 14;8(372):ra35. doi: 10.1126/scisignal.aaa0441.


The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.

Herhaus L, Sapkota GP.

Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Epub 2014 Jul 5. Review.


USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

Herhaus L, Al-Salihi MA, Dingwell KS, Cummins TD, Wasmus L, Vogt J, Ewan R, Bruce D, Macartney T, Weidlich S, Smith JC, Sapkota GP.

Open Biol. 2014 May;4(5):140065. doi: 10.1098/rsob.140065.


Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

Vogt J, Dingwell KS, Herhaus L, Gourlay R, Macartney T, Campbell D, Smith JC, Sapkota GP.

Open Biol. 2014 Feb 19;4:130210. doi: 10.1098/rsob.130210.


OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

Herhaus L, Al-Salihi M, Macartney T, Weidlich S, Sapkota GP.

Nat Commun. 2013;4:2519. doi: 10.1038/ncomms3519.


Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.

Bruce DL, Macartney T, Yong W, Shou W, Sapkota GP.

Cell Signal. 2012 Nov;24(11):1999-2006. doi: 10.1016/j.cellsig.2012.07.003. Epub 2012 Jul 7.


USP11 augments TGFβ signalling by deubiquitylating ALK5.

Al-Salihi MA, Herhaus L, Macartney T, Sapkota GP.

Open Biol. 2012 Jun;2(6):120063. doi: 10.1098/rsob.120063.


Regulation of the transforming growth factor β pathway by reversible ubiquitylation.

Al-Salihi MA, Herhaus L, Sapkota GP.

Open Biol. 2012 May;2(5):120082. doi: 10.1098/rsob.120082. Review.


Phosphatases in SMAD regulation.

Bruce DL, Sapkota GP.

FEBS Lett. 2012 Jul 4;586(14):1897-905. doi: 10.1016/j.febslet.2012.02.001. Epub 2012 Feb 11. Review.


The specificities of small molecule inhibitors of the TGFß and BMP pathways.

Vogt J, Traynor R, Sapkota GP.

Cell Signal. 2011 Nov;23(11):1831-42. doi: 10.1016/j.cellsig.2011.06.019. Epub 2011 Jun 29.


BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

Sapkota GP, Cummings L, Newell FS, Armstrong C, Bain J, Frodin M, Grauert M, Hoffmann M, Schnapp G, Steegmaier M, Cohen P, Alessi DR.

Biochem J. 2007 Jan 1;401(1):29-38.


Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.

EMBO J. 2003 Jun 16;22(12):3062-72.


Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR.

Biochem J. 2002 Dec 1;368(Pt 2):507-16.


Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP.

Biochem J. 2002 Nov 15;368(Pt 1):243-51.


Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.

Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T.

Mol Cell. 2001 Sep;8(3):693-704.


Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase.

Godber BL, Doel JJ, Sapkota GP, Blake DR, Stevens CR, Eisenthal R, Harrison R.

J Biol Chem. 2000 Mar 17;275(11):7757-63.

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