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Items: 30


Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist.

Iadarola MJ, Sapio MR, Raithel SJ, Mannes AJ, Brown DC.

Pain. 2018 Oct;159(10):2105-2114. doi: 10.1097/j.pain.0000000000001314.


Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.

Sapio MR, Neubert JK, LaPaglia DM, Maric D, Keller JM, Raithel SJ, Rohrs EL, Anderson EM, Butman JA, Caudle RM, Brown DC, Heiss JD, Mannes AJ, Iadarola MJ.

J Clin Invest. 2018 Apr 2;128(4):1657-1670. doi: 10.1172/JCI94331. Epub 2018 Mar 19.


Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.

Hall BE, Prochazkova M, Sapio MR, Minetos P, Kurochkina N, Binukumar BK, Amin ND, Terse A, Joseph J, Raithel SJ, Mannes AJ, Pant HC, Chung MK, Iadarola MJ, Kulkarni AB.

Sci Rep. 2018 Jan 19;8(1):1177. doi: 10.1038/s41598-018-19532-6.


Transcriptional Changes in Dorsal Spinal Cord Persist after Surgical Incision Despite Preemptive Analgesia with Peripheral Resiniferatoxin.

Raithel SJ, Sapio MR, LaPaglia DM, Iadarola MJ, Mannes AJ.

Anesthesiology. 2018 Mar;128(3):620-635. doi: 10.1097/ALN.0000000000002006.


Thermal A-δ Nociceptors, Identified by Transcriptomics, Express Higher Levels of Anesthesia-Sensitive Receptors Than Thermal C-Fibers and Are More Suppressible by Low-Dose Isoflurane.

Raithel SJ, Sapio MR, Iadarola MJ, Mannes AJ.

Anesth Analg. 2018 Jul;127(1):263-266. doi: 10.1213/ANE.0000000000002505.


A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.

Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ.

Sci Signal. 2017 Aug 22;10(493). pii: eaal5241. doi: 10.1126/scisignal.aal5241.


Analgesia by Deletion of Spinal Neurokinin 1 Receptor Expressing Neurons Using a Bioengineered Substance P-Pseudomonas Exotoxin Conjugate.

Iadarola MJ, Sapio MR, Wang X, Carrero H, Virata-Theimer ML, Sarnovsky R, Mannes AJ, FitzGerald DJ.

Mol Pain. 2017 Jan-Dec;13:1744806917727657. doi: 10.1177/1744806917727657.


RNA-Seq investigations of human post-mortem trigeminal ganglia.

LaPaglia DM, Sapio MR, Burbelo PD, Thierry-Mieg J, Thierry-Mieg D, Raithel SJ, Ramsden CE, Iadarola MJ, Mannes AJ.

Cephalalgia. 2018 Apr;38(5):912-932. doi: 10.1177/0333102417720216. Epub 2017 Jul 12.


Transcriptomic analyses of genes and tissues in inherited sensory neuropathies.

Sapio MR, Goswami SC, Gross JR, Mannes AJ, Iadarola MJ.

Exp Neurol. 2016 Sep;283(Pt A):375-395. doi: 10.1016/j.expneurol.2016.06.023. Epub 2016 Jun 23.


Transcriptomic Segregation of Human Autoantigens Useful for the Diagnosis of Autoimmune Diseases.

Burbelo PD, Iadarola MJ, Alevizos I, Sapio MR.

Mol Diagn Ther. 2016 Oct;20(5):415-27. doi: 10.1007/s40291-016-0211-6. Review.


Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules.

Lopes MW, Sapio MR, Leal RB, Fricker LD.

PLoS One. 2016 Apr 6;11(4):e0152905. doi: 10.1371/journal.pone.0152905. eCollection 2016.


A new splice of life for the μ-opioid receptor.

Iadarola MJ, Sapio MR, Mannes AJ.

J Clin Invest. 2015 Jul 1;125(7):2558-61. doi: 10.1172/JCI82060. Epub 2015 May 26.


Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy.

Sapio MR, Vessaz M, Thomas P, Genton P, Fricker LD, Salzmann A.

PLoS One. 2015 Apr 13;10(4):e0123180. doi: 10.1371/journal.pone.0123180. eCollection 2015.


Unique function of Kinesin Kif5A in localization of mitochondria in axons.

Campbell PD, Shen K, Sapio MR, Glenn TD, Talbot WS, Marlow FL.

J Neurosci. 2014 Oct 29;34(44):14717-32. doi: 10.1523/JNEUROSCI.2770-14.2014.


Carboxypeptidases in disease: insights from peptidomic studies.

Sapio MR, Fricker LD.

Proteomics Clin Appl. 2014 Jun;8(5-6):327-37. doi: 10.1002/prca.201300090. Epub 2014 Mar 24. Review.


Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development.

Lyons PJ, Sapio MR, Fricker LD.

J Biol Chem. 2013 Oct 18;288(42):30454-62. doi: 10.1074/jbc.M113.497933. Epub 2013 Sep 10.


Naturally occurring carboxypeptidase A6 mutations: effect on enzyme function and association with epilepsy.

Sapio MR, Salzmann A, Vessaz M, Crespel A, Lyons PJ, Malafosse A, Fricker LD.

J Biol Chem. 2012 Dec 14;287(51):42900-9. doi: 10.1074/jbc.M112.414094. Epub 2012 Oct 26.


Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity.

Guerra A, Sapio MR, Carrano M, Di Stasi V, Volpe A, Murino A, Izzo G, Vitale M.

J Endocrinol Invest. 2013 May;36(5):303-6. doi: 10.3275/8618. Epub 2012 Sep 24.


The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma.

Guerra A, Sapio MR, Marotta V, Campanile E, Rossi S, Forno I, Fugazzola L, Budillon A, Moccia T, Fenzi G, Vitale M.

J Clin Endocrinol Metab. 2012 Feb;97(2):517-24. doi: 10.1210/jc.2011-0618. Epub 2011 Dec 14.


RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint.

Marotta V, Guerra A, Sapio MR, Vitale M.

Eur J Endocrinol. 2011 Oct;165(4):499-507. doi: 10.1530/EJE-11-0499. Epub 2011 Jul 12. Review.


BRAF mutation in cytology samples as a diagnostic tool for papillary thyroid carcinoma.

Marotta V, Sapio MR, Guerra A, Vitale M.

Expert Opin Med Diagn. 2011 Jul;5(4):277-90. doi: 10.1517/17530059.2011.575058. Epub 2011 Apr 21.


High growth rate of benign thyroid nodules bearing RET/PTC rearrangements.

Sapio MR, Guerra A, Marotta V, Campanile E, Formisano R, Deandrea M, Motta M, Limone PP, Fenzi G, Rossi G, Vitale M.

J Clin Endocrinol Metab. 2011 Jun;96(6):E916-9. doi: 10.1210/jc.2010-1599. Epub 2011 Mar 16.


Prevalence of RET/PTC rearrangement in benign and malignant thyroid nodules and its clinical application.

Guerra A, Sapio MR, Marotta V, Campanile E, Moretti MI, Deandrea M, Motta M, Limone PP, Fenzi G, Rossi G, Vitale M.

Endocr J. 2011;58(1):31-8. Epub 2010 Dec 14.


Growing thyroid nodules with benign histology and RET rearrangement.

Marotta V, Guerra A, Sapio MR, Campanile E, Motta M, Fenzi G, Rossi G, Vitale M.

Endocr J. 2010;57(12):1081-7. Epub 2010 Oct 30.


Are RET/PTC rearrangements in benign thyroid nodules of biological significance?

Marotta V, Guerra A, Sapio MR, Campanile E, Motta M, Fenzi G, Rossi G, Vitale M.

Thyroid. 2010 Oct;20(10):1191-2. doi: 10.1089/thy.2010.0061. No abstract available.


The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.

Rusciano MR, Salzano M, Monaco S, Sapio MR, Illario M, De Falco V, Santoro M, Campiglia P, Pastore L, Fenzi G, Rossi G, Vitale M.

Endocr Relat Cancer. 2010 Jan 29;17(1):113-23. doi: 10.1677/ERC-09-0214. Print 2010 Mar.


Combined analysis of galectin-3 and BRAFV600E improves the accuracy of fine-needle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma.

Sapio MR, Guerra A, Posca D, Limone PP, Deandrea M, Motta M, Troncone G, Caleo A, Vallefuoco P, Rossi G, Fenzi G, Vitale M.

Endocr Relat Cancer. 2007 Dec;14(4):1089-97.


Detection of RET/PTC, TRK and BRAF mutations in preoperative diagnosis of thyroid nodules with indeterminate cytological findings.

Sapio MR, Posca D, Raggioli A, Guerra A, Marotta V, Deandrea M, Motta M, Limone PP, Troncone G, Caleo A, Rossi G, Fenzi G, Vitale M.

Clin Endocrinol (Oxf). 2007 May;66(5):678-83. Epub 2007 Mar 23.


Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA).

Sapio MR, Posca D, Troncone G, Pettinato G, Palombini L, Rossi G, Fenzi G, Vitale M.

Eur J Endocrinol. 2006 Feb;154(2):341-8.


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