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Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target.

Hughes MJ, McGettrick HM, Sapey E.

Eur Respir Rev. 2020 Mar 20;29(155). pii: 190102. doi: 10.1183/16000617.0102-2019. Print 2020 Mar 31. Review.


Comment on "E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation".

Jasper AE, Sapey E, Thickett D, Scott A.

Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C704-C705. doi: 10.1152/ajpcell.00554.2019. No abstract available.


The prevalence and significance of monoclonal gammopathy of undetermined significance in acute medical admissions.

Atkin C, Reddy-Kolanu V, Drayson MT, Sapey E, Richter AG.

Br J Haematol. 2020 Jan 30. doi: 10.1111/bjh.16487. [Epub ahead of print]


Described Practices for Assessing Fluid Resuscitation in Acute Hospital Care: A Qualitative Study.

Lloyd E, Ignatowicz A, Sapey E, Lasserson D, Seccombe A.

Acute Med. 2019;18(4):223-231.


Ageing, frailty and resilience in Botswana: rapid ageing, rapid change. Findings from a national working group meeting and literature review.

Onen BL, Harris C, Ignatowicz A, Davies J, Drouvelis M, Howes A, Nkomazana O, Onen CL, Sapey E, Tsima B, Lasserson D.

BMC Proc. 2019 Nov 19;13(Suppl 10):8. doi: 10.1186/s12919-019-0171-z. eCollection 2019.


Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.

Grudzinska FS, Brodlie M, Scholefield BR, Jackson T, Scott A, Thickett DR, Sapey E.

Thorax. 2020 Feb;75(2):164-171. doi: 10.1136/thoraxjnl-2018-212826. Epub 2019 Nov 15.


A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.


Neutrophil phenotypes in chronic lung disease.

Hughes MJ, Sapey E, Stockley R.

Expert Rev Respir Med. 2019 Oct;13(10):951-967. doi: 10.1080/17476348.2019.1654377. Epub 2019 Aug 21.


Building toolkits for COPD exacerbations: lessons from the past and present.

Sapey E, Bafadhel M, Bolton CE, Wilkinson T, Hurst JR, Quint JK.

Thorax. 2019 Sep;74(9):898-905. doi: 10.1136/thoraxjnl-2018-213035. Epub 2019 Jul 3.


Early identification of severe community-acquired pneumonia: a retrospective observational study.

Grudzinska FS, Aldridge K, Hughes S, Nightingale P, Parekh D, Bangash M, Dancer R, Patel J, Sapey E, Thickett DR, Dosanjh DP.

BMJ Open Respir Res. 2019 Jun 5;6(1):e000438. doi: 10.1136/bmjresp-2019-000438. eCollection 2019.


Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.

Sapey E, Patel JM, Greenwood H, Walton GM, Grudzinska F, Parekh D, Mahida RY, Dancer RCA, Lugg ST, Howells PA, Hazeldine J, Newby P, Scott A, Nightingale P, Hill AT, Thickett DR.

Am J Respir Crit Care Med. 2019 Nov 15;200(10):1282-1293. doi: 10.1164/rccm.201812-2328OC.


Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease?

Crossley D, Stockley R, Sapey E.

Drugs Aging. 2019 Sep;36(9):823-840. doi: 10.1007/s40266-019-00684-7. Review.


Bilateral Anterior Thigh Thickness: A New Diagnostic Tool for the Identification of Low Muscle Mass?

Wilson DV, Moorey H, Stringer H, Sahbudin I, Filer A, Lord JM, Sapey E.

J Am Med Dir Assoc. 2019 Oct;20(10):1247-1253.e2. doi: 10.1016/j.jamda.2019.04.005. Epub 2019 Jun 1.


Assessing Fluid Resuscitation in Adults with Sepsis Who Are Not Mechanically Ventilated: a Systematic Review of Diagnostic Test Accuracy Studies.

Seccombe A, McCluskey L, Moorey H, Lasserson D, Sapey E.

J Gen Intern Med. 2019 Sep;34(9):1874-1883. doi: 10.1007/s11606-019-05073-9. Epub 2019 May 31.


Getting stuck or choosing to stay? Neutrophil transit times in the lung in acute inflammation and COPD.

Sapey E, Stockley RA.

Thorax. 2019 Jul;74(7):631-632. doi: 10.1136/thoraxjnl-2018-213000. Epub 2019 May 16. No abstract available.


Understanding the role of neutrophils in chronic inflammatory airway disease.

Jasper AE, McIver WJ, Sapey E, Walton GM.

F1000Res. 2019 Apr 26;8. pii: F1000 Faculty Rev-557. doi: 10.12688/f1000research.18411.1. eCollection 2019. Review.


The challenges of muscle biopsy in a community based geriatric population.

Wilson D, Breen L, Lord JM, Sapey E.

BMC Res Notes. 2018 Nov 26;11(1):830. doi: 10.1186/s13104-018-3947-8.


What is the significance of monoclonal gammopathy of undetermined significance?

Atkin C, Richter A, Sapey E.

Clin Med (Lond). 2018 Oct;18(5):391-396. doi: 10.7861/clinmedicine.18-5-391. Review.


Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.

Crisford H, Sapey E, Stockley RA.

Respir Res. 2018 Sep 20;19(1):180. doi: 10.1186/s12931-018-0883-z. Review.


Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages.

Scott A, Lugg ST, Aldridge K, Lewis KE, Bowden A, Mahida RY, Grudzinska FS, Dosanjh D, Parekh D, Foronjy R, Sapey E, Naidu B, Thickett DR.

Thorax. 2018 Dec;73(12):1161-1169. doi: 10.1136/thoraxjnl-2018-211663. Epub 2018 Aug 13.


Neutrophilic Inflammation in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Butler A, Walton GM, Sapey E.

COPD. 2018 Jun-Aug;15(4):392-404. doi: 10.1080/15412555.2018.1476475. Epub 2018 Jul 31. Review.


What is the evidence base for fluid resuscitation in acute medicine? .

Seccombe A, Sapey E.

Clin Med (Lond). 2018 Jun;18(3):225-230. doi: 10.7861/clinmedicine.18-3-225. Review.


Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality.

Patel JM, Sapey E, Parekh D, Scott A, Dosanjh D, Gao F, Thickett DR.

Mediators Inflamm. 2018 Apr 11;2018:4065362. doi: 10.1155/2018/4065362. eCollection 2018.


COPD exacerbations: transforming outcomes through research.

Hurst JR, Bafadhel M, Bolton CE, Quint JK, Sapey E, Wilkinson TMA.

Lancet Respir Med. 2018 Mar;6(3):172-174. doi: 10.1016/S2213-2600(18)30049-3. Epub 2018 Feb 9. No abstract available.


Friend or foe? The dual role of neutrophils in lung injury and repair.

Grudzinska FS, Sapey E.

Thorax. 2018 Apr;73(4):305-307. doi: 10.1136/thoraxjnl-2017-211253. Epub 2018 Jan 29. No abstract available.


Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly.

Drew W, Wilson DV, Sapey E.

Exp Gerontol. 2018 May;105:70-77. doi: 10.1016/j.exger.2017.12.020. Epub 2017 Dec 28. Review.


Statin therapy in patients with community-acquired pneumonia.

Grudzinska FS, Dosanjh DP, Parekh D, Dancer RC, Patel J, Nightingale P, Walton GM, Sapey E, Thickett DR.

Clin Med (Lond). 2017 Oct;17(5):403-407. doi: 10.7861/clinmedicine.17-5-403.


Small airways disease: time for a revisit?

Stockley JA, Cooper BG, Stockley RA, Sapey E.

Int J Chron Obstruct Pulmon Dis. 2017 Aug 7;12:2343-2353. doi: 10.2147/COPD.S138540. eCollection 2017. Review.


Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.

Sapey E, Patel JM, Greenwood HL, Walton GM, Hazeldine J, Sadhra C, Parekh D, Dancer RCA, Nightingale P, Lord JM, Thickett DR.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1325-1336. doi: 10.1164/rccm.201704-0814OC.


Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

Hobbins S, Chapple IL, Sapey E, Stockley RA.

Int J Chron Obstruct Pulmon Dis. 2017 May 4;12:1339-1349. doi: 10.2147/COPD.S127802. eCollection 2017. Review.


Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review.

Edgar RG, Patel M, Bayliss S, Crossley D, Sapey E, Turner AM.

Int J Chron Obstruct Pulmon Dis. 2017 May 2;12:1295-1308. doi: 10.2147/COPD.S130440. eCollection 2017. Review.


Maximal mid-expiratory flow detects early lung disease in α1-antitrypsin deficiency.

Stockley JA, Ismail AM, Hughes SM, Edgar R, Stockley RA, Sapey E.

Eur Respir J. 2017 Mar 29;49(3). pii: 1602055. doi: 10.1183/13993003.02055-2016. Print 2017 Mar.


Frailty and sarcopenia: The potential role of an aged immune system.

Wilson D, Jackson T, Sapey E, Lord JM.

Ageing Res Rev. 2017 Jul;36:1-10. doi: 10.1016/j.arr.2017.01.006. Epub 2017 Feb 20. Review.


Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms.

McGuinness AJ, Sapey E.

J Clin Med. 2017 Feb 15;6(2). pii: E21. doi: 10.3390/jcm6020021. Review.


Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD?

Walton GM, Stockley JA, Griffiths D, Sadhra CS, Purvis T, Sapey E.

J Clin Med. 2016 Oct 11;5(10). pii: E89. Review.


Vitamin D Deficiency in Human and Murine Sepsis.

Parekh D, Patel JM, Scott A, Lax S, Dancer RC, D'Souza V, Greenwood H, Fraser WD, Gao F, Sapey E, Perkins GD, Thickett DR.

Crit Care Med. 2017 Feb;45(2):282-289. doi: 10.1097/CCM.0000000000002095.


Habitual physical activity is associated with the maintenance of neutrophil migratory dynamics in healthy older adults.

Bartlett DB, Fox O, McNulty CL, Greenwood HL, Murphy L, Sapey E, Goodman M, Crabtree N, Thøgersen-Ntoumani C, Fisher JP, Wagenmakers AJ, Lord JM.

Brain Behav Immun. 2016 Aug;56:12-20. doi: 10.1016/j.bbi.2016.02.024. Epub 2016 Feb 27.


Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).

Dancer RC, Parekh D, Lax S, D'Souza V, Zheng S, Bassford CR, Park D, Bartis DG, Mahida R, Turner AM, Sapey E, Wei W, Naidu B, Stewart PM, Fraser WD, Christopher KB, Cooper MS, Gao F, Sansom DM, Martineau AR, Perkins GD, Thickett DR.

Thorax. 2015 Jul;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680. Epub 2015 Apr 22.


Work-life balance in academic medicine.

Sapey E.

Lancet. 2015 Feb 26;385 Suppl 1:S6-7. doi: 10.1016/S0140-6736(15)60322-1. No abstract available.


Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial.

Greenwood H, Patel J, Mahida R, Wang Q, Parekh D, Dancer RC, Khiroya H, Sapey E, Thickett DR.

Trials. 2014 Aug 22;15:332. doi: 10.1186/1745-6215-15-332.


Red, amber and green: the role of the lung in de-priming active systemic neutrophils.

Sapey E, Stockley RA.

Thorax. 2014 Jul;69(7):606-8. doi: 10.1136/thoraxjnl-2014-205438. No abstract available.


Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.

Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM.

Aging Cell. 2014 Aug;13(4):690-8. doi: 10.1111/acel.12222. Epub 2014 Apr 30.


Children must be protected from the tobacco industry's marketing tactics.

Hopkinson N, Wallis C, Higgins B, Gaduzo S, Sherrington R, Keilty S, Stern M, Britton J, Bush A, Moxham J, Sylvester K, Griffiths V, Sutherland T, Crossingham I, Raju R, Spencer C, Safavi S, Deegan P, Seymour J, Hickman K, Hughes J, Wieboldt J, Shaheen F, Peedell C, Mackenzie N, Nicholl D, Jolley C, Crooks G, Crooks G, Dow C, Deveson P, Bintcliffe O, Gray B, Kumar S, Haney S, Docherty M, Thomas A, Chua F, Dwarakanath A, Summers G, Prowse K, Lytton S, Ong YE, Graves J, Banerjee T, English P, Leonard A, Brunet M, Chaudhry N, Ketchell RI, Cummings N, Lebus J, Sharp C, Meadows C, Harle A, Stewart T, Parry D, Templeton-Wright S, Moore-Gillon J, Stratford- Martin J, Saini S, Matusiewicz S, Merritt S, Dowson L, Satkunam K, Hodgson L, Suh ES, Durrington H, Browne E, Walters N, Steier J, Barry S, Griffiths M, Hart N, Nikolic M, Berry M, Thomas A, Miller J, McNicholl D, Marsden P, Warwick G, Barr L, Adeboyeku D, Mohd Noh MS, Griffiths P, Davies L, Quint J, Lyall R, Shribman J, Collins A, Goldman J, Bloch S, Gill A, Man W, Christopher A, Yasso R, Rajhan A, Shrikrishna D, Moore C, Absalom G, Booton R, Fowler RW, Mackinlay C, Sapey E, Lock S, Walker P, Jha A, Satia I, Bradley B, Mustfa N, Haqqee R, Thomas M, Patel A, Redington A, Pillai A, Keaney N, Fowler S, Lowe L, Brennan A, Morrison D, Murray C, Hankinson J, Dutta P, Maddocks M, Pengo M, Curtis K, Rafferty G, Hutchinson J, Whitfield R, Turner S, Breen R, Naveed SU, Goode C, Esterbrook G, Ahmed L, Walker W, Ford D, Connett G, Davidson P, Elston W, Stanton A, Morgan D, Myerson J, Maxwell D, Harrris A, Parmar S, Houghton C, Winter R, Puthucheary Z, Thomson F, Sturney S, Harvey J, Haslam PL, Patel I, Jennings D, Range S, Mallia-Milanes B, Collett A, Tate P, Russell R, Feary J, O'Driscoll R, Eaden J, Round J, Sharkey E, Montgomery M, Vaughan S, Scheele K, Lithgow A, Partridge S, Chavasse R, Restrick L, Agrawal S, Abdallah S, Lacy-Colson A, Adams N, Mitchell S, Haja Mydin H, Ward A, Denniston S, Steel M, Ghosh D, Connellan S, Rigge L, Williams R, Grove A, Anwar S, Dobson L, Hosker H, Stableforth D, Greening N, Howell T, Casswell G, Davies S, Tunnicliffe G, Mitchelmore P, Phitidis E, Robinson L, Prowse K, Bafadhel M, Robinson G, Boland A, Lipman M, Bourke S, Kaul S, Cowie C, Forrest I, Starren E, Burke H, Furness J, Bhowmik A, Everett C, Seaton D, Holmes S, Doe S, Parker S, Graham A, Paterson I, Maqsood U, Ohri C, Iles P, Kemp S, Iftikhar A, Carlin C, Fletcher T, Emerson P, Beasley V, Ramsay M, Buttery R, Mungall S, Crooks S, Ridyard J, Ross D, Guadagno A, Holden E, Coutts I, Cullen K, O'Connor S, Barker J, Sloper K, Watson J, Smith P, Anderson P, Brown L, Nyman C, Milburn H, Clive A, Serlin M, Bolton C, Fuld J, Powell H, Dayer M, Woolhouse I, Georgiadi A, Leonard H, Dodd J, Campbell I, Ruiz G, Zurek A, Paton JY, Malin A, Wood F, Hynes G, Connell D, Spencer D, Brown S, Smith D, Cooper D, O'Kane C, Hicks A, Creagh-Brown B, Lordan J, Nickol A, Primhak R, Fleming L, Powrie D, Brown J, Zoumot Z, Elkin S, Szram J, Scaffardi A, Marshall R, Macdonald I, Lightbody D, Farmer R, Wheatley I, Radnan P, Lane I, Booth A, Tilbrook S, Capstick T, Hewitt L, McHugh M, Nelson C, Wilson P, Padmanaban V, White J, Davison J, O'Callaghan U, Hodson M, Edwards J, Campbell C, Ward S, Wooler E, Ringrose E, Bridges D, Matthew Hodson, John Edwards, Colin Campbell, Simon Ward, Edwina Wooler, Elizabeth Ringrose, Diana Bridges, Rosalind Backham, Kim Randall, Tracey Mathieson, Long A, Parkes M, Clarke S, Allen B, Connelly C, Forster G, Hoadley J, Martin K, Barnham K, Khan K, Munday M, Edwards C, O'Hara D, Turner S, Pieri-Davies S, Ford K, Daniels T, Wright J, Towns R, Fern K, Butcher J, Burgin K, Winter B, Freeman D, Olive S, Gray L, Pye K, Roots D, Cox N, Davies CA, Wicker J, Hilton K, Lloyd J, MacBean V, Wood M, Kowal J, Downs J, Ryan H, Guyatt F, Nicoll D, Lyons E, Narasimhan D, Rodman A, Walmsley S, Newey A, Buxton M, Dewar M, Cooper A, Reilly J, Lloyd J, Macmillan AB, Roots D, Olley A, Voase N, Martin S, McCarvill I, Christensen A, Agate R, Heslop K, Timlett A, Hailes K, Davey C, Pawulska B, Lane A, Ioakim S, Hough A, Treharne J, Jones H, Winter-Burke A, Miller L, Connolly B, Bingham L, Fraser U, Bott J, Johnston C, Graham A, Curry D, Sumner H, Costello CA, Bartoszewicz C, Badman R, Williamson K, Taylor A, Purcell H, Barnett E, Molloy A, Crawfurd L, Collins N, Monaghan V, Mir M, Lord V, Stocks J, Edwards A, Greenhalgh T, Lenney W, McKee M, McAuley D, Majeed A, Cookson J, Baker E, Janes S, Wedzicha W, Lomas Dean D, Harrison B, Davison T, Calverley P, Wilson R, Stockley R, Ayres J, Gibson J, Simpson J, Burge S, Warner J, Lenney W, Thomson N, Davies P, Woodcock A, Woodhead M, Spiro S, Ormerod L, Bothamley G, Partridge M, Shields M, Montgomery H, Simonds A, Barnes P, Durham S, Malone S, Arabnia G, Olivier S, Gardiner K, Edwards S.

BMJ. 2013 Dec 9;347:f7358. doi: 10.1136/bmj.f7358. No abstract available.


Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.

Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall RH, Stockley RA, Lord JM.

Blood. 2014 Jan 9;123(2):239-48. doi: 10.1182/blood-2013-08-519520. Epub 2013 Nov 4.


Statins for sepsis: distinguishing signal from the noise when designing clinical trials.

Patel JM, Thickett DR, Gao F, Sapey E.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):874. doi: 10.1164/rccm.201302-0392LE. No abstract available.


Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target.

Stockley JA, Walton GM, Lord JM, Sapey E.

Int Immunopharmacol. 2013 Dec;17(4):1211-7. doi: 10.1016/j.intimp.2013.05.035. Epub 2013 Aug 27. Review.


An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity.

Duggal NA, Upton J, Phillips AC, Sapey E, Lord JM.

Aging Cell. 2013 Oct;12(5):873-81. doi: 10.1111/acel.12114. Epub 2013 Jul 19.


Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency.

Stone H, McNab G, Wood AM, Stockley RA, Sapey E.

Eur Respir J. 2012 Sep;40(3):561-9. doi: 10.1183/09031936.00162811. Epub 2012 Jun 14.

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