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Items: 1 to 50 of 411

1.

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts.

Lázaro-Gorines R, Ruiz-de-la-Herrán J, Navarro R, Sanz L, Álvarez-Vallina L, Martínez-Del-Pozo A, Gavilanes JG, Lacadena J.

Sci Rep. 2019 Aug 12;9(1):11680. doi: 10.1038/s41598-019-48285-z.

2.

Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka.

Pla D, Sanz L, Quesada-Bernat S, Villalta M, Baal J, Chowdhury MAW, León G, Gutiérrez JM, Kuch U, Calvete JJ.

J Proteomics. 2019 Jul 17;207:103443. doi: 10.1016/j.jprot.2019.103443. [Epub ahead of print]

PMID:
31325606
3.

Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness.

Annen J, Filippini MM, Bonin E, Cassol H, Aubinet C, Carrière M, Gosseries O, Thibaut A, Barra A, Wolff A, Sanz LRD, Martial C, Laureys S, Chatelle C.

Brain Inj. 2019;33(11):1409-1412. doi: 10.1080/02699052.2019.1644376. Epub 2019 Jul 18.

PMID:
31319707
4.

Substituted Aminoacetamides as Novel Leads for Malaria Treatment.

Norcross NR, Wilson C, Baragaña B, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Fletcher D, Sinden R, Delves M, Ruecker A, Duffy S, Meister S, Antonova-Koch Y, Crespo B, de Cózar C, Sanz LM, Gamo FJ, Avery VM, Frearson JA, Gray DW, Fairlamb AH, Winzeler EA, Waterson D, Campbell SF, Willis PA, Read KD, Gilbert IH.

ChemMedChem. 2019 Jul 17;14(14):1329-1335. doi: 10.1002/cmdc.201900329. Epub 2019 Jul 3.

PMID:
31188540
5.

Comparative venomics of Brazilian coral snakes: Micrurus frontalis, Micrurus spixii spixii, and Micrurus surinamensis.

Sanz L, de Freitas-Lima LN, Quesada-Bernat S, Graça-de-Souza VK, Soares AM, Calderón LA, Calvete JJ, Caldeira CAS.

Toxicon. 2019 Aug;166:39-45. doi: 10.1016/j.toxicon.2019.05.001. Epub 2019 May 12.

PMID:
31091423
6.

High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing.

Sanz LA, Chédin F.

Nat Protoc. 2019 Jun;14(6):1734-1755. doi: 10.1038/s41596-019-0159-1. Epub 2019 May 3.

PMID:
31053798
7.

New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America.

Sanz L, Quesada-Bernat S, Ramos T, Casais-E-Silva LL, Corrêa-Netto C, Silva-Haad JJ, Sasa M, Lomonte B, Calvete JJ.

J Proteomics. 2019 May 30;200:90-101. doi: 10.1016/j.jprot.2019.03.014. Epub 2019 Apr 1.

PMID:
30946991
8.

Treating Disorders of Consciousness With Apomorphine: Protocol for a Double-Blind Randomized Controlled Trial Using Multimodal Assessments.

Sanz LRD, Lejeune N, Blandiaux S, Bonin E, Thibaut A, Stender J, Farber NM, Zafonte RD, Schiff ND, Laureys S, Gosseries O.

Front Neurol. 2019 Mar 19;10:248. doi: 10.3389/fneur.2019.00248. eCollection 2019.

9.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

10.

When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species.

Zancolli G, Calvete JJ, Cardwell MD, Greene HW, Hayes WK, Hegarty MJ, Herrmann HW, Holycross AT, Lannutti DI, Mulley JF, Sanz L, Travis ZD, Whorley JR, Wüster CE, Wüster W.

Proc Biol Sci. 2019 Mar 13;286(1898):20182735. doi: 10.1098/rspb.2018.2735.

PMID:
30862287
11.

T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies.

Blanco B, Compte M, Lykkemark S, Sanz L, Alvarez-Vallina L.

Trends Immunol. 2019 Mar;40(3):243-257. doi: 10.1016/j.it.2019.01.008. Review.

PMID:
30827461
12.

Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.

Fagundez C, Sellanes D, Peña S, Scarone L, Aguiar ACC, de Souza JO, Guido RVC, Stewart L, Yardley V, Ottilie S, Winzeler EA, Gamo FJ, Sanz LM, Serra GL.

ACS Med Chem Lett. 2018 Dec 26;10(1):137-141. doi: 10.1021/acsmedchemlett.8b00543. eCollection 2019 Jan 10.

PMID:
30655961
13.

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine.

Loesbanluechai D, Kotanan N, de Cozar C, Kochakarn T, Ansbro MR, Chotivanich K, White NJ, Wilairat P, Lee MCS, Gamo FJ, Sanz LM, Chookajorn T, Kümpornsin K.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:16-22. doi: 10.1016/j.ijpddr.2018.11.004. Epub 2018 Dec 1.

14.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.

PMID:
30559138
15.

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.

Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L.

Nat Commun. 2018 Nov 15;9(1):4809. doi: 10.1038/s41467-018-07195-w.

16.

Cross-modal integration during value-driven attentional capture.

Sanz LRD, Vuilleumier P, Bourgeois A.

Neuropsychologia. 2018 Nov;120:105-112. doi: 10.1016/j.neuropsychologia.2018.10.014. Epub 2018 Oct 18.

PMID:
30342964
17.

Translational Venomics: Third-Generation Antivenomics of Anti-Siamese Russell's Viper, Daboia siamensis, Antivenom Manufactured in Taiwan CDC's Vaccine Center.

Sanz L, Quesada-Bernat S, Chen PY, Lee CD, Chiang JR, Calvete JJ.

Trop Med Infect Dis. 2018 Jun 15;3(2). pii: E66. doi: 10.3390/tropicalmed3020066.

18.

Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis.

Calvete JJ, Casewell NR, Hernández-Guzmán U, Quesada-Bernat S, Sanz L, Rokyta DR, Storey D, Albulescu LO, Wüster W, Smith CF, Schuett GW, Booth W.

Sci Rep. 2018 Aug 1;8(1):11539. doi: 10.1038/s41598-018-29791-y.

19.

DNA Topoisomerase I differentially modulates R-loops across the human genome.

Manzo SG, Hartono SR, Sanz LA, Marinello J, De Biasi S, Cossarizza A, Capranico G, Chedin F.

Genome Biol. 2018 Jul 30;19(1):100. doi: 10.1186/s13059-018-1478-1.

20.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.

21.

A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas.

Vindas J, Carrera Y, Lomonte B, Gutiérrez JM, Calvete JJ, Sanz L, Fernández J.

Int J Biol Macromol. 2018 Oct 15;118(Pt A):1-8. doi: 10.1016/j.ijbiomac.2018.06.028. Epub 2018 Jun 7.

PMID:
29886171
22.

Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies.

Mølgaard K, Harwood SL, Compte M, Merino N, Bonet J, Alvarez-Cienfuegos A, Mikkelsen K, Nuñez-Prado N, Alvarez-Mendez A, Sanz L, Blanco FJ, Alvarez-Vallina L.

Cancer Immunol Immunother. 2018 Aug;67(8):1251-1260. doi: 10.1007/s00262-018-2181-5. Epub 2018 Jun 4.

PMID:
29869168
23.

High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission-blocking drugs.

Duez J, Carucci M, Garcia-Barbazan I, Corral M, Perez O, Presa JL, Henry B, Roussel C, Ndour PA, Rosa NB, Sanz L, Gamo FJ, Buffet P.

Nat Protoc. 2018 Jun;13(6):1362-1376. doi: 10.1038/nprot.2018.035. Epub 2018 May 24.

PMID:
29844524
24.

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy.

Harwood SL, Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Hernández-Pérez S, Merino N, Bonet J, Navarro R, Van Bergen En Henegouwen PMP, Lykkemark S, Mikkelsen K, Mølgaard K, Jabs F, Sanz L, Blanco FJ, Roda-Navarro P, Alvarez-Vallina L.

Oncoimmunology. 2017 Sep 27;7(1):e1377874. doi: 10.1080/2162402X.2017.1377874. eCollection 2017.

25.

Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam.

Pla D, Petras D, Saviola AJ, Modahl CM, Sanz L, Pérez A, Juárez E, Frietze S, Dorrestein PC, Mackessy SP, Calvete JJ.

J Proteomics. 2018 Mar 1;174:71-84. doi: 10.1016/j.jprot.2017.12.020. Epub 2017 Dec 29.

PMID:
29292096
26.

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

Abla N, Bashyam S, Charman SA, Greco B, Hewitt P, Jiménez-Díaz MB, Katneni K, Kubas H, Picard D, Sambandan Y, Sanz L, Smith D, Wang T, Willis P, Wittlin S, Spangenberg T.

ACS Med Chem Lett. 2017 Nov 28;8(12):1304-1308. doi: 10.1021/acsmedchemlett.7b00391. eCollection 2017 Dec 14.

27.

Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes.

Rodríguez-Rodero S, Menéndez-Torre E, Fernández-Bayón G, Morales-Sánchez P, Sanz L, Turienzo E, González JJ, Martinez-Faedo C, Suarez-Gutiérrez L, Ares J, Díaz-Naya L, Martin-Nieto A, Fernández-Morera JL, Fraga MF, Delgado-Álvarez E.

PLoS One. 2017 Dec 11;12(12):e0189153. doi: 10.1371/journal.pone.0189153. eCollection 2017.

28.

Examination of biochemical and biological activities of Bothrops jararaca (Serpentes: Viperidae; Wied-Neuwied 1824) snake venom after up to 54 years of storage.

Hatakeyama DM, de Morais-Zani K, Serino-Silva C, Grego KF, Sant'Anna SS, Fernandes W, Aniz PAEA, Torquato RJS, Tanaka AS, Sanz L, Calvete JJ, Tanaka-Azevedo AM.

Toxicon. 2018 Jan;141:34-42. doi: 10.1016/j.toxicon.2017.11.011. Epub 2017 Nov 24.

PMID:
29179989
29.

Approximate reduction of linear population models governed by stochastic differential equations: application to multiregional models.

Sanz L, Alonso JA.

J Biol Dyn. 2017 Dec;11(1):461-479. doi: 10.1080/17513758.2017.1380852.

PMID:
28975868
30.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

31.

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.

Madrigal M, Pla D, Sanz L, Barboza E, Arroyo-Portilla C, Corrêa-Netto C, Gutiérrez JM, Alape-Girón A, Flores-Díaz M, Calvete JJ.

PLoS Negl Trop Dis. 2017 Aug 7;11(8):e0005793. doi: 10.1371/journal.pntd.0005793. eCollection 2017 Aug.

32.

Integrated Venomics and Venom Gland Transcriptome Analysis of Juvenile and Adult Mexican Rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus Revealed miRNA-modulated Ontogenetic Shifts.

Durban J, Sanz L, Trevisan-Silva D, Neri-Castro E, Alagón A, Calvete JJ.

J Proteome Res. 2017 Sep 1;16(9):3370-3390. doi: 10.1021/acs.jproteome.7b00414. Epub 2017 Aug 7.

PMID:
28731347
33.

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J.

J Med Chem. 2017 Jul 13;60(13):5889-5908. doi: 10.1021/acs.jmedchem.7b00621. Epub 2017 Jun 29.

PMID:
28635296
34.

Venom On-a-Chip: A Fast and Efficient Method for Comparative Venomics.

Zancolli G, Sanz L, Calvete JJ, Wüster W.

Toxins (Basel). 2017 May 28;9(6). pii: E179. doi: 10.3390/toxins9060179.

35.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA.

Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.

36.

Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead.

Gutiérrez JM, Solano G, Pla D, Herrera M, Segura Á, Vargas M, Villalta M, Sánchez A, Sanz L, Lomonte B, León G, Calvete JJ.

Toxins (Basel). 2017 May 13;9(5). pii: E163. doi: 10.3390/toxins9050163. Review.

37.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735.

38.

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.

Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ.

Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574.

39.

What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus.

Pla D, Sanz L, Whiteley G, Wagstaff SC, Harrison RA, Casewell NR, Calvete JJ.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):814-823. doi: 10.1016/j.bbagen.2017.01.020. Epub 2017 Jan 24.

40.

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.

Mølgaard K, Compte M, Nuñez-Prado N, Harwood SL, Sanz L, Alvarez-Vallina L.

Gene Ther. 2017 Apr;24(4):208-214. doi: 10.1038/gt.2017.3. Epub 2017 Jan 11.

41.

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.

Navarro R, Compte M, Álvarez-Vallina L, Sanz L.

Front Immunol. 2016 Nov 4;7:480. eCollection 2016. Review.

42.

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing.

Millán-Uclés Á, Zuluaga S, Marqués M, Vallejo-Díaz J, Sanz L, Cariaga-Martínez AE, Real FX, Carrera AC.

Oncotarget. 2016 Dec 20;7(51):84054-84071. doi: 10.18632/oncotarget.13414.

43.

Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken.

Atikuzzaman M, Sanz L, Pla D, Alvarez-Rodriguez M, Rubér M, Wright D, Calvete JJ, Rodriguez-Martinez H.

Comp Biochem Physiol Part D Genomics Proteomics. 2017 Mar;21:27-40. doi: 10.1016/j.cbd.2016.10.006. Epub 2016 Nov 3.

44.

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

Pla D, Sanz L, Sasa M, Acevedo ME, Dwyer Q, Durban J, Pérez A, Rodriguez Y, Lomonte B, Calvete JJ.

J Proteomics. 2017 Jan 30;152:1-12. doi: 10.1016/j.jprot.2016.10.006. Epub 2016 Oct 21.

PMID:
27777178
45.

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.

Lomonte B, Rey-Suárez P, Fernández J, Sasa M, Pla D, Vargas N, Bénard-Valle M, Sanz L, Corrêa-Netto C, Núñez V, Alape-Girón A, Alagón A, Gutiérrez JM, Calvete JJ.

Toxicon. 2016 Nov;122:7-25. doi: 10.1016/j.toxicon.2016.09.008. Epub 2016 Sep 15. Review.

PMID:
27641749
46.

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms.

Pla D, Bande BW, Welton RE, Paiva OK, Sanz L, Segura Á, Wright CE, Calvete JJ, Gutiérrez JM, Williams DJ.

J Proteomics. 2017 Jan 6;150:201-215. doi: 10.1016/j.jprot.2016.09.007. Epub 2016 Sep 17.

PMID:
27650695
47.

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif.

Camacho E, Sanz L, Escalante T, Pérez A, Villalta F, Lomonte B, Neves-Ferreira AG, Feoli A, Calvete JJ, Gutiérrez JM, Rucavado A.

Toxins (Basel). 2016 Oct 12;8(10). pii: E292.

48.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Le Bihan A, de Kanter R, Angulo-Barturen I, Binkert C, Boss C, Brun R, Brunner R, Buchmann S, Burrows J, Dechering KJ, Delves M, Ewerling S, Ferrer S, Fischli C, Gamo-Benito FJ, Gnädig NF, Heidmann B, Jiménez-Díaz MB, Leroy D, Martínez MS, Meyer S, Moehrle JJ, Ng CL, Noviyanti R, Ruecker A, Sanz LM, Sauerwein RW, Scheurer C, Schleiferboeck S, Sinden R, Snyder C, Straimer J, Wirjanata G, Marfurt J, Price RN, Weller T, Fischli W, Fidock DA, Clozel M, Wittlin S.

PLoS Med. 2016 Oct 4;13(10):e1002138. doi: 10.1371/journal.pmed.1002138. eCollection 2016 Oct.

49.

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.

Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA.

Elife. 2016 Aug 23;5. pii: e17548. doi: 10.7554/eLife.17548.

50.

Development and validation of a short version of the Spanish pediatric voice handicap index (P-VHI-10).

Sanz L, Bau P, Arribas I, Rivera T.

Int J Pediatr Otorhinolaryngol. 2016 Sep;88:113-6. doi: 10.1016/j.ijporl.2016.06.053. Epub 2016 Jul 5.

PMID:
27497397

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